KR101901467B1 - 안정성이 증가되고 보유 촉매 활성이 증가된 변종 재조합 베타-글루코세레브로시다제 단백질 - Google Patents
안정성이 증가되고 보유 촉매 활성이 증가된 변종 재조합 베타-글루코세레브로시다제 단백질 Download PDFInfo
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- KR101901467B1 KR101901467B1 KR1020137014671A KR20137014671A KR101901467B1 KR 101901467 B1 KR101901467 B1 KR 101901467B1 KR 1020137014671 A KR1020137014671 A KR 1020137014671A KR 20137014671 A KR20137014671 A KR 20137014671A KR 101901467 B1 KR101901467 B1 KR 101901467B1
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| US20220125892A1 (en) * | 2019-02-01 | 2022-04-28 | OXYRANE UK Ltd. | Glucocerebrosidase polypeptides |
| BR112021015312A2 (pt) | 2019-02-04 | 2021-11-09 | Freeline Therapeutics Ltd | Polinucleotídeos, partícula viral e composição |
| US20220325265A1 (en) | 2019-09-09 | 2022-10-13 | Hoffmann-La Roche Inc. | Glucocerebrosidase mutants |
| KR20230003492A (ko) * | 2020-03-29 | 2023-01-06 | 예다 리서치 앤드 디벨럽먼트 캄파니 리미티드 | 고셔병 치료용 베타-글루코세레브로시다아제 변이체 |
| EP4118200B1 (en) * | 2020-07-29 | 2025-10-08 | Spur Therapeutics Limited | Mutated beta-glucocerebrosidase with improved stability |
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| US20250129351A1 (en) * | 2022-01-31 | 2025-04-24 | Nippon Shokubai Co., Ltd. | Recombinant glucocerebrosidase protein having improved enzyme activity or improved stability |
| US20250145979A1 (en) * | 2022-01-31 | 2025-05-08 | Nippon Shokubai Co., Ltd. | Protein having glucocerebrosidase activity and method for producing same |
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| WO2026006173A1 (en) * | 2024-06-24 | 2026-01-02 | Denali Therapeutics Inc. | Fusion proteins comprising modified glucocerebrosidase polypeptides and methods thereof |
Citations (4)
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|---|---|---|---|---|
| US20020127219A1 (en) | 1999-12-30 | 2002-09-12 | Okkels Jens Sigurd | Lysosomal enzymes and lysosomal enzyme activators |
| US20030215435A1 (en) | 2000-04-06 | 2003-11-20 | Berent Susan L | Expression system for effeiciently producing clinically effective lysosomal enzymes (glucocerebrosidase) |
| JP2004504016A (ja) | 2000-06-30 | 2004-02-12 | マキシゲン・エイピーエス | ペプチド拡張されたグリコシル化ポリペプチド |
| US20070166813A1 (en) | 2003-04-16 | 2007-07-19 | Anthony Futerman | Gaucher disease drugs and methods of identifying same |
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| JPH03503721A (ja) * | 1988-12-23 | 1991-08-22 | ジェンザイム コーポレイション | 酵素的に活性な組換えグルコセレブロシダーゼ |
| WO1990007573A1 (en) | 1988-12-23 | 1990-07-12 | Genzyme Corporation | Enzymatically active recombinant glucocerebrosidase |
| NZ500694A (en) * | 1997-04-30 | 2001-09-28 | Univ Minnesota | Use of chimeric mutational vector (CMV), a macromolecule and a ligand for cell surface receptor adhesion molecule (clatherin) in gene therapy; the CMV vector derived from REC2 homologous pairing with Ustilago maydis |
| US6524613B1 (en) | 1997-04-30 | 2003-02-25 | Regents Of The University Of Minnesota | Hepatocellular chimeraplasty |
| IL135578A0 (en) * | 1997-10-29 | 2001-05-20 | Genzyme Corp | Compositions and methods for treating lysosomal storage disease |
| CA2340276A1 (en) | 1998-08-28 | 2000-03-09 | Duke University | Adenoviruses deleted in the iva2, 100k and/or preterminal protein sequences |
| AU2352201A (en) | 1999-12-30 | 2001-07-16 | Maxygen Aps | Improved lysosomal enzymes and lysosomal enzyme activators |
| US20050265988A1 (en) * | 2004-03-18 | 2005-12-01 | Byung-Kwon Choi | Glycosylated glucocerebrosidase expression in fungal hosts |
| EP2150254A4 (en) * | 2007-04-26 | 2010-11-10 | Amicus Therapeutics Inc | DOSAGES FOR THE TREATMENT OF LYSOSOMAL STORAGE DISEASES WITH PHARMACOLOGICAL CHAPTERONES |
| KR101650726B1 (ko) * | 2007-05-22 | 2016-08-24 | 아미쿠스 세라퓨틱스, 인코포레이티드 | 이소파고민과 이의 유도체를 제조하는 새로운 방법 |
| US9150849B2 (en) | 2007-11-02 | 2015-10-06 | The Scripps Research Institute | Directed evolution using proteins comprising unnatural amino acids |
| WO2009059056A2 (en) | 2007-11-02 | 2009-05-07 | The Scripps Research Institute | A genetically encoded boronate amino acid |
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Patent Citations (4)
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| US20020127219A1 (en) | 1999-12-30 | 2002-09-12 | Okkels Jens Sigurd | Lysosomal enzymes and lysosomal enzyme activators |
| US20030215435A1 (en) | 2000-04-06 | 2003-11-20 | Berent Susan L | Expression system for effeiciently producing clinically effective lysosomal enzymes (glucocerebrosidase) |
| JP2004504016A (ja) | 2000-06-30 | 2004-02-12 | マキシゲン・エイピーエス | ペプチド拡張されたグリコシル化ポリペプチド |
| US20070166813A1 (en) | 2003-04-16 | 2007-07-19 | Anthony Futerman | Gaucher disease drugs and methods of identifying same |
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