ES2725688T3 - Método novedoso para la producción de células diferenciadas - Google Patents

Método novedoso para la producción de células diferenciadas Download PDF

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Publication number
ES2725688T3
ES2725688T3 ES16202612T ES16202612T ES2725688T3 ES 2725688 T3 ES2725688 T3 ES 2725688T3 ES 16202612 T ES16202612 T ES 16202612T ES 16202612 T ES16202612 T ES 16202612T ES 2725688 T3 ES2725688 T3 ES 2725688T3
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cells
gene
myc
oncogene
differentiation
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Spanish (es)
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Koji Eto
Sou Nakamura
Hiromitsu Nakauchi
Naoya Takayama
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University of Tokyo NUC
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University of Tokyo NUC
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0641Erythrocytes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/18Erythrocytes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0644Platelets; Megakaryocytes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0647Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40Regulators of development
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40Regulators of development
    • C12N2501/48Regulators of apoptosis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60Transcription factors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60Transcription factors
    • C12N2501/606Transcription factors c-Myc
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/45Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Diabetes (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
ES16202612T 2009-09-15 2010-09-15 Método novedoso para la producción de células diferenciadas Active ES2725688T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2009213645 2009-09-15

Publications (1)

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ES2725688T3 true ES2725688T3 (es) 2019-09-26

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ES16202612T Active ES2725688T3 (es) 2009-09-15 2010-09-15 Método novedoso para la producción de células diferenciadas
ES10817186.9T Active ES2664194T3 (es) 2009-09-15 2010-09-15 Método novedoso para la producción de células diferenciadas

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Country Status (13)

Country Link
US (2) US9200254B2 (enExample)
EP (2) EP3159001B1 (enExample)
JP (4) JP5791191B2 (enExample)
KR (2) KR101834687B1 (enExample)
CN (2) CN102712906B (enExample)
AU (1) AU2010296415B2 (enExample)
BR (2) BR122013008030B8 (enExample)
CA (1) CA2774193C (enExample)
DK (2) DK2500418T3 (enExample)
ES (2) ES2725688T3 (enExample)
IN (1) IN2012DN02642A (enExample)
RU (2) RU2603094C2 (enExample)
WO (1) WO2011034073A1 (enExample)

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CN114558032B (zh) 2012-12-21 2025-07-29 安斯泰来再生医药协会 由多能干细胞制备血小板的方法及其组合物
US20160002599A1 (en) 2013-02-08 2016-01-07 Kyoto University Production methods for megakaryocytes and platelets
JP6385340B2 (ja) * 2013-04-12 2018-09-05 国立大学法人京都大学 巨核球の成熟化促進物質
EP2987852A4 (en) 2013-04-17 2016-09-07 Nissan Chemical Ind Ltd MEDIA COMPOSITION AND METHOD FOR THE PRODUCTION OF ERYTHROCYTES THEREWITH
CN111876387A (zh) * 2013-05-15 2020-11-03 罗切斯特大学 人广泛自我更新型成红细胞(esre)
US10112977B2 (en) 2014-06-23 2018-10-30 Toagosei Co., Ltd. Peptide for inducing multinucleation in cells, and use therefor
AU2016230059A1 (en) * 2015-03-09 2017-09-28 Kyoto University Method for producing culture containing megakaryocytes, and method for producing platelets using same
CN107709543B (zh) * 2015-04-14 2021-11-09 国立大学法人京都大学 制造适于向体细胞分化诱导的干细胞克隆的方法
KR20160129609A (ko) 2015-04-30 2016-11-09 삼성전자주식회사 Braf 저해제를 포함하는 세포 또는 개체의 노화를 감소시키기 위한 조성물 및 그의 용도
DK3372674T3 (da) * 2015-11-02 2020-10-12 Megakaryon Corp Fremgangsmåde til fremstilling af blodplader under anvendelse af røreindretning med frem- og tilbagegående rørebevægelse
EP3453759B1 (en) 2016-01-29 2023-08-30 Kyoto University Platelet production promoter and method of producing platelets using same
EP3409774B1 (en) 2016-01-29 2025-03-19 Kyoto University Screening method of platelet production promoter
WO2018164040A1 (ja) 2017-03-06 2018-09-13 国立大学法人京都大学 血小板の製造方法
FR3068366B1 (fr) * 2017-06-30 2023-11-24 Francais Du Sang Ets Procede de production de progeniteurs erythroides
US12600948B2 (en) 2017-07-07 2026-04-14 Kyoto University Method and apparatus for producing platelet and method for determining operating condition of apparatus for producing platelet
JP7323126B2 (ja) 2017-09-19 2023-08-08 株式会社メガカリオン 精製血小板の製造方法、血小板製剤の製造方法、血液製剤の製造方法、血小板保存液、血小板保存剤および血小板の保存方法
US12091683B2 (en) 2017-09-19 2024-09-17 Megakaryon Corporation Method for producing platelets, method for producing platelet product, and method for producing blood product
MX2020007071A (es) * 2018-01-05 2020-11-11 Platelet Biogenesis Inc Composiciones y metodos para producir megacariocitos.
EP3813853A4 (en) 2018-06-29 2022-04-06 Platelet Biogenesis, Inc. DELIVERY COMPOSITIONS AND METHODS OF USE
TW202045202A (zh) * 2019-02-25 2020-12-16 國立陽明大學 用於治療肺纖維化和肺氣腫的組合物及其使用方法
AU2020265737A1 (en) * 2019-05-01 2021-12-02 Immunebridge Inc. Methods of making oligopotent and unipotent precursors
US20230030814A1 (en) 2019-12-12 2023-02-02 National University Corporation Chiba University Freeze-Dried Preparations Comprising Megakaryocytes and Platelets
JP7850558B2 (ja) 2019-12-13 2026-04-23 株式会社メガカリオン 組成物およびその用途
US20230399617A1 (en) 2020-10-27 2023-12-14 Nagasaki University Osteogenic composition and use thereof
JP7716851B2 (ja) * 2020-12-28 2025-08-01 イビデン株式会社 凍結保存液
KR20240019327A (ko) 2021-06-18 2024-02-14 가부시키가이샤 메가카리온 혈소판 산생능이 증강된 다핵화 거핵구 세포의 제조 방법, 혈소판의 제조 방법, 혈소판 제제의 제조 방법 및 혈액 제제의 제조 방법
US20240301353A1 (en) 2021-06-30 2024-09-12 National University Corporation Chiba University Method for improving proliferative properties of common myeloid progenitor cells (cmp) or myelocytic progenitor cells
US20250346860A1 (en) * 2022-07-04 2025-11-13 Artblood Inc. Establishment of immortalized erythroid progenitor cell line with superior capability of differentiating into red blood cells by using genetic overexpression combination, preparation method therefor, and use thereof
WO2024085650A1 (ko) 2022-10-18 2024-04-25 의료법인 성광의료재단 줄기세포에서 혈소판 전구세포로의 분화 유도용 배지 조성물 및 이를 이용한 분화 방법
KR20250142323A (ko) 2022-12-28 2025-09-30 고쿠리츠 다이가쿠 호우징 지바 다이가쿠 세포분화도의 조절 방법
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Publication number Publication date
BR122013008030B1 (pt) 2021-01-05
RU2012114427A (ru) 2013-10-27
AU2010296415B2 (en) 2014-07-03
US20120238023A1 (en) 2012-09-20
KR20120064109A (ko) 2012-06-18
JP5791191B2 (ja) 2015-10-07
JP6265437B2 (ja) 2018-01-24
WO2011034073A1 (ja) 2011-03-24
KR20160121592A (ko) 2016-10-19
US10087419B2 (en) 2018-10-02
JPWO2011034073A1 (ja) 2013-02-14
KR101667834B1 (ko) 2016-10-20
CN105385659A (zh) 2016-03-09
CA2774193C (en) 2020-08-25
ES2664194T3 (es) 2018-04-18
RU2661107C1 (ru) 2018-07-11
CA2774193A1 (en) 2011-03-24
DK2500418T3 (en) 2018-04-30
IN2012DN02642A (enExample) 2015-09-11
CN102712906B (zh) 2015-09-30
RU2603094C2 (ru) 2016-11-20
EP2500418B1 (en) 2018-01-17
JP2017046719A (ja) 2017-03-09
JP6382917B2 (ja) 2018-08-29
JP2015213520A (ja) 2015-12-03
US20160115449A1 (en) 2016-04-28
DK3159001T3 (da) 2019-06-17
US9200254B2 (en) 2015-12-01
EP3159001B1 (en) 2019-03-06
BR122013008030A2 (pt) 2019-08-06
KR101834687B1 (ko) 2018-03-05
JP2015130866A (ja) 2015-07-23
BR112012005710B1 (pt) 2020-06-09
EP3159001A1 (en) 2017-04-26
AU2010296415A1 (en) 2012-04-05
CN102712906A (zh) 2012-10-03
BR112012005710A2 (pt) 2017-11-21
EP2500418A4 (en) 2013-04-10
EP2500418A1 (en) 2012-09-19
BR122013008030B8 (pt) 2021-07-27
CN105385659B (zh) 2019-06-28

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