BR122013008030B8 - método para produzir células eritroides e método para produzir um produto sanguíneo - Google Patents
método para produzir células eritroides e método para produzir um produto sanguíneoInfo
- Publication number
- BR122013008030B8 BR122013008030B8 BR122013008030A BR122013008030A BR122013008030B8 BR 122013008030 B8 BR122013008030 B8 BR 122013008030B8 BR 122013008030 A BR122013008030 A BR 122013008030A BR 122013008030 A BR122013008030 A BR 122013008030A BR 122013008030 B8 BR122013008030 B8 BR 122013008030B8
- Authority
- BR
- Brazil
- Prior art keywords
- cells
- producing
- differentiation
- desired stage
- blood product
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 7
- 210000000267 erythroid cell Anatomy 0.000 title abstract 3
- 239000010836 blood and blood product Substances 0.000 title abstract 2
- 229940125691 blood product Drugs 0.000 title abstract 2
- 210000004027 cell Anatomy 0.000 abstract 9
- 230000004069 differentiation Effects 0.000 abstract 4
- 108700020796 Oncogene Proteins 0.000 abstract 2
- 230000024245 cell differentiation Effects 0.000 abstract 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000026969 oncogene-induced senescence Effects 0.000 abstract 1
- -1 population of cells Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0641—Erythrocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/18—Erythrocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0644—Platelets; Megakaryocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/48—Regulators of apoptosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/606—Transcription factors c-Myc
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Developmental Biology & Embryology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Virology (AREA)
- Oncology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009-213645 | 2009-09-15 | ||
| JP2009213645 | 2009-09-15 | ||
| BR112012005710A BR112012005710B1 (pt) | 2009-09-15 | 2010-09-15 | método para produzir células megacariotícas maduras, método para produzir um produto de plaqueta, método para produzir um produto sanguíneo, população celular, composição celular congelada e kit |
| PCT/JP2010/065903 WO2011034073A1 (ja) | 2009-09-15 | 2010-09-15 | 分化細胞の新規製造法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BR122013008030A2 BR122013008030A2 (pt) | 2019-08-06 |
| BR122013008030B1 BR122013008030B1 (pt) | 2021-01-05 |
| BR122013008030B8 true BR122013008030B8 (pt) | 2021-07-27 |
Family
ID=43758674
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR122013008030A BR122013008030B8 (pt) | 2009-09-15 | 2010-09-15 | método para produzir células eritroides e método para produzir um produto sanguíneo |
| BR112012005710A BR112012005710B1 (pt) | 2009-09-15 | 2010-09-15 | método para produzir células megacariotícas maduras, método para produzir um produto de plaqueta, método para produzir um produto sanguíneo, população celular, composição celular congelada e kit |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112012005710A BR112012005710B1 (pt) | 2009-09-15 | 2010-09-15 | método para produzir células megacariotícas maduras, método para produzir um produto de plaqueta, método para produzir um produto sanguíneo, população celular, composição celular congelada e kit |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US9200254B2 (enExample) |
| EP (2) | EP3159001B1 (enExample) |
| JP (4) | JP5791191B2 (enExample) |
| KR (2) | KR101667834B1 (enExample) |
| CN (2) | CN102712906B (enExample) |
| AU (1) | AU2010296415B2 (enExample) |
| BR (2) | BR122013008030B8 (enExample) |
| CA (1) | CA2774193C (enExample) |
| DK (2) | DK2500418T3 (enExample) |
| ES (2) | ES2725688T3 (enExample) |
| IN (1) | IN2012DN02642A (enExample) |
| RU (2) | RU2603094C2 (enExample) |
| WO (1) | WO2011034073A1 (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10034900B2 (en) | 2010-09-30 | 2018-07-31 | National University Corporation Kumamoto University | Method of producing myeloid blood cells |
| KR101572344B1 (ko) * | 2011-05-13 | 2015-11-26 | 고쿠리츠다이가쿠호우진 도쿄다이가쿠 | 다핵화 거핵구 세포, 및 혈소판의 제조방법 |
| US20140227780A1 (en) * | 2011-10-03 | 2014-08-14 | Nissan Chemical Industries, Ltd. | Method for producing megakaryocytes and/or platelets from pluripotent stem cells |
| GB201210857D0 (en) | 2012-06-19 | 2012-08-01 | Cambridge Entpr Ltd | Transcription factor mediated programming towards megakaryocytes |
| CN114558032B (zh) | 2012-12-21 | 2025-07-29 | 安斯泰来再生医药协会 | 由多能干细胞制备血小板的方法及其组合物 |
| EP2955223B1 (en) * | 2013-02-08 | 2019-12-18 | Kyoto University | Production methods for megakaryocytes and platelets |
| JP6385340B2 (ja) * | 2013-04-12 | 2018-09-05 | 国立大学法人京都大学 | 巨核球の成熟化促進物質 |
| WO2014171486A1 (ja) | 2013-04-17 | 2014-10-23 | 日産化学工業株式会社 | 培地組成物及び当該培地組成物を用いた赤血球の製造方法 |
| EP2997135B1 (en) * | 2013-05-15 | 2020-04-29 | University Of Rochester | Human extensively self-renewing erythroblasts (esre) |
| WO2015199039A1 (ja) | 2014-06-23 | 2015-12-30 | 東亞合成株式会社 | 細胞の多核化を誘導するペプチドおよびその利用 |
| WO2016143836A1 (ja) | 2015-03-09 | 2016-09-15 | 株式会社メガカリオン | 巨核球を含む培養物の製造方法及びこれを用いた血小板の製造方法 |
| BR112017022219A2 (pt) * | 2015-04-14 | 2018-07-31 | Univ Kyoto | método para produzir clone de célula-tronco adequado para induzir a diferenciação em células somáticas |
| KR20160129609A (ko) | 2015-04-30 | 2016-11-09 | 삼성전자주식회사 | Ｂｒａｆ 저해제를 포함하는 세포 또는 개체의 노화를 감소시키기 위한 조성물 및 그의 용도 |
| RU2741871C2 (ru) * | 2015-11-02 | 2021-01-29 | Мегакарион Корпорейшн | Способ получения тромбоцитов с помощью устройства для возвратно-поступательного перемешивания |
| WO2017131230A1 (ja) | 2016-01-29 | 2017-08-03 | 国立大学法人京都大学 | 血小板産生促進剤及びそれを用いた血小板の製造方法 |
| ES3016741T3 (en) | 2016-01-29 | 2025-05-09 | Univ Kyoto | Screening method of platelet production promoter |
| JP7297203B2 (ja) | 2017-03-06 | 2023-06-26 | 国立大学法人京都大学 | 血小板の製造方法 |
| FR3068366B1 (fr) * | 2017-06-30 | 2023-11-24 | Francais Du Sang Ets | Procede de production de progeniteurs erythroides |
| EP3650535A4 (en) | 2017-07-07 | 2021-03-17 | Kyoto University | PROCESS AND APPARATUS FOR THE PRODUCTION OF PLATES AND METHOD FOR DETERMINING OPERATING CONDITIONS IN AN APPARATUS FOR THE PRODUCTION OF PLATES |
| WO2019059234A1 (ja) | 2017-09-19 | 2019-03-28 | 株式会社メガカリオン | 血小板の製造方法、血小板製剤の製造方法、および血液製剤の製造方法 |
| EP3679938A4 (en) | 2017-09-19 | 2021-06-09 | Megakaryon Corporation | PROCESS FOR MANUFACTURING PURIFIED BLOOD PLATES, PROCESS FOR MANUFACTURING THE PREPARATION OF BLOOD PLATES, PROCESS FOR MANUFACTURING BLOOD PREPARATION, BLOOD PLATE PRESERVATION FLUID, BLOOD PLATE CONSERVATION AGENT AND PLATELET CONSERVATION |
| JP2021509812A (ja) | 2018-01-05 | 2021-04-08 | プレートレット バイオジェネシス， インコーポレイテッド | 巨核球を産生するための組成物および方法 |
| WO2020006539A1 (en) | 2018-06-29 | 2020-01-02 | Platelet Biogenesis, Inc. | Compositions for drug delivery and methods of use thereof |
| US20200268839A1 (en) * | 2019-02-25 | 2020-08-27 | National Yang-Ming University | Composition for treating pulmonary fibrosis and emphysema and therapeutic method using the same |
| SG11202111911TA (en) * | 2019-05-01 | 2021-11-29 | Transfusion Health Llc | Methods of making oligopotent and unipotent precursors |
| WO2021117886A1 (ja) | 2019-12-12 | 2021-06-17 | 国立大学法人千葉大学 | 巨核球および血小板を含む凍結乾燥製剤 |
| US20230046238A1 (en) | 2019-12-13 | 2023-02-16 | Megakaryon Corporation | Composition and use thereof |
| US20230399617A1 (en) | 2020-10-27 | 2023-12-14 | Nagasaki University | Osteogenic composition and use thereof |
| JP7716851B2 (ja) * | 2020-12-28 | 2025-08-01 | イビデン株式会社 | 凍結保存液 |
| WO2022265117A1 (ja) | 2021-06-18 | 2022-12-22 | 株式会社メガカリオン | 血小板産生能が増強された多核化巨核球細胞の製造方法、血小板の製造方法、血小板製剤の製造方法、および血液製剤の製造方法 |
| JPWO2023277153A1 (enExample) | 2021-06-30 | 2023-01-05 | ||
| US20250346860A1 (en) * | 2022-07-04 | 2025-11-13 | Artblood Inc. | Establishment of immortalized erythroid progenitor cell line with superior capability of differentiating into red blood cells by using genetic overexpression combination, preparation method therefor, and use thereof |
| JP2025534107A (ja) | 2022-10-18 | 2025-10-09 | ソングァン メディカル ファンデーション | 幹細胞から血小板前駆細胞への分化誘導用培地組成物及びそれを用いた分化方法 |
| JPWO2024143555A1 (enExample) | 2022-12-28 | 2024-07-04 | ||
| WO2024210126A1 (ja) | 2023-04-03 | 2024-10-10 | 大塚製薬株式会社 | 巨核球の製造方法 |
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| US572333A (en) | 1896-12-01 | Evaporating apparatus | ||
| WO1993000433A1 (en) * | 1991-06-28 | 1993-01-07 | New England Deaconess Hospital | A differentiated megakaryocyte line producing novel megakaryocyte differentiation factors |
| GB9502022D0 (en) * | 1995-02-02 | 1995-03-22 | Abuljadayel Ilham M S | A method for preparing lymphohaematopoietic progenitor cells |
| EP0808364B1 (en) | 1995-02-10 | 2005-11-30 | The Regents of the University of California | Human pancreatic cell lines: developments and uses |
| US5723333A (en) | 1995-02-10 | 1998-03-03 | Regents Of The University Of California | Human pancreatic cell lines: developments and uses |
| US20050159378A1 (en) * | 2001-05-18 | 2005-07-21 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of Myc and/or Myb gene expression using short interfering nucleic acid (siNA) |
| MXPA05003260A (es) * | 2002-09-27 | 2005-09-12 | Bioe Inc | Composiciones y metodo de separacion de celulas. |
| JP3896482B2 (ja) * | 2002-10-07 | 2007-03-22 | 独立行政法人産業技術総合研究所 | 分化細胞の作製方法 |
| JP2004350601A (ja) | 2003-05-29 | 2004-12-16 | Tanabe Seiyaku Co Ltd | 霊長類動物の胚性幹細胞から造血系細胞への分化方法 |
| JP4706208B2 (ja) | 2004-08-27 | 2011-06-22 | 株式会社アイル | 造血幹細胞の製造方法 |
| JP2006141356A (ja) | 2004-11-24 | 2006-06-08 | Institute Of Physical & Chemical Research | Ｅｓ細胞から樹立された造血幹細胞 |
| CN105483088B (zh) | 2005-10-18 | 2021-05-28 | 国家犹太健康中心 | 条件无限增殖化长期干细胞和制备和使用所述细胞的方法 |
| AU2006311637A1 (en) * | 2005-11-07 | 2007-05-18 | The General Hospital Corporation | Methods and compositions for modulation of stem cell aging |
| ZA200804673B (en) * | 2005-12-13 | 2009-11-25 | Univ Kyoto | Nuclear reprogramming factor |
| US8058064B2 (en) | 2006-10-04 | 2011-11-15 | The University Of Tokyo | Sac-like structure enclosing hematopoietic progenitor cells produced from ES cells and method for preparing blood cells |
| CA2660123C (en) * | 2007-10-31 | 2017-05-09 | Kyoto University | Nuclear reprogramming method |
| CN101492676B (zh) * | 2008-09-16 | 2011-02-16 | 中国科学院广州生物医药与健康研究院 | 用脑膜细胞生成诱导的多能性干细胞的方法及其用途 |
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2010
- 2010-09-15 EP EP16202612.4A patent/EP3159001B1/en active Active
- 2010-09-15 KR KR1020127009225A patent/KR101667834B1/ko active Active
- 2010-09-15 CN CN201080042161.7A patent/CN102712906B/zh active Active
- 2010-09-15 BR BR122013008030A patent/BR122013008030B8/pt active IP Right Grant
- 2010-09-15 ES ES16202612T patent/ES2725688T3/es active Active
- 2010-09-15 DK DK10817186.9T patent/DK2500418T3/en active
- 2010-09-15 ES ES10817186.9T patent/ES2664194T3/es active Active
- 2010-09-15 US US13/496,321 patent/US9200254B2/en active Active
- 2010-09-15 BR BR112012005710A patent/BR112012005710B1/pt active IP Right Grant
- 2010-09-15 AU AU2010296415A patent/AU2010296415B2/en active Active
- 2010-09-15 WO PCT/JP2010/065903 patent/WO2011034073A1/ja not_active Ceased
- 2010-09-15 EP EP10817186.9A patent/EP2500418B1/en active Active
- 2010-09-15 RU RU2012114427/10A patent/RU2603094C2/ru active
- 2010-09-15 CN CN201510530896.9A patent/CN105385659B/zh not_active Expired - Fee Related
- 2010-09-15 KR KR1020167027550A patent/KR101834687B1/ko active Active
- 2010-09-15 IN IN2642DEN2012 patent/IN2012DN02642A/en unknown
- 2010-09-15 DK DK16202612.4T patent/DK3159001T3/da active
- 2010-09-15 RU RU2016139042A patent/RU2661107C1/ru active
- 2010-09-15 CA CA2774193A patent/CA2774193C/en active Active
- 2010-09-15 JP JP2011531940A patent/JP5791191B2/ja active Active
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2015
- 2015-02-13 JP JP2015026547A patent/JP2015130866A/ja active Pending
- 2015-08-03 JP JP2015153048A patent/JP6265437B2/ja active Active
- 2015-10-28 US US14/925,508 patent/US10087419B2/en active Active
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2016
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