IN2012DN02642A - - Google Patents
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- IN2012DN02642A IN2012DN02642A IN2642DEN2012A IN2012DN02642A IN 2012DN02642 A IN2012DN02642 A IN 2012DN02642A IN 2642DEN2012 A IN2642DEN2012 A IN 2642DEN2012A IN 2012DN02642 A IN2012DN02642 A IN 2012DN02642A
- Authority
- IN
- India
- Prior art keywords
- cells
- oncogene
- differentiation stage
- present
- desired differentiation
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0641—Erythrocytes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/18—Erythrocytes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0644—Platelets; Megakaryocytes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/48—Regulators of apoptosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/606—Transcription factors c-Myc
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Hematology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Developmental Biology & Embryology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Virology (AREA)
- Oncology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The present invention has an object of providing a method for producing specific cells by amplifying cells in a desired differentiation stage. The present invention provides a method for producing specific cells by inducing differentiation of cells, wherein an oncogene is forcibly expressed in cells in a desired differentiation stage to amplify the cells in the desired differentiation stage. The present invention also provides a method for producing specific cells, wherein oncogene-induced senescence (OIS) which is induced by the oncogene expressed in the cells in the desired differentiation stage is suppressed.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009213645 | 2009-09-15 | ||
| PCT/JP2010/065903 WO2011034073A1 (en) | 2009-09-15 | 2010-09-15 | Novel method for producing differentiated cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2012DN02642A true IN2012DN02642A (en) | 2015-09-11 |
Family
ID=43758674
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN2642DEN2012 IN2012DN02642A (en) | 2009-09-15 | 2010-09-15 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US9200254B2 (en) |
| EP (2) | EP2500418B1 (en) |
| JP (4) | JP5791191B2 (en) |
| KR (2) | KR101834687B1 (en) |
| CN (2) | CN102712906B (en) |
| AU (1) | AU2010296415B2 (en) |
| BR (2) | BR112012005710B1 (en) |
| CA (1) | CA2774193C (en) |
| DK (2) | DK2500418T3 (en) |
| ES (2) | ES2725688T3 (en) |
| IN (1) | IN2012DN02642A (en) |
| RU (2) | RU2603094C2 (en) |
| WO (1) | WO2011034073A1 (en) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012043651A1 (en) * | 2010-09-30 | 2012-04-05 | 国立大学法人 熊本大学 | Production method for myeloid blood cells |
| RU2606764C2 (en) | 2011-05-13 | 2017-01-10 | Университет Токио | Method for producing polyploidized megakaryocyte and platelets |
| WO2013051625A1 (en) | 2011-10-03 | 2013-04-11 | 日産化学工業株式会社 | Method for producing megakaryocytes and/or platelets from pluripotent stem cells |
| GB201210857D0 (en) | 2012-06-19 | 2012-08-01 | Cambridge Entpr Ltd | Transcription factor mediated programming towards megakaryocytes |
| US9763984B2 (en) | 2012-12-21 | 2017-09-19 | Astellas Institute For Regenerative Medicine | Methods for production of platelets from pluripotent stem cells and compositions thereof |
| US20160002599A1 (en) * | 2013-02-08 | 2016-01-07 | Kyoto University | Production methods for megakaryocytes and platelets |
| WO2014168255A1 (en) * | 2013-04-12 | 2014-10-16 | 国立大学法人京都大学 | Megakaryocyte maturation accelerator |
| EP2987852A4 (en) | 2013-04-17 | 2016-09-07 | Nissan Chemical Ind Ltd | Medium composition and method for producing red blood cells using same |
| WO2014186508A1 (en) * | 2013-05-15 | 2014-11-20 | University Of Rechester | Human extensively self-renewing erythroblasts (esre) |
| JP6655011B2 (en) | 2014-06-23 | 2020-02-26 | 東亞合成株式会社 | Peptide that induces multinucleation of cells and its use |
| JP6959135B2 (en) * | 2015-03-09 | 2021-11-02 | 株式会社メガカリオン | A method for producing a culture containing megakaryocytes and a method for producing platelets using the same. |
| CA2982568A1 (en) * | 2015-04-14 | 2016-10-20 | Kyoto University | Method for producing stem cell clone suitable for inducing differentiation into somatic cells |
| KR20160129609A (en) | 2015-04-30 | 2016-11-09 | 삼성전자주식회사 | Composition for reducing senescence of a cell or a subject comprising BRAF inhibitor and use thereof |
| WO2017131230A1 (en) | 2016-01-29 | 2017-08-03 | 国立大学法人京都大学 | Platelet production promoter and method of producing platelets using same |
| US11016083B2 (en) | 2016-01-29 | 2021-05-25 | Kyoto University | Method for screening for platelet production promoters |
| JP7297203B2 (en) | 2017-03-06 | 2023-06-26 | 国立大学法人京都大学 | Platelet manufacturing method |
| FR3068366B1 (en) * | 2017-06-30 | 2023-11-24 | Francais Du Sang Ets | METHOD FOR PRODUCING ERYTHROID PROGENITORS |
| US20210130781A1 (en) | 2017-07-07 | 2021-05-06 | Kyoto University | Method and apparatus for producing platelet and method for determining operating condition of apparatus for producing platelet |
| US20200216808A1 (en) | 2017-09-19 | 2020-07-09 | Megakaryon Corporation | Method for producing platelets, method for producing platelet product, and method for producing blood product |
| WO2019059235A1 (en) | 2017-09-19 | 2019-03-28 | 株式会社メガカリオン | Method for manufacturing purified blood platelets, method for manufacturing blood platelet preparation, method for manufacturing blood preparation, blood platelet preservation fluid, blood platelet preservation agent, and method for preserving blood platelets |
| TW202045202A (en) * | 2019-02-25 | 2020-12-16 | 國立陽明大學 | Composition for treating pulmonary fibrosis and emphysema and therapeutic method using the same |
| US20220315895A1 (en) * | 2019-05-01 | 2022-10-06 | Transfusion Health, Llc | Methods of making oligopotent and unipotent precursors |
| WO2021117886A1 (en) | 2019-12-12 | 2021-06-17 | 国立大学法人千葉大学 | Freeze-dried preparation containing megakaryocytes and platelets |
| WO2021117900A1 (en) | 2019-12-13 | 2021-06-17 | 株式会社メガカリオン | Composition and use thereof |
| WO2022092169A1 (en) | 2020-10-27 | 2022-05-05 | 国立大学法人 長崎大学 | Osteogenic composition and use thereof |
| JPWO2022265117A1 (en) | 2021-06-18 | 2022-12-22 | ||
| WO2023277153A1 (en) | 2021-06-30 | 2023-01-05 | 国立大学法人千葉大学 | Method for improving proliferative properties of common myeloid progenitor cells (cmp) or myelocytic progenitor cells |
| WO2024010317A1 (en) * | 2022-07-04 | 2024-01-11 | 주식회사 아트블러드 | Establishment of immortalized erythroid progenitor cell line with superior capability of differentiating into red blood cells by using genetic overexpression combination, preparation method therefor, and use thereof |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US572333A (en) | 1896-12-01 | Evaporating apparatus | ||
| JPH06508749A (en) * | 1991-06-28 | 1994-10-06 | ニュー イングランド ディーコネス ホスピタル | A lineage of differentiated megakaryocytes that produces a novel megakaryocyte differentiation factor |
| GB9502022D0 (en) * | 1995-02-02 | 1995-03-22 | Abuljadayel Ilham M S | A method for preparing lymphohaematopoietic progenitor cells |
| DE69635513T2 (en) | 1995-02-10 | 2006-08-17 | The Regents Of The University Of California, Oakland | Human Pancreas Cell Lines: Developments and Applications |
| US5723333A (en) | 1995-02-10 | 1998-03-03 | Regents Of The University Of California | Human pancreatic cell lines: developments and uses |
| US20050159378A1 (en) * | 2001-05-18 | 2005-07-21 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of Myc and/or Myb gene expression using short interfering nucleic acid (siNA) |
| JP4344696B2 (en) * | 2002-09-27 | 2009-10-14 | バイオイー， インコーポレイテッド | Cell separation composition and cell separation method |
| JP3896482B2 (en) * | 2002-10-07 | 2007-03-22 | 独立行政法人産業技術総合研究所 | Method for producing differentiated cells |
| JP2004350601A (en) | 2003-05-29 | 2004-12-16 | Tanabe Seiyaku Co Ltd | Method for differentiating embryonic stem cell of primatial animal to hemopoietic cell |
| JP4706208B2 (en) | 2004-08-27 | 2011-06-22 | 株式会社アイル | Method for producing hematopoietic stem cells |
| JP2006141356A (en) | 2004-11-24 | 2006-06-08 | Institute Of Physical & Chemical Research | Hematopoietic stem cell derived from es cell |
| JP2009511081A (en) * | 2005-10-18 | 2009-03-19 | ナショナル ジューイッシュ メディカル アンド リサーチ センター | Conditionally immortalized long-term stem cells and methods of making and using such cells |
| WO2007056423A1 (en) * | 2005-11-07 | 2007-05-18 | The General Hospital Corporation | Methods and compositions for modulation of stem cell aging |
| ES2367525T3 (en) | 2005-12-13 | 2011-11-04 | Kyoto University | CELLULAR REPROGRAMATION FACTOR. |
| US8058064B2 (en) | 2006-10-04 | 2011-11-15 | The University Of Tokyo | Sac-like structure enclosing hematopoietic progenitor cells produced from ES cells and method for preparing blood cells |
| CA2660123C (en) * | 2007-10-31 | 2017-05-09 | Kyoto University | Nuclear reprogramming method |
| CN101492676B (en) * | 2008-09-16 | 2011-02-16 | 中国科学院广州生物医药与健康研究院 | Method for producing derivational pluripotent stem cell with meninges cell and uses thereof |
-
2010
- 2010-09-15 DK DK10817186.9T patent/DK2500418T3/en active
- 2010-09-15 KR KR1020167027550A patent/KR101834687B1/en active IP Right Grant
- 2010-09-15 RU RU2012114427/10A patent/RU2603094C2/en active
- 2010-09-15 CN CN201080042161.7A patent/CN102712906B/en active Active
- 2010-09-15 WO PCT/JP2010/065903 patent/WO2011034073A1/en active Application Filing
- 2010-09-15 EP EP10817186.9A patent/EP2500418B1/en active Active
- 2010-09-15 BR BR112012005710A patent/BR112012005710B1/en active IP Right Grant
- 2010-09-15 ES ES16202612T patent/ES2725688T3/en active Active
- 2010-09-15 ES ES10817186.9T patent/ES2664194T3/en active Active
- 2010-09-15 DK DK16202612.4T patent/DK3159001T3/en active
- 2010-09-15 CA CA2774193A patent/CA2774193C/en active Active
- 2010-09-15 JP JP2011531940A patent/JP5791191B2/en active Active
- 2010-09-15 AU AU2010296415A patent/AU2010296415B2/en active Active
- 2010-09-15 KR KR1020127009225A patent/KR101667834B1/en active IP Right Grant
- 2010-09-15 CN CN201510530896.9A patent/CN105385659B/en active Active
- 2010-09-15 IN IN2642DEN2012 patent/IN2012DN02642A/en unknown
- 2010-09-15 EP EP16202612.4A patent/EP3159001B1/en active Active
- 2010-09-15 BR BR122013008030A patent/BR122013008030B8/en active IP Right Grant
- 2010-09-15 RU RU2016139042A patent/RU2661107C1/en active
- 2010-09-15 US US13/496,321 patent/US9200254B2/en active Active
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2015
- 2015-02-13 JP JP2015026547A patent/JP2015130866A/en active Pending
- 2015-08-03 JP JP2015153048A patent/JP6265437B2/en active Active
- 2015-10-28 US US14/925,508 patent/US10087419B2/en active Active
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2016
- 2016-11-29 JP JP2016231020A patent/JP6382917B2/en active Active
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