MX2020007071A - Composiciones y metodos para producir megacariocitos. - Google Patents

Composiciones y metodos para producir megacariocitos.

Info

Publication number
MX2020007071A
MX2020007071A MX2020007071A MX2020007071A MX2020007071A MX 2020007071 A MX2020007071 A MX 2020007071A MX 2020007071 A MX2020007071 A MX 2020007071A MX 2020007071 A MX2020007071 A MX 2020007071A MX 2020007071 A MX2020007071 A MX 2020007071A
Authority
MX
Mexico
Prior art keywords
methods
compositions
premks
mks
producing megakaryocytes
Prior art date
Application number
MX2020007071A
Other languages
English (en)
Inventor
Jonathan Thon
Brad Dykstra
Original Assignee
Platelet Biogenesis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Platelet Biogenesis Inc filed Critical Platelet Biogenesis Inc
Publication of MX2020007071A publication Critical patent/MX2020007071A/es

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    • C—CHEMISTRY; METALLURGY
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0644—Platelets; Megakaryocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0062—General methods for three-dimensional culture
    • C—CHEMISTRY; METALLURGY
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068—General culture methods using substrates
    • C12N5/0075—General culture methods using substrates using microcarriers
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
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    • C12N2531/00—Microcarriers
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    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/52—Fibronectin; Laminin

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Se proveen métodos para producir progenitores megacariocíticos (preMK) y megacariocitos (MK) a partir de células troncales. La presente divulgación además provee composiciones que comprenden preMK y MK y sus lisados, y también métodos de uso de los preMK, MK, sus lisados y composiciones de los mismos.
MX2020007071A 2018-01-05 2019-01-05 Composiciones y metodos para producir megacariocitos. MX2020007071A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862614117P 2018-01-05 2018-01-05
PCT/US2019/012437 WO2019136318A2 (en) 2018-01-05 2019-01-05 Compositions and methods for producing megakaryocytes

Publications (1)

Publication Number Publication Date
MX2020007071A true MX2020007071A (es) 2020-11-11

Family

ID=67144011

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020007071A MX2020007071A (es) 2018-01-05 2019-01-05 Composiciones y metodos para producir megacariocitos.

Country Status (10)

Country Link
US (1) US20210054336A1 (es)
EP (1) EP3735457A4 (es)
JP (2) JP2021509812A (es)
KR (1) KR102592176B1 (es)
CN (1) CN111836886A (es)
AU (1) AU2019205942A1 (es)
BR (1) BR112020013656A2 (es)
CA (1) CA3087344A1 (es)
MX (1) MX2020007071A (es)
WO (1) WO2019136318A2 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102543304B1 (ko) * 2022-10-05 2023-06-14 주식회사 듀셀바이오테라퓨틱스 혈소판 생성능이 우수한 세포 및 혈소판의 제조방법
WO2024076030A1 (ko) * 2022-10-05 2024-04-11 주식회사 듀셀바이오테라퓨틱스 혈소판의 제조 방법
WO2024085650A1 (ko) * 2022-10-18 2024-04-25 의료법인 성광의료재단 줄기세포에서 혈소판 전구세포로의 분화 유도용 배지 조성물 및 이를 이용한 분화 방법

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060099198A1 (en) * 2004-11-01 2006-05-11 Thomson James A Platelets from stem cells
RU2007112288A (ru) * 2007-04-03 2008-10-10 Александр Сергеевич Ботин (RU) Композиция для стимулирования роста и регенерации клеток, а также способ ее получения
KR101803562B1 (ko) * 2008-05-06 2017-12-01 아스텔라스 인스티튜트 포 리제너러티브 메디슨 다능성 줄기세포로부터 유도된 탈핵 적혈구계 세포를 생산하는 방법
KR101720961B1 (ko) * 2009-02-27 2017-03-29 셀룰러 다이내믹스 인터내셔널, 인코포레이티드 다능성 세포의 분화
ES2896354T3 (es) * 2012-12-21 2022-02-24 Astellas Inst For Regenerative Medicine Métodos para la producción de plaquetas a partir de células madre pluripotentes
AU2014248651B2 (en) * 2013-03-13 2019-01-17 Wisconsin Alumni Research Foundation Methods and materials for hematoendothelial differentiation of human pluripotent stem cells under defined conditions
CN105793413A (zh) * 2013-11-01 2016-07-20 詹森生物科技公司 用于分化成胰腺内分泌细胞的人多能干细胞的悬浮和群集
JP6807853B2 (ja) * 2015-03-03 2021-01-06 プレジデント アンド フェローズ オブ ハーバード カレッジ 機能的ヒト組織の作製方法
US10669529B2 (en) * 2015-07-17 2020-06-02 Kyoto University Method for inducing vascular endothelial cells
FR3039166B1 (fr) * 2015-07-23 2018-10-26 Institut National De La Sante Et De La Recherche Medicale Progeniteurs de megacaryocytes cd34+cd41dim et leurs utilisations pour produire des plaquettes et/ou des mk portant des proplaquettes
DK3365435T3 (da) * 2015-10-20 2021-04-06 Fujifilm Cellular Dynamics Inc Produktion af hæmatopoietiske prækursorceller med multi-afstamning med genetisk programmering

Also Published As

Publication number Publication date
CA3087344A1 (en) 2019-07-11
KR102592176B1 (ko) 2023-10-20
WO2019136318A2 (en) 2019-07-11
US20210054336A1 (en) 2021-02-25
BR112020013656A2 (pt) 2020-12-01
WO2019136318A3 (en) 2020-04-16
KR20200123414A (ko) 2020-10-29
JP2023126630A (ja) 2023-09-07
EP3735457A4 (en) 2021-08-25
JP2021509812A (ja) 2021-04-08
AU2019205942A1 (en) 2020-08-13
EP3735457A2 (en) 2020-11-11
CN111836886A (zh) 2020-10-27

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