ES2688796T3 - Análisis dimensional de conjugados de sacáridos con GPC y SEC-MALS - Google Patents

Análisis dimensional de conjugados de sacáridos con GPC y SEC-MALS Download PDF

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Publication number
ES2688796T3
ES2688796T3 ES11163751.8T ES11163751T ES2688796T3 ES 2688796 T3 ES2688796 T3 ES 2688796T3 ES 11163751 T ES11163751 T ES 11163751T ES 2688796 T3 ES2688796 T3 ES 2688796T3
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ES
Spain
Prior art keywords
conjugate
conjugates
molar mass
serogroup
mals
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES11163751.8T
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English (en)
Spanish (es)
Inventor
Giorgio Capannoli
Valeria Carinci
Sandro D'ascenzi
Claudia Magagnoli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline Biologicals SA
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GlaxoSmithKline Biologicals SA
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55544—Bacterial toxins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Spectrometry And Color Measurement (AREA)
ES11163751.8T 2004-06-21 2005-06-21 Análisis dimensional de conjugados de sacáridos con GPC y SEC-MALS Expired - Lifetime ES2688796T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0413868.1A GB0413868D0 (en) 2004-06-21 2004-06-21 Dimensional anlaysis of saccharide conjugates
GB0413868 2004-06-21

Publications (1)

Publication Number Publication Date
ES2688796T3 true ES2688796T3 (es) 2018-11-07

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
ES11163751.8T Expired - Lifetime ES2688796T3 (es) 2004-06-21 2005-06-21 Análisis dimensional de conjugados de sacáridos con GPC y SEC-MALS
ES05770612.9T Expired - Lifetime ES2443465T3 (es) 2004-06-21 2005-06-21 Análisis dimensional de conjugados de sacáridos con GPC y SEC-MALS

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES05770612.9T Expired - Lifetime ES2443465T3 (es) 2004-06-21 2005-06-21 Análisis dimensional de conjugados de sacáridos con GPC y SEC-MALS

Country Status (13)

Country Link
US (2) US8163296B2 (enExample)
EP (2) EP2374473B1 (enExample)
JP (5) JP2008503716A (enExample)
CN (1) CN1976725B (enExample)
AU (1) AU2005256961B2 (enExample)
BR (1) BRPI0512281A (enExample)
CA (1) CA2571565C (enExample)
ES (2) ES2688796T3 (enExample)
GB (1) GB0413868D0 (enExample)
MX (2) MXPA06015188A (enExample)
NZ (1) NZ552449A (enExample)
RU (1) RU2422156C2 (enExample)
WO (1) WO2006000920A2 (enExample)

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AU2011300409B2 (en) 2010-09-10 2015-03-26 Wyeth Llc Non-lipidated variants of Neisseria meningitidis ORF2086 antigens
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RU2723045C2 (ru) 2015-02-19 2020-06-08 Пфайзер Инк. Композиции neisseria meningitidis и способы их получения
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SG10202111092UA (en) 2017-01-31 2021-11-29 Pfizer Neisseria meningitidis compositions and methods thereof
CN109459523B (zh) * 2017-09-06 2022-11-08 上海绿谷制药有限公司 一种测定酸性糖可溶性盐重均分子量和含量的方法
CN109459504B (zh) * 2017-09-06 2022-05-27 绿谷(上海)医药科技有限公司 一种测定聚古罗糖醛酸硫酸酯盐重均分子量和含量的方法
CA3155669A1 (en) 2019-09-27 2021-04-01 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
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Also Published As

Publication number Publication date
WO2006000920A2 (en) 2006-01-05
JP2008503716A (ja) 2008-02-07
EP2374473A1 (en) 2011-10-12
US8163296B2 (en) 2012-04-24
EP1778291A2 (en) 2007-05-02
JP6218327B2 (ja) 2017-10-25
NZ552449A (en) 2010-05-28
JP6661568B2 (ja) 2020-03-11
US20120207781A1 (en) 2012-08-16
US20080248059A1 (en) 2008-10-09
GB0413868D0 (en) 2004-07-21
WO2006000920A3 (en) 2006-03-30
AU2005256961B2 (en) 2011-06-23
CN1976725A (zh) 2007-06-06
RU2007102016A (ru) 2008-07-27
MX344621B (es) 2017-01-03
MXPA06015188A (es) 2007-03-27
CA2571565C (en) 2014-08-12
AU2005256961A1 (en) 2006-01-05
ES2443465T3 (es) 2014-02-19
EP1778291B1 (en) 2013-10-30
JP2011246490A (ja) 2011-12-08
BRPI0512281A (pt) 2008-02-26
JP2017134084A (ja) 2017-08-03
JP2015180707A (ja) 2015-10-15
CN1976725B (zh) 2012-08-29
RU2422156C2 (ru) 2011-06-27
CA2571565A1 (en) 2006-01-05
EP2374473B1 (en) 2018-07-18
JP2014111654A (ja) 2014-06-19

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