CN1976725B - 采用gpc和sec-mals进行的糖接合物尺度分析 - Google Patents

采用gpc和sec-mals进行的糖接合物尺度分析 Download PDF

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Publication number
CN1976725B
CN1976725B CN2005800204436A CN200580020443A CN1976725B CN 1976725 B CN1976725 B CN 1976725B CN 2005800204436 A CN2005800204436 A CN 2005800204436A CN 200580020443 A CN200580020443 A CN 200580020443A CN 1976725 B CN1976725 B CN 1976725B
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Prior art keywords
conjugate
serogroup
neisseria meningitidis
capsular saccharide
molar mass
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Expired - Lifetime
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CN2005800204436A
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Chinese (zh)
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CN1976725A (zh
Inventor
G·卡潘诺利
V·卡里奇
S·达申奇
C·马加诺利
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GlaxoSmithKline Biologicals SA
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Novartis Vaccines and Diagnostics SRL
Chiron SRL
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55544—Bacterial toxins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Spectrometry And Color Measurement (AREA)
CN2005800204436A 2004-06-21 2005-06-21 采用gpc和sec-mals进行的糖接合物尺度分析 Expired - Lifetime CN1976725B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0413868.1 2004-06-21
GBGB0413868.1A GB0413868D0 (en) 2004-06-21 2004-06-21 Dimensional anlaysis of saccharide conjugates
PCT/IB2005/002532 WO2006000920A2 (en) 2004-06-21 2005-06-21 Dimensional analysis of saccharide conjugates with gpc & sec-mals

Publications (2)

Publication Number Publication Date
CN1976725A CN1976725A (zh) 2007-06-06
CN1976725B true CN1976725B (zh) 2012-08-29

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CN2005800204436A Expired - Lifetime CN1976725B (zh) 2004-06-21 2005-06-21 采用gpc和sec-mals进行的糖接合物尺度分析

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Country Link
US (2) US8163296B2 (enExample)
EP (2) EP2374473B1 (enExample)
JP (5) JP2008503716A (enExample)
CN (1) CN1976725B (enExample)
AU (1) AU2005256961B2 (enExample)
BR (1) BRPI0512281A (enExample)
CA (1) CA2571565C (enExample)
ES (2) ES2688796T3 (enExample)
GB (1) GB0413868D0 (enExample)
MX (2) MXPA06015188A (enExample)
NZ (1) NZ552449A (enExample)
RU (1) RU2422156C2 (enExample)
WO (1) WO2006000920A2 (enExample)

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EP2437882A4 (en) 2009-06-01 2016-11-23 Waters Technologies Corp HYBRID MATERIAL FOR CHROMATOGRAPHY SEPARATIONS
US8195405B2 (en) * 2009-06-30 2012-06-05 Wyatt Technology Corporation Method for characterizing reversible association of macromolecules at high concentration
SMT201700275T1 (it) 2009-10-30 2017-07-18 Glaxosmithkline Biologicals Sa Purificazione di saccaridi capsulari di staphylococcus aureus tipo 5 e tipo 8
EP4023330A1 (en) * 2009-12-15 2022-07-06 Waters Technologies Corporation Device and methods for performing size exclusion chromatography
US20110293700A1 (en) * 2010-05-26 2011-12-01 Selecta Biosciences, Inc. Nanocarrier compositions with uncoupled adjuvant
WO2012018598A1 (en) 2010-07-26 2012-02-09 Waters Technologies Corporation Superficially porous materials comprising a substantially nonporous core having narrow particle size distribution; process for the preparation thereof; and use thereof for chromatographic separations
PT3246044T (pt) 2010-08-23 2021-02-15 Wyeth Llc Formulações estáveis de antigénios de rlp2086 de neisseria meningitidis
AU2011300409B2 (en) 2010-09-10 2015-03-26 Wyeth Llc Non-lipidated variants of Neisseria meningitidis ORF2086 antigens
US8986710B2 (en) 2012-03-09 2015-03-24 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
SA115360586B1 (ar) 2012-03-09 2017-04-12 فايزر انك تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها
US10481164B2 (en) 2012-03-26 2019-11-19 Amgen Inc. Method for using light scattering in real time to directly monitor and control impurity removal in purification processes
WO2014136064A2 (en) 2013-03-08 2014-09-12 Pfizer Inc. Immunogenic fusion polypeptides
MX369534B (es) 2013-09-08 2019-11-11 Pfizer Composiciones de neisseria meningitidis y sus metodos.
RU2723045C2 (ru) 2015-02-19 2020-06-08 Пфайзер Инк. Композиции neisseria meningitidis и способы их получения
KR20190044663A (ko) 2016-09-02 2019-04-30 사노피 파스퇴르 인크 네이세리아 메닌기티디스 백신
US11951165B2 (en) 2016-12-30 2024-04-09 Vaxcyte, Inc. Conjugated vaccine carrier proteins
KR20190103256A (ko) 2016-12-30 2019-09-04 수트로박스, 인코포레이티드 비자연 아미노산을 갖는 폴리펩타이드-항원 접합체
SG10202111092UA (en) 2017-01-31 2021-11-29 Pfizer Neisseria meningitidis compositions and methods thereof
CN109459523B (zh) * 2017-09-06 2022-11-08 上海绿谷制药有限公司 一种测定酸性糖可溶性盐重均分子量和含量的方法
CN109459504B (zh) * 2017-09-06 2022-05-27 绿谷(上海)医药科技有限公司 一种测定聚古罗糖醛酸硫酸酯盐重均分子量和含量的方法
CA3155669A1 (en) 2019-09-27 2021-04-01 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
JP7409055B2 (ja) * 2019-12-05 2024-01-09 株式会社島津製作所 検出器の出力を補正する方法、および多角度光散乱検出器

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Also Published As

Publication number Publication date
WO2006000920A2 (en) 2006-01-05
JP2008503716A (ja) 2008-02-07
EP2374473A1 (en) 2011-10-12
US8163296B2 (en) 2012-04-24
EP1778291A2 (en) 2007-05-02
JP6218327B2 (ja) 2017-10-25
NZ552449A (en) 2010-05-28
JP6661568B2 (ja) 2020-03-11
US20120207781A1 (en) 2012-08-16
US20080248059A1 (en) 2008-10-09
GB0413868D0 (en) 2004-07-21
WO2006000920A3 (en) 2006-03-30
AU2005256961B2 (en) 2011-06-23
ES2688796T3 (es) 2018-11-07
CN1976725A (zh) 2007-06-06
RU2007102016A (ru) 2008-07-27
MX344621B (es) 2017-01-03
MXPA06015188A (es) 2007-03-27
CA2571565C (en) 2014-08-12
AU2005256961A1 (en) 2006-01-05
ES2443465T3 (es) 2014-02-19
EP1778291B1 (en) 2013-10-30
JP2011246490A (ja) 2011-12-08
BRPI0512281A (pt) 2008-02-26
JP2017134084A (ja) 2017-08-03
JP2015180707A (ja) 2015-10-15
RU2422156C2 (ru) 2011-06-27
CA2571565A1 (en) 2006-01-05
EP2374473B1 (en) 2018-07-18
JP2014111654A (ja) 2014-06-19

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