JP2008503716A - Ｇｐｃおよびｓｅｃ−ｍａｌｓによる結合体化糖の寸法分析 - Google Patents

Ｇｐｃおよびｓｅｃ−ｍａｌｓによる結合体化糖の寸法分析 Download PDF

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JP2008503716A
JP2008503716A JP2007516078A JP2007516078A JP2008503716A JP 2008503716 A JP2008503716 A JP 2008503716A JP 2007516078 A JP2007516078 A JP 2007516078A JP 2007516078 A JP2007516078 A JP 2007516078A JP 2008503716 A JP2008503716 A JP 2008503716A
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conjugate
sugar
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JP2008503716A5 (enExample
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ジョルジオ カパンノリ，
バレリア カリンチ，
サンドロ ダセンツィ，
クラウディア マガノーリ，
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カイロン ソチエタ ア レスポンサビリタ リミタータ
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55544—Bacterial toxins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography

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  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Spectrometry And Color Measurement (AREA)
JP2007516078A 2004-06-21 2005-06-21 Ｇｐｃおよびｓｅｃ−ｍａｌｓによる結合体化糖の寸法分析 Withdrawn JP2008503716A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0413868.1A GB0413868D0 (en) 2004-06-21 2004-06-21 Dimensional anlaysis of saccharide conjugates
PCT/IB2005/002532 WO2006000920A2 (en) 2004-06-21 2005-06-21 Dimensional analysis of saccharide conjugates with gpc & sec-mals

Related Child Applications (1)

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JP2011192126A Division JP2011246490A (ja) 2004-06-21 2011-09-02 Ｇｐｃおよびｓｅｃ−ｍａｌｓによる結合体化糖の寸法分析

Publications (2)

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JP2008503716A true JP2008503716A (ja) 2008-02-07
JP2008503716A5 JP2008503716A5 (enExample) 2008-07-17

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JP2007516078A Withdrawn JP2008503716A (ja) 2004-06-21 2005-06-21 Ｇｐｃおよびｓｅｃ−ｍａｌｓによる結合体化糖の寸法分析
JP2011192126A Withdrawn JP2011246490A (ja) 2004-06-21 2011-09-02 Ｇｐｃおよびｓｅｃ−ｍａｌｓによる結合体化糖の寸法分析
JP2014047555A Expired - Lifetime JP6218327B2 (ja) 2004-06-21 2014-03-11 Ｇｐｃおよびｓｅｃ−ｍａｌｓによる結合体化糖の寸法分析
JP2015143718A Pending JP2015180707A (ja) 2004-06-21 2015-07-21 Ｇｐｃおよびｓｅｃ−ｍａｌｓによる結合体化糖の寸法分析
JP2017084454A Expired - Lifetime JP6661568B2 (ja) 2004-06-21 2017-04-21 Ｇｐｃおよびｓｅｃ−ｍａｌｓによる結合体化糖の寸法分析

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JP2011192126A Withdrawn JP2011246490A (ja) 2004-06-21 2011-09-02 Ｇｐｃおよびｓｅｃ−ｍａｌｓによる結合体化糖の寸法分析
JP2014047555A Expired - Lifetime JP6218327B2 (ja) 2004-06-21 2014-03-11 Ｇｐｃおよびｓｅｃ−ｍａｌｓによる結合体化糖の寸法分析
JP2015143718A Pending JP2015180707A (ja) 2004-06-21 2015-07-21 Ｇｐｃおよびｓｅｃ−ｍａｌｓによる結合体化糖の寸法分析
JP2017084454A Expired - Lifetime JP6661568B2 (ja) 2004-06-21 2017-04-21 Ｇｐｃおよびｓｅｃ−ｍａｌｓによる結合体化糖の寸法分析

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US (2) US8163296B2 (enExample)
EP (2) EP2374473B1 (enExample)
JP (5) JP2008503716A (enExample)
CN (1) CN1976725B (enExample)
AU (1) AU2005256961B2 (enExample)
BR (1) BRPI0512281A (enExample)
CA (1) CA2571565C (enExample)
ES (2) ES2688796T3 (enExample)
GB (1) GB0413868D0 (enExample)
MX (2) MXPA06015188A (enExample)
NZ (1) NZ552449A (enExample)
RU (1) RU2422156C2 (enExample)
WO (1) WO2006000920A2 (enExample)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011522252A (ja) * 2008-05-30 2011-07-28 インターベツト・インターナシヨナル・ベー・ベー ワクチンの効力および安定性を監視するための分析方法
JP2013514538A (ja) * 2009-12-15 2013-04-25 ウオーターズ・テクノロジーズ・コーポレイシヨン サイズ排除クロマトグラフィーを行うための装置および方法
JP2017014217A (ja) * 2010-05-26 2017-01-19 セレクタ バイオサイエンシーズ インコーポレーテッドＳｅｌｅｃｔａ Ｂｉｏｓｃｉｅｎｃｅｓ，Ｉｎｃ． 合成ナノキャリア混合ワクチン
US10092893B2 (en) 2010-07-26 2018-10-09 Waters Technologies Corporation Superficially porous materials comprising a substantially nonporous hybrid core having narrow particle size distribution; process for the preparation thereof; and use thereof for chromatographic separations
KR20200097239A (ko) * 2017-09-06 2020-08-18 상하이 그린벨리 파머수티컬 주식회사 중량평균 분자량 및 산성 당의 가용성 염의 함량 측정방법
JP2021089234A (ja) * 2019-12-05 2021-06-10 株式会社島津製作所 検出器の出力を補正する方法、および多角度光散乱検出器
US11291974B2 (en) 2009-06-01 2022-04-05 Waters Technologies Corporation Hybrid inorganic/organic materials having novel surface modification; process for the preparation of inorganic/organic hybrid materials; and use of said particles for chromatographic separations

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX339524B (es) 2001-10-11 2016-05-30 Wyeth Corp Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica.
GB0413868D0 (en) * 2004-06-21 2004-07-21 Chiron Srl Dimensional anlaysis of saccharide conjugates
PL2878307T3 (pl) 2005-06-27 2020-01-31 Glaxosmithkline Biologicals S.A. Kompozycja immunogenna
AR064642A1 (es) 2006-12-22 2009-04-15 Wyeth Corp Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi
US8195405B2 (en) * 2009-06-30 2012-06-05 Wyatt Technology Corporation Method for characterizing reversible association of macromolecules at high concentration
SMT201700275T1 (it) 2009-10-30 2017-07-18 Glaxosmithkline Biologicals Sa Purificazione di saccaridi capsulari di staphylococcus aureus tipo 5 e tipo 8
PT3246044T (pt) 2010-08-23 2021-02-15 Wyeth Llc Formulações estáveis de antigénios de rlp2086 de neisseria meningitidis
AU2011300409B2 (en) 2010-09-10 2015-03-26 Wyeth Llc Non-lipidated variants of Neisseria meningitidis ORF2086 antigens
US8986710B2 (en) 2012-03-09 2015-03-24 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
SA115360586B1 (ar) 2012-03-09 2017-04-12 فايزر انك تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها
US10481164B2 (en) 2012-03-26 2019-11-19 Amgen Inc. Method for using light scattering in real time to directly monitor and control impurity removal in purification processes
WO2014136064A2 (en) 2013-03-08 2014-09-12 Pfizer Inc. Immunogenic fusion polypeptides
MX369534B (es) 2013-09-08 2019-11-11 Pfizer Composiciones de neisseria meningitidis y sus metodos.
RU2723045C2 (ru) 2015-02-19 2020-06-08 Пфайзер Инк. Композиции neisseria meningitidis и способы их получения
KR20190044663A (ko) 2016-09-02 2019-04-30 사노피 파스퇴르 인크 네이세리아 메닌기티디스 백신
US11951165B2 (en) 2016-12-30 2024-04-09 Vaxcyte, Inc. Conjugated vaccine carrier proteins
KR20190103256A (ko) 2016-12-30 2019-09-04 수트로박스, 인코포레이티드 비자연 아미노산을 갖는 폴리펩타이드-항원 접합체
SG10202111092UA (en) 2017-01-31 2021-11-29 Pfizer Neisseria meningitidis compositions and methods thereof
CN109459504B (zh) * 2017-09-06 2022-05-27 绿谷(上海)医药科技有限公司 一种测定聚古罗糖醛酸硫酸酯盐重均分子量和含量的方法
CA3155669A1 (en) 2019-09-27 2021-04-01 Pfizer Inc. Neisseria meningitidis compositions and methods thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002058737A2 (en) * 2001-01-23 2002-08-01 Aventis Pasteur Multivalent meningococcal polysaccharide-protein conjugate vaccine
WO2003007985A2 (en) * 2001-06-20 2003-01-30 Chiron Srl. Capsular polysaccharide solubilisation and combination vaccines

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4057685A (en) 1972-02-02 1977-11-08 Abbott Laboratories Chemically modified endotoxin immunizing agent
US4356170A (en) 1981-05-27 1982-10-26 Canadian Patents & Development Ltd. Immunogenic polysaccharide-protein conjugates
US4673574A (en) 1981-08-31 1987-06-16 Anderson Porter W Immunogenic conjugates
US4459286A (en) 1983-01-31 1984-07-10 Merck & Co., Inc. Coupled H. influenzae type B vaccine
US4663160A (en) 1983-03-14 1987-05-05 Miles Laboratories, Inc. Vaccines for gram-negative bacteria
US4761283A (en) 1983-07-05 1988-08-02 The University Of Rochester Immunogenic conjugates
US4808700A (en) 1984-07-09 1989-02-28 Praxis Biologics, Inc. Immunogenic conjugates of non-toxic E. coli LT-B enterotoxin subunit and capsular polymers
RU2023448C1 (ru) 1987-07-30 1994-11-30 Сентро Насьональ Де Биопрепарадос Способ получения вакцины против различных патогенных серотипов менингита нейссера группы в
NL8802046A (nl) 1988-08-18 1990-03-16 Gen Electric Polymeermengsel met polyester en alkaansulfonaat, daaruit gevormde voorwerpen.
DE3841091A1 (de) 1988-12-07 1990-06-13 Behringwerke Ag Synthetische antigene, verfahren zu ihrer herstellung und ihre verwendung
EP0378881B1 (en) 1989-01-17 1993-06-09 ENIRICERCHE S.p.A. Synthetic peptides and their use as universal carriers for the preparation of immunogenic conjugates suitable for the development of synthetic vaccines
EP0482068A1 (en) 1989-07-14 1992-04-29 American Cyanamid Company Cytokine and hormone carriers for conjugate vaccines
IT1237764B (it) 1989-11-10 1993-06-17 Eniricerche Spa Peptidi sintetici utili come carriers universali per la preparazione di coniugati immunogenici e loro impiego per lo sviluppo di vaccini sintetici.
SE466259B (sv) 1990-05-31 1992-01-20 Arne Forsgren Protein d - ett igd-bindande protein fraan haemophilus influenzae, samt anvaendning av detta foer analys, vacciner och uppreningsaendamaal
EP0471177B1 (en) 1990-08-13 1995-10-04 American Cyanamid Company Filamentous hemagglutinin of bordetella pertussis as a carrier molecule for conjugate vaccines
US5153312A (en) 1990-09-28 1992-10-06 American Cyanamid Company Oligosaccharide conjugate vaccines
IT1262896B (it) 1992-03-06 1996-07-22 Composti coniugati formati da proteine heat shock (hsp) e oligo-poli- saccaridi, loro uso per la produzione di vaccini.
IL102687A (en) 1992-07-30 1997-06-10 Yeda Res & Dev Conjugates of poorly immunogenic antigens and synthetic pepide carriers and vaccines comprising them
WO1996040242A1 (en) 1995-06-07 1996-12-19 Smithkline Beecham Biologicals S.A. Vaccine comprising a polysaccharide antigen-carrier protein conjugate and free carrier protein
US6299881B1 (en) 1997-03-24 2001-10-09 Henry M. Jackson Foundation For The Advancement Of Military Medicine Uronium salts for activating hydroxyls, carboxyls, and polysaccharides, and conjugate vaccines, immunogens, and other useful immunological reagents produced using uronium salts
GB9713156D0 (en) 1997-06-20 1997-08-27 Microbiological Res Authority Vaccines
US7018637B2 (en) 1998-02-23 2006-03-28 Aventis Pasteur, Inc Multi-oligosaccharide glycoconjugate bacterial meningitis vaccines
CA2340692A1 (en) 1998-08-19 2000-03-02 North American Vaccine, Inc. Immunogenic .beta.-propionamido-linked polysaccharide protein conjugate useful as a vaccine produced using an n-acryloylated polysaccharide
EP1162999B1 (en) 1999-03-19 2006-11-29 Glaxosmithkline Biologicals S.A. Vaccine against Streptococcus pneumoniae
JP2002541808A (ja) 1999-04-09 2002-12-10 テクラブ， インコーポレイテッド ポリサッカリド結合体ワクチンのための組換えトキシンａタンパク質キャリア
EP2275129A3 (en) 2000-01-17 2013-11-06 Novartis Vaccines and Diagnostics S.r.l. Outer membrane vesicle (OMV) vaccine comprising N. meningitidis serogroup B outer membrane proteins
GB0007432D0 (en) 2000-03-27 2000-05-17 Microbiological Res Authority Proteins for use as carriers in conjugate vaccines
ES2519440T3 (es) 2000-07-27 2014-11-07 Children's Hospital & Research Center At Oakland Vacunas para la protección de amplio espectro contra enfermedades causadas por Neisseria meningitidis
GB0103170D0 (en) 2001-02-08 2001-03-28 Smithkline Beecham Biolog Vaccine composition
AU2002309706A1 (en) 2001-05-11 2002-11-25 Aventis Pasteur, Inc. Novel meningitis conjugate vaccine
DE60335477D1 (de) * 2002-10-11 2011-02-03 Novartis Vaccines & Diagnostic Polypeptidimpstoffe zum breiten schutz gegen hypervirulente meningokokken-linien
PT2172213E (pt) 2003-01-30 2013-06-03 Novartis Ag Vacinas injetáveis contra múltiplos serogrupos meningocócicos
GB0323103D0 (en) 2003-10-02 2003-11-05 Chiron Srl De-acetylated saccharides
ATE506963T1 (de) * 2003-10-02 2011-05-15 Novartis Vaccines & Diagnostic Kombinationsimpfstoffe gegen meningitis
GB0408978D0 (en) 2004-04-22 2004-05-26 Chiron Srl Meningococcal fermentation for preparing conjugate vaccines
GB0413868D0 (en) * 2004-06-21 2004-07-21 Chiron Srl Dimensional anlaysis of saccharide conjugates

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002058737A2 (en) * 2001-01-23 2002-08-01 Aventis Pasteur Multivalent meningococcal polysaccharide-protein conjugate vaccine
WO2003007985A2 (en) * 2001-06-20 2003-01-30 Chiron Srl. Capsular polysaccharide solubilisation and combination vaccines

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011522252A (ja) * 2008-05-30 2011-07-28 インターベツト・インターナシヨナル・ベー・ベー ワクチンの効力および安定性を監視するための分析方法
US11291974B2 (en) 2009-06-01 2022-04-05 Waters Technologies Corporation Hybrid inorganic/organic materials having novel surface modification; process for the preparation of inorganic/organic hybrid materials; and use of said particles for chromatographic separations
JP2018021929A (ja) * 2009-12-15 2018-02-08 ウオーターズ・テクノロジーズ・コーポレイシヨン サイズ排除クロマトグラフィーを行うための装置および方法
JP2013514538A (ja) * 2009-12-15 2013-04-25 ウオーターズ・テクノロジーズ・コーポレイシヨン サイズ排除クロマトグラフィーを行うための装置および方法
JP2017014217A (ja) * 2010-05-26 2017-01-19 セレクタ バイオサイエンシーズ インコーポレーテッドＳｅｌｅｃｔａ Ｂｉｏｓｃｉｅｎｃｅｓ，Ｉｎｃ． 合成ナノキャリア混合ワクチン
JP2018052940A (ja) * 2010-05-26 2018-04-05 セレクタ バイオサイエンシーズ インコーポレーテッドＳｅｌｅｃｔａ Ｂｉｏｓｃｉｅｎｃｅｓ，Ｉｎｃ． 多価合成ナノキャリアワクチン
US10092893B2 (en) 2010-07-26 2018-10-09 Waters Technologies Corporation Superficially porous materials comprising a substantially nonporous hybrid core having narrow particle size distribution; process for the preparation thereof; and use thereof for chromatographic separations
US11478775B2 (en) 2010-07-26 2022-10-25 Waters Technologies Corporation Superficially porous materials comprising a substantially nonporous hybrid core having narrow particle size distribution
US12427502B2 (en) 2010-07-26 2025-09-30 Waters Technologies Corporation Superficially porous materials comprising a substantially nonporous core having narrow particle size distribution; process for the preparation thereof; and use thereof for chromatographic separations
KR20200097239A (ko) * 2017-09-06 2020-08-18 상하이 그린벨리 파머수티컬 주식회사 중량평균 분자량 및 산성 당의 가용성 염의 함량 측정방법
KR102338499B1 (ko) 2017-09-06 2021-12-14 상하이 그린벨리 파머수티컬 주식회사 중량평균 분자량 및 산성 당의 가용성 염의 함량 측정방법
US11366086B2 (en) 2017-09-06 2022-06-21 Shanghai Green Valley Pharmaceutical Co., Ltd. Method for determining weight-average molecular weight and content of soluble salt of acidic carbohydrates
JP2021089234A (ja) * 2019-12-05 2021-06-10 株式会社島津製作所 検出器の出力を補正する方法、および多角度光散乱検出器
JP7409055B2 (ja) 2019-12-05 2024-01-09 株式会社島津製作所 検出器の出力を補正する方法、および多角度光散乱検出器

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WO2006000920A2 (en) 2006-01-05
EP2374473A1 (en) 2011-10-12
US8163296B2 (en) 2012-04-24
EP1778291A2 (en) 2007-05-02
JP6218327B2 (ja) 2017-10-25
NZ552449A (en) 2010-05-28
JP6661568B2 (ja) 2020-03-11
US20120207781A1 (en) 2012-08-16
US20080248059A1 (en) 2008-10-09
GB0413868D0 (en) 2004-07-21
WO2006000920A3 (en) 2006-03-30
AU2005256961B2 (en) 2011-06-23
ES2688796T3 (es) 2018-11-07
CN1976725A (zh) 2007-06-06
RU2007102016A (ru) 2008-07-27
MX344621B (es) 2017-01-03
MXPA06015188A (es) 2007-03-27
CA2571565C (en) 2014-08-12
AU2005256961A1 (en) 2006-01-05
ES2443465T3 (es) 2014-02-19
EP1778291B1 (en) 2013-10-30
JP2011246490A (ja) 2011-12-08
BRPI0512281A (pt) 2008-02-26
JP2017134084A (ja) 2017-08-03
JP2015180707A (ja) 2015-10-15
CN1976725B (zh) 2012-08-29
RU2422156C2 (ru) 2011-06-27
CA2571565A1 (en) 2006-01-05
EP2374473B1 (en) 2018-07-18
JP2014111654A (ja) 2014-06-19

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