ES2622716T3 - Oligonucleótido y nucleósido artificial en puente con guanidina - Google Patents
Oligonucleótido y nucleósido artificial en puente con guanidina Download PDFInfo
- Publication number
- ES2622716T3 ES2622716T3 ES13838365.8T ES13838365T ES2622716T3 ES 2622716 T3 ES2622716 T3 ES 2622716T3 ES 13838365 T ES13838365 T ES 13838365T ES 2622716 T3 ES2622716 T3 ES 2622716T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- amino
- nucleic acid
- compound
- oxo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012208906 | 2012-09-21 | ||
| JP2012208906 | 2012-09-21 | ||
| JP2013022360 | 2013-02-07 | ||
| JP2013022360 | 2013-02-07 | ||
| PCT/JP2013/075370 WO2014046212A1 (ja) | 2012-09-21 | 2013-09-19 | グアニジン架橋を有する人工ヌクレオシドおよびオリゴヌクレオチド |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2622716T3 true ES2622716T3 (es) | 2017-07-07 |
Family
ID=50341516
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES13838365.8T Active ES2622716T3 (es) | 2012-09-21 | 2013-09-19 | Oligonucleótido y nucleósido artificial en puente con guanidina |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US10377789B2 (esLanguage) |
| EP (1) | EP2899197B1 (esLanguage) |
| JP (1) | JP6048982B2 (esLanguage) |
| KR (1) | KR101707437B1 (esLanguage) |
| CN (1) | CN104768964B (esLanguage) |
| CA (1) | CA2885719C (esLanguage) |
| ES (1) | ES2622716T3 (esLanguage) |
| IN (1) | IN2015DN02238A (esLanguage) |
| WO (1) | WO2014046212A1 (esLanguage) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014126229A1 (ja) * | 2013-02-18 | 2014-08-21 | 塩野義製薬株式会社 | 含窒素複素環構造を有するヌクレオシド及びヌクレオチド |
| TW201718618A (zh) * | 2015-09-18 | 2017-06-01 | 田邊三菱製藥股份有限公司 | 架橋型核酸ＧｕＮＡ，其製造方法，及中間體化合物 |
| WO2017119463A1 (ja) * | 2016-01-07 | 2017-07-13 | 国立大学法人大阪大学 | α－シヌクレイン発現抑制剤 |
| EP3587432A4 (en) | 2017-02-21 | 2021-01-06 | Osaka University | NUCLEIC ACID COMPOUND AND OLIGONUCLEOTIDE |
| WO2018155450A1 (ja) | 2017-02-21 | 2018-08-30 | 国立大学法人大阪大学 | アンチセンスオリゴ核酸 |
| WO2019009298A1 (ja) * | 2017-07-05 | 2019-01-10 | 国立大学法人大阪大学 | α－シヌクレイン発現抑制剤 |
| CN115920031A (zh) | 2017-08-31 | 2023-04-07 | 田边三菱制药株式会社 | 含有il-33拮抗剂的子宫内膜异位症治疗剂 |
| WO2019216433A1 (ja) * | 2018-05-10 | 2019-11-14 | 日本新薬株式会社 | オリゴ核酸化合物の製造方法 |
| JP7473113B2 (ja) * | 2018-07-31 | 2024-04-23 | 国立大学法人大阪大学 | オリゴヌクレオチドを含有する小細胞肺癌治療薬 |
| US12071624B2 (en) | 2018-09-05 | 2024-08-27 | Osaka University | Antisense oligonucleotide targeting ARL4C molecule, and nucleic acid drug using antisense oligonucleotide |
| JP7356448B2 (ja) | 2018-11-12 | 2023-10-04 | 田辺三菱製薬株式会社 | 架橋型人工核酸ａｌｎａ |
| SG11202110674XA (en) | 2019-03-29 | 2021-10-28 | Mitsubishi Tanabe Pharma Corp | Compound, method and pharmaceutical composition for modulating expression of dux4 |
| WO2020203896A1 (ja) | 2019-03-29 | 2020-10-08 | シスメックス株式会社 | 新規人工核酸、その製造方法及び用途 |
| AU2020282828A1 (en) | 2019-05-31 | 2022-01-27 | Aligos Therapeutics, Inc. | Modified gapmer oligonucleotides and methods of use |
| CA3142593C (en) * | 2019-06-19 | 2025-05-20 | Yamasa Corporation | Cross-linked nucleoside intermediate crystal and its manufacturing method, and manufacturing method of cross-linked nucleoside amidite |
| BR112021025497A2 (pt) * | 2019-06-20 | 2022-02-01 | Hoffmann La Roche | Oligonucleotídeos, processo para a preparação de um oligonucleotídeo, uso do oligonucleotídeo, método para a determinação da biodistribuição e farmacocinética de um oligonucleotídeo no tecido ou fluido corporal |
| EP4151237A4 (en) | 2020-05-12 | 2024-08-14 | Mitsubishi Tanabe Pharma Corporation | Compound, method and pharmaceutical composition for regulating expression of ataxin 3 |
| EP4219517A4 (en) | 2020-09-25 | 2024-09-25 | Riken Genesis Co., Ltd. | NOVEL ARTIFICIAL NUCLEIC ACID, METHOD FOR PRODUCING THE SAME AND USE THEREOF |
| US20240018516A1 (en) | 2020-11-06 | 2024-01-18 | Sumitomo Pharma Co., Ltd. | Agent for Regulating Expression and/or Function of RPS25 Gene |
| WO2022181807A1 (ja) | 2021-02-25 | 2022-09-01 | 国立大学法人大阪大学 | ＲＥＳＴ ｍＲＮＡ前駆体のプロセシングにおけるＮエキソンのスキッピングを誘導するオリゴヌクレオチド |
| JP2024105742A (ja) * | 2021-05-26 | 2024-08-07 | ルクサナバイオテク株式会社 | 心疾患治療薬 |
| MX2023014092A (es) | 2021-05-28 | 2023-12-11 | Sumitomo Pharma Co Ltd | Acido nucleico antisentido. |
| CN113552198B (zh) * | 2021-05-31 | 2024-03-26 | 武汉维尔博生物科技有限公司 | 一种基于高响应葡萄糖适配体的电化学传感器及其制备方法 |
| EP4389893A4 (en) | 2021-08-21 | 2025-09-10 | Takeda Pharmaceuticals Co | PEPTIDE-DRUG CONJUGATE BINDING HUMAN TRANSFERRIN RECEPTOR |
| WO2023093960A1 (en) * | 2021-11-26 | 2023-06-01 | Syddansk Universitet | Modified peptide-oligonucleotide conjugate |
| JPWO2023127857A1 (esLanguage) | 2021-12-27 | 2023-07-06 | ||
| TW202345861A (zh) * | 2022-03-17 | 2023-12-01 | 美商艾利格斯醫療公司 | 經修飾之間隔體寡聚物及其使用方法 |
| KR20250108634A (ko) | 2022-11-10 | 2025-07-15 | 룩스나 바이오테크 가부시키가이샤 | 가교부에 구아니디노 구조를 갖는 수식 뉴클레오시드 및 그것을 이용한 올리고뉴클레오티드의 제조 방법 |
| WO2024181416A1 (ja) | 2023-02-28 | 2024-09-06 | 国立大学法人大阪大学 | オリゴヌクレオチド、ならびにそれを用いるｒｅｓｔ発現抑制剤および医薬組成物 |
| WO2024185775A1 (ja) | 2023-03-06 | 2024-09-12 | スペラファーマ株式会社 | 長鎖アルケニルオキシ置換ベンゾイル誘導体、及び該誘導体を用いたオリゴヌクレオチド合成方法 |
| CN121311591A (zh) | 2023-06-16 | 2026-01-09 | 住友制药株式会社 | 调节rps25基因的表达和/或其功能的反义寡核苷酸 |
| US20250368996A1 (en) | 2024-05-14 | 2025-12-04 | Aligos Therapeutics, Inc. | Modified antisense oligonucleotides for treating hepatitis b virus |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4458066A (en) * | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| US4500707A (en) * | 1980-02-29 | 1985-02-19 | University Patents, Inc. | Nucleosides useful in the preparation of polynucleotides |
| US5132418A (en) * | 1980-02-29 | 1992-07-21 | University Patents, Inc. | Process for preparing polynucleotides |
| US4668777A (en) * | 1981-03-27 | 1987-05-26 | University Patents, Inc. | Phosphoramidite nucleoside compounds |
| US4973679A (en) * | 1981-03-27 | 1990-11-27 | University Patents, Inc. | Process for oligonucleo tide synthesis using phosphormidite intermediates |
| US5696253A (en) * | 1994-06-30 | 1997-12-09 | The Regents Of The University Of California | Polynucleoside chain with 3'→5' guanidyl linkages |
| JP3756313B2 (ja) | 1997-03-07 | 2006-03-15 | 武 今西 | 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体 |
| JP4151751B2 (ja) * | 1999-07-22 | 2008-09-17 | 第一三共株式会社 | 新規ビシクロヌクレオシド類縁体 |
| DK2354148T3 (da) | 2002-02-13 | 2013-10-14 | Takeshi Imanishi | Nukleosidanaloger og oligonukleotiderivate omfattende nukleotidanalog deraf |
| ES2382807T3 (es) | 2003-08-28 | 2012-06-13 | Takeshi Imanishi | Nuevos ácidos nucleicos artificiales del tipo de enlace N-O con reticulación |
| WO2007026824A1 (ja) * | 2005-08-31 | 2007-03-08 | Osaka University | オリゴヌクレオチド類縁体 |
| CN102596983B (zh) * | 2009-10-29 | 2016-06-15 | 国立大学法人大阪大学 | 交联型人工核苷和核苷酸 |
| US9206216B2 (en) * | 2010-04-21 | 2015-12-08 | Pierce Biotechnology, Inc. | Modified nucleotides methods and kits |
| US8536323B2 (en) * | 2010-04-21 | 2013-09-17 | Pierce Biotechnology, Inc. | Modified nucleotides |
-
2013
- 2013-09-19 EP EP13838365.8A patent/EP2899197B1/en active Active
- 2013-09-19 CN CN201380057335.0A patent/CN104768964B/zh active Active
- 2013-09-19 ES ES13838365.8T patent/ES2622716T3/es active Active
- 2013-09-19 KR KR1020157010144A patent/KR101707437B1/ko active Active
- 2013-09-19 WO PCT/JP2013/075370 patent/WO2014046212A1/ja not_active Ceased
- 2013-09-19 JP JP2014536921A patent/JP6048982B2/ja active Active
- 2013-09-19 IN IN2238DEN2015 patent/IN2015DN02238A/en unknown
- 2013-09-19 US US14/428,646 patent/US10377789B2/en active Active
- 2013-09-19 CA CA2885719A patent/CA2885719C/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| IN2015DN02238A (esLanguage) | 2015-08-21 |
| CN104768964A (zh) | 2015-07-08 |
| KR20150056647A (ko) | 2015-05-26 |
| EP2899197A4 (en) | 2016-03-09 |
| JPWO2014046212A1 (ja) | 2016-08-18 |
| CN104768964B (zh) | 2017-03-29 |
| US20150266917A1 (en) | 2015-09-24 |
| US10377789B2 (en) | 2019-08-13 |
| EP2899197B1 (en) | 2017-03-22 |
| WO2014046212A1 (ja) | 2014-03-27 |
| JP6048982B2 (ja) | 2016-12-21 |
| EP2899197A1 (en) | 2015-07-29 |
| CA2885719A1 (en) | 2014-03-27 |
| KR101707437B1 (ko) | 2017-02-16 |
| CA2885719C (en) | 2017-07-11 |
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