ES2585328T3 - Variantes no lipidadas de antígenos ORF2086 de Neisseria meningitidis - Google Patents

Variantes no lipidadas de antígenos ORF2086 de Neisseria meningitidis Download PDF

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Publication number
ES2585328T3
ES2585328T3 ES11768133.8T ES11768133T ES2585328T3 ES 2585328 T3 ES2585328 T3 ES 2585328T3 ES 11768133 T ES11768133 T ES 11768133T ES 2585328 T3 ES2585328 T3 ES 2585328T3
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Prior art keywords
neisseria meningitidis
orf2086
lipidated variants
seq
antigens
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ES11768133.8T
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ES2585328T5 (es
Inventor
Annaliesa Sybil Anderson
Susan Kay Hoiseth
Kathrin Ute Jansen
Justin Keith Moran
Mark Edward Ruppen
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Wyeth LLC
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Wyeth LLC
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C07K16/1217—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Neisseriaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Una composición que comprende un polipéptido de ORF2086 no lipidado no piruvilado aislado en el que el polipéptido comprende la secuencia de aminoácidos seleccionada del grupo que consiste en SEC ID N.º: 13, SEC ID N.º: 18 y SEC ID N.º: 21, en la que la cisteína en la posición 1 está delecionada.
ES11768133T 2010-09-10 2011-09-08 Variantes no lipidadas de antígenos ORF2086 de Neisseria meningitidis Active ES2585328T5 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38183710P 2010-09-10 2010-09-10
US381837P 2010-09-10
PCT/IB2011/053934 WO2012032489A1 (en) 2010-09-10 2011-09-08 Non-lipidated variants of neisseria meningitidis orf2086 antigens

Publications (2)

Publication Number Publication Date
ES2585328T3 true ES2585328T3 (es) 2016-10-05
ES2585328T5 ES2585328T5 (es) 2022-12-14

Family

ID=44789535

Family Applications (3)

Application Number Title Priority Date Filing Date
ES16157773T Active ES2728282T3 (es) 2010-09-10 2011-09-08 Variantes no lipidadas de antígenos ORF2086 de Neisseria meningitidis
ES19166124T Active ES2864635T3 (es) 2010-09-10 2011-09-08 Variantes no lipidadas de antígenos ORF2086 de Neisseria meningitidis
ES11768133T Active ES2585328T5 (es) 2010-09-10 2011-09-08 Variantes no lipidadas de antígenos ORF2086 de Neisseria meningitidis

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES16157773T Active ES2728282T3 (es) 2010-09-10 2011-09-08 Variantes no lipidadas de antígenos ORF2086 de Neisseria meningitidis
ES19166124T Active ES2864635T3 (es) 2010-09-10 2011-09-08 Variantes no lipidadas de antígenos ORF2086 de Neisseria meningitidis

Country Status (22)

Country Link
US (3) US9757443B2 (es)
EP (3) EP3549601B1 (es)
JP (1) JP5976652B2 (es)
KR (1) KR101584871B1 (es)
CN (1) CN103096920B (es)
AR (2) AR082952A1 (es)
AU (1) AU2011300409B2 (es)
BR (1) BR112013005329A2 (es)
CA (1) CA2809758C (es)
CO (1) CO6690760A2 (es)
ES (3) ES2728282T3 (es)
HK (1) HK1188385A1 (es)
IL (1) IL225126A (es)
MX (2) MX362802B (es)
MY (1) MY166172A (es)
NZ (1) NZ607224A (es)
PE (1) PE20140173A1 (es)
RU (1) RU2546873C2 (es)
SG (1) SG187912A1 (es)
TW (1) TWI508739B (es)
WO (1) WO2012032489A1 (es)
ZA (1) ZA201301150B (es)

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DK2411048T3 (da) 2009-03-24 2020-06-15 Glaxosmithkline Biologicals Sa Adjuvanterende meningokok-faktor h-bindingsprotein
PL2608805T3 (pl) 2010-08-23 2017-12-29 Wyeth Llc Trwałe preparaty antygenów rLP2086 Neisseria meningitidis
CN103096920B (zh) 2010-09-10 2016-03-23 惠氏有限责任公司 脑膜炎奈瑟球菌orf2086抗原的非脂质化变体
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WO2020165711A1 (en) 2019-02-11 2020-08-20 Pfizer Inc. Neisseria meningitidiscompositions and methods thereof
KR20220069992A (ko) 2019-09-27 2022-05-27 화이자 인코포레이티드 네이세리아 메닌기티디스 조성물 및 그의 방법
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