DK0606921T3 - Fremgangsmåde til isolering af Haemophilus influenzae protein E - Google Patents

Fremgangsmåde til isolering af Haemophilus influenzae protein E

Info

Publication number
DK0606921T3
DK0606921T3 DK94100492T DK94100492T DK0606921T3 DK 0606921 T3 DK0606921 T3 DK 0606921T3 DK 94100492 T DK94100492 T DK 94100492T DK 94100492 T DK94100492 T DK 94100492T DK 0606921 T3 DK0606921 T3 DK 0606921T3
Authority
DK
Denmark
Prior art keywords
isolating
extracting
haemophilus influenzae
protein
influenzae protein
Prior art date
Application number
DK94100492T
Other languages
English (en)
Inventor
Bruce A Green
Gary W Zlotnick
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Application granted granted Critical
Publication of DK0606921T3 publication Critical patent/DK0606921T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C07K16/1242—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/285—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
DK94100492T 1989-03-09 1990-03-09 Fremgangsmåde til isolering af Haemophilus influenzae protein E DK0606921T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US32097189A 1989-03-09 1989-03-09

Publications (1)

Publication Number Publication Date
DK0606921T3 true DK0606921T3 (da) 2000-09-04

Family

ID=23248627

Family Applications (2)

Application Number Title Priority Date Filing Date
DK90905112.0T DK0462210T3 (da) 1989-03-09 1990-03-09 Vacciner mod ikke-typebestemmelige Haemophilus influenzae
DK94100492T DK0606921T3 (da) 1989-03-09 1990-03-09 Fremgangsmåde til isolering af Haemophilus influenzae protein E

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK90905112.0T DK0462210T3 (da) 1989-03-09 1990-03-09 Vacciner mod ikke-typebestemmelige Haemophilus influenzae

Country Status (13)

Country Link
US (4) US5601831A (da)
EP (2) EP0606921B1 (da)
JP (1) JP2955014B2 (da)
KR (1) KR100188323B1 (da)
AT (2) ATE110965T1 (da)
AU (1) AU648251B2 (da)
CA (1) CA2047681C (da)
DE (2) DE69033600T2 (da)
DK (2) DK0462210T3 (da)
ES (2) ES2063965T3 (da)
FI (1) FI914241A0 (da)
NO (1) NO913518L (da)
WO (1) WO1990010458A1 (da)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1340888C (en) * 1988-09-01 2000-02-01 Algis Anilionis Vaccines and diagnostic assays for haemophilus influenzae
AU2699192A (en) * 1991-10-16 1993-05-21 University Of Saskatchewan Enhanced immunogenicity using leukotoxin chimeras
US5422110A (en) * 1991-10-16 1995-06-06 University Of Saskatchewan Enhanced immunogenicity using leukotoxin chimeras
US6797272B1 (en) 1991-10-16 2004-09-28 University Of Saskatchewan Enhanced immunogenicity using leukotoxin chimeras
ATE190502T1 (de) * 1993-05-13 2000-04-15 American Cyanamid Co Herstellung und verwendungen von los-verminderten aussenmembran-proteinen von gram-negativen kokken
US5681570A (en) * 1995-01-12 1997-10-28 Connaught Laboratories Limited Immunogenic conjugate molecules
US20020032316A1 (en) * 1995-03-31 2002-03-14 Cantab Pharmaceuticals Research Limited Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same
JPH11508225A (ja) * 1995-04-17 1999-07-21 ヘンリー エム．ジャクソン ファンデーション フォー ザ アドバンスメント オブ ミリタリー メディシン 細菌のリポ蛋白質を用いた多糖類に対する免疫応答の誘導および増強
AR003125A1 (es) * 1995-06-01 1998-07-08 Astra Ab Antigenos bacterianos para el diagnostico de infecciones con helicobacter pylori, una molecula de adn que lo codifica, un vector, una celula huesped,procedimiento para producir el polipeptido, composiciones para vacunas adecuadas para uso terapeutico y profilactico, el uso del polipeptido en la
GB9513074D0 (en) 1995-06-27 1995-08-30 Cortecs Ltd Novel anigen
US6207157B1 (en) * 1996-04-23 2001-03-27 The United States Of America As Represented By The Department Of Health And Human Services Conjugate vaccine for nontypeable Haemophilus influenzae
US20040126381A1 (en) * 1996-04-23 2004-07-01 Xin-Xing Gu Intranasal immunization with detoxified lipooligosaccharide from nontypeable haemophilus influenzae or moraxella
KR20040031107A (ko) * 1997-11-12 2004-04-09 에프. 호프만-라 로슈 아게 레티노이드 길항제를 이용한 제2형 ｔ-보조세포 중재면역질환의 치료
US6255050B1 (en) * 1998-05-22 2001-07-03 Lorne Park Research, Inc. Dynamic hybridization system
IL146894A0 (en) * 1999-06-25 2002-08-14 American Cyanamid Co Extraction of integral membrane proteins
US7101989B1 (en) 1999-07-09 2006-09-05 University Of North Carolina At Chapel Hill DsrA protein and polynucleotides encoding the same
US6391313B1 (en) * 1999-07-15 2002-05-21 Aventis Pasteur Limited Multi-component vaccine to protect against disease caused by Haemophilus influenzae and Moraxella catarrhalis
EP1210114A4 (en) * 1999-08-20 2004-01-02 Gen Hospital Corp OUTER MEMBRANE PROTEIN A, PEPTIDOGLYCAN ASSOCIATED LIPOPROTEIN AND MUREINLIPOPROTEIN AS THERAPEUTIC OBJECTIVES FOR THE TREATMENT OF SEPSIS
US7384640B1 (en) * 1999-09-30 2008-06-10 Wyeth Holdings Corporation Mutant cholera holotoxin as an adjuvant
AU8640501A (en) * 2000-07-31 2002-02-13 Univ Yale Innate immune system-directed vaccines
US20030232055A1 (en) * 2000-07-31 2003-12-18 Ruslan Medzhitov Innate immune system-directed vaccines
GB0025486D0 (en) * 2000-10-17 2000-11-29 Smithkline Beecham Biolog Novel compounds
US20030175287A1 (en) * 2001-01-03 2003-09-18 Yale University Innate immune system-directed vaccines
AT410798B (de) * 2001-01-26 2003-07-25 Cistem Biotechnologies Gmbh Verfahren zur identifizierung, isolierung und herstellung von antigenen gegen ein spezifisches pathogen
US6834384B2 (en) * 2001-03-14 2004-12-21 General Instrument Corporation Methods and apparatus for upgrading firmware in an embedded system
CA2446355A1 (en) * 2001-05-03 2002-11-14 The Government Of The United States Of America Intranasal immunization with detoxified lipooligosaccharide from nontypeable haemophilus influenzae or moraxella catarrhalis
IL159210A0 (en) * 2001-06-07 2004-06-01 Wyeth Corp Mutant forms of cholera holotoxin as an adjuvant
IL159209A0 (en) * 2001-06-07 2004-06-01 Wyeth Corp Mutant forms of cholera holotoxin as an adjuvant
AU2002310760A1 (en) * 2001-06-12 2002-12-23 Glaxosmithkline Biologicals S.A. Proteins derived from non-typable haemophilus influenzae (nthi) strain
GB0117762D0 (en) * 2001-07-20 2001-09-12 Glaxosmithkline Biolog Sa Novel compounds
MX339524B (es) 2001-10-11 2016-05-30 Wyeth Corp Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica.
CN100593544C (zh) * 2002-03-15 2010-03-10 惠氏控股有限公司 酶活性减少的非典型流感嗜血杆菌的p4蛋白突变体
KR101730748B1 (ko) 2005-04-08 2017-04-26 와이어쓰 엘엘씨 다가 폐렴구균 다당류-단백질 접합체 조성물
US7709001B2 (en) 2005-04-08 2010-05-04 Wyeth Llc Multivalent pneumococcal polysaccharide-protein conjugate composition
KR20070047455A (ko) * 2005-11-02 2007-05-07 삼성에스디아이 주식회사 전자 방출 표시 디바이스
TW200745158A (en) * 2006-03-07 2007-12-16 Vaxinnate Corp Compositions that include hemagglutinin, methods of making and methods of use thereof
PL1915913T3 (pl) * 2006-10-23 2016-06-30 Nestec Sa Modulowanie smaku oraz aromatu w mlecznych produktach poprzez biotransformację
AR064642A1 (es) 2006-12-22 2009-04-15 Wyeth Corp Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi
KR20110111381A (ko) * 2009-01-07 2011-10-11 오츠카 세이야쿠 가부시키가이샤 전 인플루엔자균의 측정방법
WO2012025873A2 (en) 2010-08-23 2012-03-01 Wyeth Llc STABLE FORMULATIONS OF NEISSERIA MENINGITIDIS rLP2086 ANTIGENS
PE20140173A1 (es) 2010-09-10 2014-02-20 Wyeth Llc Variantes no lipidadas de antigenos orf2086 de neisseria meningitidis
TW201302779A (zh) * 2011-04-13 2013-01-16 Glaxosmithkline Biolog Sa 融合蛋白質及組合疫苗
SA115360586B1 (ar) 2012-03-09 2017-04-12 فايزر انك تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها
SG10201602558UA (en) 2012-03-09 2016-05-30 Pfizer Neisseria meningitidis compositions and methods thereof
EP2964665B1 (en) 2013-03-08 2018-08-01 Pfizer Inc Immunogenic fusion polypeptides
CA2923129C (en) 2013-09-08 2020-06-09 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
BR112017017460A2 (pt) 2015-02-19 2018-04-10 Pfizer Inc. composições de neisseria meningitidis e métodos das mesmas
AU2018215585B2 (en) 2017-01-31 2022-03-17 Pfizer Inc. Neisseria meningitidis compositions and methods thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4220717A (en) * 1977-12-22 1980-09-02 American Cyanamid Company Isolation and purification of polyribosyl ribitol phosphate from Haemophilus influenzae type b.
US4220722A (en) * 1978-02-10 1980-09-02 Syva Company Method for conjugating to polyamino compounds employing haloacyl groups and compositions prepared thereby
US4356170A (en) * 1981-05-27 1982-10-26 Canadian Patents & Development Ltd. Immunogenic polysaccharide-protein conjugates
US4496538A (en) * 1982-07-06 1985-01-29 Connaught Laboratories, Inc. Haemophilus influenzae b polysaccharide-diphtheria toxoid conjugate vaccine
US4661347A (en) * 1982-11-12 1987-04-28 Scripps Clinic Cytotoxic compositions
US4762713A (en) * 1983-07-05 1988-08-09 The University Of Rochester Boosting of immunogenic conjugate vaccinations by unconjugated bacterial capsular polymers
NZ214503A (en) * 1984-12-20 1990-02-26 Merck & Co Inc Covalently-modified neutral bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins, and methods of preparing such polysaccharides and conjugates
JPS62502262A (ja) * 1985-03-27 1987-09-03 ブロンコスタット・プロプライアタリー・リミテツド アジユバントを含有しないワクチン
US4707543A (en) * 1985-09-17 1987-11-17 The United States Of America As Represented By The Secretary Of The Army Process for the preparation of detoxified polysaccharide-outer membrane protein complexes, and their use as antibacterial vaccines
JP2534529B2 (ja) * 1986-07-24 1996-09-18 ブリティシュ・テレコミュニケ−ションズ・パブリック・リミテッド・カンパニ 放射発生器
US5173294A (en) * 1986-11-18 1992-12-22 Research Foundation Of State University Of New York Dna probe for the identification of haemophilus influenzae
AU623353B2 (en) * 1987-12-10 1992-05-14 Board Of Regents, The University Of Texas System Methods and compositions for the production of haemophilus influenzae type b major outer membrane protein antigens

Also Published As

Publication number Publication date
CA2047681A1 (en) 1990-09-10
DE69033600T2 (de) 2001-04-05
EP0462210A1 (en) 1991-12-27
EP0462210B1 (en) 1994-09-07
CA2047681C (en) 2000-02-01
US5780601A (en) 1998-07-14
ES2150450T3 (es) 2000-12-01
WO1990010458A1 (en) 1990-09-20
NO913518D0 (no) 1991-09-06
US5601831A (en) 1997-02-11
DE69012318T2 (de) 1995-03-09
EP0606921A1 (en) 1994-07-20
JPH07508972A (ja) 1995-10-05
ATE110965T1 (de) 1994-09-15
ATE195076T1 (de) 2000-08-15
EP0606921B1 (en) 2000-08-02
US6420134B1 (en) 2002-07-16
US5955580A (en) 1999-09-21
DE69033600D1 (de) 2000-09-07
AU5332690A (en) 1990-10-09
DE69012318D1 (de) 1994-10-13
ES2063965T3 (es) 1995-01-16
KR100188323B1 (ko) 1999-06-01
NO913518L (no) 1991-10-29
AU648251B2 (en) 1994-04-21
DK0462210T3 (da) 1994-10-10
JP2955014B2 (ja) 1999-10-04
FI914241A0 (fi) 1991-09-09

Similar Documents

Publication Publication Date Title
DK0606921T3 (da) Fremgangsmåde til isolering af Haemophilus influenzae protein E
IT8619684A0 (it) Preparato di acido ialuronico chimicamente modificato e metodo per recuperarlo da tessuti animali.
ATE126223T1 (de) Verfahren zur herstellung von ascorbinsäure.
DE3752362T2 (de) Optisch aktive Verbindungen
CA2005291A1 (en) Feline infectious peritonitis virus diagnostic tools
ES2088016T3 (es) Procedimiento para la preparacion de glucolipidos purificados mediante un procedimiento de separacion por membrana.
DE69403210T3 (de) Verfahren zur herstellung von n-acetylneuraminsäure
NO873198L (no) Fremgangsmaate for gjenvinning av metaller.
DK498183D0 (da) Fremgangsmade til fjernelse af oligomere og langsom monomer fra leukocyt-interferon (ifn-alfa)-praeparater
AU7881481A (en) Recovery of l-phenylalanine and l-aspartic acid
DE3671742D1 (de) Verfahren zur herstellung von dialkalisalzen der naphthalin-2,6-dicarbonsaeure.
DE3761767D1 (de) Verfahren zur herstellung optisch aktiver 2-hydroxyethyl-azol- derivate.
AU7816487A (en) Process for concentration of an aqueous solution of amino acid
DE3581541D1 (de) Verfahren zur herstellung von zyklischen urea-derivaten.
JPS53127808A (en) Preparation of human albumin
DE3763312D1 (de) Verfahren zur herstellung von hexaalkyldisilan.
DE3676899D1 (de) Verfahren zur herstellung von n-methyl-lysergol.
JPS5559146A (en) Isolation of phenylalanine
PT86745A (pt) Process for preparing oxime ethers of 2,6-dioxabicyclo ]3.3.o" octanones
ATA257786A (de) Verfahren zur herstellung galenischer zubereitungen
Kamoi et al. Method of permanent fixation by an alveolar bar
IE863232L (en) Method for the recovery of proteins
ATE59651T1 (de) Natriumsalz von etodolsaeure und verfahren zur herstellung.
BG42585A1 (en) Derivatives of 2- aminoethylthiophosphoric acid, method for its preparation and use thereof
BG42261A1 (en) Derivatives of 1- hydroxyethylidene- 1, 1- disphophoric acid and method for its preparation