DK0462210T3 - Vacciner mod ikke-typebestemmelige Haemophilus influenzae - Google Patents
Vacciner mod ikke-typebestemmelige Haemophilus influenzaeInfo
- Publication number
- DK0462210T3 DK0462210T3 DK90905112.0T DK90905112T DK0462210T3 DK 0462210 T3 DK0462210 T3 DK 0462210T3 DK 90905112 T DK90905112 T DK 90905112T DK 0462210 T3 DK0462210 T3 DK 0462210T3
- Authority
- DK
- Denmark
- Prior art keywords
- determinable
- vaccines
- extracting
- haemophilus influenzae
- influenzae
- Prior art date
Links
- 241000606768 Haemophilus influenzae Species 0.000 title abstract 3
- 229940047650 haemophilus influenzae Drugs 0.000 title 1
- 229960005486 vaccine Drugs 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 239000007864 aqueous solution Substances 0.000 abstract 2
- IZWSFJTYBVKZNK-UHFFFAOYSA-N lauryl sulfobetaine Chemical compound CCCCCCCCCCCC[N+](C)(C)CCCS([O-])(=O)=O IZWSFJTYBVKZNK-UHFFFAOYSA-N 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1242—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/285—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Communicable Diseases (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US32097189A | 1989-03-09 | 1989-03-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0462210T3 true DK0462210T3 (da) | 1994-10-10 |
Family
ID=23248627
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK90905112.0T DK0462210T3 (da) | 1989-03-09 | 1990-03-09 | Vacciner mod ikke-typebestemmelige Haemophilus influenzae |
DK94100492T DK0606921T3 (da) | 1989-03-09 | 1990-03-09 | Fremgangsmåde til isolering af Haemophilus influenzae protein E |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK94100492T DK0606921T3 (da) | 1989-03-09 | 1990-03-09 | Fremgangsmåde til isolering af Haemophilus influenzae protein E |
Country Status (13)
Country | Link |
---|---|
US (4) | US5601831A (da) |
EP (2) | EP0462210B1 (da) |
JP (1) | JP2955014B2 (da) |
KR (1) | KR100188323B1 (da) |
AT (2) | ATE195076T1 (da) |
AU (1) | AU648251B2 (da) |
CA (1) | CA2047681C (da) |
DE (2) | DE69012318T2 (da) |
DK (2) | DK0462210T3 (da) |
ES (2) | ES2063965T3 (da) |
FI (1) | FI914241A0 (da) |
NO (1) | NO913518L (da) |
WO (1) | WO1990010458A1 (da) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1340888C (en) * | 1988-09-01 | 2000-02-01 | Algis Anilionis | Vaccines and diagnostic assays for haemophilus influenzae |
US6797272B1 (en) | 1991-10-16 | 2004-09-28 | University Of Saskatchewan | Enhanced immunogenicity using leukotoxin chimeras |
US5422110A (en) * | 1991-10-16 | 1995-06-06 | University Of Saskatchewan | Enhanced immunogenicity using leukotoxin chimeras |
WO1993008290A1 (en) * | 1991-10-16 | 1993-04-29 | University Of Saskatchewan | Enhanced immunogenicity using leukotoxin chimeras |
DK0624376T3 (da) * | 1993-05-13 | 2000-07-24 | American Cyanamid Co | Fremstilling og anvendelse af LOS-udtømte ydre membranproteiner af gram-negative cocci |
US5681570A (en) * | 1995-01-12 | 1997-10-28 | Connaught Laboratories Limited | Immunogenic conjugate molecules |
US20020032316A1 (en) * | 1995-03-31 | 2002-03-14 | Cantab Pharmaceuticals Research Limited | Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same |
JPH11508225A (ja) * | 1995-04-17 | 1999-07-21 | ヘンリー エム.ジャクソン ファンデーション フォー ザ アドバンスメント オブ ミリタリー メディシン | 細菌のリポ蛋白質を用いた多糖類に対する免疫応答の誘導および増強 |
AR003125A1 (es) * | 1995-06-01 | 1998-07-08 | Astra Ab | Antigenos bacterianos para el diagnostico de infecciones con helicobacter pylori, una molecula de adn que lo codifica, un vector, una celula huesped,procedimiento para producir el polipeptido, composiciones para vacunas adecuadas para uso terapeutico y profilactico, el uso del polipeptido en la |
GB9513074D0 (en) * | 1995-06-27 | 1995-08-30 | Cortecs Ltd | Novel anigen |
WO2002089839A1 (en) * | 2001-05-03 | 2002-11-14 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Intranasal immunization with detoxified lipooligosaccharide from nontypeable haemophilus influenzae or moraxella catarrhalis |
US6207157B1 (en) * | 1996-04-23 | 2001-03-27 | The United States Of America As Represented By The Department Of Health And Human Services | Conjugate vaccine for nontypeable Haemophilus influenzae |
US20040126381A1 (en) * | 1996-04-23 | 2004-07-01 | Xin-Xing Gu | Intranasal immunization with detoxified lipooligosaccharide from nontypeable haemophilus influenzae or moraxella |
AU749810B2 (en) * | 1997-11-12 | 2002-07-04 | Basilea Pharmaceutica Ag | Treatment of T-helper cell type 2 mediated immune diseases |
US6255050B1 (en) * | 1998-05-22 | 2001-07-03 | Lorne Park Research, Inc. | Dynamic hybridization system |
EP1189935B1 (en) | 1999-06-25 | 2008-10-22 | Wyeth Holdings Corporation | Extraction of integral membrane proteins |
US7101989B1 (en) | 1999-07-09 | 2006-09-05 | University Of North Carolina At Chapel Hill | DsrA protein and polynucleotides encoding the same |
US6391313B1 (en) * | 1999-07-15 | 2002-05-21 | Aventis Pasteur Limited | Multi-component vaccine to protect against disease caused by Haemophilus influenzae and Moraxella catarrhalis |
JP2003507433A (ja) * | 1999-08-20 | 2003-02-25 | ザ ゼネラル ホスピタル コーポレーション | 敗血症治療において治療に用いる対象としての外膜タンパク質a、ペプチドグリカン関連リポタンパク質およびムレインリポタンパク質 |
US7384640B1 (en) * | 1999-09-30 | 2008-06-10 | Wyeth Holdings Corporation | Mutant cholera holotoxin as an adjuvant |
US20030232055A1 (en) * | 2000-07-31 | 2003-12-18 | Ruslan Medzhitov | Innate immune system-directed vaccines |
WO2002009748A1 (en) * | 2000-07-31 | 2002-02-07 | Yale University | Innate immune system-directed vaccines |
GB0025486D0 (en) * | 2000-10-17 | 2000-11-29 | Smithkline Beecham Biolog | Novel compounds |
US20030175287A1 (en) * | 2001-01-03 | 2003-09-18 | Yale University | Innate immune system-directed vaccines |
AT410798B (de) * | 2001-01-26 | 2003-07-25 | Cistem Biotechnologies Gmbh | Verfahren zur identifizierung, isolierung und herstellung von antigenen gegen ein spezifisches pathogen |
US6834384B2 (en) * | 2001-03-14 | 2004-12-21 | General Instrument Corporation | Methods and apparatus for upgrading firmware in an embedded system |
KR20080078717A (ko) * | 2001-06-07 | 2008-08-27 | 와이어쓰 홀딩스 코포레이션 | 보조제로서 콜레라 홀로톡신의 돌연변이체 형태 |
EP1404368B1 (en) | 2001-06-07 | 2009-12-09 | Wyeth Holdings Corporation | Mutant forms of cholera holotoxin as an adjuvant |
AU2002310760A1 (en) * | 2001-06-12 | 2002-12-23 | Glaxosmithkline Biologicals S.A. | Proteins derived from non-typable haemophilus influenzae (nthi) strain |
GB0117762D0 (en) * | 2001-07-20 | 2001-09-12 | Glaxosmithkline Biolog Sa | Novel compounds |
MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
MXPA04008890A (es) * | 2002-03-15 | 2005-10-18 | Wyeth Corp | Mutantes de la proteina p4 de haemophilus influenzae no tipicable con actividad enzimatica reducida. |
US7709001B2 (en) | 2005-04-08 | 2010-05-04 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
EP2425855A1 (en) | 2005-04-08 | 2012-03-07 | Wyeth LLC | Multivalent pneumococcal polysaccharide-protein conjugate composition |
KR20070047455A (ko) * | 2005-11-02 | 2007-05-07 | 삼성에스디아이 주식회사 | 전자 방출 표시 디바이스 |
ES2534332T3 (es) * | 2006-03-07 | 2015-04-21 | Vaxinnate Corporation | Composiciones que incluyen hemaglutinina, métodos de preparación y métodos de uso de las mismas |
PL1915913T3 (pl) * | 2006-10-23 | 2016-06-30 | Nestec Sa | Modulowanie smaku oraz aromatu w mlecznych produktach poprzez biotransformację |
AR064642A1 (es) | 2006-12-22 | 2009-04-15 | Wyeth Corp | Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi |
US20110294143A1 (en) * | 2009-01-07 | 2011-12-01 | Otsuka Pharmaceutical Co., Ltd. | Method for detecting all haemophilus influenzae |
SI3246044T2 (sl) | 2010-08-23 | 2024-06-28 | Wyeth Llc | Stabilne formulacije antigenov neisseria meningitidis RLP2086 |
ES2585328T5 (es) | 2010-09-10 | 2022-12-14 | Wyeth Llc | Variantes no lipidadas de antígenos ORF2086 de Neisseria meningitidis |
TW201302779A (zh) | 2011-04-13 | 2013-01-16 | Glaxosmithkline Biolog Sa | 融合蛋白質及組合疫苗 |
RU2665841C2 (ru) | 2012-03-09 | 2018-09-04 | Пфайзер Инк. | Композиции neisseria meningitidis и способы их применения |
SA115360586B1 (ar) | 2012-03-09 | 2017-04-12 | فايزر انك | تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها |
JP6446377B2 (ja) | 2013-03-08 | 2018-12-26 | ファイザー・インク | 免疫原性融合ポリペプチド |
EP3041502A2 (en) | 2013-09-08 | 2016-07-13 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
RU2723045C2 (ru) | 2015-02-19 | 2020-06-08 | Пфайзер Инк. | Композиции neisseria meningitidis и способы их получения |
IL267733B2 (en) | 2017-01-31 | 2023-10-01 | Pfizer | NEISSERIA MENINGITIDIS preparations and methods therefor |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4220717A (en) * | 1977-12-22 | 1980-09-02 | American Cyanamid Company | Isolation and purification of polyribosyl ribitol phosphate from Haemophilus influenzae type b. |
US4220722A (en) | 1978-02-10 | 1980-09-02 | Syva Company | Method for conjugating to polyamino compounds employing haloacyl groups and compositions prepared thereby |
US4356170A (en) * | 1981-05-27 | 1982-10-26 | Canadian Patents & Development Ltd. | Immunogenic polysaccharide-protein conjugates |
US4496538A (en) * | 1982-07-06 | 1985-01-29 | Connaught Laboratories, Inc. | Haemophilus influenzae b polysaccharide-diphtheria toxoid conjugate vaccine |
US4661347A (en) * | 1982-11-12 | 1987-04-28 | Scripps Clinic | Cytotoxic compositions |
US4762713A (en) * | 1983-07-05 | 1988-08-09 | The University Of Rochester | Boosting of immunogenic conjugate vaccinations by unconjugated bacterial capsular polymers |
NZ214503A (en) * | 1984-12-20 | 1990-02-26 | Merck & Co Inc | Covalently-modified neutral bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins, and methods of preparing such polysaccharides and conjugates |
US4873090A (en) * | 1985-03-27 | 1989-10-10 | Broncostat Pty. Limited | Non-adjuvenated vaccine |
US4707543A (en) * | 1985-09-17 | 1987-11-17 | The United States Of America As Represented By The Secretary Of The Army | Process for the preparation of detoxified polysaccharide-outer membrane protein complexes, and their use as antibacterial vaccines |
JP2534529B2 (ja) * | 1986-07-24 | 1996-09-18 | ブリティシュ・テレコミュニケ−ションズ・パブリック・リミテッド・カンパニ | 放射発生器 |
US5173294A (en) * | 1986-11-18 | 1992-12-22 | Research Foundation Of State University Of New York | Dna probe for the identification of haemophilus influenzae |
AU623353B2 (en) * | 1987-12-10 | 1992-05-14 | Board Of Regents, The University Of Texas System | Methods and compositions for the production of haemophilus influenzae type b major outer membrane protein antigens |
-
1990
- 1990-03-09 KR KR1019910701102A patent/KR100188323B1/ko not_active IP Right Cessation
- 1990-03-09 DE DE69012318T patent/DE69012318T2/de not_active Expired - Lifetime
- 1990-03-09 CA CA002047681A patent/CA2047681C/en not_active Expired - Lifetime
- 1990-03-09 AT AT94100492T patent/ATE195076T1/de not_active IP Right Cessation
- 1990-03-09 DK DK90905112.0T patent/DK0462210T3/da active
- 1990-03-09 ES ES90905112T patent/ES2063965T3/es not_active Expired - Lifetime
- 1990-03-09 US US07/491,466 patent/US5601831A/en not_active Expired - Lifetime
- 1990-03-09 AT AT90905112T patent/ATE110965T1/de not_active IP Right Cessation
- 1990-03-09 EP EP90905112A patent/EP0462210B1/en not_active Expired - Lifetime
- 1990-03-09 WO PCT/US1990/001317 patent/WO1990010458A1/en active IP Right Grant
- 1990-03-09 DE DE69033600T patent/DE69033600T2/de not_active Expired - Lifetime
- 1990-03-09 EP EP94100492A patent/EP0606921B1/en not_active Expired - Lifetime
- 1990-03-09 AU AU53326/90A patent/AU648251B2/en not_active Expired
- 1990-03-09 ES ES94100492T patent/ES2150450T3/es not_active Expired - Lifetime
- 1990-03-09 DK DK94100492T patent/DK0606921T3/da active
- 1990-03-09 JP JP2505084A patent/JP2955014B2/ja not_active Expired - Lifetime
-
1991
- 1991-09-06 NO NO91913518A patent/NO913518L/no unknown
- 1991-09-09 FI FI914241A patent/FI914241A0/fi not_active Application Discontinuation
-
1995
- 1995-05-23 US US08/448,097 patent/US6420134B1/en not_active Expired - Fee Related
- 1995-05-23 US US08/449,406 patent/US5955580A/en not_active Expired - Lifetime
- 1995-05-23 US US08/447,653 patent/US5780601A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US6420134B1 (en) | 2002-07-16 |
DE69012318D1 (de) | 1994-10-13 |
DE69033600D1 (de) | 2000-09-07 |
ES2150450T3 (es) | 2000-12-01 |
EP0462210A1 (en) | 1991-12-27 |
NO913518L (no) | 1991-10-29 |
US5780601A (en) | 1998-07-14 |
JP2955014B2 (ja) | 1999-10-04 |
NO913518D0 (no) | 1991-09-06 |
EP0606921A1 (en) | 1994-07-20 |
FI914241A0 (fi) | 1991-09-09 |
EP0462210B1 (en) | 1994-09-07 |
KR100188323B1 (ko) | 1999-06-01 |
ATE110965T1 (de) | 1994-09-15 |
CA2047681A1 (en) | 1990-09-10 |
ES2063965T3 (es) | 1995-01-16 |
AU648251B2 (en) | 1994-04-21 |
AU5332690A (en) | 1990-10-09 |
US5955580A (en) | 1999-09-21 |
US5601831A (en) | 1997-02-11 |
DE69033600T2 (de) | 2001-04-05 |
JPH07508972A (ja) | 1995-10-05 |
WO1990010458A1 (en) | 1990-09-20 |
ATE195076T1 (de) | 2000-08-15 |
CA2047681C (en) | 2000-02-01 |
DK0606921T3 (da) | 2000-09-04 |
EP0606921B1 (en) | 2000-08-02 |
DE69012318T2 (de) | 1995-03-09 |
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