ES2564097T3 - Formas cristalinas de un macrólido, y usos de las mismas - Google Patents

Formas cristalinas de un macrólido, y usos de las mismas Download PDF

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Publication number
ES2564097T3
ES2564097T3 ES11760068.4T ES11760068T ES2564097T3 ES 2564097 T3 ES2564097 T3 ES 2564097T3 ES 11760068 T ES11760068 T ES 11760068T ES 2564097 T3 ES2564097 T3 ES 2564097T3
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water
solid
dissolved
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added
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ES11760068.4T
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English (en)
Spanish (es)
Inventor
David E. Pereira
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Cempra Pharmaceuticals Inc
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Cempra Pharmaceuticals Inc
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/04—Nitro compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
ES11760068.4T 2010-03-22 2011-03-22 Formas cristalinas de un macrólido, y usos de las mismas Active ES2564097T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US31606310P 2010-03-22 2010-03-22
US316063P 2010-03-22
PCT/US2011/029424 WO2011119604A1 (en) 2010-03-22 2011-03-22 Crystalline forms of a macrolide, and uses therefor

Publications (1)

Publication Number Publication Date
ES2564097T3 true ES2564097T3 (es) 2016-03-17

Family

ID=44673574

Family Applications (1)

Application Number Title Priority Date Filing Date
ES11760068.4T Active ES2564097T3 (es) 2010-03-22 2011-03-22 Formas cristalinas de un macrólido, y usos de las mismas

Country Status (19)

Country Link
US (4) US8975386B2 (OSRAM)
EP (2) EP3009442B1 (OSRAM)
JP (4) JP5711352B2 (OSRAM)
KR (2) KR20180101643A (OSRAM)
CN (2) CN103080122A (OSRAM)
AU (2) AU2011232627B2 (OSRAM)
BR (1) BR112012023950A2 (OSRAM)
CA (1) CA2793884C (OSRAM)
DK (1) DK2550286T3 (OSRAM)
ES (1) ES2564097T3 (OSRAM)
HR (1) HRP20160168T1 (OSRAM)
IL (1) IL222018B (OSRAM)
MX (1) MX361413B (OSRAM)
MY (1) MY162411A (OSRAM)
NZ (1) NZ602544A (OSRAM)
PL (1) PL2550286T3 (OSRAM)
RU (1) RU2650883C2 (OSRAM)
SI (1) SI2550286T1 (OSRAM)
WO (1) WO2011119604A1 (OSRAM)

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AU2008316830B2 (en) 2007-10-25 2016-03-17 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
WO2010048600A1 (en) 2008-10-24 2010-04-29 Cempra Pharmaceuticals, Inc. Methods for treating resistant diseases using triazole containing macrolides
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
US9480679B2 (en) 2009-09-10 2016-11-01 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and MAC diseases
HRP20160168T1 (hr) 2010-03-22 2016-03-25 Cempra Pharmaceuticals Inc Kristalne forme makrolida i njihova uporaba
EP2571506B1 (en) 2010-05-20 2017-05-10 Cempra Pharmaceuticals, Inc. Processes for preparing macrolides and ketolides and intermediates therefor
KR20130120458A (ko) 2010-09-10 2013-11-04 셈프라 파마슈티컬스, 인크. 질환을 치료하기 위한 수소결합 형성 플루오로 케토라이드
WO2013148891A1 (en) 2012-03-27 2013-10-03 Cempra Pharmaceuticals, Inc. Parenteral formulations for administering macrolide antibiotics
EP2968801B1 (en) 2013-03-14 2018-09-26 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
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CN105246334A (zh) 2013-04-04 2016-01-13 哈佛大学的校长及成员们 大环内酯及其制备和使用方法
CN106604729A (zh) * 2014-08-05 2017-04-26 森普拉制药公司 抗菌剂的粉末口服混悬制剂
CN104151382B (zh) * 2014-08-08 2016-09-14 广东东阳光药业有限公司 一种固态大环内酯的晶型
CN104311611B (zh) * 2014-08-13 2017-01-18 广东东阳光药业有限公司 一种制备固态大环内酯的方法
HK1242920A1 (zh) 2014-10-08 2018-07-06 哈佛大学的校长及成员们 14-元酮内酯及其制备和使用方法
WO2016154591A1 (en) 2015-03-25 2016-09-29 President And Fellows Of Harvard College Macrolides with modified desosamine sugars and uses thereof
JP6112696B1 (ja) * 2015-10-05 2017-04-12 富山化学工業株式会社 ソリスロマイシンを含む錠剤
EP3190122A1 (en) * 2016-01-08 2017-07-12 LEK Pharmaceuticals d.d. A novel synthetic pathway towards solithromycin and purification thereof
WO2018045294A1 (en) * 2016-09-02 2018-03-08 Cempra Pharmaceuticals, Inc. Processes for preparing fluoroketolides
AU2020395150A1 (en) * 2019-12-02 2022-06-23 AliquantumRx, Inc. Salts and polymorphs of cethromycin for the treatment of disease salts and polymorphs of cethromycin

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Also Published As

Publication number Publication date
KR20130056226A (ko) 2013-05-29
JP2017081953A (ja) 2017-05-18
IL222018B (en) 2019-05-30
US20190040096A1 (en) 2019-02-07
AU2011232627A1 (en) 2012-10-18
RU2012144614A (ru) 2014-04-27
CN103080122A (zh) 2013-05-01
JP2013522367A (ja) 2013-06-13
EP2550286A4 (en) 2013-10-02
US8975386B2 (en) 2015-03-10
US8759500B2 (en) 2014-06-24
HRP20160168T1 (hr) 2016-03-25
MX2012010895A (es) 2013-02-15
KR102006200B1 (ko) 2019-08-01
KR20180101643A (ko) 2018-09-12
MY162411A (en) 2017-06-15
CA2793884A1 (en) 2011-09-29
HK1177937A1 (en) 2013-08-30
AU2016203986A1 (en) 2016-06-30
EP2550286B1 (en) 2015-12-09
EP3009442A1 (en) 2016-04-20
EP3009442B1 (en) 2019-06-19
MX361413B (es) 2018-12-05
RU2650883C2 (ru) 2018-04-18
CN108570083A (zh) 2018-09-25
US20130252915A1 (en) 2013-09-26
NZ602544A (en) 2014-11-28
JP6121387B2 (ja) 2017-04-26
DK2550286T3 (en) 2016-02-29
EP2550286A1 (en) 2013-01-30
SI2550286T1 (sl) 2016-04-29
JP2020002168A (ja) 2020-01-09
WO2011119604A1 (en) 2011-09-29
JP2015063536A (ja) 2015-04-09
CA2793884C (en) 2019-09-10
AU2011232627B2 (en) 2016-03-17
US20160244472A1 (en) 2016-08-25
JP5711352B2 (ja) 2015-04-30
BR112012023950A2 (pt) 2016-07-05
AU2016203986B2 (en) 2016-10-06
US20130018008A1 (en) 2013-01-17
PL2550286T3 (pl) 2016-07-29

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