NZ602544A - Crystalline forms of a macrolide, and uses therefor - Google Patents
Crystalline forms of a macrolide, and uses thereforInfo
- Publication number
- NZ602544A NZ602544A NZ602544A NZ60254411A NZ602544A NZ 602544 A NZ602544 A NZ 602544A NZ 602544 A NZ602544 A NZ 602544A NZ 60254411 A NZ60254411 A NZ 60254411A NZ 602544 A NZ602544 A NZ 602544A
- Authority
- NZ
- New Zealand
- Prior art keywords
- crystalline forms
- macrolide
- uses therefor
- infection
- marcolide
- Prior art date
Links
- 239000003120 macrolide antibiotic agent Substances 0.000 title 1
- IXXFZUPTQVDPPK-ZAWHAJPISA-N (1r,2r,4r,6r,7r,8r,10s,13r,14s)-17-[4-[4-(3-aminophenyl)triazol-1-yl]butyl]-7-[(2s,3r,4s,6r)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-13-ethyl-10-fluoro-6-methoxy-2,4,6,8,10,14-hexamethyl-12,15-dioxa-17-azabicyclo[12.3.0]heptadecane-3,9,11,16-tet Chemical compound O([C@@H]1[C@@H](C)C(=O)[C@](C)(F)C(=O)O[C@@H]([C@]2(OC(=O)N(CCCCN3N=NC(=C3)C=3C=C(N)C=CC=3)[C@@H]2[C@@H](C)C(=O)[C@H](C)C[C@@]1(C)OC)C)CC)[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O IXXFZUPTQVDPPK-ZAWHAJPISA-N 0.000 abstract 2
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000028172 protozoa infectious disease Diseases 0.000 abstract 1
- 229950008588 solithromycin Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/04—Nitro compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31606310P | 2010-03-22 | 2010-03-22 | |
| PCT/US2011/029424 WO2011119604A1 (en) | 2010-03-22 | 2011-03-22 | Crystalline forms of a macrolide, and uses therefor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ602544A true NZ602544A (en) | 2014-11-28 |
Family
ID=44673574
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ602544A NZ602544A (en) | 2010-03-22 | 2011-03-22 | Crystalline forms of a macrolide, and uses therefor |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US8975386B2 (OSRAM) |
| EP (2) | EP2550286B1 (OSRAM) |
| JP (4) | JP5711352B2 (OSRAM) |
| KR (2) | KR102006200B1 (OSRAM) |
| CN (2) | CN108570083A (OSRAM) |
| AU (2) | AU2011232627B2 (OSRAM) |
| BR (1) | BR112012023950A2 (OSRAM) |
| CA (1) | CA2793884C (OSRAM) |
| DK (1) | DK2550286T3 (OSRAM) |
| ES (1) | ES2564097T3 (OSRAM) |
| HR (1) | HRP20160168T1 (OSRAM) |
| IL (1) | IL222018B (OSRAM) |
| MX (1) | MX361413B (OSRAM) |
| MY (1) | MY162411A (OSRAM) |
| NZ (1) | NZ602544A (OSRAM) |
| PL (1) | PL2550286T3 (OSRAM) |
| RU (1) | RU2650883C2 (OSRAM) |
| SI (1) | SI2550286T1 (OSRAM) |
| WO (1) | WO2011119604A1 (OSRAM) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1638549A4 (en) | 2003-03-10 | 2011-06-15 | Optimer Pharmaceuticals Inc | NEW ANTIBACTERIAL AGENTS |
| CA2703475A1 (en) | 2007-10-25 | 2009-04-30 | Cempra Pharmaceuticals, Inc. | Process for the preparation of macrolide antibacterial agents |
| EP2358379B1 (en) | 2008-10-24 | 2015-12-16 | Cempra Pharmaceuticals, Inc. | Biodefenses using triazole-containing macrolides |
| US9937194B1 (en) | 2009-06-12 | 2018-04-10 | Cempra Pharmaceuticals, Inc. | Compounds and methods for treating inflammatory diseases |
| ES2608285T3 (es) | 2009-09-10 | 2017-04-07 | Cempra Pharmaceuticals, Inc. | Procedimientos para el tratamiento de paludismo, tuberculosis y enfermedades por MAC |
| MX361413B (es) * | 2010-03-22 | 2018-12-05 | Cempra Pharmaceuticals Inc Star | Formas cristalinas de un macrólido y usos para las mismas. |
| KR101945324B1 (ko) | 2010-05-20 | 2019-02-07 | 셈프라 파마슈티컬스, 인크. | 매크로라이드들 및 케톨라이드들과 이의 중간체들을 제조하는 공정들 |
| US9815863B2 (en) | 2010-09-10 | 2017-11-14 | Cempra Pharmaceuticals, Inc. | Hydrogen bond forming fluoro ketolides for treating diseases |
| KR20140139083A (ko) | 2012-03-27 | 2014-12-04 | 셈프라 파마슈티컬스, 인크. | 마크롤라이드계 항생제를 투여하기 위한 비경구 제제 |
| RU2015138796A (ru) | 2013-03-14 | 2017-04-19 | Семпра Фармасьютикалс, Инк. | Способы и составы для лечения респираторных заболеваний |
| JP6675973B2 (ja) | 2013-03-15 | 2020-04-08 | センプラ ファーマシューティカルズ，インコーポレイテッド | マクロライド抗菌薬を調製するための集束的な方法 |
| AU2014248014B2 (en) | 2013-04-04 | 2018-11-08 | President And Fellows Of Harvard College | Macrolides and methods of their preparation and use |
| AU2015301154A1 (en) * | 2014-08-05 | 2017-02-23 | Cempra Pharmaceuticals, Inc. | Powder oral suspension formulations of antibacterial agents |
| CN104151382B (zh) * | 2014-08-08 | 2016-09-14 | 广东东阳光药业有限公司 | 一种固态大环内酯的晶型 |
| CN104311611B (zh) * | 2014-08-13 | 2017-01-18 | 广东东阳光药业有限公司 | 一种制备固态大环内酯的方法 |
| EP3211997A4 (en) | 2014-10-08 | 2018-10-24 | President and Fellows of Harvard College | 14-membered ketolides and methods of their preparation and use |
| EP3273969A4 (en) | 2015-03-25 | 2018-11-21 | President and Fellows of Harvard College | Macrolides with modified desosamine sugars and uses thereof |
| WO2017061431A1 (ja) * | 2015-10-05 | 2017-04-13 | 富山化学工業株式会社 | ソリスロマイシンを含む錠剤 |
| EP3190122A1 (en) * | 2016-01-08 | 2017-07-12 | LEK Pharmaceuticals d.d. | A novel synthetic pathway towards solithromycin and purification thereof |
| TW201811811A (zh) * | 2016-09-02 | 2018-04-01 | 森普拉製藥公司 | 製備氟酮內酯之方法 |
| AU2020395150A1 (en) * | 2019-12-02 | 2022-06-23 | AliquantumRx, Inc. | Salts and polymorphs of cethromycin for the treatment of disease salts and polymorphs of cethromycin |
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| US5527780A (en) | 1992-11-05 | 1996-06-18 | Roussel Uclaf | Erythromycin derivatives |
| FR2718450B1 (fr) | 1994-04-08 | 1997-01-10 | Roussel Uclaf | Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments. |
| FR2719587B1 (fr) | 1994-05-03 | 1996-07-12 | Roussel Uclaf | Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments. |
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| EP2358379B1 (en) * | 2008-10-24 | 2015-12-16 | Cempra Pharmaceuticals, Inc. | Biodefenses using triazole-containing macrolides |
| JP5890785B2 (ja) | 2010-03-10 | 2016-03-22 | センプラ ファーマシューティカルズ，インコーポレイテッド | マクロライド抗生物質の非経口製剤 |
| MX361413B (es) * | 2010-03-22 | 2018-12-05 | Cempra Pharmaceuticals Inc Star | Formas cristalinas de un macrólido y usos para las mismas. |
-
2011
- 2011-03-22 MX MX2012010895A patent/MX361413B/es active IP Right Grant
- 2011-03-22 US US13/636,510 patent/US8975386B2/en not_active Expired - Fee Related
- 2011-03-22 AU AU2011232627A patent/AU2011232627B2/en not_active Ceased
- 2011-03-22 WO PCT/US2011/029424 patent/WO2011119604A1/en not_active Ceased
- 2011-03-22 CN CN201810569806.0A patent/CN108570083A/zh active Pending
- 2011-03-22 CA CA2793884A patent/CA2793884C/en not_active Expired - Fee Related
- 2011-03-22 DK DK11760068.4T patent/DK2550286T3/en active
- 2011-03-22 NZ NZ602544A patent/NZ602544A/en not_active IP Right Cessation
- 2011-03-22 SI SI201130745T patent/SI2550286T1/sl unknown
- 2011-03-22 PL PL11760068T patent/PL2550286T3/pl unknown
- 2011-03-22 BR BR112012023950A patent/BR112012023950A2/pt not_active Application Discontinuation
- 2011-03-22 KR KR1020127027222A patent/KR102006200B1/ko not_active Expired - Fee Related
- 2011-03-22 MY MYPI2012004183A patent/MY162411A/en unknown
- 2011-03-22 EP EP11760068.4A patent/EP2550286B1/en not_active Revoked
- 2011-03-22 KR KR1020187025895A patent/KR20180101643A/ko not_active Ceased
- 2011-03-22 HR HRP20160168T patent/HRP20160168T1/hr unknown
- 2011-03-22 CN CN2011800174629A patent/CN103080122A/zh active Pending
- 2011-03-22 EP EP15194057.4A patent/EP3009442B1/en active Active
- 2011-03-22 RU RU2012144614A patent/RU2650883C2/ru not_active IP Right Cessation
- 2011-03-22 JP JP2013501396A patent/JP5711352B2/ja active Active
- 2011-03-22 ES ES11760068.4T patent/ES2564097T3/es active Active
-
2012
- 2012-09-20 IL IL222018A patent/IL222018B/en not_active IP Right Cessation
-
2013
- 2013-05-22 US US13/900,147 patent/US8759500B2/en not_active Expired - Fee Related
-
2014
- 2014-11-14 JP JP2014231987A patent/JP6121387B2/ja active Active
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2015
- 2015-09-21 US US14/859,736 patent/US20160244472A1/en not_active Abandoned
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2016
- 2016-06-15 AU AU2016203986A patent/AU2016203986B2/en not_active Ceased
- 2016-12-16 JP JP2016244733A patent/JP2017081953A/ja active Pending
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2018
- 2018-02-26 US US15/904,826 patent/US20190040096A1/en not_active Abandoned
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2019
- 2019-09-09 JP JP2019163614A patent/JP2020002168A/ja active Pending
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