ES2444126T3 - Gen para la fucosiltransferasa - Google Patents

Gen para la fucosiltransferasa

Info

Publication number
ES2444126T3
ES2444126T3 ES09154489.0T ES09154489T ES2444126T3 ES 2444126 T3 ES2444126 T3 ES 2444126T3 ES 09154489 T ES09154489 T ES 09154489T ES 2444126 T3 ES2444126 T3 ES 2444126T3
Authority
ES
Spain
Prior art keywords
fucosyltransferase
glcnac
sequence
activity
plants
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES09154489.0T
Other languages
English (en)
Spanish (es)
Inventor
Friedrich Altmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=3486087&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2444126(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of ES2444126T3 publication Critical patent/ES2444126T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1048Glycosyltransferases (2.4)
    • C12N9/1051Hexosyltransferases (2.4.1)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52Genes encoding for enzymes or proenzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10Cells modified by introduction of foreign genetic material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/18Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/005Glycopeptides, glycoproteins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8201Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C12N15/8218Antisense, co-suppression, viral induced gene silencing [VIGS], post-transcriptional induced gene silencing [PTGS]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Pulmonology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ES09154489.0T 1999-02-18 2000-02-17 Gen para la fucosiltransferasa Expired - Lifetime ES2444126T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT0027099A AT408446B (de) 1999-02-18 1999-02-18 Fucosyltransferase-gen
AT27099 1999-02-18

Publications (1)

Publication Number Publication Date
ES2444126T3 true ES2444126T3 (es) 2014-02-24

Family

ID=3486087

Family Applications (2)

Application Number Title Priority Date Filing Date
ES09154489.0T Expired - Lifetime ES2444126T3 (es) 1999-02-18 2000-02-17 Gen para la fucosiltransferasa
ES00904677T Expired - Lifetime ES2246222T3 (es) 1999-02-18 2000-02-17 Gen para la fucosiltransferasa.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES00904677T Expired - Lifetime ES2246222T3 (es) 1999-02-18 2000-02-17 Gen para la fucosiltransferasa.

Country Status (29)

Country Link
US (3) US8198078B2 (enExample)
EP (3) EP2062977B1 (enExample)
JP (2) JP5514386B2 (enExample)
KR (1) KR20010108234A (enExample)
CN (1) CN1360633A (enExample)
AT (2) AT408446B (enExample)
AU (1) AU771995B2 (enExample)
BG (1) BG65140B1 (enExample)
BR (1) BR0010114A (enExample)
CA (1) CA2362964C (enExample)
CZ (2) CZ299622B6 (enExample)
DE (1) DE50011116D1 (enExample)
DK (2) DK1151109T3 (enExample)
EE (1) EE200100432A (enExample)
ES (2) ES2444126T3 (enExample)
HR (1) HRP20010681A2 (enExample)
HU (1) HU230075B1 (enExample)
IL (2) IL144777A0 (enExample)
IS (1) IS6041A (enExample)
MX (1) MXPA01008372A (enExample)
NO (1) NO20013993L (enExample)
NZ (1) NZ513685A (enExample)
PL (2) PL205785B1 (enExample)
PT (1) PT2062977E (enExample)
SK (1) SK286416B6 (enExample)
TR (1) TR200102393T2 (enExample)
WO (1) WO2000049153A1 (enExample)
YU (1) YU58901A (enExample)
ZA (1) ZA200106735B (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL143641A0 (en) 1998-12-09 2002-04-21 A method for manufacturing glycoproteins having human-type glycosylation
AT408446B (de) * 1999-02-18 2001-11-26 Altmann Friedrich Dr Fucosyltransferase-gen
EP2278003B2 (en) 1999-04-09 2020-08-05 Kyowa Kirin Co., Ltd. Method for controlling the activity of immunologically functional molecule
DE60035285T2 (de) 1999-10-26 2008-02-21 Plant Research International B.V. Glykolisierung des säugetiertyps in pflanzen
US6946292B2 (en) 2000-10-06 2005-09-20 Kyowa Hakko Kogyo Co., Ltd. Cells producing antibody compositions with increased antibody dependent cytotoxic activity
WO2002057468A2 (en) 2001-01-19 2002-07-25 The Dow Chemical Company Method for secretory production of glycoprotein having human-type sugar chain using plant cell
JP4532118B2 (ja) 2002-03-19 2010-08-25 スティヒティング ディーンスト ランドバウクンディフ オンデルズーク 植物体内のグリカンプロセシングの最適化
EP2319934B1 (en) 2002-03-19 2015-09-02 Stichting Dienst Landbouwkundig Onderzoek GnTIII (UDP-N-acetylglucosamine:Beta -D mannoside Beta (1,4)-N-acetylglucosaminyltransferase III) expression in plants.
ATE503829T1 (de) 2002-04-09 2011-04-15 Kyowa Hakko Kirin Co Ltd Zelle mit erniedrigter oder deletierter aktivität eines am gdp-fucosetransport beteiligten proteins
CL2003002461A1 (es) 2002-11-27 2005-01-07 Dow Chemical Company Agroscien Inmunoglobulina que comprende al menos un glicano afucosilado, composicion que la contiene, secuencia nucleotidica y vector que la comprende, procedimiento para producir dicha inmunoglobulina en plantas.
DE60326716D1 (de) 2003-08-11 2009-04-30 Greenovation Biotech Gmbh Promoter Sequenzen aus Moos und dessen Verwendung
FI20055398A0 (fi) 2005-07-08 2005-07-08 Suomen Punainen Risti Veripalv Menetelmä solupopulaatioiden evaluoimiseksi
US20090060921A1 (en) * 2006-01-17 2009-03-05 Biolex Therapeutics, Inc. Glycan-optimized anti-cd20 antibodies
AU2007205939B2 (en) 2006-01-17 2012-12-13 Synthon Biopharmaceuticals B.V. Compositions and methods for humanization and optimization of N-glycans in plants
CN102094020B (zh) * 2007-01-15 2012-11-28 燕秋 用于抑制LeY糖抗原合成的岩藻糖基转移酶I的RNA干涉序列及重组干涉质粒
CN102094019B (zh) * 2007-01-15 2012-11-28 燕秋 用于抑制LeY糖抗原合成的岩藻糖基转移酶Ⅳ的RNA干涉序列及重组干涉质粒
EP2535418B1 (en) 2007-04-17 2016-03-30 Stichting Dienst Landbouwkundig Onderzoek Mammalian-type glycosylation in plants by expression of non-mammalian glycosyltransferases
CN101855554B (zh) * 2007-09-07 2014-05-14 儿童医院医学中心 分泌者、Lewis和唾液酸化抗原水平作为疾病预测指标的用途
WO2009056155A1 (en) * 2007-10-31 2009-05-07 Bayer Bioscience N.V. Method to produce modified plants with altered n-glycosylation pattern
EP2166085A1 (en) 2008-07-16 2010-03-24 Suomen Punainen Risti Veripalvelu Divalent modified cells
EP2944690B1 (en) 2010-10-11 2017-12-20 Jennewein Biotechnologie GmbH Novel fucosyltransferases and their applications
KR101293658B1 (ko) * 2010-12-30 2013-08-07 대한민국 알파-1,3-푸코실트랜스퍼라아제 및/또는 베타-1,2-자일로실트렌스퍼라아제 유전자를 포함하는 벼 형질전환용 벡터 및 형질전환된 벼
DK2479263T3 (da) * 2011-01-20 2014-02-03 Jennewein Biotechnologie Gmbh Nye fucosyltransferaser og deres anvendelser
EP2789686A1 (en) 2013-04-11 2014-10-15 Greenovation Biotech GmbH Expression of phosphorylated glycoproteins in plants
EP3050973A1 (en) * 2015-01-30 2016-08-03 Jennewein Biotechnologie GmbH Fermentation process for producing monosaccharides in free form from nucleotide-activated sugars
CN110317799A (zh) * 2019-07-18 2019-10-11 江南大学 一种人源岩藻糖转移酶8的原核表达方法及其产品
EP3871687A1 (en) 2020-02-27 2021-09-01 eleva GmbH Enzyme replacement therapy for treating pompe disease

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5272066A (en) 1986-03-07 1993-12-21 Massachusetts Institute Of Technology Synthetic method for enhancing glycoprotein stability
EP0643132B1 (en) 1993-03-29 2006-05-31 Kyowa Hakko Kogyo Co., Ltd. Alpha-1,3-fucosyltransferase
US6509149B2 (en) * 1995-06-06 2003-01-21 Hybridon, Inc. HPV-specific oligonucleotides
US5770420A (en) * 1995-09-08 1998-06-23 The Regents Of The University Of Michigan Methods and products for the synthesis of oligosaccharide structures on glycoproteins, glycolipids, or as free molecules, and for the isolation of cloned genetic sequences that determine these structures
AT408446B (de) * 1999-02-18 2001-11-26 Altmann Friedrich Dr Fucosyltransferase-gen

Also Published As

Publication number Publication date
AU771995B2 (en) 2004-04-08
TR200102393T2 (tr) 2002-04-22
US20090199306A1 (en) 2009-08-06
ATE304053T1 (de) 2005-09-15
YU58901A (sh) 2004-03-12
PL205785B1 (pl) 2010-05-31
PT2062977E (pt) 2014-04-07
ATA27099A (de) 2001-04-15
CZ308081B6 (cs) 2019-12-27
HUP0200394A3 (en) 2006-06-28
HUP0200394A2 (hu) 2002-05-29
CA2362964A1 (en) 2000-08-24
DE50011116D1 (en) 2005-10-13
KR20010108234A (ko) 2001-12-07
PL363438A1 (en) 2004-11-15
US8895806B2 (en) 2014-11-25
DK1151109T3 (da) 2006-01-16
EP2062977B1 (de) 2014-01-08
HRP20010681A2 (en) 2003-08-31
EE200100432A (et) 2002-12-16
PL205710B1 (pl) 2010-05-31
AU2646000A (en) 2000-09-04
NO20013993D0 (no) 2001-08-16
US8198078B2 (en) 2012-06-12
IL144777A0 (en) 2002-06-30
BG65140B1 (bg) 2007-03-30
DK2062977T3 (da) 2014-04-07
BG105899A (en) 2002-12-29
CA2362964C (en) 2012-03-27
NO20013993L (no) 2001-10-17
AT408446B (de) 2001-11-26
IL144777A (en) 2007-12-03
WO2000049153A1 (de) 2000-08-24
JP2011120592A (ja) 2011-06-23
SK286416B6 (sk) 2008-09-05
US20080234471A1 (en) 2008-09-25
CN1360633A (zh) 2002-07-24
JP2002536978A (ja) 2002-11-05
SK11182001A3 (sk) 2002-01-07
EP1151109A1 (de) 2001-11-07
ES2246222T3 (es) 2006-02-16
HU230075B1 (hu) 2015-06-29
US20130212740A1 (en) 2013-08-15
JP5514386B2 (ja) 2014-06-04
CZ299622B6 (cs) 2008-09-24
BR0010114A (pt) 2002-06-04
EP1151109B1 (de) 2005-09-07
EP2062977A1 (de) 2009-05-27
ZA200106735B (en) 2002-08-15
EP1642979A1 (de) 2006-04-05
CZ20012943A3 (cs) 2002-04-17
IS6041A (is) 2001-08-08
MXPA01008372A (es) 2003-06-06
NZ513685A (en) 2001-09-28

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