ES2387404T3 - Derivados de purina como agonistas del receptor de la adenosina A2A - Google Patents
Derivados de purina como agonistas del receptor de la adenosina A2A Download PDFInfo
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- ES2387404T3 ES2387404T3 ES06791541T ES06791541T ES2387404T3 ES 2387404 T3 ES2387404 T3 ES 2387404T3 ES 06791541 T ES06791541 T ES 06791541T ES 06791541 T ES06791541 T ES 06791541T ES 2387404 T3 ES2387404 T3 ES 2387404T3
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- Prior art keywords
- amino
- ethyl
- purin
- trans
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| GBGB0514809.3A GB0514809D0 (en) | 2005-07-19 | 2005-07-19 | Compounds |
| GB0514809 | 2005-07-19 | ||
| PCT/EP2006/007078 WO2007009757A1 (en) | 2005-07-19 | 2006-07-17 | Purine derivatives as agonists of the adenosine a2a receptor |
Publications (1)
| Publication Number | Publication Date |
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| ES2387404T3 true ES2387404T3 (es) | 2012-09-21 |
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| ES06791541T Active ES2387404T3 (es) | 2005-07-19 | 2006-07-17 | Derivados de purina como agonistas del receptor de la adenosina A2A |
Country Status (9)
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| EP (1) | EP1904512B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5010599B2 (cg-RX-API-DMAC7.html) |
| AR (1) | AR054559A1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2387404T3 (cg-RX-API-DMAC7.html) |
| GB (1) | GB0514809D0 (cg-RX-API-DMAC7.html) |
| PE (1) | PE20070179A1 (cg-RX-API-DMAC7.html) |
| TW (1) | TW200740814A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2007009757A1 (cg-RX-API-DMAC7.html) |
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| CA2460911C (en) * | 2001-10-01 | 2011-08-30 | University Of Virginia Patent Foundation | 2-propynyl adenosine analogs having a2a agonist activity and compositions thereof |
| SG155182A1 (en) * | 2004-08-02 | 2009-09-30 | Univ Virginia | 2-propynyl adenosine analogs with modified 5æ-ribose groups having a2a agonist activity |
| GT200500281A (es) * | 2004-10-22 | 2006-04-24 | Novartis Ag | Compuestos organicos. |
| GB0500785D0 (en) * | 2005-01-14 | 2005-02-23 | Novartis Ag | Organic compounds |
| GB0523778D0 (en) * | 2005-11-23 | 2006-01-04 | Glaxo Group Ltd | Novel method |
| WO2007120972A2 (en) * | 2006-02-10 | 2007-10-25 | University Of Virginia Patent Foundation | Method to treat sickle cell disease |
| EP2013211B1 (en) | 2006-04-21 | 2012-03-14 | Novartis AG | Purine derivatives for use as adenosin a2a receptor agonists |
| GB0607950D0 (en) * | 2006-04-21 | 2006-05-31 | Novartis Ag | Organic compounds |
| US8188063B2 (en) * | 2006-06-19 | 2012-05-29 | University Of Virginia Patent Foundation | Use of adenosine A2A modulators to treat spinal cord injury |
| ES2361886T3 (es) * | 2006-06-27 | 2011-06-24 | Cbt Development Limited | Profármacos adenosina acetil 2',3'-metilideno novedosos para uso como profármacos para agonistas del receptor adenosina. |
| EP1889846A1 (en) * | 2006-07-13 | 2008-02-20 | Novartis AG | Purine derivatives as A2a agonists |
| EP1903044A1 (en) * | 2006-09-14 | 2008-03-26 | Novartis AG | Adenosine Derivatives as A2A Receptor Agonists |
| RU2009121819A (ru) * | 2006-11-10 | 2010-12-20 | Новартис АГ (CH) | Производные моноацетата циклопентендиола |
| US8058259B2 (en) | 2007-12-20 | 2011-11-15 | University Of Virginia Patent Foundation | Substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as A2AR agonists |
| US8916570B2 (en) | 2008-03-31 | 2014-12-23 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | A3 adenosine receptor agonists and antagonists |
| EP2260038B1 (en) | 2008-03-31 | 2014-12-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Purine derivatives as a3 adenosine receptor-selective agonists |
| US9181253B2 (en) | 2008-08-01 | 2015-11-10 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Adenosine receptor agonists, partial agonists, and antagonists |
| JP5431476B2 (ja) | 2008-08-01 | 2014-03-05 | アメリカ合衆国 | Ａ３アデノシン受容体アンタゴニストおよびａ３アデノシン受容体部分アゴニスト |
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-
2005
- 2005-07-19 GB GBGB0514809.3A patent/GB0514809D0/en not_active Ceased
-
2006
- 2006-07-17 ES ES06791541T patent/ES2387404T3/es active Active
- 2006-07-17 US US11/995,921 patent/US7985740B2/en not_active Expired - Fee Related
- 2006-07-17 WO PCT/EP2006/007078 patent/WO2007009757A1/en not_active Ceased
- 2006-07-17 AR ARP060103052A patent/AR054559A1/es not_active Application Discontinuation
- 2006-07-17 EP EP06791541A patent/EP1904512B1/en active Active
- 2006-07-17 JP JP2008521876A patent/JP5010599B2/ja not_active Expired - Fee Related
- 2006-07-17 PE PE2006000855A patent/PE20070179A1/es not_active Application Discontinuation
- 2006-07-17 TW TW095126065A patent/TW200740814A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US7985740B2 (en) | 2011-07-26 |
| GB0514809D0 (en) | 2005-08-24 |
| TW200740814A (en) | 2007-11-01 |
| JP2009501746A (ja) | 2009-01-22 |
| WO2007009757A1 (en) | 2007-01-25 |
| AR054559A1 (es) | 2007-06-27 |
| US20080214581A1 (en) | 2008-09-04 |
| EP1904512B1 (en) | 2012-06-20 |
| EP1904512A1 (en) | 2008-04-02 |
| PE20070179A1 (es) | 2007-03-06 |
| JP5010599B2 (ja) | 2012-08-29 |
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