ES2384094T3 - Producción de liposomas multivesiculares - Google Patents
Producción de liposomas multivesiculares Download PDFInfo
- Publication number
- ES2384094T3 ES2384094T3 ES98957937T ES98957937T ES2384094T3 ES 2384094 T3 ES2384094 T3 ES 2384094T3 ES 98957937 T ES98957937 T ES 98957937T ES 98957937 T ES98957937 T ES 98957937T ES 2384094 T3 ES2384094 T3 ES 2384094T3
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65G—TRANSPORT OR STORAGE DEVICES, e.g. CONVEYORS FOR LOADING OR TIPPING, SHOP CONVEYOR SYSTEMS OR PNEUMATIC TUBE CONVEYORS
- B65G67/00—Loading or unloading vehicles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65G—TRANSPORT OR STORAGE DEVICES, e.g. CONVEYORS FOR LOADING OR TIPPING, SHOP CONVEYOR SYSTEMS OR PNEUMATIC TUBE CONVEYORS
- B65G2814/00—Indexing codes relating to loading or unloading articles or bulk materials
- B65G2814/03—Loading or unloading means
- B65G2814/0397—Loading or unloading means for ships
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Aviation & Aerospace Engineering (AREA)
- Mechanical Engineering (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6585697P | 1997-11-14 | 1997-11-14 | |
| US65856P | 1997-11-14 | ||
| PCT/US1998/024261 WO1999025319A1 (en) | 1997-11-14 | 1998-11-13 | Production of multivesicular liposomes |
Publications (1)
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|---|---|
| ES2384094T3 true ES2384094T3 (es) | 2012-06-29 |
Family
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Family Applications (1)
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| ES98957937T Expired - Lifetime ES2384094T3 (es) | 1997-11-14 | 1998-11-13 | Producción de liposomas multivesiculares |
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| EP (1) | EP1030652B1 (enExample) |
| JP (2) | JP4575592B2 (enExample) |
| AT (1) | ATE554748T1 (enExample) |
| AU (5) | AU752802C (enExample) |
| CA (1) | CA2309548A1 (enExample) |
| ES (1) | ES2384094T3 (enExample) |
| IL (3) | IL135989A0 (enExample) |
| NZ (1) | NZ504188A (enExample) |
| WO (1) | WO1999025319A1 (enExample) |
Families Citing this family (90)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU771706B2 (en) * | 1999-07-15 | 2004-04-01 | University Of British Columbia, The | Methods and apparatus for preparation of lipid vesicles |
| US6495166B1 (en) * | 1999-11-12 | 2002-12-17 | Alkermes Controlled Therapeutics Inc. | Apparatus and method for preparing microparticles using in-line solvent extraction |
| ES2260070T3 (es) * | 1999-11-19 | 2006-11-01 | Mgi Pharma Biologics, Inc. | Metodo en flujo continuo para preparar microparticulas. |
| US20050037086A1 (en) * | 1999-11-19 | 2005-02-17 | Zycos Inc., A Delaware Corporation | Continuous-flow method for preparing microparticles |
| CN1190454C (zh) * | 2000-04-28 | 2005-02-23 | 田边制药株式会社 | 用于制备微球的方法 |
| ATE275625T1 (de) * | 2000-07-19 | 2004-09-15 | Technodop Ltd Soc De Droit Irl | Kulturraum und bioreaktor zur ausserkörperlichen tierzellenkultur |
| US6471995B1 (en) * | 2000-09-27 | 2002-10-29 | Alkermes Controlled Therapeutics, Inc. Ii | Apparatus and method for preparing microparticles using liquid-liquid extraction |
| JP4709367B2 (ja) * | 2000-10-19 | 2011-06-22 | テルモ株式会社 | 無菌的なリポソームの製造方法 |
| ATE381963T1 (de) † | 2001-10-26 | 2008-01-15 | Octoplus Technologies B V | Verfahren zur herstellung von gereinigten partikeln |
| US20030180348A1 (en) * | 2002-03-22 | 2003-09-25 | Levinson R. Saul | Transcellular drug delivery system |
| US20040082521A1 (en) * | 2002-03-29 | 2004-04-29 | Azaya Therapeutics Inc. | Novel formulations of digitalis glycosides for treating cell-proliferative and other diseases |
| US20040001889A1 (en) | 2002-06-25 | 2004-01-01 | Guohua Chen | Short duration depot formulations |
| EP1537846A1 (en) * | 2002-09-11 | 2005-06-08 | Tanabe Seiyaku Co., Ltd. | Process for the production of microspheres and unit therefor |
| AU2003287526A1 (en) * | 2002-11-06 | 2004-06-03 | Protein-stabilized liposomal formulations of pharmaceutical agents | |
| DE04708802T1 (de) * | 2003-02-07 | 2006-06-22 | Prometic Biosciences Inc., Montreal | Fettsäuren mittlerer kettenlänge, glyceride und analoga als stimulatoren der erythropoiese |
| BE1016051A5 (nl) | 2004-05-18 | 2006-02-07 | Utexbel Nv | Insectenwerende behandeling van textiel. |
| RU2519454C2 (ru) | 2008-05-19 | 2014-06-10 | Оцука Америка Фармасьютикал, Инк. | Способ и устройство для приготовления раствора чувствительного к сдвигу вещества |
| JP5371030B2 (ja) * | 2008-05-23 | 2013-12-18 | 国立大学法人 筑波大学 | ベシクルの製造方法、この製造方法によって得られるベシクルおよびベシクルを製造するためのｗ／ｏ／ｗエマルション |
| JP5107220B2 (ja) * | 2008-12-11 | 2012-12-26 | 三菱重工業株式会社 | 燃料供給装置及びガスタービン |
| US8815971B2 (en) | 2008-12-22 | 2014-08-26 | ATRP Solutions, Inc. | Control over controlled radical polymerization processes |
| US8822610B2 (en) | 2008-12-22 | 2014-09-02 | ATRP Solutions, Inc. | Control over controlled radical polymerization processes |
| WO2010121307A1 (en) * | 2009-04-21 | 2010-10-28 | The University Of Queensland | Complex emulsions |
| US8173750B2 (en) * | 2009-04-23 | 2012-05-08 | ATRP Solutions, Inc. | Star macromolecules for personal and home care |
| US9783628B2 (en) | 2009-04-23 | 2017-10-10 | ATRP Solutions, Inc. | Dual-mechanism thickening agents for hydraulic fracturing fluids |
| JP4900536B2 (ja) * | 2009-07-02 | 2012-03-21 | コニカミノルタホールディングス株式会社 | 特定の分散剤を含有する外水相を利用する二段階乳化法による単胞リポソームの製造方法、ならびに当該単胞リポソームの製造方法を用いる単胞リポソーム分散液またはその乾燥粉末の製造方法 |
| WO2011062132A1 (ja) | 2009-11-20 | 2011-05-26 | コニカミノルタホールディングス株式会社 | Ｗ／ｏ／ｗエマルションの製造方法およびこれを用いたリポソームの製造方法、並びにこれらの方法に用いられる孔膜 |
| EP3175844A1 (en) * | 2010-04-09 | 2017-06-07 | Pacira Pharmaceuticals, Inc. | Large diameter synthetic membrane vesicles |
| US9770414B2 (en) * | 2010-05-13 | 2017-09-26 | Pacira Pharmaceuticals, Inc. | Sustained release formulation of methotrexate as a disease-modifying antirheumatic drug (DMARD) and an anti-cancer agent |
| ES2770575T3 (es) | 2010-10-28 | 2020-07-02 | Pacira Pharmaceuticals Inc | Formulación de liberación sostenida de un fármaco antiinflamatorio no esteroideo |
| WO2014121188A1 (en) | 2013-02-04 | 2014-08-07 | ATRP Solutions, Inc. | Salt-tolerant star macromolecules |
| US9587064B2 (en) | 2010-12-08 | 2017-03-07 | ATRP Solutions, Inc. | Salt-tolerant star macromolecules |
| RU2577683C2 (ru) | 2010-12-27 | 2016-03-20 | Терумо Кабусики Кайся | Липосомная композиция и способ ее получения |
| ES2634669T3 (es) | 2011-02-08 | 2017-09-28 | Halozyme, Inc. | Composición y formulación lipídica de una enzima de degradación de hialuronano y uso de la misma para el tratamiento de la hiperplasia benigna de próstata |
| WO2012133121A1 (ja) | 2011-03-25 | 2012-10-04 | テルモ株式会社 | 持続徐放性リポソーム組成物およびその製造方法 |
| AU2013257546B2 (en) | 2012-05-10 | 2017-12-14 | Painreform Ltd. | Depot formulations of a local anesthetic and methods for preparation thereof |
| JP5314794B2 (ja) * | 2012-08-27 | 2013-10-16 | 三菱重工業株式会社 | 燃料供給装置及びガスタービン |
| CA2882832C (en) | 2012-08-30 | 2021-08-24 | ATRP Solutions, Inc. | Dual mechanism thickening agents for hydraulic fracturing fluids |
| JPWO2014046191A1 (ja) | 2012-09-21 | 2016-08-18 | テルモ株式会社 | 局所麻酔薬持続徐放性リポソーム製剤 |
| US20140093952A1 (en) * | 2012-10-02 | 2014-04-03 | David Serway | Bioreactor Tangential Flow Perfusion Filter System |
| US10711238B2 (en) | 2012-10-02 | 2020-07-14 | Repligen Corporation | Method for proliferation of cells within a bioreactor using a disposable pumphead and filter assembly |
| WO2015036046A1 (en) * | 2013-09-13 | 2015-03-19 | N.V. Nutricia | Improved process for preparing infant formula using a static mixer |
| MX383879B (es) | 2014-05-13 | 2025-03-14 | Amgen Inc | Sistema y métodos de control del proceso para usar con filtros y procesos de filtración. |
| EP3466432B1 (en) | 2014-05-15 | 2020-07-08 | Insmed Incorporated | Methods for treating pulmonary non-tuberculous mycobacterial infections |
| US10336848B2 (en) | 2014-07-03 | 2019-07-02 | Pilot Polymer Technologies, Inc. | Surfactant-compatible star macromolecules |
| US9439864B2 (en) * | 2014-07-07 | 2016-09-13 | Antriabio, Inc. | Solvent extraction from biodegradable microparticles |
| WO2016010840A1 (en) * | 2014-07-16 | 2016-01-21 | Novartis Ag | Method of encapsulating a nucleic acid in a lipid nanoparticle host |
| JP6312226B2 (ja) * | 2014-08-11 | 2018-04-18 | 国立大学法人大阪大学 | 透析装置、リポソーム製造装置、及びリポソーム製造方法 |
| HRP20190881T1 (hr) | 2014-08-28 | 2019-07-12 | Halozyme, Inc. | Kombinacijska terapija s hijaluronan-razgrađujućim enzimom i inhibitorom imunološke kontrolne točke |
| JP6316182B2 (ja) | 2014-12-19 | 2018-04-25 | 富士フイルム株式会社 | リポソームの製造方法及びリポソーム製造装置 |
| CN107427482A (zh) * | 2015-01-21 | 2017-12-01 | 帕西拉制药有限公司 | 凝血酸的多囊脂质体制剂 |
| CN107750156B (zh) | 2015-05-04 | 2020-08-21 | 沃桑缇斯股份公司 | 用于制备跨膜pH梯度囊泡的方法 |
| US10213284B2 (en) | 2015-06-30 | 2019-02-26 | Tela Bio, Inc. | Corner-lock stitch patterns |
| WO2017015421A1 (en) | 2015-07-21 | 2017-01-26 | Tela Bio, Inc. | Compliance control stitching in substrate materials |
| US9820843B2 (en) | 2016-04-26 | 2017-11-21 | Tela Bio, Inc. | Hernia repair grafts having anti-adhesion barriers |
| EP3541815A4 (en) | 2016-11-18 | 2020-07-15 | Pacira Pharmaceuticals, Inc. | ZINC MELXICAM COMPLEX MICROPARTICLE MULTIVESICULAR LIPOSOME FORMULATIONS AND METHODS OF MAKING THE SAME |
| WO2018160027A1 (ko) * | 2017-03-02 | 2018-09-07 | 단디바이오사이언스 주식회사 | 면역억제인자 제어물질을 포함하는 다중도메인캡슐, 이의 제조방법, 및 이를 포함하는 면역조절 조성물 |
| KR102069680B1 (ko) * | 2017-03-02 | 2020-01-23 | 단디바이오사이언스 주식회사 | 면역억제인자 제어물질을 포함하는 다중도메인캡슐, 이의 제조방법, 및 이를 포함하는 면역조절 조성물 |
| WO2018160026A1 (ko) * | 2017-03-02 | 2018-09-07 | 단디바이오사이언스 주식회사 | 면역활성물질을 포함하는 다중도메인캡슐, 이의 제조방법, 및 이를 포함하는 면역조절 조성물 |
| WO2019173792A1 (en) | 2018-03-09 | 2019-09-12 | Tela Bio, Inc. | Surgical repair graft |
| WO2019191627A1 (en) * | 2018-03-30 | 2019-10-03 | Insmed Incorporated | Methods for continuous manufacture of liposomal drug products |
| CN108636122B (zh) * | 2018-06-22 | 2023-05-23 | 南京航空航天大学 | 一种多膜蒸馏组件与压缩机等压降排布系统及工作方法 |
| JP7219344B2 (ja) * | 2019-01-07 | 2023-02-07 | プサン ナショナル ユニバーシティ インダストリー－ユニバーシティ コーポレーション ファウンデーション | 血液脳関門の透過性を増進させるｗ／ｏ／ｗ型トリオレインエマルジョンを利用した薬物伝達プラットホーム |
| EP4585235A3 (en) | 2019-03-08 | 2025-08-20 | Tela Bio, Inc. | Textured medical textiles |
| CN110179752B (zh) * | 2019-05-31 | 2024-02-20 | 常州吾合生物医药有限责任公司 | 高浓度布比卡因多囊脂质体及其制备工艺、配液系统 |
| EP3821972B1 (de) | 2019-11-12 | 2024-07-10 | Fresenius Medical Care Deutschland GmbH | Verwendung eines filtermoduls zur filtration einer biotechnologischen flüssigkeit und filtermodul zur filtration einer biotechnologischen flüssigkeit |
| CN115605182A (zh) * | 2020-01-06 | 2023-01-13 | 帕西拉制药股份有限公司（Us） | 用缓释脂质体麻醉组合物治疗剖宫产手术相关疼痛 |
| WO2021141959A1 (en) | 2020-01-10 | 2021-07-15 | Pacira Pharmaceuticals, Inc. | Treatment of pain by administration of sustained-release liposomal anesthetic compositions |
| US20230080593A1 (en) * | 2020-01-10 | 2023-03-16 | Pacira Pharmaceuticals, Inc. | Treatment of pain by subarachnoid administration of sustained-release liposomal anesthetic compositions |
| KR20220140711A (ko) | 2020-01-13 | 2022-10-18 | 듀렉트 코퍼레이션 | 불순물이 감소된 지속 방출 약물 전달 시스템 및 관련 방법 |
| BR112022019370A2 (pt) * | 2020-03-27 | 2022-11-29 | Alastin Skincare Inc | Composições e métodos relativos à pigmentação |
| US11918688B2 (en) | 2021-01-11 | 2024-03-05 | Pacira Pharmaceuticals, Inc. | Treatment of hip pain with sustained-release liposomal anesthetic compositions |
| KR20230145053A (ko) | 2021-01-12 | 2023-10-17 | 듀렉트 코퍼레이션 | 지속 방출 약물 전달 시스템 및 관련 방법 |
| US12151024B2 (en) * | 2021-01-22 | 2024-11-26 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
| US11033495B1 (en) | 2021-01-22 | 2021-06-15 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
| US11278494B1 (en) * | 2021-01-22 | 2022-03-22 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
| WO2022159564A1 (en) | 2021-01-22 | 2022-07-28 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
| US11357727B1 (en) | 2021-01-22 | 2022-06-14 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
| WO2022197899A2 (en) | 2021-03-19 | 2022-09-22 | Pacira Pharmaceuticals, Inc. | Treatment of pain in pediatric patients by administration of sustained-release liposomal anesthetic compositions |
| CN116887912A (zh) * | 2021-05-18 | 2023-10-13 | 花王株式会社 | 水包油型乳化物的制造方法 |
| CN113616524B (zh) * | 2021-06-07 | 2024-05-14 | 浙江圣兆药物科技股份有限公司 | 一种用于制备储库泡沫脂质体的装置及工艺 |
| EP4415759A4 (en) * | 2021-10-14 | 2025-08-06 | Pacira Pharmaceuticals Inc | DEXAMETHASONE MULTIVESICULAR LIPOSOME FORMULATIONS |
| CN117979970A (zh) | 2021-10-14 | 2024-05-03 | 帕西拉制药有限公司 | 布比卡因多囊脂质体制剂及其用途 |
| CN118742307A (zh) | 2022-02-24 | 2024-10-01 | 帕西拉制药股份有限公司 | 布比卡因多囊脂质体作为星状神经节阻滞剂的用途 |
| US11918565B1 (en) | 2022-11-03 | 2024-03-05 | Pacira Pharmaceuticals, Inc. | Treatment of post-operative pain via sciatic nerve block with sustained-release liposomal anesthetic compositions |
| US12226610B2 (en) | 2022-11-03 | 2025-02-18 | Pacira Pharmaceuticals, Inc. | Treatment of pain associated with total knee arthroplasty with sustained-release liposomal anesthetic compositions |
| CN116370413A (zh) * | 2023-03-14 | 2023-07-04 | 常州吾合生物医药有限责任公司 | 一种制备布比卡因脂质体过程中去除有机溶剂的方法 |
| US12251472B1 (en) | 2024-05-20 | 2025-03-18 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
| US12246092B1 (en) | 2024-05-20 | 2025-03-11 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
| WO2025245023A1 (en) | 2024-05-20 | 2025-11-27 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
| US12251468B1 (en) | 2024-05-20 | 2025-03-18 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
Family Cites Families (171)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3684251A (en) | 1970-09-08 | 1972-08-15 | Us Army | Apparatus for continuous emulsification |
| US3946994A (en) | 1974-04-10 | 1976-03-30 | Petrolite Corporation | System for producing emulsions |
| IT1015665B (it) | 1974-07-04 | 1977-05-20 | Snam Progetti | Metodo per la preparazione in con tinuo di emulsioni acqua olio ed apparecchiatura adatta allo scopo |
| CH588887A5 (enExample) * | 1974-07-19 | 1977-06-15 | Battelle Memorial Institute | |
| US4113765A (en) | 1975-03-21 | 1978-09-12 | Standard Oil Company (Indiana) | Continuous process for sulfonating alkyl aromatics |
| US4897308A (en) * | 1975-06-30 | 1990-01-30 | L'oreal | Compositions comprising aqueous dispersions of lipid spheres |
| US4078052A (en) * | 1976-06-30 | 1978-03-07 | The United States Of America As Represented By The Secretary Of Health, Education And Welfare | Large unilamellar vesicles (LUV) and method of preparing same |
| US4086257A (en) * | 1976-10-12 | 1978-04-25 | Sears Barry D | Phosphatidyl quaternary ammonium compounds |
| CH624011A5 (enExample) * | 1977-08-05 | 1981-07-15 | Battelle Memorial Institute | |
| US4235871A (en) * | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4310506A (en) * | 1979-02-22 | 1982-01-12 | California Institute Of Technology | Means of preparation and applications of liposomes containing high concentrations of entrapped ionic species |
| DE2909906A1 (de) | 1979-03-14 | 1980-10-02 | Bayer Ag | Verfahren zur kontinuierlichen herstellung von mikrokapseln |
| US4235587A (en) * | 1979-04-09 | 1980-11-25 | Honeywell Inc. | Flame responsive control circuit |
| JPS55153713A (en) | 1979-05-02 | 1980-11-29 | Kureha Chem Ind Co Ltd | Pharmaceutical preparation of ribosome containing active substance |
| JPS6127918Y2 (enExample) | 1979-11-07 | 1986-08-19 | ||
| US4394372A (en) * | 1980-12-22 | 1983-07-19 | The Procter & Gamble Company | Process for making lipid membrane structures |
| US4420398A (en) * | 1981-08-13 | 1983-12-13 | American National Red Cross | Filteration method for cell produced antiviral substances |
| US4454083A (en) | 1981-12-21 | 1984-06-12 | Appleton Papers Inc. | Continuous microencapsulation |
| US4522803A (en) * | 1983-02-04 | 1985-06-11 | The Liposome Company, Inc. | Stable plurilamellar vesicles, their preparation and use |
| US5387410A (en) * | 1983-03-18 | 1995-02-07 | Mallinckrodt, Inc. | Method for enhancing magnetic resonance with compositions containing paramagnetic elements carried by liposomes |
| US5169637A (en) | 1983-03-24 | 1992-12-08 | The Liposome Company, Inc. | Stable plurilamellar vesicles |
| US4588578A (en) | 1983-08-08 | 1986-05-13 | The Liposome Company, Inc. | Lipid vesicles prepared in a monophase |
| JPH0768117B2 (ja) | 1983-05-06 | 1995-07-26 | ベスター・インコーポレイテツド | 薬剤放出調整用小胞製剤 |
| US5186941A (en) | 1983-05-06 | 1993-02-16 | Vestar, Inc. | Vesicle formulation for the controlled release of therapeutic agents |
| FR2548043A1 (fr) | 1983-06-14 | 1985-01-04 | Saint Gobain Vitrage | Procede et dispositif pour la fabrication par coulee d'une couche optiquement homogene transparente a partir d'un melange de composants |
| US4622219A (en) | 1983-06-17 | 1986-11-11 | Haynes Duncan H | Method of inducing local anesthesia using microdroplets of a general anesthetic |
| US4725442A (en) | 1983-06-17 | 1988-02-16 | Haynes Duncan H | Microdroplets of water-insoluble drugs and injectable formulations containing same |
| US4478824A (en) * | 1983-08-08 | 1984-10-23 | Franco Robert S | Method for altering red blood cell function and survival |
| JPS60100516A (ja) * | 1983-11-04 | 1985-06-04 | Takeda Chem Ind Ltd | 徐放型マイクロカプセルの製造法 |
| US4599227A (en) * | 1983-11-07 | 1986-07-08 | Wisconsin Alumni Research Foundation | Injectable pharmaceutical preparation for the induction of multiple follicular growth |
| US4888115A (en) | 1983-12-29 | 1989-12-19 | Cuno, Incorporated | Cross-flow filtration |
| US4599342A (en) | 1984-01-16 | 1986-07-08 | The Procter & Gamble Company | Pharmaceutical products providing enhanced analgesia |
| US4744989A (en) | 1984-02-08 | 1988-05-17 | E. R. Squibb & Sons, Inc. | Method of preparing liposomes and products produced thereby |
| US5141674A (en) | 1984-03-08 | 1992-08-25 | Phares Pharmaceutical Research N.V. | Methods of preparing pro-liposome dispersions and aerosols |
| JPH0753661B2 (ja) | 1984-03-08 | 1995-06-07 | フアレス フアーマスーチカル リサーチ エヌブイ | プロ―リポソーム組成物及びリポソームの水性分散物を作る方法 |
| US4610868A (en) | 1984-03-20 | 1986-09-09 | The Liposome Company, Inc. | Lipid matrix carriers for use in drug delivery systems |
| DE3421865A1 (de) | 1984-06-13 | 1985-12-19 | Bayer Ag, 5090 Leverkusen | Kontinuierliche herstellung von mikrokapseldispersionen |
| US5077056A (en) * | 1984-08-08 | 1991-12-31 | The Liposome Company, Inc. | Encapsulation of antineoplastic agents in liposomes |
| DE3432718C1 (de) * | 1984-09-06 | 1986-05-22 | Biotest Pharma GmbH, 6000 Frankfurt | Verfahren zur Herstellung einer Loesung von Milch- und/oder Kolostralimmunglobulinen |
| US4761288A (en) | 1984-09-24 | 1988-08-02 | Mezei Associates Limited | Multiphase liposomal drug delivery system |
| US4788001A (en) * | 1985-04-02 | 1988-11-29 | Dow Corning Corporation | Oil-in-water emulsion |
| GB2176715A (en) | 1985-06-27 | 1987-01-07 | Apv Int Ltd | Beer filtration |
| US5292701A (en) * | 1985-08-29 | 1994-03-08 | W. R. Grace & Co.-Conn. | High pore volume and pore diameter aluminum phosphate and method of making the same |
| IE58981B1 (en) * | 1985-10-15 | 1993-12-15 | Vestar Inc | Anthracycline antineoplastic agents encapsulated in phospholipid micellular particles |
| ES2039203T3 (es) | 1985-11-22 | 1993-09-16 | Takeda Chemical Industries, Ltd. | Composicion de liposomas. |
| US5244678A (en) | 1986-01-14 | 1993-09-14 | Ire-Celltarg S.A. | Pharmaceutical composition containing a local anesthetic and/or centrally acting analgesic encapsulated in liposomes |
| JPH0751496B2 (ja) | 1986-04-02 | 1995-06-05 | 武田薬品工業株式会社 | リポソ−ムの製造法 |
| DE3776966D1 (de) | 1986-05-20 | 1992-04-09 | Wako Pure Chem Ind Ltd | Funktionelle gruppen tragende liposome und verfahren zu deren herstellung. |
| US5204112A (en) * | 1986-06-16 | 1993-04-20 | The Liposome Company, Inc. | Induction of asymmetry in vesicles |
| US5147134A (en) | 1986-08-21 | 1992-09-15 | Petrolite Corporation | Process for the continuous production of high-internal-phase-ratio emulsions |
| US4877619A (en) | 1986-08-25 | 1989-10-31 | Vestar, Inc. | Liposomal vesicles for intraperitoneal administration of therapeutic agents |
| US4776991A (en) * | 1986-08-29 | 1988-10-11 | The United States Of America As Represented By The Secretary Of The Navy | Scaled-up production of liposome-encapsulated hemoglobin |
| US4781871A (en) * | 1986-09-18 | 1988-11-01 | Liposome Technology, Inc. | High-concentration liposome processing method |
| US4752425A (en) * | 1986-09-18 | 1988-06-21 | Liposome Technology, Inc. | High-encapsulation liposome processing method |
| US4844620A (en) | 1986-11-24 | 1989-07-04 | Petrolite Corporation | System for producing high-internal-phase-ratio emulsion products on a continuous basis |
| US4781831A (en) * | 1986-12-19 | 1988-11-01 | Goldsmith Robert L | Cross-flow filtration device with filtrate flow conduits and method of forming same |
| US4920016A (en) * | 1986-12-24 | 1990-04-24 | Linear Technology, Inc. | Liposomes with enhanced circulation time |
| GB8704171D0 (en) | 1987-02-23 | 1987-04-01 | Clayton Found Res | Multivesicular liposomes |
| US5723147A (en) * | 1987-02-23 | 1998-03-03 | Depotech Corporation | Multivesicular liposomes having a biologically active substance encapsulated therein in the presence of a hydrochloride |
| DK86988A (da) | 1987-02-25 | 1988-08-26 | Takeda Chemical Industries Ltd | Liposompraeparat og anvendelse deraf |
| JP2666345B2 (ja) | 1987-04-16 | 1997-10-22 | 武田薬品工業株式会社 | リポソーム製剤およびその製造法 |
| US5069936A (en) * | 1987-06-25 | 1991-12-03 | Yen Richard C K | Manufacturing protein microspheres |
| ATE113468T1 (de) * | 1987-07-29 | 1994-11-15 | Liposome Co Inc | Verfahren zur trennung von teilchen nach grösse. |
| CA1337273C (en) | 1987-07-29 | 1995-10-10 | Robert P. Lenk | Method for size separation of particles |
| IE63518B1 (en) | 1987-11-18 | 1995-05-03 | Vestar Inc | Multiple step entrapment/loading procedure for preparing lipophilic drug-containing liposomes |
| US5807572A (en) * | 1988-02-18 | 1998-09-15 | Depotech Corporation | Multivesicular liposomes having a biologically active substance encapsulated therein in the presence of a hydrochloride |
| ATE77051T1 (de) * | 1988-03-04 | 1992-06-15 | Takeda Chemical Industries Ltd | Liposom-zusammensetzung. |
| US5948441A (en) * | 1988-03-07 | 1999-09-07 | The Liposome Company, Inc. | Method for size separation of particles |
| US5261903A (en) * | 1988-04-11 | 1993-11-16 | M.D. Inc. | Composite anesthetic article and method of use |
| MX9203504A (es) * | 1988-04-20 | 1992-07-01 | Liposome Co Inc | Complejo agente: lipido activo de alta proporcion. |
| US5576017A (en) | 1988-05-30 | 1996-11-19 | Depotech Corporation | Heterovesicular liposomes |
| US5422120A (en) * | 1988-05-30 | 1995-06-06 | Depotech Corporation | Heterovesicular liposomes |
| US4937078A (en) | 1988-08-26 | 1990-06-26 | Mezei Associates Limited | Liposomal local anesthetic and analgesic products |
| IL91664A (en) | 1988-09-28 | 1993-05-13 | Yissum Res Dev Co | Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release |
| BE1001869A3 (fr) * | 1988-10-12 | 1990-04-03 | Franz Legros | Procede d'encapsulation liposomiale d'antibiotiques aminoglucosidiques, en particulier de la gentamycine. |
| US4921853A (en) * | 1988-11-14 | 1990-05-01 | Michigan State University | Method for producing analgesia in mammals |
| US4908463A (en) | 1988-12-05 | 1990-03-13 | Ethyl Corporation | Aluminoxane process |
| US5049392A (en) | 1989-01-18 | 1991-09-17 | The Liposome Company, Inc. | Osmotically dependent vesicles |
| US4956290A (en) * | 1989-03-27 | 1990-09-11 | Phillips Petroleum Company | Large scale process for the purification of alcohol oxidase |
| US5364632A (en) | 1989-04-05 | 1994-11-15 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Medicinal emulsions |
| US5227170A (en) * | 1989-06-22 | 1993-07-13 | Vestar, Inc. | Encapsulation process |
| FR2651680B1 (fr) * | 1989-09-14 | 1991-12-27 | Medgenix Group Sa | Nouveau procede de preparation de microparticules lipidiques. |
| US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5225212A (en) | 1989-10-20 | 1993-07-06 | Liposome Technology, Inc. | Microreservoir liposome composition and method |
| US5227165A (en) | 1989-11-13 | 1993-07-13 | Nova Pharmaceutical Corporation | Liposphere delivery systems for local anesthetics |
| US5334381A (en) | 1989-12-22 | 1994-08-02 | Unger Evan C | Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same |
| US5580575A (en) | 1989-12-22 | 1996-12-03 | Imarx Pharmaceutical Corp. | Therapeutic drug delivery systems |
| NZ237464A (en) | 1990-03-21 | 1995-02-24 | Depotech Corp | Liposomes with at least two separate chambers encapsulating two separate biologically active substances |
| US5246707A (en) * | 1990-04-26 | 1993-09-21 | Haynes Duncan H | Sustained release delivery of water-soluble bio-molecules and drugs using phospholipid-coated microcrystals, microdroplets and high-concentration liposomes |
| US5091187A (en) * | 1990-04-26 | 1992-02-25 | Haynes Duncan H | Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs |
| US5169934A (en) * | 1990-05-14 | 1992-12-08 | Anergen, Inc. | Intracellularly cleavable compounds |
| USRE35192E (en) * | 1990-11-13 | 1996-03-26 | Phoenix Surgical Products, Inc. | Post-surgical anesthesia at a continuous and progressively decreasing administration rate |
| IS1685B (is) | 1990-12-11 | 1998-02-24 | Bracco International B.V. | Aðferð við að búa til fitukúlur (liposomes) sem eru gæddar auknum hæfileika til að draga í sig og halda í sér aðskotaefnum |
| SE506930C2 (sv) * | 1991-03-25 | 1998-03-02 | Svedala Pumps & Process Ab | Förfarande och anordning för förtjockning av finpartikulära suspensioner |
| US5885260A (en) * | 1991-05-30 | 1999-03-23 | Mehl, Sr.; Thomas L. | Freeze-dried liposome delivery system for application of skin treatment agents |
| ES2078034T3 (es) | 1991-07-03 | 1995-12-01 | Vestar Inc | Tecnica de carga para preparar liposomas que contienen farmacos. |
| US5977326A (en) | 1991-08-06 | 1999-11-02 | Salford Ultrafine Chemicals And Research Limited | Process for making morphine-6-glucuronide or substituted morphine-6-glucuronide |
| SE9200952D0 (sv) | 1992-03-27 | 1992-03-27 | Kabi Pharmacia Ab | Pharmaceutical carrier system containing defined lipids |
| US5922340A (en) | 1992-09-10 | 1999-07-13 | Children's Medical Center Corporation | High load formulations and methods for providing prolonged local anesthesia |
| CA2146963A1 (en) * | 1992-10-16 | 1994-04-28 | Andreas Sachse | Process and device for producing liquid, dispersed systems |
| US5321012A (en) * | 1993-01-28 | 1994-06-14 | Virginia Commonwealth University Medical College | Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance |
| JPH06247842A (ja) | 1993-02-23 | 1994-09-06 | Green Cross Corp:The | リポソーム組成物の製造方法 |
| EP0616801B1 (de) * | 1993-03-24 | 1998-05-27 | Novartis AG | Verfahren zur Herstellung einer Liposomendispersion im Hochdruckbereich |
| JPH09502700A (ja) * | 1993-04-02 | 1997-03-18 | ザ リポソーム カンパニー、インコーポレーテッド | リポソームの製造方法 |
| US5891842A (en) | 1993-04-09 | 1999-04-06 | Trustees Of Tufts College | Methodology for eliciting an analgesic response in a living subject |
| AU6818094A (en) | 1993-04-22 | 1994-11-08 | Depotech Corporation | Cyclodextrin liposomes encapsulating pharmacologic compounds and methods for their use |
| US5455044A (en) | 1993-05-14 | 1995-10-03 | Depotech Corporation | Method for treating neurological disorders |
| JPH09503743A (ja) | 1993-05-14 | 1997-04-15 | デポテック コーポレーション | 神経学的疾患の治療方法 |
| US5776486A (en) * | 1993-05-28 | 1998-07-07 | Aphios Corporation | Methods and apparatus for making liposomes containing hydrophobic drugs |
| US5554382A (en) * | 1993-05-28 | 1996-09-10 | Aphios Corporation | Methods and apparatus for making liposomes |
| EP0706374B1 (en) * | 1993-06-30 | 1997-12-10 | Genentech, Inc. | Method for preparing liposomes |
| SE503277C2 (sv) * | 1993-07-20 | 1996-05-13 | Alfa Laval Brewery Syst Ab | Filter avsett för tvärströmsfiltrering |
| US5543158A (en) * | 1993-07-23 | 1996-08-06 | Massachusetts Institute Of Technology | Biodegradable injectable nanoparticles |
| US5853755A (en) | 1993-07-28 | 1998-12-29 | Pharmaderm Laboratories Ltd. | Biphasic multilamellar lipid vesicles |
| US5387387A (en) * | 1993-09-30 | 1995-02-07 | Alex James & Associates, Inc. | Method and apparatus for dry spinning spandex |
| GB9320668D0 (en) | 1993-10-07 | 1993-11-24 | Secr Defence | Liposomes containing particulare materials |
| US5849763A (en) | 1993-10-13 | 1998-12-15 | Darwin Discovery Limited | Use of levobupivacaine as an anesthetic agent |
| GB9321061D0 (en) | 1993-10-13 | 1993-12-01 | Chiroscience Ltd | Analgestic agent and its use |
| EP0727210B1 (en) * | 1993-10-13 | 2001-12-19 | Darwin Discovery Limited | Analgesic agent and its use |
| AU683957B2 (en) * | 1993-11-05 | 1997-11-27 | Amgen, Inc. | Liposome preparation and material encapsulation method |
| NZ276305A (en) | 1993-11-16 | 1997-10-24 | Depotech Corp | Controlled release vesicle compositions |
| US5766627A (en) | 1993-11-16 | 1998-06-16 | Depotech | Multivescular liposomes with controlled release of encapsulated biologically active substances |
| US5879672A (en) * | 1994-10-07 | 1999-03-09 | Regeneron Pharmaceuticals, Inc. | Tie-2 ligand 1 |
| US5451408A (en) | 1994-03-23 | 1995-09-19 | Liposome Pain Management, Ltd. | Pain management with liposome-encapsulated analgesic drugs |
| SE518578C2 (sv) | 1994-06-15 | 2002-10-29 | Gs Dev Ab | Lipidbaserad komposition |
| US5741516A (en) | 1994-06-20 | 1998-04-21 | Inex Pharmaceuticals Corporation | Sphingosomes for enhanced drug delivery |
| US6048545A (en) | 1994-06-24 | 2000-04-11 | Biozone Laboratories, Inc. | Liposomal delivery by iontophoresis |
| US6066331A (en) | 1994-07-08 | 2000-05-23 | Barenholz; Yechezkel | Method for preparation of vesicles loaded with biological structures, biopolymers and/or oligomers |
| SE9402453D0 (sv) | 1994-07-12 | 1994-07-12 | Astra Ab | New pharmaceutical preparation |
| DE4430592A1 (de) | 1994-08-20 | 1996-02-22 | Max Delbrueck Centrum | Liposomale Zubereitung, ihre Herstellung und ihre Verwendung |
| US5993850A (en) | 1994-09-13 | 1999-11-30 | Skyepharma Inc. | Preparation of multivesicular liposomes for controlled release of encapsulated biologically active substances |
| US5589189A (en) * | 1994-09-14 | 1996-12-31 | Nexstar Pharmaceuticals, Inc. | Liposome dispersion |
| US5702722A (en) * | 1994-09-30 | 1997-12-30 | Bracco Research S.A. | Liposomes with enhanced entrapment capacity, method and use |
| IL115849A0 (en) * | 1994-11-03 | 1996-01-31 | Merz & Co Gmbh & Co | Tangential filtration preparation of liposomal drugs and liposome product thereof |
| EP0711557A1 (de) * | 1994-11-09 | 1996-05-15 | Ciba-Geigy Ag | Pharmazeutische Formulierungsgrundlage |
| CA2212165A1 (en) | 1995-02-10 | 1996-08-15 | Matthew A. Bergan | Method and device for administering analgesics |
| CA2211995A1 (en) * | 1995-02-24 | 1996-08-29 | Cantab Pharmaceuticals Research Limited | Polypeptides useful as immunotherapeutic agents and methods of polypeptide preparation |
| US6007838A (en) * | 1995-06-07 | 1999-12-28 | The United States Of America As Represented By The Secretary Of The Army | Process for making liposome preparation |
| DK0752245T3 (da) | 1995-07-05 | 2002-09-09 | Europ Economic Community | Biokompatible og bionedbrydelige nanopartikler udviklet til absorption og afgivelse af proteinholdige lægemidler |
| US5931809A (en) | 1995-07-14 | 1999-08-03 | Depotech Corporation | Epidural administration of therapeutic compounds with sustained rate of release |
| AU6698196A (en) * | 1995-08-15 | 1997-03-12 | Universite Libre De Bruxelles | Liposomes preparation method and plant |
| US5942253A (en) * | 1995-10-12 | 1999-08-24 | Immunex Corporation | Prolonged release of GM-CSF |
| GB9605915D0 (en) | 1996-03-21 | 1996-05-22 | Univ Bruxelles | Liposome encapsulated amphiphilic drug compositions |
| EP0914094A4 (en) | 1996-03-28 | 2000-03-01 | Univ Illinois | MATERIALS AND METHOD FOR PRODUCING IMPROVED LIPOSOMAL AGENTS |
| GB9614902D0 (en) * | 1996-07-16 | 1996-09-04 | Rhodes John | Sustained release composition |
| US6046187A (en) | 1996-09-16 | 2000-04-04 | Children's Medical Center Corporation | Formulations and methods for providing prolonged local anesthesia |
| US5997899A (en) | 1996-10-01 | 1999-12-07 | Skyepharma Inc. | Method for producing liposomes with increased percent of compound encapsulated |
| NZ336538A (en) | 1996-10-15 | 2001-11-30 | Liposome Co Inc | N-acyl phosphatidylethanolamine-mediated liposomal drug delivery |
| US5837282A (en) * | 1996-10-30 | 1998-11-17 | University Of British Columbia | Ionophore-mediated liposome loading |
| WO1998024415A1 (en) | 1996-12-02 | 1998-06-11 | The Regents Of The University Of California | A bilayer structure which encapsulates multiple containment units and uses thereof |
| US5865184A (en) | 1997-01-13 | 1999-02-02 | Takiguchi; Tetsuo | Combined spinal and epidural anesthesia |
| US5891467A (en) | 1997-01-31 | 1999-04-06 | Depotech Corporation | Method for utilizing neutral lipids to modify in vivo release from multivesicular liposomes |
| US5827533A (en) | 1997-02-06 | 1998-10-27 | Duke University | Liposomes containing active agents aggregated with lipid surfactants |
| US5945126A (en) * | 1997-02-13 | 1999-08-31 | Oakwood Laboratories L.L.C. | Continuous microsphere process |
| GB9704351D0 (en) | 1997-03-03 | 1997-04-23 | Chiroscience Ltd | Levobupivacaine and its use |
| GB9704352D0 (en) | 1997-03-03 | 1997-04-23 | Chiroscience Ltd | Levobupivacaine and its use |
| ATE219674T1 (de) | 1997-03-13 | 2002-07-15 | James N Campbell | Zusammensetzung enthaltend capsaicin oder seine analogen und lokalanästhetika |
| US5947689A (en) * | 1997-05-07 | 1999-09-07 | Scilog, Inc. | Automated, quantitative, system for filtration of liquids having a pump controller |
| WO1998055105A1 (en) * | 1997-06-05 | 1998-12-10 | Hemosphere, Inc. | Fibrinogen-coated microspheres |
| US6287587B2 (en) | 1997-07-15 | 2001-09-11 | Takeda Chemical Industries, Ltd. | Process for producing sustained-release preparation by in-water drying |
| CA2294950C (en) | 1997-07-21 | 2009-04-07 | Darwin Discovery Limited | Levobupivacaine and its use |
| WO1999004772A2 (en) | 1997-07-22 | 1999-02-04 | Darwin Discovery Limited | Use of levobupivacaine |
| US5776915A (en) * | 1997-08-12 | 1998-07-07 | Clarion Pharmaceuticals Inc. | Phosphocholines of retinoids |
| US6306432B1 (en) * | 1997-09-08 | 2001-10-23 | Chiron Corporation | High and low load formulations of IGF-I in multivesicular liposomes |
| US6106858A (en) * | 1997-09-08 | 2000-08-22 | Skyepharma, Inc. | Modulation of drug loading in multivescular liposomes |
| ES2373861T3 (es) * | 1997-09-18 | 2012-02-09 | Pacira Pharmaceuticals, Inc. | Composiciones anestésicas liposomiales de liberación sostenida. |
| US6033708A (en) * | 1997-09-30 | 2000-03-07 | The United States Of America As Represented By The Secretary Of The Navy | Method for producing sterile filterable liposome dispersion |
| IL140899A0 (en) | 1998-07-17 | 2002-02-10 | Skyepharma Inc | Lipid/polymer containing pharmaceutical compositions and processes for the preparation thereof |
| US6358060B2 (en) * | 1998-09-03 | 2002-03-19 | Jsr Llc | Two-stage transmucosal medicine delivery system for symptom relief |
| US6270802B1 (en) * | 1998-10-28 | 2001-08-07 | Oakwood Laboratories L.L.C. | Method and apparatus for formulating microspheres and microcapsules |
| US6248760B1 (en) * | 1999-04-14 | 2001-06-19 | Paul C Wilhelmsen | Tablet giving rapid release of nicotine for transmucosal administration |
-
1998
- 1998-11-13 AT AT98957937T patent/ATE554748T1/de active
- 1998-11-13 IL IL13598998A patent/IL135989A0/xx active IP Right Grant
- 1998-11-13 JP JP2000520753A patent/JP4575592B2/ja not_active Expired - Lifetime
- 1998-11-13 NZ NZ504188A patent/NZ504188A/en not_active IP Right Cessation
- 1998-11-13 EP EP98957937A patent/EP1030652B1/en not_active Expired - Lifetime
- 1998-11-13 CA CA002309548A patent/CA2309548A1/en not_active Abandoned
- 1998-11-13 AU AU14075/99A patent/AU752802C/en not_active Expired
- 1998-11-13 ES ES98957937T patent/ES2384094T3/es not_active Expired - Lifetime
- 1998-11-13 US US09/192,064 patent/US20020039596A1/en not_active Abandoned
- 1998-11-13 WO PCT/US1998/024261 patent/WO1999025319A1/en not_active Ceased
-
2000
- 2000-05-05 IL IL135989A patent/IL135989A/en not_active IP Right Cessation
-
2002
- 2002-10-01 AU AU2002301268A patent/AU2002301268B2/en not_active Expired
-
2006
- 2006-01-06 AU AU2006200044A patent/AU2006200044A1/en not_active Abandoned
-
2007
- 2007-02-25 US US11/678,615 patent/US9585838B2/en not_active Expired - Fee Related
-
2008
- 2008-07-09 AU AU2008203032A patent/AU2008203032B2/en not_active Expired
- 2008-08-31 IL IL193778A patent/IL193778A0/en unknown
-
2010
- 2010-07-20 JP JP2010162514A patent/JP2010285438A/ja active Pending
- 2010-08-13 AU AU2010212347A patent/AU2010212347B2/en not_active Expired
-
2013
- 2013-03-08 US US13/791,302 patent/US20140004173A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| IL193778A0 (en) | 2009-05-04 |
| CA2309548A1 (en) | 1999-05-27 |
| AU2010212347B2 (en) | 2012-03-22 |
| US9585838B2 (en) | 2017-03-07 |
| AU2002301268B2 (en) | 2005-10-06 |
| US20070235889A1 (en) | 2007-10-11 |
| ATE554748T1 (de) | 2012-05-15 |
| NZ504188A (en) | 2001-10-26 |
| IL135989A (en) | 2009-02-11 |
| AU2006200044A1 (en) | 2006-02-02 |
| AU2008203032B2 (en) | 2010-05-13 |
| JP4575592B2 (ja) | 2010-11-04 |
| AU2008203032A1 (en) | 2008-07-31 |
| JP2010285438A (ja) | 2010-12-24 |
| AU2010212347A1 (en) | 2010-09-09 |
| EP1030652A1 (en) | 2000-08-30 |
| US20140004173A1 (en) | 2014-01-02 |
| AU752802C (en) | 2006-04-13 |
| JP2001522870A (ja) | 2001-11-20 |
| IL135989A0 (en) | 2001-05-20 |
| WO1999025319A1 (en) | 1999-05-27 |
| US20020039596A1 (en) | 2002-04-04 |
| AU752802B2 (en) | 2002-10-03 |
| EP1030652B1 (en) | 2012-04-25 |
| EP1030652A4 (en) | 2006-05-24 |
| AU1407599A (en) | 1999-06-07 |
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