ES2373253T3 - Pirazolopirrolidinos como inhibidores de gamma secretasa. - Google Patents

Pirazolopirrolidinos como inhibidores de gamma secretasa. Download PDF

Info

Publication number
ES2373253T3
ES2373253T3 ES08756023T ES08756023T ES2373253T3 ES 2373253 T3 ES2373253 T3 ES 2373253T3 ES 08756023 T ES08756023 T ES 08756023T ES 08756023 T ES08756023 T ES 08756023T ES 2373253 T3 ES2373253 T3 ES 2373253T3
Authority
ES
Spain
Prior art keywords
alkyl
formula
compounds
quot
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES08756023T
Other languages
English (en)
Spanish (es)
Inventor
Darren Dressen
Simeon Bowers
Albert W. Garofalo
Roy K. Hom
Matthew N. Mattson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Elan Pharmaceuticals LLC
Original Assignee
Elan Pharmaceuticals LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Pharmaceuticals LLC filed Critical Elan Pharmaceuticals LLC
Application granted granted Critical
Publication of ES2373253T3 publication Critical patent/ES2373253T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ES08756023T 2007-05-25 2008-05-21 Pirazolopirrolidinos como inhibidores de gamma secretasa. Active ES2373253T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US93184007P 2007-05-25 2007-05-25
US931840P 2007-05-25
PCT/US2008/064324 WO2008147800A1 (en) 2007-05-25 2008-05-21 Pyrazolopyrrolidines as inhibitors of gamma secretase

Publications (1)

Publication Number Publication Date
ES2373253T3 true ES2373253T3 (es) 2012-02-01

Family

ID=39679310

Family Applications (1)

Application Number Title Priority Date Filing Date
ES08756023T Active ES2373253T3 (es) 2007-05-25 2008-05-21 Pirazolopirrolidinos como inhibidores de gamma secretasa.

Country Status (17)

Country Link
US (1) US7977368B2 (zh)
EP (1) EP2152713B1 (zh)
JP (1) JP2010528036A (zh)
AR (1) AR066712A1 (zh)
AT (1) ATE523511T1 (zh)
AU (1) AU2008256940A1 (zh)
BR (1) BRPI0812014A2 (zh)
CA (1) CA2687765A1 (zh)
CL (1) CL2008001516A1 (zh)
CO (1) CO6241122A2 (zh)
ES (1) ES2373253T3 (zh)
MX (1) MX2009012525A (zh)
NZ (1) NZ582039A (zh)
PE (1) PE20090280A1 (zh)
TW (1) TW200904413A (zh)
WO (1) WO2008147800A1 (zh)
ZA (1) ZA200908919B (zh)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102203089A (zh) * 2008-09-05 2011-09-28 伊兰医药品公司 N-磺酰氨基多环吡唑基化合物
CA2765461C (en) * 2009-08-03 2017-04-11 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F.S.P.A. Process for the preparation of 1-benzyl-3-hydr0xymethyl-1h-indaz0le and its derivatives and required magnesium intermediates
EA022007B1 (ru) 2009-09-11 2015-10-30 Пробиодруг Аг Гетероциклические производные в качестве ингибиторов глутаминилциклазы
US8481541B2 (en) 2010-03-22 2013-07-09 Hoffmann-La Roche Inc. Pyrrolopyrazine kinase inhibitors
US8518945B2 (en) 2010-03-22 2013-08-27 Hoffmann-La Roche Inc. Pyrrolopyrazine kinase inhibitors
TWI496785B (zh) 2010-05-20 2015-08-21 Hoffmann La Roche 吡咯并吡激酶抑制劑
MX2012013378A (es) 2010-05-20 2013-01-24 Hoffmann La Roche Derivados de pirrolo [2, 3-b] pirazina-7-carboxamida y sus uso como inhibidores de cinasa janus (jak) y cinasa tirosina del brazo (syk).
JP6644017B2 (ja) * 2017-03-30 2020-02-12 長弘生物科技股▲ふん▼有限公司 ブチリデンフタリドの用途、その使用方法及びそれを使用して医薬組成物を製造する方法
PL3461819T3 (pl) 2017-09-29 2020-11-30 Probiodrug Ag Inhibitory cyklazy glutaminylowej

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1283178A (zh) * 1997-12-27 2001-02-07 钟渊化学工业株式会社 β－卤代－α－氨基－羧酸和苯基半胱氨酸衍生物及其中间体的制备方法
US6887898B1 (en) * 1999-10-22 2005-05-03 Darrick S. H. L. Kim Pharmaceutical compositions useful in prevention and treatment of beta-Amyloid protein-induced disease
US6559174B2 (en) 2001-03-20 2003-05-06 Merck & Co., Inc. N-arylsulfonyl aryl aza-bicyclic derivatives as potent cell adhesion inhibitors
US7256186B2 (en) 2002-02-06 2007-08-14 Schering Corporation Gamma secretase inhibitors
TW200302717A (en) * 2002-02-06 2003-08-16 Schering Corp Novel gamma secretase inhibitors
US20040171614A1 (en) * 2002-02-06 2004-09-02 Schering-Plough Corporation Novel gamma secretase inhibitors
MXPA05000947A (es) * 2002-07-25 2005-05-16 Pharmacia Italia Spa Biciclo-pirazoles activos como inhibidores de cinasa, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.
US20060264380A1 (en) 2003-07-21 2006-11-23 Mats Hellstrom Compounds and Methods for Promoting Angiogenesis
EP1668013B1 (en) * 2003-09-23 2012-02-22 Vertex Pharmaceuticals Incorporated Pyrazolopyrrole derivatives as protein kinase inhibitors
BRPI0614944A2 (pt) 2005-08-19 2011-04-26 Elan Pharm Inc inibidores sulfonamido n-bicìclicos ponte de gama-secretase
JP2009518301A (ja) * 2005-12-01 2009-05-07 エラン ファーマシューティカルズ，インコーポレイテッド ５−（アリールスルホニル）−ピラゾロピペリジン
TW200813054A (en) 2006-06-02 2008-03-16 Elan Pharm Inc Fused, tricyclic sulfonamide inhibitors of gamma secretase

Also Published As

Publication number Publication date
PE20090280A1 (es) 2009-03-19
CO6241122A2 (es) 2011-01-20
WO2008147800A1 (en) 2008-12-04
AR066712A1 (es) 2009-09-09
CL2008001516A1 (es) 2008-10-10
CA2687765A1 (en) 2008-12-04
TW200904413A (en) 2009-02-01
EP2152713B1 (en) 2011-09-07
NZ582039A (en) 2012-02-24
ATE523511T1 (de) 2011-09-15
MX2009012525A (es) 2009-12-09
EP2152713A1 (en) 2010-02-17
ZA200908919B (en) 2010-08-25
US20090099235A1 (en) 2009-04-16
AU2008256940A1 (en) 2008-12-04
JP2010528036A (ja) 2010-08-19
US7977368B2 (en) 2011-07-12
BRPI0812014A2 (pt) 2014-11-18

Similar Documents

Publication Publication Date Title
ES2373253T3 (es) Pirazolopirrolidinos como inhibidores de gamma secretasa.
ES2433223T3 (es) Derivados de espiroaminodihidrotiazina
JP6782255B2 (ja) ヒストンデアセチラーゼ阻害薬及び組成物並びにそれらの使用の方法
JP5651692B2 (ja) 縮合アミノジヒドロ−オキサジン誘導体
JP5666304B2 (ja) 新規な縮合アミノジヒドロチアジン誘導体
JP5699146B2 (ja) 縮合アミノジヒドロピリミドン誘導体
BR112021000964A2 (pt) inibidores do inflamassoma de nlrp3
ES2394364T3 (es) Derivado de cinamida bicíclico
CA3042710A1 (en) Cyclobutane- and azetidine-containing mono and spirocyclic compounds as .alpha.v integrin inhibitors
WO2016105484A1 (en) Derivatives of 5-(hetero)arylpyrazol-3-carboxylic amide or 1-(hetero)aryltriazol-4-carboxylic amide useful for the treatment of inter alia cystic fibrosis
CN109715613A (zh) 杂环化合物
AU2015229188A1 (en) Compounds, compositions, and methods for increasing CFTR activity
TW201309710A (zh) 經稠合之胺基二氫噻□衍生物
TW201302763A (zh) 用於減少β－類澱粉產生之化合物
FR2926555A1 (fr) Derives bicycliques de carboxamides azabicycliques, leur preparation et leur application en therapeutique
EA014906B1 (ru) 5-(арилсульфонил)пиразолопиперидины
JP7130873B2 (ja) バニン阻害剤としてのヘテロ芳香族化合物
CA2980395A1 (en) Heterocyclic compounds and their use in preventing or treating bacterial infections
JP6805172B2 (ja) ヒストンデアセチラーゼ阻害薬及び組成物並びにそれらの使用の方法
BRPI0712123A2 (pt) inibidores de sulfonamida tricìclica fundida, de gama secretase.
ES2784398T3 (es) Compuestos heterocíclicos de 3,3-difluoropiperidina carbamato como antagonistas del receptor de NMDA NR2B
TW201815390A (zh) 包含抗生素化合物及雜環化合物之組合物及其於預防或治療細菌感染之用途
AU2014365915C1 (en) Tetrahydro-tetrazolo[1,5-a]pyrazines as ROR-gamma inhibitors
CA3178361A1 (en) Dihydrooxazole and thiourea derivatives modulating the nlrp3 inflammasome pathway