ES2373022T3 - (dihidro)pirrolo[2,1-a]isoquinolinas. - Google Patents

(dihidro)pirrolo[2,1-a]isoquinolinas. Download PDF

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Publication number
ES2373022T3
ES2373022T3 ES09708584T ES09708584T ES2373022T3 ES 2373022 T3 ES2373022 T3 ES 2373022T3 ES 09708584 T ES09708584 T ES 09708584T ES 09708584 T ES09708584 T ES 09708584T ES 2373022 T3 ES2373022 T3 ES 2373022T3
Authority
ES
Spain
Prior art keywords
alkyl
pyrrolo
methoxy
dihydro
thiophene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES09708584T
Other languages
English (en)
Spanish (es)
Inventor
Rachel Deborah Van Rijn
Hubert Jan Jozef Loozen
Cornelis Marius Timmers
Lars Anders Van Der Veen
Willem Frederik Johan Karstens
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme BV
Organon NV
Original Assignee
Organon NV
MSD Oss BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organon NV, MSD Oss BV filed Critical Organon NV
Application granted granted Critical
Publication of ES2373022T3 publication Critical patent/ES2373022T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Reproductive Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
ES09708584T 2008-02-08 2009-02-06 (dihidro)pirrolo[2,1-a]isoquinolinas. Active ES2373022T3 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US2706208P 2008-02-08 2008-02-08
EP08151199 2008-02-08
US27062 2008-02-08
EP08151199 2008-02-08
PCT/EP2009/051366 WO2009098283A1 (fr) 2008-02-08 2009-02-06 (dihydro)pyrrolo[2,1-α]isoquinolines

Publications (1)

Publication Number Publication Date
ES2373022T3 true ES2373022T3 (es) 2012-01-30

Family

ID=39516937

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09708584T Active ES2373022T3 (es) 2008-02-08 2009-02-06 (dihidro)pirrolo[2,1-a]isoquinolinas.

Country Status (27)

Country Link
US (1) US8394789B2 (fr)
EP (1) EP2252611B1 (fr)
JP (1) JP5620823B2 (fr)
KR (1) KR101586870B1 (fr)
CN (1) CN102216297B (fr)
AR (1) AR070345A1 (fr)
AT (1) ATE527260T1 (fr)
AU (1) AU2009211296B2 (fr)
BR (1) BRPI0906937A2 (fr)
CA (1) CA2713173C (fr)
CL (1) CL2009000281A1 (fr)
CO (1) CO6241120A2 (fr)
DK (1) DK2252611T3 (fr)
EC (1) ECSP10010303A (fr)
ES (1) ES2373022T3 (fr)
HK (1) HK1150597A1 (fr)
HR (1) HRP20110942T1 (fr)
IL (1) IL206378A0 (fr)
MX (1) MX2010008717A (fr)
NZ (1) NZ587164A (fr)
PE (1) PE20091413A1 (fr)
PL (1) PL2252611T3 (fr)
PT (1) PT2252611E (fr)
RU (1) RU2495037C2 (fr)
SI (1) SI2252611T1 (fr)
TW (1) TW200944523A (fr)
WO (1) WO2009098283A1 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI461426B (zh) * 2009-05-27 2014-11-21 Merck Sharp & Dohme （二氫）咪唑並異〔５，１－ａ〕喹啉類
US8071587B2 (en) * 2009-05-27 2011-12-06 N. V. Organon (Dihydro)imidazoiso[5,1-A]quinolines
EP2504316A1 (fr) 2009-11-23 2012-10-03 MSD Oss B.V. Composés hétérocyliques en tant qu'antagonistes des récepteurs d'orexine
US20120174381A1 (en) 2011-01-10 2012-07-12 David Messick Apparatus and method for frame crimping
WO2012112958A2 (fr) * 2011-02-19 2012-08-23 The Broad Institute, Inc Dosages à grand rendement destinés à détecter la leucémie dans la niche stromale
WO2013041458A1 (fr) 2011-09-22 2013-03-28 Msd Oss B.V. Antagonistes du récepteur de la fsh
AU2012357296B2 (en) * 2011-12-21 2017-04-13 Jiangsu Hengrui Medicine Co., Ltd. Pyrrole six-membered heteroaryl ring derivative, preparation method therefor, and medicinal uses thereof
CN102718695B (zh) * 2012-06-25 2014-04-02 华东师范大学 一种氮杂双环[3.3.0]辛烷衍生物的合成方法
JP6272897B2 (ja) 2012-11-29 2018-01-31 ケモセントリックス，インコーポレイティド Ｃｘｃｒ７アンタゴニスト
RU2550366C1 (ru) * 2014-05-22 2015-05-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Российский университет дружбы народов" (РУДН) СПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНЫХ 5,6-ДИГИДРОПИРРОЛО[2,1-a]ИЗОХИНОЛИНОВ
BR112021011222A2 (pt) 2018-12-12 2021-08-24 Chemocentryx, Inc. Inibidores de cxcr7 para o tratamento de câncer
CN110540519B (zh) * 2019-09-05 2022-12-02 宁波大学 一种1,6-烯炔类化合物与酮类化合物的自由基环化反应方法
CN113999103A (zh) * 2021-11-26 2022-02-01 八叶草健康产业研究院(厦门)有限公司 一种α-羟基-环丁烷甲酸的制备方法
WO2024184461A2 (fr) 2023-03-08 2024-09-12 Ferring B.V. Modulateurs du récepteur fsh à petites molécules

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8718980D0 (en) * 1987-08-11 1987-09-16 May & Baker Ltd Compositions of matter
DE4343649A1 (de) * 1993-12-21 1995-06-22 Boehringer Ingelheim Kg Neue Pyridazino[4',5':3,4]pyrrolo-[2,1-a]isochinoline und deren Verwendung für die Herstellung von pharmazeutischen Zubereitungen
FR2761358B1 (fr) * 1997-03-27 1999-05-07 Adir Nouveaux composes de n-aryl piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US6235755B1 (en) * 1998-08-07 2001-05-22 Applied Research Systems Ars Holding N.A. FSH mimetics for the treatment of infertility
WO2000048144A1 (fr) 1999-02-15 2000-08-17 Medailles Souvenirs Dispositif de personnalisation et de distribution de medailles
EP1307193A1 (fr) 2000-07-27 2003-05-07 Affymax Research Institute Agoniste d'activite hormonale stimulant un follicule
JP2004517843A (ja) * 2000-12-13 2004-06-17 バイエル アクチェンゲゼルシャフト ピロロ［２．１−ａ］ジヒドロイソキノリンおよびホスホジエステラーゼ１０ａ阻害薬としてのその使用
EP1406628B1 (fr) 2001-07-02 2006-03-08 Akzo Nobel N.V. Derives de tetrahydroquinoline
US20030236276A1 (en) 2001-08-06 2003-12-25 Ulrich Niewohner Pyrrolo[2.1-a]isoquinoline derivatives
WO2003014115A1 (fr) 2001-08-06 2003-02-20 Bayer Aktiengesellschaft Derives de la pyrrolo (2.1-a) isoquinoleine substitues en 3
WO2003051877A1 (fr) * 2001-12-18 2003-06-26 Bayer Corporation 2-substitues pyrrolo[2.1-a]isoquinolines contre le cancer
US7754722B2 (en) * 2002-09-20 2010-07-13 Merck Serono Sa Piperazine derivatives and methods of use
EP1641457B1 (fr) 2003-06-30 2009-08-05 Nycomed GmbH Derives de pyrrolo-dihydroisoquinolines en tant qu' inhibiteurs de la pde10
US20060148838A1 (en) 2003-06-30 2006-07-06 Altana Pharma Ag Novel pyrrolodihydroisoquinolines useful in the treatment of cancer
US20080004263A1 (en) 2004-03-04 2008-01-03 Santora Vincent J Ligands of Follicle Stimulating Hormone Receptor and Methods of Use Thereof
US20080064714A1 (en) 2005-01-12 2008-03-13 Nycomed Gmbh Novel Pyrrolodihydroisoquinolines
US20080161338A1 (en) 2005-01-12 2008-07-03 Altana Pharma Ag Novel Pyrrolodihydroisoquinolines as Pde 10 Inhibitors
UA92009C2 (ru) 2005-05-04 2010-09-27 Н.В. Органон Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодия
UA92007C2 (ru) 2005-05-04 2010-09-27 Н.В. Органон Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодности
ES2361674T3 (es) 2005-05-04 2011-06-21 N.V. Organon Derivados de dihidropiridina.
UA92008C2 (en) 2005-05-04 2010-09-27 Н.В. Органон 4-PHENYL-5-OXO-l,4,5,6,7,8-HEXAHYDROQUINOLINE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF INFERTILITY

Also Published As

Publication number Publication date
KR20100124279A (ko) 2010-11-26
PL2252611T3 (pl) 2012-03-30
US20110039832A1 (en) 2011-02-17
BRPI0906937A2 (pt) 2016-04-19
WO2009098283A1 (fr) 2009-08-13
JP5620823B2 (ja) 2014-11-05
AR070345A1 (es) 2010-03-31
AU2009211296B2 (en) 2014-01-30
CN102216297B (zh) 2014-06-25
US8394789B2 (en) 2013-03-12
PT2252611E (pt) 2011-12-20
RU2495037C2 (ru) 2013-10-10
DK2252611T3 (da) 2012-01-30
CA2713173C (fr) 2016-04-19
NZ587164A (en) 2011-06-30
JP2011511041A (ja) 2011-04-07
IL206378A0 (en) 2010-12-30
ECSP10010303A (es) 2010-07-30
AU2009211296A1 (en) 2009-08-13
SI2252611T1 (sl) 2012-02-29
RU2010136057A (ru) 2012-03-20
CL2009000281A1 (es) 2009-06-26
ATE527260T1 (de) 2011-10-15
TW200944523A (en) 2009-11-01
CA2713173A1 (fr) 2009-08-13
KR101586870B1 (ko) 2016-01-19
EP2252611A1 (fr) 2010-11-24
HK1150597A1 (fr) 2012-01-06
MX2010008717A (es) 2010-09-24
HRP20110942T1 (hr) 2012-01-31
CN102216297A (zh) 2011-10-12
EP2252611B1 (fr) 2011-10-05
CO6241120A2 (es) 2011-01-20
PE20091413A1 (es) 2009-09-23

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