ES2346108T3 - Composicion farmaceutica. - Google Patents
Composicion farmaceutica. Download PDFInfo
- Publication number
- ES2346108T3 ES2346108T3 ES08151841T ES08151841T ES2346108T3 ES 2346108 T3 ES2346108 T3 ES 2346108T3 ES 08151841 T ES08151841 T ES 08151841T ES 08151841 T ES08151841 T ES 08151841T ES 2346108 T3 ES2346108 T3 ES 2346108T3
- Authority
- ES
- Spain
- Prior art keywords
- phenyl
- methyl
- fluoro
- trifluoromethyl
- piperidine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0025354.2A GB0025354D0 (en) | 2000-10-17 | 2000-10-17 | Chemical compounds |
GB0025354 | 2000-10-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2346108T3 true ES2346108T3 (es) | 2010-10-08 |
Family
ID=9901397
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES01976453T Expired - Lifetime ES2227287T3 (es) | 2000-10-17 | 2001-10-12 | Compuestos quimicos. |
ES08151841T Expired - Lifetime ES2346108T3 (es) | 2000-10-17 | 2001-10-12 | Composicion farmaceutica. |
ES04077714T Expired - Lifetime ES2282794T3 (es) | 2000-10-17 | 2001-10-12 | Composicion farmaceutica. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES01976453T Expired - Lifetime ES2227287T3 (es) | 2000-10-17 | 2001-10-12 | Compuestos quimicos. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES04077714T Expired - Lifetime ES2282794T3 (es) | 2000-10-17 | 2001-10-12 | Composicion farmaceutica. |
Country Status (29)
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9923748D0 (en) | 1999-10-07 | 1999-12-08 | Glaxo Group Ltd | Chemical compounds |
USRE39921E1 (en) | 1999-10-07 | 2007-11-13 | Smithkline Beecham Corporation | Chemical compounds |
GB0025354D0 (en) * | 2000-10-17 | 2000-11-29 | Glaxo Group Ltd | Chemical compounds |
GB0108595D0 (en) | 2001-04-05 | 2001-05-23 | Glaxo Group Ltd | Chemical compounds |
GB0119797D0 (en) | 2001-08-14 | 2001-10-03 | Glaxo Group Ltd | Chemical compounds |
GB0203020D0 (en) | 2002-02-08 | 2002-03-27 | Glaxo Group Ltd | Chemical compounds |
US7482365B2 (en) | 2002-02-08 | 2009-01-27 | Glaxo Group Limited | Piperidylcarboxamide derivatives and their use in the treatment of tachykinin-mediated diseases |
GB0203022D0 (en) * | 2002-02-08 | 2002-03-27 | Glaxo Group Ltd | Chemical compounds |
TWI283241B (en) * | 2002-05-29 | 2007-07-01 | Tanabe Seiyaku Co | Novel piperidine compound |
JP4079727B2 (ja) * | 2002-09-06 | 2008-04-23 | セントラル硝子株式会社 | 光学活性1−(フルオロ、トリフルオロメチルまたはトリフルオロメトキシ置換フェニル)アルキルアミンn−モノアルキル誘導体とその製造方法 |
ATE400568T1 (de) * | 2002-12-23 | 2008-07-15 | Janssen Pharmaceutica Nv | Substituierte 4-(4-piperidin-yl-piperazin-1-yl)- azepan-derivate und ihre verwendung als tachykinin-antagonisten |
JO2485B1 (en) * | 2002-12-23 | 2009-01-20 | شركة جانسين فارماسوتيكا ان. في | 1-Piperidine-3-Yl-4-Piperidine-4-Yl-Piperazine derivatives substituted and used as quinine antagonists |
JO2696B1 (en) * | 2002-12-23 | 2013-03-03 | شركة جانسين فارماسوتيكا ان. في | Derivatives of 1-piperdine-4-yl-4-biprolidine-3-yl-piperazine substituted and used as quinine antagonists |
US7435736B2 (en) | 2002-12-23 | 2008-10-14 | Janssen Pharmaceutica, N.V. | Substituted 1-piperidin-4-yl-4-azetidin-3-yl-piperazine derivatives and their use as neurokinin antagonists |
JP2006516581A (ja) * | 2003-01-27 | 2006-07-06 | グラクソ グループ リミテッド | 機能性消化不良を治療するための化学化合物の使用 |
FR2853648B1 (fr) * | 2003-04-11 | 2006-08-18 | Fournier Lab Sa | Nouveaux derives de benzenesulfonamides et leur utilisation en therapeutique |
WO2004087654A2 (en) * | 2003-03-31 | 2004-10-14 | Janssen Pharmaceutica N.V. | Phospholipase c inhibitors for use in treating inflammatory disorders |
US20040235855A1 (en) * | 2003-03-31 | 2004-11-25 | Bharat Lagu | Phospholipase C inhibitors for use in treating inflammatory disorders |
US20040242639A1 (en) * | 2003-03-31 | 2004-12-02 | Bharat Lagu | Phospholipase C inhibitors for use in treating inflammatory disorders |
GB0308968D0 (en) * | 2003-04-17 | 2003-05-28 | Glaxo Group Ltd | Medicaments |
DE602004013772D1 (de) * | 2003-06-10 | 2008-06-26 | Janssen Pharmaceutica Nv | Kombination von opioiden und einem piperazin-derivat für die behandlung von schmerzen |
MXPA05013770A (es) * | 2003-06-19 | 2006-03-08 | Pfizer Prod Inc | Antagonista de neuroquinina 1. |
JO2525B1 (en) * | 2004-04-08 | 2010-03-17 | شركة جانسين فارماسوتيكا ان. في | Derived 4-alkyl-and-4-canoelperidine derivatives and their use as anti-neroquin |
WO2006062110A1 (ja) * | 2004-12-06 | 2006-06-15 | Banyu Pharmaceutical Co., Ltd. | ピペラジン誘導体 |
GB0426942D0 (en) * | 2004-12-08 | 2005-01-12 | Glaxo Group Ltd | Medicament |
DE602006016244D1 (de) | 2005-03-08 | 2010-09-30 | Janssen Pharmaceutica Nv | Diazaspiro-ä4,4ü-nonanderivate als neurokinin-(nk1)-antagonisten |
GB0514705D0 (en) * | 2005-07-18 | 2005-08-24 | Glaxo Group Ltd | Chemical compounds |
GB0514707D0 (en) * | 2005-07-18 | 2005-08-24 | Glaxo Group Ltd | Chemical compounds |
GB0514704D0 (en) * | 2005-07-18 | 2005-08-24 | Glaxo Group Ltd | Chemical compounds |
JP4904945B2 (ja) | 2006-06-30 | 2012-03-28 | セントラル硝子株式会社 | 光学活性1−(フルオロ、トリフルオロメチルまたはトリフルオロメトキシ置換フェニル)アルキルアミンn−モノアルキル誘導体の製造方法 |
MX2009007916A (es) | 2007-01-24 | 2009-07-31 | Glaxo Group Ltd | Composiciones farmaceuticas que comprenden 3,5-diamino-6-(2,3-dicl orofenil)-l,2,4,-triazina; o r(-)-2,4-diamino-5-(2,3-diclorofenil) -6-fluorometil pirimidina y un receptor neuroquinina 1. |
AU2008299921B2 (en) | 2007-09-13 | 2012-03-01 | Concert Pharmaceuticals, Inc. | Synthesis of deuterated catechols and benzo[d][1,3] dioxoles and derivatives thereof |
GB0812849D0 (en) * | 2008-07-14 | 2008-08-20 | Glaxo Wellcome Mfg Pte Ltd | Novel compounds |
US9782397B2 (en) | 2011-07-04 | 2017-10-10 | Irbm Science Park S.P.A. | Treatment of corneal neovascularization |
WO2013124286A1 (en) | 2012-02-22 | 2013-08-29 | Leo Pharma A/S | Novel neurokinin 1 receptor antagonist compounds |
WO2015024203A1 (en) * | 2013-08-20 | 2015-02-26 | Leo Pharma A/S | Novel neurokinin 1 receptor antagonist compounds ii |
US11160809B2 (en) | 2017-04-10 | 2021-11-02 | Chase Therapeutics Corporation | NK1-antagonist combination and method for treating synucleinopathies |
CN111032158A (zh) | 2017-06-30 | 2020-04-17 | 才思治疗公司 | 用于治疗抑郁的nk-1拮抗剂组合物和方法 |
CN111116514B (zh) * | 2020-01-10 | 2024-03-19 | 广州科锐特生物科技有限公司 | 一种1-环丙甲酰基哌嗪盐酸盐的制备方法 |
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-
2000
- 2000-10-17 GB GBGB0025354.2A patent/GB0025354D0/en not_active Ceased
-
2001
- 2001-10-12 EP EP04077714A patent/EP1524266B1/en not_active Expired - Lifetime
- 2001-10-12 ES ES01976453T patent/ES2227287T3/es not_active Expired - Lifetime
- 2001-10-12 SI SI200130206T patent/SI1326832T1/xx unknown
- 2001-10-12 PL PL361180A patent/PL203071B1/pl unknown
- 2001-10-12 JP JP2002536051A patent/JP3940359B2/ja not_active Expired - Fee Related
- 2001-10-12 AT AT04077714T patent/ATE355271T1/de active
- 2001-10-12 AU AU9572301A patent/AU9572301A/xx active Pending
- 2001-10-12 CZ CZ20031082A patent/CZ299824B6/cs not_active IP Right Cessation
- 2001-10-12 DK DK01976453T patent/DK1326832T3/da active
- 2001-10-12 WO PCT/GB2001/004580 patent/WO2002032867A1/en active Application Filing
- 2001-10-12 EP EP08151841A patent/EP1921064B1/en not_active Expired - Lifetime
- 2001-10-12 US US10/398,264 patent/US7119092B2/en not_active Expired - Fee Related
- 2001-10-12 AU AU2001295723A patent/AU2001295723B2/en not_active Ceased
- 2001-10-12 BR BR0114637-8A patent/BR0114637A/pt not_active Application Discontinuation
- 2001-10-12 AT AT08151841T patent/ATE468324T1/de not_active IP Right Cessation
- 2001-10-12 SI SI200130727T patent/SI1524266T1/sl unknown
- 2001-10-12 DE DE60106287T patent/DE60106287T2/de not_active Expired - Lifetime
- 2001-10-12 NZ NZ525091A patent/NZ525091A/en not_active IP Right Cessation
- 2001-10-12 ES ES08151841T patent/ES2346108T3/es not_active Expired - Lifetime
- 2001-10-12 DK DK04077714T patent/DK1524266T3/da active
- 2001-10-12 DE DE60142197T patent/DE60142197D1/de not_active Expired - Lifetime
- 2001-10-12 DE DE60127002T patent/DE60127002T2/de not_active Expired - Lifetime
- 2001-10-12 IL IL15516501A patent/IL155165A0/xx active IP Right Grant
- 2001-10-12 KR KR1020037005286A patent/KR100847414B1/ko not_active IP Right Cessation
- 2001-10-12 CA CA002425876A patent/CA2425876C/en not_active Expired - Fee Related
- 2001-10-12 CN CNB018175325A patent/CN1231468C/zh not_active Expired - Fee Related
- 2001-10-12 PT PT01976453T patent/PT1326832E/pt unknown
- 2001-10-12 EP EP01976453A patent/EP1326832B1/en not_active Expired - Lifetime
- 2001-10-12 ES ES04077714T patent/ES2282794T3/es not_active Expired - Lifetime
- 2001-10-12 MX MXPA03003536A patent/MXPA03003536A/es active IP Right Grant
- 2001-10-12 AT AT01976453T patent/ATE278669T1/de active
- 2001-10-12 EP EP06122021A patent/EP1752449A1/en not_active Withdrawn
- 2001-10-12 HU HU0301459A patent/HU228146B1/hu not_active IP Right Cessation
- 2001-10-12 PT PT04077714T patent/PT1524266E/pt unknown
- 2001-10-15 MY MYPI20014779A patent/MY124957A/en unknown
- 2001-10-15 TW TW090125397A patent/TWI299730B/zh not_active IP Right Cessation
- 2001-10-15 AR ARP010104833A patent/AR034268A1/es not_active Application Discontinuation
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2003
- 2003-03-31 IL IL155165A patent/IL155165A/en not_active IP Right Cessation
- 2003-04-07 NO NO20031561A patent/NO324468B1/no not_active IP Right Cessation
- 2003-04-10 ZA ZA200302801A patent/ZA200302801B/en unknown
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2004
- 2004-01-13 HK HK04100241A patent/HK1058788A1/xx not_active IP Right Cessation
- 2004-11-22 US US10/994,605 patent/US7060702B2/en not_active Expired - Lifetime
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2005
- 2005-05-23 HK HK05104289A patent/HK1075889A1/xx not_active IP Right Cessation
- 2005-08-24 AU AU2005204234A patent/AU2005204234B2/en not_active Ceased
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2006
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2007
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2008
- 2008-05-15 IL IL191486A patent/IL191486A0/en unknown
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2009
- 2009-04-09 AU AU2009201407A patent/AU2009201407B2/en not_active Ceased
- 2009-12-03 US US12/630,037 patent/US20100081667A1/en not_active Abandoned
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