ES2342783T3 - Aril aciltioureas sustituidas y compuestos relacionados, inhibidores de la replicacion viral. - Google Patents

Aril aciltioureas sustituidas y compuestos relacionados, inhibidores de la replicacion viral. Download PDF

Info

Publication number
ES2342783T3
ES2342783T3 ES05856726T ES05856726T ES2342783T3 ES 2342783 T3 ES2342783 T3 ES 2342783T3 ES 05856726 T ES05856726 T ES 05856726T ES 05856726 T ES05856726 T ES 05856726T ES 2342783 T3 ES2342783 T3 ES 2342783T3
Authority
ES
Spain
Prior art keywords
thiourea
phenyl
pentyloxy
carbonyl
trifluoromethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES05856726T
Other languages
English (en)
Inventor
Avinash Phadke
Dawei Chen
Milind Deshpande
Andrew Thurkauf
Xiangzhu Wang
Yiping Shen
Liu Cuixian
Quinn Jesse
Shouming Li
Junko Ohkanda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Achillion Pharmaceuticals Inc
Original Assignee
Achillion Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Achillion Pharmaceuticals Inc filed Critical Achillion Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2342783T3 publication Critical patent/ES2342783T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/24—Derivatives of thiourea containing any of the groups, X being a hetero atom, Y being any atom
    • C07C335/26—Y being a hydrogen or a carbon atom, e.g. benzoylthioureas
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/78—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/56—Amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/12—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/06—1,2,3-Thiadiazoles; Hydrogenated 1,2,3-thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C07D309/38—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms one oxygen atom in position 2 or 4, e.g. pyrones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
    • C07D419/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D419/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Quinoline Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Furan Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

Un compuesto o sal farmacéuticamente aceptable del mismo, en que el compuesto es: 1-(4-pentilfenil)-3-(1,2,3-tiadiazol-4-carbonil)-tiourea; 1-(3-(4-fenil-benciloxi)fenil)-3-(2-morfolinoacetil)-tiourea; 1-(3-cianobenzoil)-3-(3-benciloxi-fenil)-tiourea; 1-(1-metilpiperidino-3-carbonil)-3-(4-pentiloxifenil)-tiourea; 1-(1-metilpiperidino-3-carbonil)-3-(4-pentilfenil)-tiourea; 1-(4-(pentiloxi)fenil)-3-(quinoxalino-7-carbonil)-tiourea; 1-(4-pentilfenil)-3-(quinolino-3-carbonil)-tiourea; 1-(4-(pentiloxi)fenil)-3-(quinoxalino-7-carbonil)-tiourea; 1-(4-pentilfenil)-3-(quinoxalino-7-carbonil)-tiourea; 1-(2-metil-5-(trifluorometil)oxazol-4-carbonil)-3-(4-pentilfenil)-tiourea; 1-(2-metil-5-(trifluorometil)oxazol-4-carbonil)-3-(4-(pentiloxi)fenil)-tiourea; 1-(4-pentilfenil)-3-(1,2,3-tiadiazol-4-carbonil)-tiourea; 1-(3-fluoro-4-(pentiloxi)fenil)-3-(H-imidazo[1,2-a]piridino-6-carbonil)-tiourea; 1-(1-(2-amino-2-oxoetil)-2-oxo-1,2-dihidropiridino-5-carbonil)-3-(4-(pentiloxi)-3-(trifluorometil)fenil)-tiourea; 1-(3-ciclopropil-4-(pentiloxi)fenil)-3-nicotinoiltiourea; 1-(1-metil-2-oxo-1,2-dihidropiridino-5-carbonil)-3-(4-(pentiloxi)-3-(trifluorometil)fenil)-tiourea; 1-(4-(hexiloxi)fenil)-3-(1-metil-2-oxo-1,2-dihidropiridino-5-carbonil)-tiourea; 2-oxo-2-(5-((3-(4-(pentiloxi)-3-(trifluorometil)-fenil)tioureido)carbonil)piridin-2-ilamino)acetato de metilo; 2-(5-((3-(4-(heptiloxi)fenil)tioureido)carbonil)-piridin-2-ilamino)-2-oxoacetato de metilo; 1-(2-(2-amino-2-oxoacetamido)nicotinoil)-3-(4-(pentiloxi)-3-(trifluorometil)fenil)-tiourea; 1-(5-metil-4,5,6,7-tetrahidrofuro[3,2-c]piridino-2-carbonil)-3-(4-(pentiloxi)fenil)-tiourea; 1-(2-(1H-imidazol-1-il)acetil)-3-(4-(pentiloxi)fenil)-tiourea; 1-(4-(pentiloxi)fenil)-3-(3-(piridin-3-il)propanoil)-tiourea; 1-(3-fluoro-4-(4-fenilpiperidin-1-il)fenil)-3-nicotinoiltiourea; 1-(4-(ciclohexilmetoxi)-3-fluorofenil)-3-nicotinoiltiourea; 1-(4-(4-hexilbiciclo[2.2.2]octan-1-il)fenil)-3-nicotinoiltiourea; 1-nicotinoil-3-(4-((1s,4r)-4-propilciclohexil)fenil)-tiourea; 1-(4-((1s,4r)-4-hexilciclohexil)fenil)-3-nicotinoiltiourea; 1-(3-fenoxifenil)-3-(2-(pirrolidin-1-il)nicotinoil)-tiourea; 1-(3-(benciloxi)fenil)-3-(2-(pirrolidin-1-il)nicotinoil)-tiourea; 1-(6-(pentiloxi)piridin-3-il)-3-(2-(pirrolidin-1-il)nicotinoil)-tiourea; 1-(3-(2,3-dihidro-1H-inden-2-iloxi)fenil)-3-(2-(pirrolidin-1-il)nicotinoil)-tiourea; 1-(6-(2-(dimetilamino)etoxi)nicotinoil)-3-(4-(pentiloxi)-3-(trifluorometil)fenil)-tiourea; 1-(5-metilisoxazol-3-carbonil)-3-(6-(pentiloxi)piridin-3-il)-tiourea; 1-(4-metil-1,2,3-tiadiazol-5-carbonil)-3-(4-(pentiloxi)-3-(trifluorometil)fenil)-tiourea; 1-(3-terc-butil-1-metil-1H-pirazol-5-carbonil)-3-(4-(pentiloxi)-3-(trifluorometil)fenil)-tiourea; 1-(2-metilnicotinoil)-3-(6-(pentiloxi)piridin-3-il)-tiourea; 1-(1,3-dimetil-1H-pirazol-5-carbonil)-3-(4-(pentiloxi)-3-(trifluorometil)fenil)-tiourea; 1-(6-(pentiloxi)piridin-3-il)-3-(2-(piridin-4-il)tiazol-4-carbonil)-tiourea; 1-(6-(pentiloxi)piridin-3-il)-3-(2-fenil-5-(trifluorometil)oxazol-4-carbonil)-tiourea; 1-(4-(pentiloxi)-3-(trifluorometil)fenil)-3-(2-(piridin-3-il)tiazol-4-carbonil)-tiourea; 1-(2-metil-1,8-naftiridino-3-carbonil)-3-(6-(pentiloxi)piridin-3-il)-tiourea; 1-(2,7-dimetilpirazolo[1,5-a]pirimidino-6-carbonil)-3-(4-(pentiloxi)-3-(trifluorometil)fenil)-tiourea; 1-(2-metil-5-(trifluorometil)oxazol-4-carbonil)-3-(6-(pentiloxi)piridin-3-il)-tiourea; 1-(4-metil-2-fenil-2H-1,2,3-triazol-5-carbonil)-3-(4-(pentiloxi)-3-(trifluorometil)fenil)-tiourea; 1-(5-metilisoxazol-4-carbonil)-3-(4-(pentiloxi)-3-(trifluorometil)fenil)-tiourea; 1-(5-metilisoxazol-3-carbonil)-3-(4-(pentiloxi)-3-(trifluorometil)fenil)-tiourea; 1-(6-(pentiloxi)piridin-3-il)-3-(1,2,3-tiadiazol-4-carbonil)-tiourea; 1-(2-metil-H-imidazo[1,2-a]piridino-3-carbonil)-3-(4-(pentiloxi)-3-(trifluorometil)fenil)-tiourea; 1-(isoxazol-5-carbonil)-3-(6-(pentiloxi)piridin-3-il)-tiourea; 1-(2-metilnicotinoil)-3-(4-(pentiloxi)-3-(trifluorometil)fenil)-tiourea; 1-(benzo[c][1,2,5]oxadiazol-6-carbonil)-3-(6-(pentiloxi)piridin-3-il)-tiourea; 1-(4-(pentiloxi)-3-(trifluorometil)fenil)-3-(2-(piridin-4-il)tiazol-4-carbonil)-tiourea; 1-(1,3-dimetil-1H-tieno[2,3-c]pirazol-5-carbonil)-3-(6-(pentiloxi)piridin-3-il)-tiourea; 1-(2-metil-1,8-naftiridino-3-carbonil)-3-(4-(pentiloxi)-3-(trifluorometil)fenil)-tiourea; 1-(2-metil-5-(trifluorometil)oxazol-4-carbonil)-3-(4-(pentiloxi)-3-(trifluorometil)fenil)-tiourea; 1-(4-(pentiloxi)-3-(trifluorometil)fenil)-3-(1,2,3-tiadiazol-4-carbonil)-tiourea; 1-(isoxazol-5-carbonil)-3-(4-(pentiloxi)-3-(trifluorometil)fenil)-tiourea; 1-(benzo[c][1,2,5]oxadiazol-6-carbonil)-3-(4-(pentiloxi)-3-(trifluorometil)fenil)-tiourea; 1-(3-fluoro-4-(pentiloxi)fenil)-3-(4-metil-1,2,3-tiadiazol-5-carbonil)-tiourea; 1-(3-fluoro-4-(pentiloxi)fenil)-3-(4-metil-1,2,3-tiadiazol-5-carbonil)-tiourea; 1-(3-fluoro-4-(pentiloxi)fenil)-3-(2-(piridin-3-il)tiazol-4-carbonil)-tiourea; 1-(2,7-dimetilpirazolo[1,5-a]pirimidino-6-carbonil)-3-(3-fluoro-4-(pentiloxi)fenil)-tiourea; 1-(3-fluoro-4-(pentiloxi)fenil)-3-(4-metil-2-fenil-2H-1,2,3-triazol-5-carbonil)-tiourea; 1-(3-fluoro-4-(pentiloxi)fenil)-3-(5-metilisoxazol-4-carbonil)-tiourea; 1-(3-fluoro-4-(pentiloxi)fenil)-3-(5-metilisoxazol-3-carbonil)-tiourea; 1-(3-fluoro-4-(pentiloxi)fenil)-3-(2-(piridin-4-il)tiazol-4-carbonil)-tiourea; 1-(3-fluoro-4-(pentiloxi)fenil)-3-(2-fenil-5-(trifluorometil)oxazol-4-carbonil)-tiourea; 1-(3-fluoro-4-(pentiloxi)fenil)-3-(2-metil-1,8-naftiridino-3-carbonil)-tiourea; 1-(3-fluoro-4-(pentiloxi)fenil)-3-(2-metil-5-(trifluorometil)oxazol-4-carbonil)-tiourea; 1-(3-fluoro-4-(pentiloxi)fenil)-3-(1,2,3-tiadiazol-4-carbonil)-tiourea; 1-(3-fluoro-4-(pentiloxi)fenil)-3-(isoxazol-5-carbonil)-tiourea; 1-(benzo[c][1,2,5]oxadiazol-6-carbonil)-3-(3-fluoro-4-(pentiloxi)fenil)-tiourea; 1-(1,3-dimetil-1H-tieno[2,3-c]pirazol-5-carbonil)-3-(3-fluoro-4-(pentiloxi)fenil)-tiourea; 1-(4-metil-1,2,3-tiadiazol-5-carbonil)-3-(6-(pentiloxi)piridin-3-il)-tiourea; 1-(1,3-dimetil-1H-pirazol-5-carbonil)-3-(6-(pentiloxi)piridin-3-il)-tiourea; 1-(6-(pentiloxi)piridin-3-il)-3-(2-(piridin-3-il)tiazol-4-carbonil)-tiourea; 1-(2,7-dimetilpirazolo[1,5-a]pirimidino-6-carbonil)-3-(6-(pentiloxi)piridin-3-il)-tiourea; 1-(4-metil-2-fenil-2H-1,2,3-triazol-5-carbonil)-3-(6-(pentiloxi)piridin-3-il)-tiourea; 1-(3-(benciloxi)fenil)-3-(6-(4-metilpiperazin-1-il)nicotinoil)-tiourea; 1-(6-(4-metilpiperazin-1-il)nicotinoil)-3-(3-fenoxifenil)-tiourea; 1-(6-(4-metilpiperazin-1-il)nicotinoil)-3-(4-pentilfenil)-tiourea; 1-(6-(4-metilpiperazin-1-il)nicotinoil)-3-(4-(pentiloxi)fenil)-tiourea; 1-(3-fluoro-4-(pentiloxi)fenil)-3-(2-(4-metilpiperazin-1-il)nicotinoil)-tiourea; 1-(6-(4-metilpiperazin-1-il)nicotinoil)-3-(6-(pentiloxi)piridin-3-il)-tiourea; 1-(6-(4-metilpiperazin-1-il)nicotinoil)-3-(4-(pentiloxi)-3-(trifluorometil)fenil)-tiourea; 1-(3-metil-4-(pentiloxi)fenil)-3-(2-(4-metilpiperazin-1-il)nicotinoil)-tiourea; 1-(6-hidroxinicotinoil)-3-(3-fenoxifenil)-tiourea; 1-(6-hidroxinicotinoil)-3-(4-(pentiloxi)fenil)-tiourea; 1-(6-hidroxinicotinoil)-3-(4-pentilfenil)-tiourea; 1-(3-fluoro-4-(pentiloxi)fenil)-3-(2-hidroxinicotinoil)-tiourea; 1-(6-hidroxinicotinoil)-3-(4-(pentiloxi)-3-(trifluorometil)fenil)-tiourea; 1-(6-hidroxinicotinoil)-3-(4-(piperidin-1-il)-3-(trifluorometil)fenil)-tiourea; 1-(4-(metil(pentil)amino)-3-(trifluorometil)fenil)-3-nicotinoiltiourea; 1-(5-hidroxinicotinoil)-3-(4-(pentiloxi)-3-(trifluorometil)fenil)-tiourea; 1-(5-hidroxinicotinoil)-3-(3-fenoxifenil)-tiourea; 1-(3-fluoro-4-(pentiloxi)fenil)-3-(3-hidroxinicotinoil)-tiourea; 1-(4-(pentiloxi)-3-(trifluorometil)fenil)-3-(pirazolo[1,5-a]pirimidino-6-carbonil)-tiourea; 1-(4-(pentiloxi)fenil)-3-(pirazolo[1,5-a]pirimidino-6-carbonil)-tiourea; 1-(4-pentilfenil)-3-(pirazolo[1,5-a]pirimidino-6-carbonil)-tiourea; 1-(3-fenoxifenil)-3-(pirazolo[1,5-a]pirimidino-6-carbonil)-tiourea; 1-(6-(pentiloxi)piridin-3-il)-3-(pirazolo[1,5-a]pirimidino-6-carbonil)-tiourea; 1-(3-fluoro-4-(pentiloxi)fenil)-3-(pirazolo[1,5-a]pirimidino-6-carbonil)-tiourea; 1-(6-(morfolino-4-carbonil)nicotinoil)-3-(4-(pentiloxi)-3-(trifluorometil)fenil)-tiourea; 1-(6-(morfolino-4-carbonil)nicotinoil)-3-(3-fenoxifenil)-tiourea; 1-(6-((dimetilamino)metil)nicotinoil)-3-(4-(pentiloxi)-3-(trifluorometil)fenil)-tiourea; 1-(6-acetamidonicotinoil)-3-(4-(pentiloxi)-3-(trifluorometil)fenil)-tiourea; acetato de (5-((3-(4-(pentiloxi)-3-(trifluorometil)fenil)tioureido)carbonil)piridin-2-il)metilo; 1-(6-(hidroximetil)nicotinoil)-3-(4-(pentiloxi)-3-(trifluorometil)fenil)-tiourea; 1-nicotinoil-3-(3-(trifluorometil)-4-(4-(trifluorometil)piperidin-1-il)fenil)-tiourea; 1-(3-fluoro-4-(4-(trifluorometil)piperidin-1-il)fenil)-3-nicotinoiltiourea; 1-(6-(morfolino-4-carbonil)nicotinoil)-3-(2-fenilbenzo[d][1,3]dioxol-5-il)-tiourea; 1-(6-(morfolinometil)nicotinoil)-3-(4-(pentiloxi)fenil)-tiourea; 1-(6-(morfolinometil)nicotinoil)-3-(4-(pentiloxi)-3-(trifluorometil)fenil)-tiourea; 1-(6-((dimetilamino)metil)nicotinoil)-3-(4-pentilfenil)-tiourea; 1-(3-(benciloxi)fenil)-3-(2-((dimetilamino)metil)nicotinoil)-tiourea; 1-(6-((dimetilamino)metil)nicotinoil)-3-(3-fenoxifenil)-tiourea; 1-(4-(heptiloxi)fenil)-3-(2-(morfolino-4-carbonil)nicotinoil)-tiourea; 1-(6-(morfolino-4-carbonil)nicotinoil)-3-(4-(octiloxi)fenil)-tiourea; 1-(6-(morfolino-4-carbonil)nicotinoil)-3-(3-fenoxifenil)-tiourea; 1-(6-(morfolino-4-carbonil)nicotinoil)-3-(4-pentilfenil)-tiourea; 1-(4-(heptiloxi)fenil)-3-(2-((4-metilpiperazin-1-il)metil)nicotinoil)-tiourea; 1-(6-((4-metilpiperazin-1-il)metil)nicotinoil)-3-(4-(pentiloxi)-3-(trifluorometil)fenil)-tiourea; 1-(6-((dimetilamino)metil)nicotinoil)-3-(4-(pentiloxi)fenil)-tiourea; 1-(2-oxo-2H-piran-5-carbonil)-3-(4-(pentiloxi)-3-(trifluorometil)fenil)-tiourea; 1-(4-(heptiloxi)fenil)-3-(2-hidroxinicotinoil)-tiourea; 1-(6-((dimetilamino)metil)nicotinoil)-3-(4-(hexiloxi)fenil)-tiourea; 1-(6-((dimetilamino)metil)nicotinoil)-3-(2-fenilbenzo[d][1,3]dioxol-5-il)-tiourea; 1-(6-(morfolinometil)nicotinoil)-3-(3-fenoxifenil)-tiourea; 1-(4-(hexiloxi)fenil)-3-(2-(morfolinometil)-nicotinoil)-tioure
ES05856726T 2004-05-18 2005-05-17 Aril aciltioureas sustituidas y compuestos relacionados, inhibidores de la replicacion viral. Expired - Lifetime ES2342783T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57215604P 2004-05-18 2004-05-18
US572156P 2004-05-18

Publications (1)

Publication Number Publication Date
ES2342783T3 true ES2342783T3 (es) 2010-07-14

Family

ID=35485177

Family Applications (1)

Application Number Title Priority Date Filing Date
ES05856726T Expired - Lifetime ES2342783T3 (es) 2004-05-18 2005-05-17 Aril aciltioureas sustituidas y compuestos relacionados, inhibidores de la replicacion viral.

Country Status (19)

Country Link
US (2) US7365068B2 (es)
EP (1) EP1747196B1 (es)
JP (2) JP4109271B2 (es)
KR (1) KR20070010183A (es)
CN (1) CN101087755A (es)
AP (1) AP2006003808A0 (es)
AR (1) AR049427A1 (es)
AT (1) ATE457301T1 (es)
BR (1) BRPI0511283A (es)
CA (1) CA2566809A1 (es)
DE (1) DE602005019282D1 (es)
EA (1) EA009882B1 (es)
ES (1) ES2342783T3 (es)
IL (1) IL178967A0 (es)
MX (1) MXPA06013374A (es)
NO (1) NO20065736L (es)
NZ (1) NZ551115A (es)
TW (1) TW200600492A (es)
WO (1) WO2006083271A2 (es)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL147302A0 (en) * 1999-06-28 2002-08-14 California Inst Of Techn Microfabricated elastomeric valve and pump systems
US7855289B2 (en) 2005-08-04 2010-12-21 Sirtris Pharmaceuticals, Inc. Sirtuin modulating compounds
CA2618370A1 (en) 2005-08-04 2007-02-15 Sirtris Pharmaceuticals, Inc. Oxazolopyridine derivatives as sirtuin modulators
US8088928B2 (en) 2005-08-04 2012-01-03 Sirtris Pharmaceuticals, Inc. Sirtuin modulating compounds
US8093401B2 (en) 2005-08-04 2012-01-10 Sirtris Pharmaceuticals, Inc. Sirtuin modulating compounds
WO2007031791A1 (en) 2005-09-16 2007-03-22 Arrow Therapeutics Limited Biphenyl derivatives and their use in treating hepatitis c
AR059358A1 (es) * 2006-02-09 2008-03-26 Schering Corp Formulaciones farmaceuticas
US7480400B2 (en) * 2006-03-16 2009-01-20 Siemens Medical Solutions Usa, Inc. Detection of fiber pathways
EP2038253A1 (en) * 2006-05-30 2009-03-25 Arrow Therapeutics Limited Biphenyl derivatives and their use in treating hepatitis c
TWI329102B (en) * 2006-08-15 2010-08-21 Nat Health Research Institutes Thiourea compounds and method for inhibiting hepatitis c virus infection
WO2008029096A2 (en) 2006-09-04 2008-03-13 University Court Of The University Of Dundee P53 activating benzoyl urea and benzoyl thiourea compounds
US20100029652A1 (en) * 2006-12-18 2010-02-04 Achillion Pharmaceuticals, Inc. Combination Therapy For Treating Hepatitis C Infections
UY30892A1 (es) * 2007-02-07 2008-09-02 Smithkline Beckman Corp Inhibidores de la actividad akt
US7985763B2 (en) 2007-04-10 2011-07-26 National Health Research Institutes Hepatitis C virus inhibitors
US7897764B2 (en) 2007-06-08 2011-03-01 National Health Research Institutes Thiourea derivatives
CL2008001822A1 (es) 2007-06-20 2009-03-13 Sirtris Pharmaceuticals Inc Compuestos derivados de tiazolo[5,4-b]piridina; composicion farmaceutica que comprende a dichos compuestos; y uso del compuesto en el tratamiento de la resistencia a la insulina, sindrome metabolico, diabetes, entre otras.
CN101387381A (zh) * 2007-09-14 2009-03-18 富士迈半导体精密工业（上海）有限公司 光源模组
TWI361808B (en) 2008-01-08 2012-04-11 Nat Health Research Institutes Imidazolidinone and imidazolidinethione derivatives
US8198284B2 (en) 2008-04-30 2012-06-12 National Health Research Institutes Treatment of neurodegenerative disorders with thiourea compounds
JP5628828B2 (ja) 2008-12-19 2014-11-19 サートリス ファーマシューティカルズ， インコーポレイテッド チアゾロピリジンサーチュイン調節化合物
GB0909912D0 (en) 2009-06-09 2009-07-22 Univ Dundee Compounds
WO2011000566A2 (en) * 2009-06-30 2011-01-06 Savira Pharmaceuticals Gmbh Compounds and pharmaceutical compositions for the treatment of negative-sense ssrna virus infections
WO2012031196A1 (en) 2010-09-03 2012-03-08 Forma Therapeutics, Inc. 4- { [ ( pyridin- 3 - yl -methyl) aminocarbonyl] amino} benzene - sulfone derivatives as nampt inhibitors for therapy of diseases such as cancer
CN102101846B (zh) * 2010-12-06 2012-07-18 周玉莲 一种噻唑类硫脲衍生物的制备方法
US9032677B1 (en) * 2014-06-17 2015-05-19 Tindall Corporation Pipe racks
CN105503678A (zh) * 2015-12-08 2016-04-20 江苏远征化工有限公司 一种1-(3,4-二氯苯基)-2-硫脲的清洁生产方法
PE20181884A1 (es) 2016-04-07 2018-12-07 Glaxosmithkline Ip Dev Ltd Amidas heterociclicas utiles como moduladores de proteinas
WO2017197051A1 (en) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. Amine-linked c3-glutarimide degronimers for target protein degradation
WO2017197046A1 (en) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. C3-carbon linked glutarimide degronimers for target protein degradation
CN109562113A (zh) 2016-05-10 2019-04-02 C4医药公司 用于靶蛋白降解的螺环降解决定子体
ES2989988T3 (es) 2016-05-10 2024-11-28 C4 Therapeutics Inc Degronímeros heterorocíclicos para la degradación de proteínas diana
CN110769822A (zh) 2017-06-20 2020-02-07 C4医药公司 用于蛋白降解的n/o-连接的降解决定子和降解决定子体
WO2019195197A1 (en) 2018-04-02 2019-10-10 Dropworks, Inc. Systems and methods for serial flow emulsion processes
CN109970675A (zh) * 2018-05-28 2019-07-05 中国医学科学院医药生物技术研究所 一组硫脲化合物及其制备方法和应用
CN112807294B (zh) * 2019-11-18 2023-09-05 武汉大学 一种酰基硫脲类化合物在制备治疗或预防单纯疱疹病毒i型感染药物中的应用

Family Cites Families (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL160809C (nl) 1970-05-15 1979-12-17 Duphar Int Res Werkwijze ter bereiding van benzoylureumverbindingen, alsmede werkwijze ter bereiding van insekticide prepara- ten op basis van benzoylureumverbindingen.
US3699110A (en) 1970-11-05 1972-10-17 Monsanto Co Certain 1-aryl or aralkyl-3-(pyridyl) formimidoyl-ureas or thioureas
DE2303761A1 (de) 1973-01-26 1974-08-01 Henkel & Cie Gmbh Neue n,n'-disubstituierte thioharnstoffe, deren herstellung sowie verwendung als antimikrobielle substanzen
GB1433934A (en) 1973-05-31 1976-04-28 Wyeth John & Brother Ltd Thioureas
BR7701058A (pt) 1976-02-23 1977-11-01 Gulf Research Development Co Processo e composto para combater insetos
US4160037A (en) 1977-09-30 1979-07-03 The Upjohn Company Compounds, compositions and methods of combatting pest employing thioureas
ZA793186B (en) 1978-07-06 1981-02-25 Duphar Int Res New urea and thiourea compounds, method of preparing the new compounds, as well as insecticidal compositions on the basis of these compounds
JPS5625148A (en) 1979-08-08 1981-03-10 Ishihara Sangyo Kaisha Ltd N-benzoyl-n'-phenoxyphenylurea-based compound, and insecticide comprising it
US4338257A (en) 1980-03-04 1982-07-06 Gulf Oil Corporation Benzoyl arylthioureas and use as plant growth regulators
GB2115419B (en) 1981-08-24 1985-10-02 Rorer International Heterocyclic amidino substituted ureas and their pharmaceutical uses
DE3217620A1 (de) 1982-05-11 1983-11-17 Bayer Ag, 5090 Leverkusen 2,5-dihalogenbenzoyl-(thio)harnstoffe, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel
US4880838A (en) 1982-06-30 1989-11-14 Rhone-Poulenc Pesticidal 1-(4-Phenoxyphenyl)-5-Benzoyl urea compounds and process for preparation
US4868215A (en) 1982-07-26 1989-09-19 The Dow Chemical Company Substituted N-aroyl N'-phenyl urea compounds
US5001266A (en) 1982-07-26 1991-03-19 The Dow Chemical Company Substituted aniline compounds
US4602109A (en) 1982-12-30 1986-07-22 Union Carbide Corporation Novel pesticidal phenoxyphenyl and phenoxypyridyl benzoyl ureas and process for preparation
DK147084A (da) 1983-03-19 1984-09-20 Bayer Ag 1-phenyl-3-benzoyl-(thio)-urinstoffer, deres fremstilling og anvendelse som skadedyrsbekaempelsesmidler
US4665097A (en) 1983-03-31 1987-05-12 Union Carbide Corporation Novel bicyclooxyaryl thioureas and process for preparation
US4873264A (en) 1983-05-20 1989-10-10 Rhone-Poulenc Nederlands B.V. Novel pesticidal 1-(alkyl-phenoxy-aryl)-3-benzoyl ureas and process for preparation
US4659736A (en) 1984-01-21 1987-04-21 Bayer Aktiengesellschaft Benzoyl urea compounds as agents for repelling snails and slugs
JPS61106551A (ja) 1984-10-30 1986-05-24 Sumitomo Chem Co Ltd ジフエニルエ−テル誘導体、その製造法およびそれを有効成分として含有する殺虫剤
US4638088A (en) 1984-11-15 1987-01-20 Union Carbide Corporation Pesticidal biphenylyloxy and biphenylylalkoxy aryl acyl urea compounds
US5166180A (en) 1988-01-11 1992-11-24 Duphar International Research B.V. Method of treating hematologic diseases and pharmaceutical composition to be used therefor
HUT56662A (en) * 1990-02-08 1991-09-30 Philips Nv Electric lamp
JP2840629B2 (ja) * 1990-08-29 1998-12-24 三田工業株式会社 トナーカートリッジ
JP2955953B2 (ja) * 1990-11-30 1999-10-04 株式会社東京興業貿易商会 ヒーティングチューブ
JPH04366852A (ja) 1991-06-13 1992-12-18 Canon Inc 電子写真感光体、該電子写真感光体を備えた電子写真装置並びにファクシミリ
EP0539709A1 (en) 1991-09-18 1993-05-05 FUJIREBIO Inc. 3,5-Dihydroxyheptanoic acid derivatives and lactones thereof as HMG-CoA reductase inhibitors
US5591842A (en) 1991-11-29 1997-01-07 Banyu Pharmaceutical Co., Ltd. Indolopyrrolocarbazole derivatives
US5589365A (en) 1991-11-29 1996-12-31 Banyu Pharmaceutical Co., Ltd. Process for producing glycosylated indolopyrrolocarbazole derivatives by culturing certain microorganisms
US5437996A (en) 1992-11-24 1995-08-01 Banyu Pharmaceutical Co., Ltd. Microtetraspora strain for preparation of indolopyrrolocarbazole derivatives
AU665073B2 (en) 1992-06-03 1995-12-14 Ciba-Geigy Ag Novel thiosemicarbazone derivatives
JPH063787A (ja) 1992-06-18 1994-01-14 Konica Corp ハロゲン化銀写真感光材料用固形発色現像処理剤及び該固形発色現像処理剤を用いた処理方法
DE4225750A1 (de) 1992-08-04 1994-02-10 Siemens Nixdorf Inf Syst Hochintegrierte Schaltkreise
DE4236902A1 (de) 1992-10-31 1994-05-05 Hoechst Ag Neue Phenylsulfonylharnstoffe, Darstellung und Verwendung als Herbizide und Pflanzenwachstumsregulatoren
US5723409A (en) 1992-10-31 1998-03-03 Hoechst Schering Agrevo Gmbh Intermediates for the preparation of phenylsulfonylurea herbicides and plant growth regulators
JPH06287171A (ja) 1993-02-05 1994-10-11 Takeda Chem Ind Ltd セミカルバジド誘導体、その製造法およびその殺虫組成物
DE69430861T2 (de) 1993-04-07 2003-01-23 Otsuka Pharmaceutical Co., Ltd. N-acylierte 4-aminopiperidin derivate als aktive bestandteile von peripher gefässerweiternden wikstoffen
JP3203108B2 (ja) 1993-08-26 2001-08-27 協和メデックス株式会社 グルコース−６−リン酸デヒドロゲナーゼの安定化方法
DE4442236A1 (de) 1994-11-28 1996-05-30 Hoechst Schering Agrevo Gmbh N-substituierte Hydrazinophenylsulfonylharnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung als Herbizide und Pflanzenwachstumsregulatoren
DE19506742A1 (de) 1995-02-27 1996-08-29 Bayer Ag Verwendung von Chinoxalinen in Kombination mit Protease-Inhibitoren als Arzneimittel zur Behandlung von AIDS und/oder HIV-Infektionen
GB9504460D0 (en) 1995-03-06 1995-04-26 Bayer Ag N-(3-Benzofuranyl)urea-derivatives
IL117940A (en) 1995-04-19 2003-06-24 Kumiai Chemical Industry Co Benzylsulfide derivatives, process for their production and insecticide compositions containing them
AU6470396A (en) 1995-07-21 1997-02-18 Nissan Chemical Industries Ltd. Semicarbazone derivatives and pesticides
CN1055083C (zh) 1995-09-08 2000-08-02 化学工业部沈阳化工研究院 用于杀虫杀螨的吡唑类化合物及其制剂
AU7000996A (en) 1995-09-19 1997-04-09 Ube Industries, Ltd. Benzylidenehydrazine compounds, process for producing the same, and agricultural and horticultural pesticides
EP0852498A1 (en) 1995-09-26 1998-07-15 Takeda Chemical Industries, Ltd. Phosphorylamides, their preparation and use
KR100444697B1 (ko) 1995-11-15 2005-01-13 야마노우치세이야쿠 가부시키가이샤 피리도티아진유도체및이를포함하는약제학적조성물
GB9525262D0 (en) 1995-12-11 1996-02-07 Bayer Ag Heterocyclylcarbonyl substituted benzofuranyl-ureas
AU1730497A (en) 1996-02-17 1997-09-02 Agrevo Uk Limited Fungicidal 1,2,4-oxadiazoles and analogues
EP0806205A3 (en) 1996-05-06 1997-11-19 Eli Lilly And Company Urea, thiourea and guanidine compounds and their use as anti-viral agents
GB9614718D0 (en) 1996-07-12 1996-09-04 Bayer Ag 3-ureido-pyridofurans and -pyridothiophenes
US6794392B1 (en) 1996-09-30 2004-09-21 Schering Aktiengesellschaft Cell differentiation inducer
US6174905B1 (en) 1996-09-30 2001-01-16 Mitsui Chemicals, Inc. Cell differentiation inducer
WO1998042323A1 (en) 1997-03-25 1998-10-01 Takeda Chemical Industries, Ltd. Stabilized urease inhibitor
US6093742A (en) 1997-06-27 2000-07-25 Vertex Pharmaceuticals, Inc. Inhibitors of p38
CA2300197A1 (en) 1997-12-23 1999-07-01 Warner-Lambert Company Thiourea and benzamide compounds, compositions and methods of treating or preventing inflammatory diseases and atherosclerosis
US6093258A (en) * 1998-01-29 2000-07-25 Mc Lean; Ildiko M. Tint stain remover
US20020128301A1 (en) 1998-02-13 2002-09-12 Medivir AB Non-nucleoside reverse transcriptase inhibitors
US5998411A (en) 1998-03-17 1999-12-07 Hughes Institute Heterocyclic nonnucleoside inhibitors of reverse transcriptase
US5874615A (en) 1998-03-17 1999-02-23 American Cyanamid Co Method for the preparation of insecticidal benzoylurea compounds
WO1999051613A1 (en) 1998-04-03 1999-10-14 Medivir Ab Prodrugs of phosphorous-containing pharmaceuticals
WO1999059586A1 (en) 1998-05-19 1999-11-25 Regents Of The University Of California Thiazolidine and oxazolidine derivatives for the treatment of acute myocardial infarction and inhibition of cardiomyocyte apoptosis
JPH11335375A (ja) 1998-05-20 1999-12-07 Mitsui Chem Inc ヒストン脱アセチル化酵素阻害作用を有するベンズアミド誘導体
US6255349B1 (en) 1998-12-09 2001-07-03 American Home Products Corporation Alph-methylbenzyl-containing thiourea inhibitors of herpes viruses containing a phenylenediamine group
EP1144399A3 (en) 1998-12-09 2002-09-11 Wyeth Heterocyclic carboxamide-containing thiourea inhibitors of herpes viruses containing a substituted phenylenediamine group
US6207715B1 (en) 1998-12-09 2001-03-27 American Home Products Corporation Alpha-methylbenzyl-containing thiourea inhibitors of herpes viruses containing a substituted phenylene-diamine group
US6335350B1 (en) 1998-12-09 2002-01-01 American Home Products Corporation Acetamide and substituted acetamide-containing thiourea inhibitors of herpes viruses
US6420396B1 (en) 1998-12-16 2002-07-16 Beiersdorf Ag Biphenyl and biphenyl-analogous compounds as integrin antagonists
PL348260A1 (en) 1998-12-16 2002-05-20 Bayer Ag New biphenyl and biphenyl-analogous compounds as integrin antagonists
US6677360B2 (en) 1998-12-16 2004-01-13 Bayer Aktiengesellschaft Biphenyl and biphenyl-analogous compounds as integrin antagonists
US6136335A (en) 1998-12-31 2000-10-24 Hughes Institute Phenethyl-5-bromopyridylthiourea (PBT) and dihydroalkoxybenzyloxopyrimidine (DABO) derivatives exhibiting spermicidal activity
US7186736B1 (en) 1999-03-20 2007-03-06 Parker Hughes Institute NNI for treatment of multi-drug resistant HIV
US6245788B1 (en) * 1999-03-31 2001-06-12 The Procter & Gamble Company Viral treatment
US6258831B1 (en) * 1999-03-31 2001-07-10 The Procter & Gamble Company Viral treatment
ATE246177T1 (de) 1999-05-28 2003-08-15 Cheil Jedang Corp Katecholhydrazon-derivate, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen die diese enthalten
US6541485B1 (en) 1999-06-10 2003-04-01 3M Innovative Properties Company Urea substituted imidazoquinolines
US6331539B1 (en) 1999-06-10 2001-12-18 3M Innovative Properties Company Sulfonamide and sulfamide substituted imidazoquinolines
CO5200760A1 (es) 1999-06-16 2002-09-27 Smithkline Beecham Corp Antagonistas del receptor de la il-8 ceptor il-8
US6469034B1 (en) 1999-06-23 2002-10-22 Parker Hughes Institute Cyclohexenyl-ethyl-thiourea compounds for inhibiting HIV reverse transcriptase
EP1215200B1 (en) 1999-09-24 2005-03-16 Nihon Nohyaku Co., Ltd. Aromatic diamide derivatives or salts thereof, agricultural/horticultural chemicals and method of using the same
GB9929988D0 (en) 1999-12-17 2000-02-09 Celltech Therapeutics Ltd Chemical compounds
US7256192B2 (en) 1999-12-22 2007-08-14 Nihon Nohyaku Co., Ltd. Aromatic diamide derivatives, chemicals for agricultural or horticultural use and usage thereof
TWI281915B (en) 1999-12-24 2007-06-01 Kirin Brewery Quinoline and quinazoline derivatives and drugs containing the same
WO2001047931A1 (en) 1999-12-24 2001-07-05 Kyowa Hakko Kogyo Co., Ltd. Fused purine derivatives
TWI284639B (en) 2000-01-24 2007-08-01 Shionogi & Co A compound having thrombopoietin receptor agonistic effect
US20040034041A1 (en) 2000-05-10 2004-02-19 Dashyant Dhanak Novel anti-infectives
CZ2003182A3 (cs) 2000-06-21 2003-06-18 F. Hoffmann-La Roche Ag Deriváty benzothiazolu
GB0017676D0 (en) 2000-07-19 2000-09-06 Angeletti P Ist Richerche Bio Inhibitors of viral polymerase
DE10123163A1 (de) 2001-05-09 2003-01-16 Gruenenthal Gmbh Substituierte Cyclohexan-1,4-diaminderivate
US7220877B2 (en) 2001-10-17 2007-05-22 Novo Nordisk A/S Compounds, their preparation and use
DE60222921T2 (de) 2001-11-01 2008-08-07 Janssen Pharmaceutica N.V. Amidderivate als inhibitoren der glycogensynthasekinase-3-beta
CN100548987C (zh) 2002-05-16 2009-10-14 拜尔作物科学股份公司 杀虫的吡啶甲酰胺衍生物
BR0309972A (pt) 2002-05-16 2005-03-01 Bayer Cropscience Gmbh Derivados de piridina carboxamida e seu uso como pesticidas
FR2839974B1 (fr) 2002-05-24 2004-07-16 Pf Medicament Derives de phenyl-furane ou de phenyl-thiophene,leur preparation et leur application a titre de medicament
US7517894B2 (en) 2002-07-31 2009-04-14 Bayer Schering Pharma Ag VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridines
US7148357B2 (en) 2002-07-31 2006-12-12 Schering Ag VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridines
DE10239905A1 (de) 2002-08-30 2004-03-04 Bayer Cropscience Gmbh Substituierte Pyridine oder Pyrimidine, Verfahren zu ihrer Herstellung, sie enthaltende Mittel und ihre Verwendung als Schädlingsbekämpfungsmittel
WO2004037166A2 (en) * 2002-09-17 2004-05-06 Isis Pharmaceuticals, Inc. Therapeutic guanidines
CA2506415A1 (en) * 2002-11-19 2004-06-03 Achillion Pharmaceuticals, Inc. Substituted aryl thioureas and releated compounds; inhibitors of viral replication
EP2666481B9 (en) 2003-12-26 2019-05-22 HAGIWARA, Masatoshi Method of regulating phosphorylation of sr protein and antiviral agents comprising sr protein activity regulator as the active ingredient
TW200528459A (en) * 2004-01-06 2005-09-01 Achillion Pharmaceuticals Inc Azabenzofuran substituted thioureas; inhibitors of viral replication

Also Published As

Publication number Publication date
KR20070010183A (ko) 2007-01-22
JP2005330284A (ja) 2005-12-02
CA2566809A1 (en) 2006-08-10
BRPI0511283A (pt) 2007-12-04
EP1747196A2 (en) 2007-01-31
US20060025416A1 (en) 2006-02-02
AR049427A1 (es) 2006-08-02
EA009882B1 (ru) 2008-04-28
ATE457301T1 (de) 2010-02-15
IL178967A0 (en) 2007-03-08
WO2006083271A2 (en) 2006-08-10
US7767706B2 (en) 2010-08-03
MXPA06013374A (es) 2007-03-01
DE602005019282D1 (de) 2010-03-25
CN101087755A (zh) 2007-12-12
EP1747196B1 (en) 2010-02-10
JP4109271B2 (ja) 2008-07-02
US7365068B2 (en) 2008-04-29
JP2006225394A (ja) 2006-08-31
WO2006083271A3 (en) 2006-10-26
EA200602130A1 (ru) 2007-04-27
NZ551115A (en) 2010-07-30
NO20065736L (no) 2007-02-08
TW200600492A (en) 2006-01-01
AP2006003808A0 (en) 2006-12-31
US20090023730A1 (en) 2009-01-22

Similar Documents

Publication Publication Date Title
ES2342783T3 (es) Aril aciltioureas sustituidas y compuestos relacionados, inhibidores de la replicacion viral.
JP6985299B2 (ja) 新規（ヘテロ）アリール置換ピペリジニル誘導体、それを調製するためのプロセス、及びそれを含有する医薬組成物
JP5911638B2 (ja) ベンゾチアゾール−６−イル酢酸誘導体およびｈｉｖ感染を処置するためのそれらの使用
CN105339370B (zh) 用于治疗炎症性疾病的化合物和及其药物组合物
AU2016276806B9 (en) Tricyclic derivative compound, method for preparing same, and pharmaceutical composition comprising same
KR102011534B1 (ko) 인자 ＸＩａ 억제제로서 피리디논 및 피리미디논 유도체
ES2434467T3 (es) Compuestos multicíclicos y métodos para su uso
US9862716B2 (en) TRKA kinase inhibitors, compositions and methods thereof
JP2020514267A5 (es)
JP2010513444A5 (es)
JP2019112433A (ja) ４−アザインドール誘導体
JP2009529047A5 (es)
JP2016534023A5 (es)
HRP20230789T1 (hr) Derivati benzhidroksamske kiseline kao selektivni inhibitori hdac6
JPWO2002088107A1 (ja) ピラゾリル基を置換基として有する含窒素縮合環化合物およびその医薬組成物
CN102617567A (zh) 含有内酰胺的化合物及其衍生物作为Xa因子的抑制剂
TW200529830A (en) A thiazole derivative
JP2020516671A5 (es)
RU2008141511A (ru) Конденсированные гетероциклические соединения и их применение в качестве модуляторов mglur5
WO2015181633A2 (en) Methods of blocking the cxcr-4/sdf-1 signaling pathway with inhibitors of bruton's tyrosine kinase
KR20190095301A (ko) PDE1 저해제로서 피라졸로[3,4-b]피리딘 및 이미다조[1,5-b]피리다진
KR102329235B1 (ko) Irak4 저해제로서 신규의 삼중고리 화합물
WO2014017803A1 (ko) 퓨란-함유 융합 고리 화합물 또는 그의 염 및 이를 포함하는 약학 조성물
FR3052451A1 (es)
WO2015185998A2 (en) Methods of blocking the cxcr-4/sdf-1 signaling pathway with inhibitors of bone marrow x kinase