ES2291374T3 - Derivados de indol y su empleo como ligandos receptores de 5-ht2b y 5-ht2c. - Google Patents

Info

Publication number

ES2291374T3

ES2291374T3 ES01989597T ES01989597T ES2291374T3 ES 2291374 T3 ES2291374 T3 ES 2291374T3 ES 01989597 T ES01989597 T ES 01989597T ES 01989597 T ES01989597 T ES 01989597T ES 2291374 T3 ES2291374 T3 ES 2291374T3

Authority

ES

Spain

Prior art keywords

aza

dihydro

inden

methyl

cyclopenta

Prior art date

2000-12-27

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired - Lifetime

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• 229940116892 5 Hydroxytryptamine 2B receptor antagonist Drugs 0.000 title description 3
• 101710138092 5-hydroxytryptamine receptor 2B Proteins 0.000 title description 2
• 102100024956 5-hydroxytryptamine receptor 2B Human genes 0.000 title description 2
• 101710138093 5-hydroxytryptamine receptor 2C Proteins 0.000 title description 2
• 102100024959 5-hydroxytryptamine receptor 2C Human genes 0.000 title description 2
• 150000001875 compounds Chemical class 0.000 claims abstract description 189
• -1 methoxyethyl Chemical group 0.000 claims abstract description 97
• 150000002148 esters Chemical class 0.000 claims abstract description 36
• 150000003839 salts Chemical class 0.000 claims abstract description 25
• 239000001257 hydrogen Substances 0.000 claims abstract description 20
• 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 20
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract description 12
• GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 claims abstract description 10
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims abstract description 10
• 125000001153 fluoro group Chemical group F* 0.000 claims abstract description 10
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 8
• 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims abstract description 7
• 125000005448 ethoxyethyl group Chemical group [H]C([H])([H])C([H])([H])OC([H])([H])C([H])([H])* 0.000 claims abstract description 5
• 239000012453 solvate Substances 0.000 claims abstract description 5
• 125000006232 ethoxy propyl group Chemical group [H]C([H])([H])C([H])([H])OC([H])([H])C([H])([H])C([H])([H])* 0.000 claims abstract description 4
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• AHLBNYSZXLDEJQ-FWEHEUNISA-N orlistat Chemical group CCCCCCCCCCC[C@H](OC(=O)[C@H](CC(C)C)NC=O)C[C@@H]1OC(=O)[C@H]1CCCCCC AHLBNYSZXLDEJQ-FWEHEUNISA-N 0.000 claims description 27
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