ES2268362T3 - Metodo para purificacion de albumina. - Google Patents

Metodo para purificacion de albumina. Download PDF

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Publication number
ES2268362T3
ES2268362T3 ES03725953T ES03725953T ES2268362T3 ES 2268362 T3 ES2268362 T3 ES 2268362T3 ES 03725953 T ES03725953 T ES 03725953T ES 03725953 T ES03725953 T ES 03725953T ES 2268362 T3 ES2268362 T3 ES 2268362T3
Authority
ES
Spain
Prior art keywords
matrix
hsar
ccs
stage
cation exchange
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES03725953T
Other languages
English (en)
Spanish (es)
Inventor
Makonnen Amersham Biosciences AB BELEW
Mei Yan North China Pharmaceutical Group Corp LI
Wei North China Pharmaceutical Group Corp. ZHANG
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
North China Pharmaceutical Group
NORTH CHINA PHARMACEUTICAL GROUP Corp
Global Life Sciences Solutions USA LLC
Original Assignee
North China Pharmaceutical Group
NORTH CHINA PHARMACEUTICAL GROUP Corp
GE Healthcare Bio Sciences Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by North China Pharmaceutical Group, NORTH CHINA PHARMACEUTICAL GROUP Corp, GE Healthcare Bio Sciences Corp filed Critical North China Pharmaceutical Group
Application granted granted Critical
Publication of ES2268362T3 publication Critical patent/ES2268362T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
ES03725953T 2002-05-15 2003-05-09 Metodo para purificacion de albumina. Expired - Lifetime ES2268362T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0201518 2002-05-15
SE0201518A SE526227C2 (sv) 2002-05-15 2002-05-15 Metod för rening av rekombinant humant serumalbumin

Publications (1)

Publication Number Publication Date
ES2268362T3 true ES2268362T3 (es) 2007-03-16

Family

ID=20287916

Family Applications (1)

Application Number Title Priority Date Filing Date
ES03725953T Expired - Lifetime ES2268362T3 (es) 2002-05-15 2003-05-09 Metodo para purificacion de albumina.

Country Status (13)

Country Link
US (2) US7423124B2 (OSRAM)
EP (2) EP1504031B1 (OSRAM)
JP (2) JP2006502098A (OSRAM)
CN (1) CN100463921C (OSRAM)
AT (1) ATE335006T1 (OSRAM)
AU (2) AU2003228193B2 (OSRAM)
BR (2) BRPI0309992B1 (OSRAM)
CA (2) CA2483612A1 (OSRAM)
DE (1) DE60307262T2 (OSRAM)
ES (1) ES2268362T3 (OSRAM)
IL (1) IL164844A (OSRAM)
SE (1) SE526227C2 (OSRAM)
WO (2) WO2003097692A1 (OSRAM)

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* Cited by examiner, † Cited by third party
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US8802146B2 (en) * 1998-11-06 2014-08-12 Neomend, Inc. Systems, methods, and compositions for prevention of tissue adhesion
VN23181A1 (en) * 2003-01-28 2010-07-26 Du Pont Cyano anthranilamide insecticides
WO2004080575A1 (en) * 2003-03-12 2004-09-23 Fresenius Kabi Deutschland Gmbh Use of recombinant albumin in dialysis after liver failure
CA2564031A1 (en) * 2004-04-23 2005-11-03 Conjuchem Biotechnologies Inc. Method for the purification of albumin conjugates
CN1854155B (zh) * 2005-04-29 2010-11-17 华北制药集团新药研究开发有限责任公司 一种纯化rHSA的方法
CL2008002054A1 (es) * 2007-07-17 2009-05-29 Hoffmann La Roche Metodo para la regeneracion de una columna de cromatografia de intercambio cationico despues de la elusion de eritropoyetina monopeguilada y metodo para obtener una eritropoyetina monopeguilada, incorporando el metodo de regeneracion de la columna de intercambio cationico.
CL2008002053A1 (es) * 2007-07-17 2009-05-22 Hoffmann La Roche Metodo para la purificacion de una eritropoyetina monopeguilada (epompeg) que consiste en proporcionar una solucion que contiene eritropoyetina mono, poli y no peguilada y hacerla pasar por dos pasos de cromatografia de intercambio cationico y metodo para producir epo mpeg que incluye metodo de purificacion.
CN101978268B (zh) * 2008-03-31 2014-04-23 积水医疗株式会社 纯化血清白蛋白及免疫学测定方法
US8753868B2 (en) 2008-08-04 2014-06-17 General Electric Company Method and system for selective isolation of target biological molecules in a general purpose system
CN101768206B (zh) * 2008-12-31 2013-05-15 华北制药集团新药研究开发有限责任公司 一种重组人血清白蛋白的纯化方法及其应用
WO2010096588A2 (en) 2009-02-20 2010-08-26 Ventria Bioscience Cell culture media containing combinations of proteins
EP4492053A3 (en) * 2010-05-25 2025-03-19 F. Hoffmann-La Roche AG Methods of purifying polypeptides
CN102127164B (zh) 2010-12-20 2013-01-30 武汉禾元生物科技有限公司 一种从水稻种子中提取重组人血清白蛋白的方法
CN102532254B (zh) * 2010-12-24 2015-06-24 武汉禾元生物科技股份有限公司 一种从水稻种子中分离纯化重组人血清白蛋白的方法
WO2013134251A2 (en) * 2012-03-08 2013-09-12 Bio-Rad Laboratories, Inc. Anionic exchange-hydrophobic mixed mode
CN103880947B (zh) 2012-12-21 2016-01-13 武汉禾元生物科技股份有限公司 一种分离纯化高纯度重组人血清白蛋白的层析方法
CN103923211A (zh) * 2014-05-08 2014-07-16 齐智 一种医药级重组人血清白蛋白的纯化方法
CN107709552B (zh) * 2015-06-10 2022-05-13 南克维斯特公司 用于治疗癌症的修饰的nk-92细胞
CN106146631A (zh) * 2015-12-09 2016-11-23 烟台大学 一种离心技术结合疏水层析介质制备藻红蛋白的方法
CN106117326A (zh) * 2015-12-09 2016-11-16 烟台大学 一种离心法结合阴离子交换层析介质制备藻红蛋白的方法
CN106117347A (zh) * 2015-12-09 2016-11-16 烟台大学 一种疏水层析制备高纯度藻红蛋白的方法
IL291020B2 (en) * 2019-09-24 2025-04-01 Regeneron Pharma Systems and methods for use in chromatography and regeneration
US11739166B2 (en) 2020-07-02 2023-08-29 Davol Inc. Reactive polysaccharide-based hemostatic agent
US12161777B2 (en) 2020-07-02 2024-12-10 Davol Inc. Flowable hemostatic suspension
JP7674630B2 (ja) 2020-12-08 2025-05-12 通化安睿特生物製薬股▲フェン▼有限公司 組換えタンパク質を精製する方法
CN116744984A (zh) 2020-12-28 2023-09-12 达沃有限公司 包含蛋白质和多官能化改性的基于聚乙二醇的交联剂的反应性干粉状止血材料
CN113461804A (zh) * 2021-08-09 2021-10-01 山东健通生物科技有限公司 减少重组人血白蛋白发酵过程中色素的方法
CN113880908B (zh) * 2021-08-25 2024-05-14 北京伟德杰生物科技有限公司 纯化重组人血清白蛋白的融合蛋白的方法
CN113735962B (zh) * 2021-08-27 2023-11-10 常熟纳微生物科技有限公司 一种从猪血中纯化重组人血清白蛋白的方法及应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4093612A (en) * 1975-08-04 1978-06-06 Research Corporation Selective removal of albumin from blood fluids and compositions therefore
FR2403098A1 (fr) * 1977-09-19 1979-04-13 Merieux Inst Nouveau materiau capable de fixer de facon reversible des macromolecules biologiques, sa preparation et son application
JPH06501033A (ja) * 1991-07-12 1994-01-27 ギスト　ブロカデス　ナムローゼ　フェンノートシャップ 血清アルブミンの精製方法
US5849874A (en) * 1991-07-12 1998-12-15 Gist-Brocades, N.V. Process for the purification of serum albumin
JPH07102148B2 (ja) * 1992-05-20 1995-11-08 株式会社ミドリ十字 遺伝子操作により得られるヒト血清アルブミンの製造方法、およびそれにより得られるヒト血清アルブミン含有組成物
US5440018A (en) * 1992-05-20 1995-08-08 The Green Cross Corporation Recombinant human serum albumin, process for producing the same and pharmaceutical preparation containing the same
US5521287A (en) * 1992-05-20 1996-05-28 The Green Cross Corporation Recombinant human serum albumin, process for producing the same and pharmaceutical preparation containing the same
CA2116385A1 (en) 1993-02-25 1994-08-26 Akinori Sumi Human serum albumin and process for producing the same
DE69434126T3 (de) * 1993-12-17 2009-07-09 Mitsubishi Pharma Corp. Verfahren zum Entfärben von menschlichemn Serum-Albumin
CA2157219C (en) * 1994-08-31 2010-10-05 Munehiro Noda Process for purifying recombinant human serum albumin
JP3840674B2 (ja) * 1994-08-31 2006-11-01 三菱ウェルファーマ株式会社 遺伝子操作に由来するヒト血清アルブミンの精製方法
GB9902000D0 (en) * 1999-01-30 1999-03-17 Delta Biotechnology Ltd Process
SE0002688D0 (sv) * 2000-07-17 2000-07-17 Amersham Pharm Biotech Ab Adsorption method and ligands
JP4798832B2 (ja) * 2000-10-24 2011-10-19 一般財団法人化学及血清療法研究所 ヒト血清アルブミン多量体の除去方法

Also Published As

Publication number Publication date
DE60307262D1 (de) 2006-09-14
AU2003228193A1 (en) 2003-12-02
ATE335006T1 (de) 2006-08-15
JP2006512283A (ja) 2006-04-13
JP2006502098A (ja) 2006-01-19
US7351801B2 (en) 2008-04-01
EP1504032A1 (en) 2005-02-09
SE0201518D0 (sv) 2002-05-15
WO2003097693A1 (en) 2003-11-27
JP4559216B2 (ja) 2010-10-06
EP1504031A1 (en) 2005-02-09
US20050215765A1 (en) 2005-09-29
SE526227C2 (sv) 2005-08-02
EP1504031B1 (en) 2006-08-02
US7423124B2 (en) 2008-09-09
CA2483616A1 (en) 2003-11-27
CA2483612A1 (en) 2003-11-27
AU2003232704A1 (en) 2003-12-02
BRPI0309992B1 (pt) 2020-12-22
BRPI0309992B8 (pt) 2023-03-21
AU2003228193B2 (en) 2009-05-07
DE60307262T2 (de) 2007-06-28
BR0309992A (pt) 2005-03-01
CN100463921C (zh) 2009-02-25
IL164844A (en) 2009-09-01
IL164844A0 (en) 2005-12-18
US20050214902A1 (en) 2005-09-29
WO2003097692A1 (en) 2003-11-27
CN1496993A (zh) 2004-05-19

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