ATE335006T1 - Verfahren zur aufreinigung von albumin - Google Patents
Verfahren zur aufreinigung von albuminInfo
- Publication number
- ATE335006T1 ATE335006T1 AT03725953T AT03725953T ATE335006T1 AT E335006 T1 ATE335006 T1 AT E335006T1 AT 03725953 T AT03725953 T AT 03725953T AT 03725953 T AT03725953 T AT 03725953T AT E335006 T1 ATE335006 T1 AT E335006T1
- Authority
- AT
- Austria
- Prior art keywords
- matrix
- rhsa
- cation exchange
- bimodal
- cell culture
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 102000009027 Albumins Human genes 0.000 title 1
- 108010088751 Albumins Proteins 0.000 title 1
- 239000011159 matrix material Substances 0.000 abstract 5
- 230000002902 bimodal effect Effects 0.000 abstract 3
- 238000005341 cation exchange Methods 0.000 abstract 3
- 238000004113 cell culture Methods 0.000 abstract 2
- 239000012228 culture supernatant Substances 0.000 abstract 2
- 238000004191 hydrophobic interaction chromatography Methods 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 102000008100 Human Serum Albumin Human genes 0.000 abstract 1
- 108091006905 Human Serum Albumin Proteins 0.000 abstract 1
- 238000005349 anion exchange Methods 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 238000010790 dilution Methods 0.000 abstract 1
- 239000012895 dilution Substances 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/765—Serum albumin, e.g. HSA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0201518A SE526227C2 (sv) | 2002-05-15 | 2002-05-15 | Metod för rening av rekombinant humant serumalbumin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE335006T1 true ATE335006T1 (de) | 2006-08-15 |
Family
ID=20287916
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03725953T ATE335006T1 (de) | 2002-05-15 | 2003-05-09 | Verfahren zur aufreinigung von albumin |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US7423124B2 (OSRAM) |
| EP (2) | EP1504031B1 (OSRAM) |
| JP (2) | JP2006502098A (OSRAM) |
| CN (1) | CN100463921C (OSRAM) |
| AT (1) | ATE335006T1 (OSRAM) |
| AU (2) | AU2003228193B2 (OSRAM) |
| BR (2) | BRPI0309992B1 (OSRAM) |
| CA (2) | CA2483612A1 (OSRAM) |
| DE (1) | DE60307262T2 (OSRAM) |
| ES (1) | ES2268362T3 (OSRAM) |
| IL (1) | IL164844A (OSRAM) |
| SE (1) | SE526227C2 (OSRAM) |
| WO (2) | WO2003097692A1 (OSRAM) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8802146B2 (en) * | 1998-11-06 | 2014-08-12 | Neomend, Inc. | Systems, methods, and compositions for prevention of tissue adhesion |
| VN23181A1 (en) * | 2003-01-28 | 2010-07-26 | Du Pont | Cyano anthranilamide insecticides |
| WO2004080575A1 (en) * | 2003-03-12 | 2004-09-23 | Fresenius Kabi Deutschland Gmbh | Use of recombinant albumin in dialysis after liver failure |
| CA2564031A1 (en) * | 2004-04-23 | 2005-11-03 | Conjuchem Biotechnologies Inc. | Method for the purification of albumin conjugates |
| CN1854155B (zh) * | 2005-04-29 | 2010-11-17 | 华北制药集团新药研究开发有限责任公司 | 一种纯化rHSA的方法 |
| CL2008002054A1 (es) * | 2007-07-17 | 2009-05-29 | Hoffmann La Roche | Metodo para la regeneracion de una columna de cromatografia de intercambio cationico despues de la elusion de eritropoyetina monopeguilada y metodo para obtener una eritropoyetina monopeguilada, incorporando el metodo de regeneracion de la columna de intercambio cationico. |
| CL2008002053A1 (es) * | 2007-07-17 | 2009-05-22 | Hoffmann La Roche | Metodo para la purificacion de una eritropoyetina monopeguilada (epompeg) que consiste en proporcionar una solucion que contiene eritropoyetina mono, poli y no peguilada y hacerla pasar por dos pasos de cromatografia de intercambio cationico y metodo para producir epo mpeg que incluye metodo de purificacion. |
| CN101978268B (zh) * | 2008-03-31 | 2014-04-23 | 积水医疗株式会社 | 纯化血清白蛋白及免疫学测定方法 |
| US8753868B2 (en) | 2008-08-04 | 2014-06-17 | General Electric Company | Method and system for selective isolation of target biological molecules in a general purpose system |
| CN101768206B (zh) * | 2008-12-31 | 2013-05-15 | 华北制药集团新药研究开发有限责任公司 | 一种重组人血清白蛋白的纯化方法及其应用 |
| WO2010096588A2 (en) | 2009-02-20 | 2010-08-26 | Ventria Bioscience | Cell culture media containing combinations of proteins |
| EP4492053A3 (en) * | 2010-05-25 | 2025-03-19 | F. Hoffmann-La Roche AG | Methods of purifying polypeptides |
| CN102127164B (zh) | 2010-12-20 | 2013-01-30 | 武汉禾元生物科技有限公司 | 一种从水稻种子中提取重组人血清白蛋白的方法 |
| CN102532254B (zh) * | 2010-12-24 | 2015-06-24 | 武汉禾元生物科技股份有限公司 | 一种从水稻种子中分离纯化重组人血清白蛋白的方法 |
| WO2013134251A2 (en) * | 2012-03-08 | 2013-09-12 | Bio-Rad Laboratories, Inc. | Anionic exchange-hydrophobic mixed mode |
| CN103880947B (zh) | 2012-12-21 | 2016-01-13 | 武汉禾元生物科技股份有限公司 | 一种分离纯化高纯度重组人血清白蛋白的层析方法 |
| CN103923211A (zh) * | 2014-05-08 | 2014-07-16 | 齐智 | 一种医药级重组人血清白蛋白的纯化方法 |
| CN107709552B (zh) * | 2015-06-10 | 2022-05-13 | 南克维斯特公司 | 用于治疗癌症的修饰的nk-92细胞 |
| CN106146631A (zh) * | 2015-12-09 | 2016-11-23 | 烟台大学 | 一种离心技术结合疏水层析介质制备藻红蛋白的方法 |
| CN106117326A (zh) * | 2015-12-09 | 2016-11-16 | 烟台大学 | 一种离心法结合阴离子交换层析介质制备藻红蛋白的方法 |
| CN106117347A (zh) * | 2015-12-09 | 2016-11-16 | 烟台大学 | 一种疏水层析制备高纯度藻红蛋白的方法 |
| IL291020B2 (en) * | 2019-09-24 | 2025-04-01 | Regeneron Pharma | Systems and methods for use in chromatography and regeneration |
| US11739166B2 (en) | 2020-07-02 | 2023-08-29 | Davol Inc. | Reactive polysaccharide-based hemostatic agent |
| US12161777B2 (en) | 2020-07-02 | 2024-12-10 | Davol Inc. | Flowable hemostatic suspension |
| JP7674630B2 (ja) | 2020-12-08 | 2025-05-12 | 通化安睿特生物製薬股▲フェン▼有限公司 | 組換えタンパク質を精製する方法 |
| CN116744984A (zh) | 2020-12-28 | 2023-09-12 | 达沃有限公司 | 包含蛋白质和多官能化改性的基于聚乙二醇的交联剂的反应性干粉状止血材料 |
| CN113461804A (zh) * | 2021-08-09 | 2021-10-01 | 山东健通生物科技有限公司 | 减少重组人血白蛋白发酵过程中色素的方法 |
| CN113880908B (zh) * | 2021-08-25 | 2024-05-14 | 北京伟德杰生物科技有限公司 | 纯化重组人血清白蛋白的融合蛋白的方法 |
| CN113735962B (zh) * | 2021-08-27 | 2023-11-10 | 常熟纳微生物科技有限公司 | 一种从猪血中纯化重组人血清白蛋白的方法及应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4093612A (en) * | 1975-08-04 | 1978-06-06 | Research Corporation | Selective removal of albumin from blood fluids and compositions therefore |
| FR2403098A1 (fr) * | 1977-09-19 | 1979-04-13 | Merieux Inst | Nouveau materiau capable de fixer de facon reversible des macromolecules biologiques, sa preparation et son application |
| JPH06501033A (ja) * | 1991-07-12 | 1994-01-27 | ギスト ブロカデス ナムローゼ フェンノートシャップ | 血清アルブミンの精製方法 |
| US5849874A (en) * | 1991-07-12 | 1998-12-15 | Gist-Brocades, N.V. | Process for the purification of serum albumin |
| JPH07102148B2 (ja) * | 1992-05-20 | 1995-11-08 | 株式会社ミドリ十字 | 遺伝子操作により得られるヒト血清アルブミンの製造方法、およびそれにより得られるヒト血清アルブミン含有組成物 |
| US5440018A (en) * | 1992-05-20 | 1995-08-08 | The Green Cross Corporation | Recombinant human serum albumin, process for producing the same and pharmaceutical preparation containing the same |
| US5521287A (en) * | 1992-05-20 | 1996-05-28 | The Green Cross Corporation | Recombinant human serum albumin, process for producing the same and pharmaceutical preparation containing the same |
| CA2116385A1 (en) | 1993-02-25 | 1994-08-26 | Akinori Sumi | Human serum albumin and process for producing the same |
| DE69434126T3 (de) * | 1993-12-17 | 2009-07-09 | Mitsubishi Pharma Corp. | Verfahren zum Entfärben von menschlichemn Serum-Albumin |
| CA2157219C (en) * | 1994-08-31 | 2010-10-05 | Munehiro Noda | Process for purifying recombinant human serum albumin |
| JP3840674B2 (ja) * | 1994-08-31 | 2006-11-01 | 三菱ウェルファーマ株式会社 | 遺伝子操作に由来するヒト血清アルブミンの精製方法 |
| GB9902000D0 (en) * | 1999-01-30 | 1999-03-17 | Delta Biotechnology Ltd | Process |
| SE0002688D0 (sv) * | 2000-07-17 | 2000-07-17 | Amersham Pharm Biotech Ab | Adsorption method and ligands |
| JP4798832B2 (ja) * | 2000-10-24 | 2011-10-19 | 一般財団法人化学及血清療法研究所 | ヒト血清アルブミン多量体の除去方法 |
-
2002
- 2002-05-15 SE SE0201518A patent/SE526227C2/sv not_active IP Right Cessation
-
2003
- 2003-05-09 CN CNB031235026A patent/CN100463921C/zh not_active Expired - Fee Related
- 2003-05-09 EP EP03725953A patent/EP1504031B1/en not_active Expired - Lifetime
- 2003-05-09 BR BRPI0309992-0A patent/BRPI0309992B1/pt active IP Right Grant
- 2003-05-09 US US10/514,536 patent/US7423124B2/en not_active Expired - Lifetime
- 2003-05-09 DE DE60307262T patent/DE60307262T2/de not_active Expired - Lifetime
- 2003-05-09 WO PCT/SE2003/000766 patent/WO2003097692A1/en not_active Ceased
- 2003-05-09 AT AT03725953T patent/ATE335006T1/de not_active IP Right Cessation
- 2003-05-09 ES ES03725953T patent/ES2268362T3/es not_active Expired - Lifetime
- 2003-05-09 JP JP2004506364A patent/JP2006502098A/ja active Pending
- 2003-05-09 AU AU2003228193A patent/AU2003228193B2/en not_active Ceased
- 2003-05-09 CA CA002483612A patent/CA2483612A1/en not_active Abandoned
- 2003-05-09 BR BRPI0309992A patent/BRPI0309992B8/pt active IP Right Grant
- 2003-05-15 EP EP03752962A patent/EP1504032A1/en not_active Withdrawn
- 2003-05-15 JP JP2004506365A patent/JP4559216B2/ja not_active Expired - Fee Related
- 2003-05-15 WO PCT/SE2003/000792 patent/WO2003097693A1/en not_active Ceased
- 2003-05-15 AU AU2003232704A patent/AU2003232704A1/en not_active Abandoned
- 2003-05-15 US US10/514,544 patent/US7351801B2/en not_active Expired - Fee Related
- 2003-05-15 CA CA002483616A patent/CA2483616A1/en not_active Abandoned
-
2004
- 2004-10-26 IL IL164844A patent/IL164844A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE60307262D1 (de) | 2006-09-14 |
| AU2003228193A1 (en) | 2003-12-02 |
| JP2006512283A (ja) | 2006-04-13 |
| JP2006502098A (ja) | 2006-01-19 |
| US7351801B2 (en) | 2008-04-01 |
| EP1504032A1 (en) | 2005-02-09 |
| SE0201518D0 (sv) | 2002-05-15 |
| WO2003097693A1 (en) | 2003-11-27 |
| JP4559216B2 (ja) | 2010-10-06 |
| EP1504031A1 (en) | 2005-02-09 |
| US20050215765A1 (en) | 2005-09-29 |
| SE526227C2 (sv) | 2005-08-02 |
| EP1504031B1 (en) | 2006-08-02 |
| US7423124B2 (en) | 2008-09-09 |
| CA2483616A1 (en) | 2003-11-27 |
| CA2483612A1 (en) | 2003-11-27 |
| AU2003232704A1 (en) | 2003-12-02 |
| BRPI0309992B1 (pt) | 2020-12-22 |
| BRPI0309992B8 (pt) | 2023-03-21 |
| AU2003228193B2 (en) | 2009-05-07 |
| ES2268362T3 (es) | 2007-03-16 |
| DE60307262T2 (de) | 2007-06-28 |
| BR0309992A (pt) | 2005-03-01 |
| CN100463921C (zh) | 2009-02-25 |
| IL164844A (en) | 2009-09-01 |
| IL164844A0 (en) | 2005-12-18 |
| US20050214902A1 (en) | 2005-09-29 |
| WO2003097692A1 (en) | 2003-11-27 |
| CN1496993A (zh) | 2004-05-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1504031 Country of ref document: EP |
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| REN | Ceased due to non-payment of the annual fee |