ES2232168T3 - Pirroloquinolinas para el tratamiento de la obesidad. - Google Patents
Pirroloquinolinas para el tratamiento de la obesidad.Info
- Publication number
- ES2232168T3 ES2232168T3 ES99943093T ES99943093T ES2232168T3 ES 2232168 T3 ES2232168 T3 ES 2232168T3 ES 99943093 T ES99943093 T ES 99943093T ES 99943093 T ES99943093 T ES 99943093T ES 2232168 T3 ES2232168 T3 ES 2232168T3
- Authority
- ES
- Spain
- Prior art keywords
- compound according
- disorders
- hydrogen
- pyrrolo
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- 235000020824 obesity Nutrition 0.000 title claims abstract description 18
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- -1 alkylsulfoxyl Chemical group 0.000 claims abstract description 33
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 32
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- 239000001257 hydrogen Substances 0.000 claims abstract description 27
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 23
- 208000035475 disorder Diseases 0.000 claims abstract description 17
- 125000003118 aryl group Chemical group 0.000 claims abstract description 14
- 125000003545 alkoxy group Chemical group 0.000 claims abstract description 11
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 11
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- 125000004093 cyano group Chemical group *C#N 0.000 claims abstract description 8
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- 125000004104 aryloxy group Chemical group 0.000 claims abstract description 7
- MBVFRSJFKMJRHA-UHFFFAOYSA-N 4-fluoro-1-benzofuran-7-carbaldehyde Chemical group FC1=CC=C(C=O)C2=C1C=CO2 MBVFRSJFKMJRHA-UHFFFAOYSA-N 0.000 claims abstract description 5
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- 125000004466 alkoxycarbonylamino group Chemical group 0.000 claims abstract description 5
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims abstract description 5
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- 125000004663 dialkyl amino group Chemical group 0.000 claims abstract description 5
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- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims abstract description 5
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims abstract description 5
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 10
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- DBBQAOGBHMWNBA-UHFFFAOYSA-N 1-pyrrolo[2,3-f]isoquinolin-1-ylpropan-2-amine Chemical compound C1=NC=CC2=C3N(CC(N)C)C=CC3=CC=C21 DBBQAOGBHMWNBA-UHFFFAOYSA-N 0.000 claims description 2
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- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 17
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 16
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A61P13/00—Drugs for disorders of the urinary system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
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- Endocrinology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9819019.2A GB9819019D0 (en) | 1998-09-01 | 1998-09-01 | Chemical compounds II |
| GB9819019 | 1998-09-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2232168T3 true ES2232168T3 (es) | 2005-05-16 |
Family
ID=10838154
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES99943093T Expired - Lifetime ES2232168T3 (es) | 1998-09-01 | 1999-09-01 | Pirroloquinolinas para el tratamiento de la obesidad. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6365598B1 (enExample) |
| EP (1) | EP1109809B1 (enExample) |
| JP (1) | JP2002523506A (enExample) |
| AT (1) | ATE282613T1 (enExample) |
| AU (1) | AU5637799A (enExample) |
| CA (1) | CA2341986A1 (enExample) |
| DE (1) | DE69922024T2 (enExample) |
| DK (1) | DK1109809T3 (enExample) |
| ES (1) | ES2232168T3 (enExample) |
| GB (1) | GB9819019D0 (enExample) |
| PT (1) | PT1109809E (enExample) |
| WO (1) | WO2000012502A1 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9902047D0 (en) * | 1999-01-29 | 1999-03-17 | Cerebrus Ltd | Chemical compounds XI |
| US6465467B1 (en) | 1999-05-21 | 2002-10-15 | Biovitrum Ab | Certain aryl-aliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases |
| GB9918965D0 (en) | 1999-08-11 | 1999-10-13 | Cerebrus Ltd | Chemical compounds xxi |
| SE0004245D0 (sv) | 2000-11-20 | 2000-11-20 | Pharmacia Ab | Novel compounds and their use |
| DE60139021D1 (de) | 2000-11-20 | 2009-07-30 | Biovitrum Ab Publ | Piperazinylpyrazinverbindungen als antagonisten des serotonin-5-ht2-rezeptors |
| US7026484B2 (en) | 2001-02-23 | 2006-04-11 | Ligand Pharmaceuticals Incorporated | Tricyclic androgen receptor modulator compounds and methods |
| US7214690B2 (en) | 2001-02-23 | 2007-05-08 | Ligand Pharmaceuticals Incorporated | Tricyclic quinolinone and tricyclic quinoline androgen receptor modulator compounds and methods |
| EP1513831B1 (en) | 2002-06-19 | 2010-01-06 | Biovitrum AB (publ) | Novel compounds, their use and preparation |
| US20040033228A1 (en) | 2002-08-16 | 2004-02-19 | Hans-Juergen Krause | Formulation of human antibodies for treating TNF-alpha associated disorders |
| CA2495192A1 (en) * | 2002-08-30 | 2004-03-11 | Alcon, Inc. | Substituted 5-chroman-5-yl-ethylamine compounds and their use for the treatment of glaucoma |
| CL2004000826A1 (es) | 2003-04-25 | 2005-03-04 | Pfizer | Uso de un agonista para el receptor 5-ht2c para preparar un medicamento util en el tratamiento de la incontinencia urinaria provocada por estres, con la condicion de que el agonista no sea 1-[6-cloro-5-(trifluorometil)-2-piridinil]piperazina (org-129 |
| GB0314967D0 (en) | 2003-06-26 | 2003-07-30 | Hoffmann La Roche | Piperazine derivatives |
| EP2400300A1 (en) | 2004-08-25 | 2011-12-28 | Takeda Pharmaceutical Company Limited | Method of screening preventives/remedies for stress urinary incontinence |
| AP2007004144A0 (en) | 2005-03-31 | 2007-08-31 | Pfizer Prod Inc | Cyclopentapyridine and tetrahydroquinoline derivatives |
| WO2006138347A2 (en) | 2005-06-17 | 2006-12-28 | Ligand Pharmaceuticals Incorporated | Androgen receptor modulator compounds and methods |
| WO2007053353A2 (en) * | 2005-10-28 | 2007-05-10 | Wyeth | Pyrrolo[2,3-f] and [3,2-f]isoquinolinone derivatives as 5-hydroxytryptamine-6 ligands |
| EP1991531A1 (en) * | 2006-02-28 | 2008-11-19 | Amgen Inc. | Cinnoline and quinoxaline derivates as phosphodiesterase 10 inhibitors |
| WO2007132841A1 (ja) | 2006-05-16 | 2007-11-22 | Takeda Pharmaceutical Company Limited | 縮合複素環化合物およびその用途 |
| ATE496894T1 (de) * | 2006-07-14 | 2011-02-15 | Pfizer Prod Inc | Tartratsalz von (7s)-7-ä(5-fluor-2- |
| JP5520051B2 (ja) | 2007-11-15 | 2014-06-11 | 武田薬品工業株式会社 | 縮合ピリジン誘導体およびその用途 |
| KR101062376B1 (ko) | 2008-04-10 | 2011-09-06 | 한국화학연구원 | 신규 인돌 카르복실산 비스피리딜 카르복사마이드 유도체,이의 제조방법 및 이를 유효성분으로 함유하는 조성물 |
| JPWO2011071136A1 (ja) | 2009-12-11 | 2013-04-22 | アステラス製薬株式会社 | 線維筋痛症治療剤 |
| WO2015012704A1 (en) * | 2013-07-25 | 2015-01-29 | Uniwersytet Jagielloński | Pyrroloquinoline derivatives as 5-ht6 antagonists, preparation method and use thereof |
| WO2015066344A1 (en) | 2013-11-01 | 2015-05-07 | Arena Pharmaceuticals, Inc. | 5-ht2c receptor agonists and compositions and methods of use |
| US20210052600A1 (en) | 2017-12-27 | 2021-02-25 | Takeda Pharmaceutical Company Limited | Therapeutic agents for stress urinary incontinence and incotinence of feces |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW334423B (en) * | 1993-10-22 | 1998-06-21 | Hoffmann La Roche | Tricyclic 1-aminoethylpyrrole-derivatives |
| TW270114B (enExample) * | 1993-10-22 | 1996-02-11 | Hoffmann La Roche | |
| TW403738B (en) * | 1994-08-12 | 2000-09-01 | Hoffmann La Roche | Tricyclic pyrazole derivatives |
| AU5343298A (en) | 1997-01-13 | 1998-08-03 | Yamanouchi Pharmaceutical Co., Ltd. | 5-ht2c receptor agonists and aminoalkylindazole derivatives |
| AU727654B2 (en) * | 1997-06-13 | 2000-12-21 | Yamanouchi Pharmaceutical Co., Ltd. | Tricyclic pyrazole derivative |
-
1998
- 1998-09-01 GB GBGB9819019.2A patent/GB9819019D0/en not_active Ceased
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1999
- 1999-09-01 AU AU56377/99A patent/AU5637799A/en not_active Abandoned
- 1999-09-01 WO PCT/GB1999/002887 patent/WO2000012502A1/en not_active Ceased
- 1999-09-01 CA CA002341986A patent/CA2341986A1/en not_active Abandoned
- 1999-09-01 DE DE69922024T patent/DE69922024T2/de not_active Expired - Fee Related
- 1999-09-01 PT PT99943093T patent/PT1109809E/pt unknown
- 1999-09-01 DK DK99943093T patent/DK1109809T3/da active
- 1999-09-01 AT AT99943093T patent/ATE282613T1/de not_active IP Right Cessation
- 1999-09-01 EP EP99943093A patent/EP1109809B1/en not_active Expired - Lifetime
- 1999-09-01 JP JP2000567530A patent/JP2002523506A/ja active Pending
- 1999-09-01 ES ES99943093T patent/ES2232168T3/es not_active Expired - Lifetime
- 1999-09-01 US US09/786,159 patent/US6365598B1/en not_active Expired - Fee Related
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|---|---|
| US6365598B1 (en) | 2002-04-02 |
| CA2341986A1 (en) | 2000-03-09 |
| EP1109809A1 (en) | 2001-06-27 |
| PT1109809E (pt) | 2005-02-28 |
| DE69922024D1 (de) | 2004-12-23 |
| JP2002523506A (ja) | 2002-07-30 |
| AU5637799A (en) | 2000-03-21 |
| ATE282613T1 (de) | 2004-12-15 |
| EP1109809B1 (en) | 2004-11-17 |
| DE69922024T2 (de) | 2005-09-15 |
| WO2000012502A1 (en) | 2000-03-09 |
| DK1109809T3 (da) | 2005-03-14 |
| GB9819019D0 (en) | 1998-10-28 |
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