ES2219031T3 - Nuevos benzoxazoles con actividad inhibidora de pde. - Google Patents

Nuevos benzoxazoles con actividad inhibidora de pde.

Info

Publication number
ES2219031T3
ES2219031T3 ES99931198T ES99931198T ES2219031T3 ES 2219031 T3 ES2219031 T3 ES 2219031T3 ES 99931198 T ES99931198 T ES 99931198T ES 99931198 T ES99931198 T ES 99931198T ES 2219031 T3 ES2219031 T3 ES 2219031T3
Authority
ES
Spain
Prior art keywords
compounds
compound
formula
alkoxy
salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99931198T
Other languages
English (en)
Spanish (es)
Inventor
Wolf-Rudiger Ulrich
Hermann Amschler
Thomas Bar
Dieter Flockerzi
Beate Schmidt
Ulrich Thibaut
Armin Hatzelmann
Hildegard Boss
Rolf Beume
Hans-Peter Kley
Dietrich Hafner
Thomas Martin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda GmbH
Original Assignee
Altana Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altana Pharma AG filed Critical Altana Pharma AG
Application granted granted Critical
Publication of ES2219031T3 publication Critical patent/ES2219031T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
ES99931198T 1998-07-06 1999-06-26 Nuevos benzoxazoles con actividad inhibidora de pde. Expired - Lifetime ES2219031T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98112469 1998-07-06
EP98112469 1998-07-06

Publications (1)

Publication Number Publication Date
ES2219031T3 true ES2219031T3 (es) 2004-11-16

Family

ID=8232222

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99931198T Expired - Lifetime ES2219031T3 (es) 1998-07-06 1999-06-26 Nuevos benzoxazoles con actividad inhibidora de pde.

Country Status (14)

Country Link
US (1) US6376485B1 (enExample)
EP (1) EP1095040B1 (enExample)
JP (1) JP2002519423A (enExample)
AT (1) ATE263166T1 (enExample)
AU (1) AU761647B2 (enExample)
CA (1) CA2336894A1 (enExample)
DE (1) DE69916066T2 (enExample)
DK (1) DK1095040T3 (enExample)
ES (1) ES2219031T3 (enExample)
IL (1) IL140468A0 (enExample)
PT (1) PT1095040E (enExample)
SI (1) SI1095040T1 (enExample)
WO (1) WO2000001695A1 (enExample)
ZA (1) ZA200100088B (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA83620C2 (ru) 2001-12-05 2008-08-11 Уайт Замещенные бензоксазолы и их аналоги как эстрогенные агенты
EP2258358A3 (en) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
JP2009506069A (ja) 2005-08-26 2009-02-12 ブレインセルス，インコーポレイティド ムスカリン性受容体調節による神経発生
CA2625153A1 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by pde inhibition
CA2625210A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
EP2382975A3 (en) 2006-05-09 2012-02-29 Braincells, Inc. Neurogenesis by modulating angiotensin
MX2008014320A (es) 2006-05-09 2009-03-25 Braincells Inc Neurogenesis mediada por el receptor de 5-hidroxitriptamina.
JP2010502722A (ja) 2006-09-08 2010-01-28 ブレインセルス，インコーポレイティド ４−アシルアミノピリジン誘導体を含む組み合わせ
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
EP2225215A1 (en) * 2007-11-21 2010-09-08 Decode Genetics EHF Substituted benzoazole pde4 inhibitors for treating inflammatory, cardiovascular and cns disorders
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
EP2804603A1 (en) 2012-01-10 2014-11-26 President and Fellows of Harvard College Beta-cell replication promoting compounds and methods of their use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4405633A (en) * 1982-03-01 1983-09-20 Usv Pharmaceutical Corporation Method of treatment of asthma
US4490373A (en) * 1983-05-20 1984-12-25 Usv Pharmaceutical Corporation Method of treating asthma
KR100237962B1 (ko) * 1994-10-12 2000-02-01 그린 마틴 신규한 벤즈옥사졸
DE59610031D1 (de) * 1995-05-18 2003-02-06 Altana Pharma Ag Cyclohexyldihydrobenzofurane
WO1996036624A1 (en) * 1995-05-19 1996-11-21 Kyowa Hakko Kogyo Co., Ltd. Oxygen-containing heterocyclic compounds

Also Published As

Publication number Publication date
IL140468A0 (en) 2002-02-10
DK1095040T3 (da) 2004-07-26
SI1095040T1 (en) 2004-10-31
ZA200100088B (en) 2002-05-06
WO2000001695A1 (en) 2000-01-13
CA2336894A1 (en) 2000-01-13
PT1095040E (pt) 2004-08-31
ATE263166T1 (de) 2004-04-15
AU761647B2 (en) 2003-06-05
DE69916066D1 (de) 2004-05-06
DE69916066T2 (de) 2005-02-24
JP2002519423A (ja) 2002-07-02
AU4778699A (en) 2000-01-24
US6376485B1 (en) 2002-04-23
EP1095040A1 (en) 2001-05-02
EP1095040B1 (en) 2004-03-31

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