CA2336894A1 - New benzoxazoles with pde-inhibiting activity - Google Patents
New benzoxazoles with pde-inhibiting activity Download PDFInfo
- Publication number
- CA2336894A1 CA2336894A1 CA002336894A CA2336894A CA2336894A1 CA 2336894 A1 CA2336894 A1 CA 2336894A1 CA 002336894 A CA002336894 A CA 002336894A CA 2336894 A CA2336894 A CA 2336894A CA 2336894 A1 CA2336894 A1 CA 2336894A1
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- Prior art keywords
- compounds
- compound
- formula
- alkoxy
- hydroxyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 239000012312 sodium hydride Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 238000009121 systemic therapy Methods 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 description 1
- 210000000626 ureter Anatomy 0.000 description 1
- 230000000304 vasodilatating effect Effects 0.000 description 1
- HJMQDJPMQIHLPB-UHFFFAOYSA-N zardaverine Chemical compound C1=C(OC(F)F)C(OC)=CC(C2=NNC(=O)C=C2)=C1 HJMQDJPMQIHLPB-UHFFFAOYSA-N 0.000 description 1
- 229950001080 zardaverine Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98112469.6 | 1998-07-06 | ||
| EP98112469 | 1998-07-06 | ||
| PCT/EP1999/004451 WO2000001695A1 (en) | 1998-07-06 | 1999-06-26 | New benzoxazoles with pde-inhibiting activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2336894A1 true CA2336894A1 (en) | 2000-01-13 |
Family
ID=8232222
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002336894A Abandoned CA2336894A1 (en) | 1998-07-06 | 1999-06-26 | New benzoxazoles with pde-inhibiting activity |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6376485B1 (enExample) |
| EP (1) | EP1095040B1 (enExample) |
| JP (1) | JP2002519423A (enExample) |
| AT (1) | ATE263166T1 (enExample) |
| AU (1) | AU761647B2 (enExample) |
| CA (1) | CA2336894A1 (enExample) |
| DE (1) | DE69916066T2 (enExample) |
| DK (1) | DK1095040T3 (enExample) |
| ES (1) | ES2219031T3 (enExample) |
| IL (1) | IL140468A0 (enExample) |
| PT (1) | PT1095040E (enExample) |
| SI (1) | SI1095040T1 (enExample) |
| WO (1) | WO2000001695A1 (enExample) |
| ZA (1) | ZA200100088B (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA83620C2 (ru) | 2001-12-05 | 2008-08-11 | Уайт | Замещенные бензоксазолы и их аналоги как эстрогенные агенты |
| EP2258358A3 (en) | 2005-08-26 | 2011-09-07 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
| JP2009506069A (ja) | 2005-08-26 | 2009-02-12 | ブレインセルス，インコーポレイティド | ムスカリン性受容体調節による神経発生 |
| CA2625153A1 (en) | 2005-10-21 | 2007-04-26 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
| CA2625210A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| EP2382975A3 (en) | 2006-05-09 | 2012-02-29 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| MX2008014320A (es) | 2006-05-09 | 2009-03-25 | Braincells Inc | Neurogenesis mediada por el receptor de 5-hidroxitriptamina. |
| JP2010502722A (ja) | 2006-09-08 | 2010-01-28 | ブレインセルス，インコーポレイティド | ４−アシルアミノピリジン誘導体を含む組み合わせ |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| EP2225215A1 (en) * | 2007-11-21 | 2010-09-08 | Decode Genetics EHF | Substituted benzoazole pde4 inhibitors for treating inflammatory, cardiovascular and cns disorders |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| EP2804603A1 (en) | 2012-01-10 | 2014-11-26 | President and Fellows of Harvard College | Beta-cell replication promoting compounds and methods of their use |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4405633A (en) * | 1982-03-01 | 1983-09-20 | Usv Pharmaceutical Corporation | Method of treatment of asthma |
| US4490373A (en) * | 1983-05-20 | 1984-12-25 | Usv Pharmaceutical Corporation | Method of treating asthma |
| KR100237962B1 (ko) * | 1994-10-12 | 2000-02-01 | 그린 마틴 | 신규한 벤즈옥사졸 |
| DE59610031D1 (de) * | 1995-05-18 | 2003-02-06 | Altana Pharma Ag | Cyclohexyldihydrobenzofurane |
| WO1996036624A1 (en) * | 1995-05-19 | 1996-11-21 | Kyowa Hakko Kogyo Co., Ltd. | Oxygen-containing heterocyclic compounds |
-
1999
- 1999-06-26 WO PCT/EP1999/004451 patent/WO2000001695A1/en not_active Ceased
- 1999-06-26 SI SI9930588T patent/SI1095040T1/xx unknown
- 1999-06-26 DK DK99931198T patent/DK1095040T3/da active
- 1999-06-26 PT PT99931198T patent/PT1095040E/pt unknown
- 1999-06-26 ES ES99931198T patent/ES2219031T3/es not_active Expired - Lifetime
- 1999-06-26 ZA ZA200100088A patent/ZA200100088B/en unknown
- 1999-06-26 DE DE69916066T patent/DE69916066T2/de not_active Expired - Fee Related
- 1999-06-26 IL IL14046899A patent/IL140468A0/xx not_active IP Right Cessation
- 1999-06-26 AT AT99931198T patent/ATE263166T1/de not_active IP Right Cessation
- 1999-06-26 CA CA002336894A patent/CA2336894A1/en not_active Abandoned
- 1999-06-26 US US09/720,812 patent/US6376485B1/en not_active Expired - Fee Related
- 1999-06-26 JP JP2000558098A patent/JP2002519423A/ja not_active Withdrawn
- 1999-06-26 EP EP99931198A patent/EP1095040B1/en not_active Expired - Lifetime
- 1999-06-26 AU AU47786/99A patent/AU761647B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| IL140468A0 (en) | 2002-02-10 |
| DK1095040T3 (da) | 2004-07-26 |
| SI1095040T1 (en) | 2004-10-31 |
| ZA200100088B (en) | 2002-05-06 |
| WO2000001695A1 (en) | 2000-01-13 |
| ES2219031T3 (es) | 2004-11-16 |
| PT1095040E (pt) | 2004-08-31 |
| ATE263166T1 (de) | 2004-04-15 |
| AU761647B2 (en) | 2003-06-05 |
| DE69916066D1 (de) | 2004-05-06 |
| DE69916066T2 (de) | 2005-02-24 |
| JP2002519423A (ja) | 2002-07-02 |
| AU4778699A (en) | 2000-01-24 |
| US6376485B1 (en) | 2002-04-23 |
| EP1095040A1 (en) | 2001-05-02 |
| EP1095040B1 (en) | 2004-03-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |