ES2218222T3 - Conjugados de 4-bencilaminoquinolinas con acidos biliares y sus heteroanalogos, procedimiento para su preparacion, medicamentos que contienen estos compuestos y su uso. - Google Patents

Conjugados de 4-bencilaminoquinolinas con acidos biliares y sus heteroanalogos, procedimiento para su preparacion, medicamentos que contienen estos compuestos y su uso.

Info

Publication number
ES2218222T3
ES2218222T3 ES00964126T ES00964126T ES2218222T3 ES 2218222 T3 ES2218222 T3 ES 2218222T3 ES 00964126 T ES00964126 T ES 00964126T ES 00964126 T ES00964126 T ES 00964126T ES 2218222 T3 ES2218222 T3 ES 2218222T3
Authority
ES
Spain
Prior art keywords
alkyl
benzyl
hydrogen
methyl
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES00964126T
Other languages
English (en)
Spanish (es)
Inventor
Armin Hofmeister
Eugen Falk
Heinz-Werner Kleeman
Hans-Willi Jansen
Martin Bickel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Aventis Pharma Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1999145385 external-priority patent/DE19945385A1/de
Priority claimed from DE2000128193 external-priority patent/DE10028193A1/de
Application filed by Aventis Pharma Deutschland GmbH filed Critical Aventis Pharma Deutschland GmbH
Application granted granted Critical
Publication of ES2218222T3 publication Critical patent/ES2218222T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
ES00964126T 1999-09-22 2000-09-06 Conjugados de 4-bencilaminoquinolinas con acidos biliares y sus heteroanalogos, procedimiento para su preparacion, medicamentos que contienen estos compuestos y su uso. Expired - Lifetime ES2218222T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19945385 1999-09-22
DE1999145385 DE19945385A1 (de) 1999-09-22 1999-09-22 Substituierte 4-Benzylaminochinoline und ihre Heteroanlagen, Verfahren zu ihrer Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
DE2000128193 DE10028193A1 (de) 2000-06-09 2000-06-09 Substituierte 4-Benzylamminochinoline und ihre Heteroanalogen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikamente oder Diagnostika, sowie sie enthaltende Medikamente
DE10028193 2000-06-09

Publications (1)

Publication Number Publication Date
ES2218222T3 true ES2218222T3 (es) 2004-11-16

Family

ID=26005994

Family Applications (1)

Application Number Title Priority Date Filing Date
ES00964126T Expired - Lifetime ES2218222T3 (es) 1999-09-22 2000-09-06 Conjugados de 4-bencilaminoquinolinas con acidos biliares y sus heteroanalogos, procedimiento para su preparacion, medicamentos que contienen estos compuestos y su uso.

Country Status (26)

Country Link
US (1) US6339077B1 (https=)
EP (1) EP1218401B1 (https=)
JP (1) JP4833471B2 (https=)
KR (1) KR20030010575A (https=)
CN (1) CN1158299C (https=)
AT (1) ATE269352T1 (https=)
AU (1) AU779412B2 (https=)
BR (1) BR0014233A (https=)
CA (1) CA2385445A1 (https=)
CZ (1) CZ2002992A3 (https=)
DE (1) DE50006842D1 (https=)
DK (1) DK1218401T3 (https=)
EE (1) EE200200143A (https=)
ES (1) ES2218222T3 (https=)
HK (1) HK1049169B (https=)
HR (1) HRP20020238A2 (https=)
HU (1) HUP0203045A3 (https=)
IL (1) IL148739A0 (https=)
NO (1) NO20021337L (https=)
NZ (1) NZ517899A (https=)
PL (1) PL353992A1 (https=)
PT (1) PT1218401E (https=)
RU (1) RU2247125C2 (https=)
SK (1) SK3862002A3 (https=)
WO (1) WO2001021642A1 (https=)
YU (1) YU19302A (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6576644B2 (en) 2000-09-06 2003-06-10 Bristol-Myers Squibb Co. Quinoline inhibitors of cGMP phosphodiesterase
ITMI20021025A1 (it) * 2002-05-14 2003-11-14 Nicox Sa Farmaci per il trattamento acuto di disfunzioni del circolo venoso epatico e portale
CZ301037B6 (cs) * 2007-09-06 2009-10-21 Vysoká škola chemicko-technologická v Praze Amidové konjugáty steroidních a žlucových kyselin s D-glukosaminem a zpusob jejich prípravy
BRPI1009854A2 (pt) * 2009-03-24 2015-08-25 Abbott Lab Processo para preparar composto antiviral
CA2792068A1 (en) 2010-04-02 2011-10-06 Senomyx, Inc. Sweet flavor modifier
MX336378B (es) 2011-08-12 2016-01-15 Senomyx Inc Modificador del sabor dulce.
CA2963901A1 (en) 2014-11-07 2016-05-12 Senomyx, Inc. Substituted 4-amino-5-(cyclohexyloxy)quinoline-3-carboxylic acids as sweet flavor modifiers
US12186329B2 (en) 2018-08-23 2025-01-07 President And Fellows Of Harvard College Compositions and methods related to cholic acid 7-sulfate as a treatment for diabetes
WO2020117945A1 (en) 2018-12-04 2020-06-11 President And Fellows Of Harvard College Synthetic derivatives of cholic acid 7-sulfate and uses thereof
AU2020274319B2 (en) 2019-05-10 2026-02-12 President And Fellows Of Harvard College Small molecule modulators of gut bacterial bile acid metabolism

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4789678A (en) * 1986-08-25 1988-12-06 Hoechst-Roussel Pharmaceuticals, Inc. Memory enhancing α-alkyl-4-amino-3-quinolinemethanols and 1-(4-aralkylamino-3-quinolinyl)alkanones and related compounds
JPH0667846B2 (ja) * 1989-04-28 1994-08-31 一 滝川 利胆剤
IT1259419B (it) * 1991-05-24 1996-03-18 Erba Carlo Spa Steroidi 3-carbossi 17b - sostituiti insaturi utili come inibitori della testosterone 5 a reduttasi
TW289021B (https=) * 1993-05-08 1996-10-21 Hoechst Ag
IT1274000B (it) * 1994-04-06 1997-07-14 Alfa Wassermann Spa Derivati di acidi biliari utili nella terapia della calcolosi biliare da colesterolo e nelle patologie indotte da colestasi
DE4432708A1 (de) 1994-09-14 1996-03-21 Hoechst Ag Modifizierte Gallensäuren, Verfahren zu ihrer Herstellung und ihre Verwendung
JPH09315979A (ja) * 1996-05-24 1997-12-09 Tokyo Tanabe Co Ltd 利胆剤
WO1998056757A1 (fr) * 1997-06-11 1998-12-17 Sankyo Company, Limited Derives de benzylamine

Also Published As

Publication number Publication date
HK1049169A1 (en) 2003-05-02
AU779412B2 (en) 2005-01-20
AU7515600A (en) 2001-04-24
EP1218401A1 (de) 2002-07-03
HUP0203045A3 (en) 2004-06-28
CN1158299C (zh) 2004-07-21
WO2001021642A1 (de) 2001-03-29
CZ2002992A3 (cs) 2002-06-12
RU2247125C2 (ru) 2005-02-27
HUP0203045A2 (hu) 2003-01-28
ATE269352T1 (de) 2004-07-15
CA2385445A1 (en) 2001-03-29
KR20030010575A (ko) 2003-02-05
EE200200143A (et) 2003-04-15
BR0014233A (pt) 2002-05-21
PT1218401E (pt) 2004-10-29
JP4833471B2 (ja) 2011-12-07
US6339077B1 (en) 2002-01-15
NZ517899A (en) 2004-03-26
NO20021337D0 (no) 2002-03-18
PL353992A1 (en) 2003-12-15
DE50006842D1 (de) 2004-07-22
NO20021337L (no) 2002-05-15
SK3862002A3 (en) 2003-01-09
JP2003510255A (ja) 2003-03-18
EP1218401B1 (de) 2004-06-16
CN1374968A (zh) 2002-10-16
HK1049169B (zh) 2005-04-22
YU19302A (sh) 2004-11-25
HRP20020238A2 (en) 2004-04-30
IL148739A0 (en) 2002-09-12
DK1218401T3 (da) 2004-10-04

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