ES2218024T3 - Derivados de aminoacido enantiomerico anticonvulsionante. - Google Patents
Derivados de aminoacido enantiomerico anticonvulsionante.Info
- Publication number
- ES2218024T3 ES2218024T3 ES00109377T ES00109377T ES2218024T3 ES 2218024 T3 ES2218024 T3 ES 2218024T3 ES 00109377 T ES00109377 T ES 00109377T ES 00109377 T ES00109377 T ES 00109377T ES 2218024 T3 ES2218024 T3 ES 2218024T3
- Authority
- ES
- Spain
- Prior art keywords
- compound
- mmol
- compounds
- liver
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- 230000002265 prevention Effects 0.000 description 1
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- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
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- 229940042055 systemic antimycotics triazole derivative Drugs 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1352296P | 1996-03-15 | 1996-03-15 | |
| US13522P | 1996-03-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2218024T3 true ES2218024T3 (es) | 2004-11-16 |
Family
ID=21760388
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES00109377T Expired - Lifetime ES2218024T3 (es) | 1996-03-15 | 1997-03-17 | Derivados de aminoacido enantiomerico anticonvulsionante. |
| ES97916897T Expired - Lifetime ES2157567T3 (es) | 1996-03-15 | 1997-03-17 | Derivados de aminoacidos enantiomericos que tienen efecto anticonvulsivo. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES97916897T Expired - Lifetime ES2157567T3 (es) | 1996-03-15 | 1997-03-17 | Derivados de aminoacidos enantiomericos que tienen efecto anticonvulsivo. |
Country Status (12)
| Country | Link |
|---|---|
| EP (2) | EP0888289B1 (enExample) |
| JP (1) | JP3145414B2 (enExample) |
| AT (2) | ATE202079T1 (enExample) |
| AU (1) | AU718577B2 (enExample) |
| CA (1) | CA2248317C (enExample) |
| DE (3) | DE69705210T2 (enExample) |
| DK (2) | DK1038522T3 (enExample) |
| ES (2) | ES2218024T3 (enExample) |
| FR (1) | FR09C0006I2 (enExample) |
| NL (1) | NL300376I1 (enExample) |
| PT (2) | PT888289E (enExample) |
| WO (1) | WO1997033861A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6048899A (en) * | 1997-03-17 | 2000-04-11 | Research Corporation Tech., Inc. | Anticonvulsant enantiomeric amino acid derivatives |
| EP1642889A1 (en) * | 2004-10-02 | 2006-04-05 | Schwarz Pharma Ag | Improved synthesis scheme for lacosamide |
| EP1873527A1 (en) | 2006-06-30 | 2008-01-02 | Schwarz Pharma Ag | Method for identifying CRMP modulators |
| US8093426B2 (en) * | 2007-12-04 | 2012-01-10 | Ranbaxy Laboratories Limited | Intermediate compounds and their use in preparation of lacosamide |
| DE102008059155A1 (de) | 2008-11-27 | 2010-06-02 | Ratiopharm Gmbh | Trockenverarbeitung und neue Formen von Lacosamid |
| WO2011015617A1 (en) | 2009-08-06 | 2011-02-10 | Medichem, S.A. | Solid forms of an n-(phenylmethyl)propanamide derivative and processes of preparation |
| EP2480524A1 (en) * | 2009-09-25 | 2012-08-01 | Cadila Healthcare Limited | Processes for the preparation of lacosamide and intermediates thereof |
| IT1398044B1 (it) * | 2010-01-29 | 2013-02-07 | Archimica Srl | Processo per la preparazione della lacosamide |
| US8759582B2 (en) | 2010-02-08 | 2014-06-24 | Natco Pharma Limited | Process for the preparation of lacosamide |
| US8907132B2 (en) * | 2010-02-09 | 2014-12-09 | Msn Laboratories Private Limited | Process for preparing (R)-2-acetamido-N-benzyl-3-methoxy-propionamide |
| EP2399901A1 (en) | 2010-06-23 | 2011-12-28 | Archimica GmbH | Intermediate for producing lacosamide and a process for its preparation and conversion to lacosamide |
| EP2621893A1 (en) | 2010-10-01 | 2013-08-07 | UCB Pharma GmbH | Process for the preparation of amino acid derivatives |
| EP2627639B1 (en) | 2010-10-15 | 2021-12-22 | Nektar Therapeutics | N-optionally substituted aryl-2-oligomer-3-alkoxypropionamides |
| PL2444390T3 (pl) | 2010-10-19 | 2017-06-30 | Euticals Gmbh | Sposób wytwarzania Lakozamidu |
| EP2646001A2 (en) | 2010-12-02 | 2013-10-09 | UCB Pharma GmbH | Formulation of lacosamide |
| EP2468261A1 (en) | 2010-12-02 | 2012-06-27 | UCB Pharma GmbH | Formulation of lacosamide |
| CN104771356A (zh) * | 2014-01-09 | 2015-07-15 | 山东方明药业集团股份有限公司 | 一种拉科酰胺注射液及其制备方法 |
| US11278634B1 (en) | 2021-02-12 | 2022-03-22 | Extrovis Ag | Stable parenteral composition of lacosamide |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK173553B1 (da) * | 1985-02-15 | 2001-03-12 | Res Corp Technologies Inc | Aminosyrederivater, antikonvulsant præparat som indeholder aminosyrederivat samt anvendelse af aminosyrederivater til frems |
| US5378729A (en) * | 1985-02-15 | 1995-01-03 | Research Corporation Technologies, Inc. | Amino acid derivative anticonvulsant |
-
1997
- 1997-03-17 AT AT97916897T patent/ATE202079T1/de active
- 1997-03-17 WO PCT/US1997/004579 patent/WO1997033861A1/en not_active Ceased
- 1997-03-17 DK DK00109377T patent/DK1038522T3/da active
- 1997-03-17 EP EP97916897A patent/EP0888289B1/en not_active Expired - Lifetime
- 1997-03-17 DE DE69705210T patent/DE69705210T2/de not_active Expired - Lifetime
- 1997-03-17 AU AU25394/97A patent/AU718577B2/en not_active Expired
- 1997-03-17 ES ES00109377T patent/ES2218024T3/es not_active Expired - Lifetime
- 1997-03-17 JP JP53292897A patent/JP3145414B2/ja not_active Expired - Lifetime
- 1997-03-17 PT PT97916897T patent/PT888289E/pt unknown
- 1997-03-17 DK DK97916897T patent/DK0888289T3/da active
- 1997-03-17 ES ES97916897T patent/ES2157567T3/es not_active Expired - Lifetime
- 1997-03-17 DE DE69729392T patent/DE69729392T2/de not_active Expired - Lifetime
- 1997-03-17 EP EP00109377A patent/EP1038522B1/en not_active Expired - Lifetime
- 1997-03-17 CA CA002248317A patent/CA2248317C/en not_active Expired - Lifetime
- 1997-03-17 DE DE122009000010C patent/DE122009000010I2/de active Active
- 1997-03-17 AT AT00109377T patent/ATE268169T1/de active
- 1997-03-17 PT PT00109377T patent/PT1038522E/pt unknown
-
2009
- 2009-02-16 NL NL300376C patent/NL300376I1/nl unknown
- 2009-02-26 FR FR09C0006C patent/FR09C0006I2/fr active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP1038522B1 (en) | 2004-06-02 |
| DK1038522T3 (da) | 2004-10-11 |
| NL300376I1 (nl) | 2009-05-06 |
| DE122009000010I2 (de) | 2010-10-21 |
| DE69729392T2 (de) | 2005-06-02 |
| CA2248317A1 (en) | 1997-09-18 |
| AU2539497A (en) | 1997-10-01 |
| PT888289E (pt) | 2001-09-28 |
| JP3145414B2 (ja) | 2001-03-12 |
| PT1038522E (pt) | 2004-10-29 |
| ATE202079T1 (de) | 2001-06-15 |
| FR09C0006I1 (enExample) | 2009-04-17 |
| DE69729392D1 (de) | 2004-07-08 |
| EP1038522A3 (en) | 2003-01-15 |
| WO1997033861A1 (en) | 1997-09-18 |
| EP0888289A1 (en) | 1999-01-07 |
| DK0888289T3 (da) | 2001-09-03 |
| ATE268169T1 (de) | 2004-06-15 |
| ES2157567T3 (es) | 2001-08-16 |
| DE69705210T2 (de) | 2001-09-20 |
| FR09C0006I2 (fr) | 2009-12-18 |
| CA2248317C (en) | 2003-12-02 |
| DE69705210D1 (de) | 2001-07-19 |
| EP0888289B1 (en) | 2001-06-13 |
| AU718577B2 (en) | 2000-04-13 |
| EP1038522A2 (en) | 2000-09-27 |
| DE122009000010I1 (de) | 2009-05-20 |
| JP2000505476A (ja) | 2000-05-09 |
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