ATE202079T1 - Krampflösende, enantiomere aminosäure-derivate - Google Patents
Krampflösende, enantiomere aminosäure-derivateInfo
- Publication number
- ATE202079T1 ATE202079T1 AT97916897T AT97916897T ATE202079T1 AT E202079 T1 ATE202079 T1 AT E202079T1 AT 97916897 T AT97916897 T AT 97916897T AT 97916897 T AT97916897 T AT 97916897T AT E202079 T1 ATE202079 T1 AT E202079T1
- Authority
- AT
- Austria
- Prior art keywords
- antispasmodic
- amino acid
- acid derivatives
- enantiomeric amino
- animal
- Prior art date
Links
- 150000003862 amino acid derivatives Chemical class 0.000 title 1
- 230000002921 anti-spasmodic effect Effects 0.000 title 1
- 239000000812 cholinergic antagonist Substances 0.000 title 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 230000001773 anti-convulsant effect Effects 0.000 abstract 1
- 239000001961 anticonvulsive agent Substances 0.000 abstract 1
- 229960003965 antiepileptics Drugs 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1352296P | 1996-03-15 | 1996-03-15 | |
| PCT/US1997/004579 WO1997033861A1 (en) | 1996-03-15 | 1997-03-17 | Anticonvulsant enantiomeric amino acid derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE202079T1 true ATE202079T1 (de) | 2001-06-15 |
Family
ID=21760388
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97916897T ATE202079T1 (de) | 1996-03-15 | 1997-03-17 | Krampflösende, enantiomere aminosäure-derivate |
| AT00109377T ATE268169T1 (de) | 1996-03-15 | 1997-03-17 | Antikonvulsive enantiomerische aminosäurederivate |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00109377T ATE268169T1 (de) | 1996-03-15 | 1997-03-17 | Antikonvulsive enantiomerische aminosäurederivate |
Country Status (12)
| Country | Link |
|---|---|
| EP (2) | EP1038522B1 (enExample) |
| JP (1) | JP3145414B2 (enExample) |
| AT (2) | ATE202079T1 (enExample) |
| AU (1) | AU718577B2 (enExample) |
| CA (1) | CA2248317C (enExample) |
| DE (3) | DE122009000010I2 (enExample) |
| DK (2) | DK1038522T3 (enExample) |
| ES (2) | ES2157567T3 (enExample) |
| FR (1) | FR09C0006I2 (enExample) |
| NL (1) | NL300376I1 (enExample) |
| PT (2) | PT888289E (enExample) |
| WO (1) | WO1997033861A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6048899A (en) * | 1997-03-17 | 2000-04-11 | Research Corporation Tech., Inc. | Anticonvulsant enantiomeric amino acid derivatives |
| EP1642889A1 (en) * | 2004-10-02 | 2006-04-05 | Schwarz Pharma Ag | Improved synthesis scheme for lacosamide |
| EP1873527A1 (en) | 2006-06-30 | 2008-01-02 | Schwarz Pharma Ag | Method for identifying CRMP modulators |
| US8093426B2 (en) | 2007-12-04 | 2012-01-10 | Ranbaxy Laboratories Limited | Intermediate compounds and their use in preparation of lacosamide |
| DE102008059155A1 (de) | 2008-11-27 | 2010-06-02 | Ratiopharm Gmbh | Trockenverarbeitung und neue Formen von Lacosamid |
| AR080275A1 (es) | 2009-08-06 | 2012-03-28 | Medichem Sa | Formas solidas de un derivado de n-( fenilmetil) propanamida y procedimientos de preparacion |
| JP5564570B2 (ja) * | 2009-09-25 | 2014-07-30 | カディラ・ヘルスケア・リミテッド | ラコサミドおよびその中間体の調製方法 |
| IT1398044B1 (it) * | 2010-01-29 | 2013-02-07 | Archimica Srl | Processo per la preparazione della lacosamide |
| CA2788451A1 (en) | 2010-02-08 | 2011-08-11 | Natco Pharma Limited | A process for the preparation of lacosamide |
| EP2534127A4 (en) * | 2010-02-09 | 2013-11-27 | Msn Lab Ltd | PROCESS FOR PREPARING (R) 2-ACETAMIDO-N-BENZYL-3-METHOXY-PROPIONAMIDE |
| EP2399901A1 (en) | 2010-06-23 | 2011-12-28 | Archimica GmbH | Intermediate for producing lacosamide and a process for its preparation and conversion to lacosamide |
| US8969620B2 (en) | 2010-10-01 | 2015-03-03 | Ucb Pharma Gmbh | Process for the preparation of amino acid derivatives |
| EP2627639B1 (en) | 2010-10-15 | 2021-12-22 | Nektar Therapeutics | N-optionally substituted aryl-2-oligomer-3-alkoxypropionamides |
| EP2444390B1 (en) | 2010-10-19 | 2017-02-01 | Euticals GmbH | Process for producing Lacosamide |
| JP6027539B2 (ja) | 2010-12-02 | 2016-11-16 | ウーツェーベー ファルマ ゲーエムベーハーＵｃｂ Ｐｈａｒｍａ Ｇｍｂｈ | ラコサミドの１日１回投与用製剤 |
| EP2468261A1 (en) | 2010-12-02 | 2012-06-27 | UCB Pharma GmbH | Formulation of lacosamide |
| CN104771356A (zh) * | 2014-01-09 | 2015-07-15 | 山东方明药业集团股份有限公司 | 一种拉科酰胺注射液及其制备方法 |
| US11278634B1 (en) | 2021-02-12 | 2022-03-22 | Extrovis Ag | Stable parenteral composition of lacosamide |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0194464B1 (en) * | 1985-02-15 | 1991-04-03 | Research Corporation Technologies, Inc. (a Delaware corp.) | Amino acid derivatives and use thereof for the preparation of an anticonvulsant |
| US5378729A (en) * | 1985-02-15 | 1995-01-03 | Research Corporation Technologies, Inc. | Amino acid derivative anticonvulsant |
-
1997
- 1997-03-17 EP EP00109377A patent/EP1038522B1/en not_active Expired - Lifetime
- 1997-03-17 PT PT97916897T patent/PT888289E/pt unknown
- 1997-03-17 DK DK00109377T patent/DK1038522T3/da active
- 1997-03-17 DK DK97916897T patent/DK0888289T3/da active
- 1997-03-17 AT AT97916897T patent/ATE202079T1/de active
- 1997-03-17 EP EP97916897A patent/EP0888289B1/en not_active Expired - Lifetime
- 1997-03-17 PT PT00109377T patent/PT1038522E/pt unknown
- 1997-03-17 DE DE122009000010C patent/DE122009000010I2/de active Active
- 1997-03-17 WO PCT/US1997/004579 patent/WO1997033861A1/en not_active Ceased
- 1997-03-17 JP JP53292897A patent/JP3145414B2/ja not_active Expired - Lifetime
- 1997-03-17 DE DE69705210T patent/DE69705210T2/de not_active Expired - Lifetime
- 1997-03-17 AU AU25394/97A patent/AU718577B2/en not_active Expired
- 1997-03-17 AT AT00109377T patent/ATE268169T1/de active
- 1997-03-17 ES ES97916897T patent/ES2157567T3/es not_active Expired - Lifetime
- 1997-03-17 DE DE69729392T patent/DE69729392T2/de not_active Expired - Lifetime
- 1997-03-17 CA CA002248317A patent/CA2248317C/en not_active Expired - Lifetime
- 1997-03-17 ES ES00109377T patent/ES2218024T3/es not_active Expired - Lifetime
-
2009
- 2009-02-16 NL NL300376C patent/NL300376I1/nl unknown
- 2009-02-26 FR FR09C0006C patent/FR09C0006I2/fr active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP3145414B2 (ja) | 2001-03-12 |
| FR09C0006I1 (enExample) | 2009-04-17 |
| DK1038522T3 (da) | 2004-10-11 |
| DE69729392T2 (de) | 2005-06-02 |
| CA2248317C (en) | 2003-12-02 |
| DE122009000010I1 (de) | 2009-05-20 |
| DE69705210T2 (de) | 2001-09-20 |
| WO1997033861A1 (en) | 1997-09-18 |
| DE69729392D1 (de) | 2004-07-08 |
| CA2248317A1 (en) | 1997-09-18 |
| ES2218024T3 (es) | 2004-11-16 |
| DK0888289T3 (da) | 2001-09-03 |
| EP1038522B1 (en) | 2004-06-02 |
| DE69705210D1 (de) | 2001-07-19 |
| ES2157567T3 (es) | 2001-08-16 |
| AU718577B2 (en) | 2000-04-13 |
| PT1038522E (pt) | 2004-10-29 |
| EP1038522A2 (en) | 2000-09-27 |
| EP0888289A1 (en) | 1999-01-07 |
| EP0888289B1 (en) | 2001-06-13 |
| AU2539497A (en) | 1997-10-01 |
| EP1038522A3 (en) | 2003-01-15 |
| JP2000505476A (ja) | 2000-05-09 |
| DE122009000010I2 (de) | 2010-10-21 |
| FR09C0006I2 (fr) | 2009-12-18 |
| PT888289E (pt) | 2001-09-28 |
| ATE268169T1 (de) | 2004-06-15 |
| NL300376I1 (nl) | 2009-05-06 |
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