ES2157567T3 - Derivados de aminoacidos enantiomericos que tienen efecto anticonvulsivo. - Google Patents

Derivados de aminoacidos enantiomericos que tienen efecto anticonvulsivo.

Info

Publication number
ES2157567T3
ES2157567T3 ES97916897T ES97916897T ES2157567T3 ES 2157567 T3 ES2157567 T3 ES 2157567T3 ES 97916897 T ES97916897 T ES 97916897T ES 97916897 T ES97916897 T ES 97916897T ES 2157567 T3 ES2157567 T3 ES 2157567T3
Authority
ES
Spain
Prior art keywords
derivatives
amino acids
enantiomeric amino
anticonvulsive effect
animal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97916897T
Other languages
English (en)
Inventor
Harold Kohn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Corp Technologies Inc
Original Assignee
Research Corp Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21760388&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2157567(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Research Corp Technologies Inc filed Critical Research Corp Technologies Inc
Application granted granted Critical
Publication of ES2157567T3 publication Critical patent/ES2157567T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A UN COMPUESTO DE CONFIGURACION R RESPECTO AL CARBONO ASIMETRICO DE LA FORMULA (I), SIENDO AR FENILO, EL CUAL ESTA SIN SUSTITUIR O SUSTITUIDO CON AL MENOS UN GRUPO HALO; Q ES UN GRUPO ALCOXI INFERIOR, Y Q 1 ES METILO. SE PRESENTAN ASIMISMO COMPOSICIONES FARMACEUTICAS QUE CONTIENEN DICHOS DERIVADOS Y LA UTILIZACION DE LAS MISMAS PARA EL TRATAMIENTO DE ALTERACIONES DEL SISTEMA NERVIOSO CENTRAL (SNC) EN ANIMALES.
ES97916897T 1996-03-15 1997-03-17 Derivados de aminoacidos enantiomericos que tienen efecto anticonvulsivo. Expired - Lifetime ES2157567T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1352296P 1996-03-15 1996-03-15

Publications (1)

Publication Number Publication Date
ES2157567T3 true ES2157567T3 (es) 2001-08-16

Family

ID=21760388

Family Applications (2)

Application Number Title Priority Date Filing Date
ES97916897T Expired - Lifetime ES2157567T3 (es) 1996-03-15 1997-03-17 Derivados de aminoacidos enantiomericos que tienen efecto anticonvulsivo.
ES00109377T Expired - Lifetime ES2218024T3 (es) 1996-03-15 1997-03-17 Derivados de aminoacido enantiomerico anticonvulsionante.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES00109377T Expired - Lifetime ES2218024T3 (es) 1996-03-15 1997-03-17 Derivados de aminoacido enantiomerico anticonvulsionante.

Country Status (12)

Country Link
EP (2) EP1038522B1 (es)
JP (1) JP3145414B2 (es)
AT (2) ATE202079T1 (es)
AU (1) AU718577B2 (es)
CA (1) CA2248317C (es)
DE (3) DE122009000010I2 (es)
DK (2) DK0888289T3 (es)
ES (2) ES2157567T3 (es)
FR (1) FR09C0006I2 (es)
NL (1) NL300376I1 (es)
PT (2) PT1038522E (es)
WO (1) WO1997033861A1 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6048899A (en) * 1997-03-17 2000-04-11 Research Corporation Tech., Inc. Anticonvulsant enantiomeric amino acid derivatives
EP1642889A1 (en) * 2004-10-02 2006-04-05 Schwarz Pharma Ag Improved synthesis scheme for lacosamide
EP1873527A1 (en) 2006-06-30 2008-01-02 Schwarz Pharma Ag Method for identifying CRMP modulators
US8093426B2 (en) * 2007-12-04 2012-01-10 Ranbaxy Laboratories Limited Intermediate compounds and their use in preparation of lacosamide
DE102008059155A1 (de) 2008-11-27 2010-06-02 Ratiopharm Gmbh Trockenverarbeitung und neue Formen von Lacosamid
EP2462107A1 (en) 2009-08-06 2012-06-13 Medichem, S.A. Solid forms of an n-(phenylmethyl)propanamide derivative and processes of preparation
JP5564570B2 (ja) * 2009-09-25 2014-07-30 カディラ・ヘルスケア・リミテッド ラコサミドおよびその中間体の調製方法
IT1398044B1 (it) * 2010-01-29 2013-02-07 Archimica Srl Processo per la preparazione della lacosamide
EP2534128A1 (en) 2010-02-08 2012-12-19 Natco Pharma Limited A process for the preparation of lacosamide
WO2011099033A1 (en) * 2010-02-09 2011-08-18 Msn Laboratories Limited Process for preparing (r)-2-acetamido-n-benzyl-3-methoxy-propionamide
EP2399901A1 (en) 2010-06-23 2011-12-28 Archimica GmbH Intermediate for producing lacosamide and a process for its preparation and conversion to lacosamide
EP2621893A1 (en) 2010-10-01 2013-08-07 UCB Pharma GmbH Process for the preparation of amino acid derivatives
EP2627639B1 (en) * 2010-10-15 2021-12-22 Nektar Therapeutics N-optionally substituted aryl-2-oligomer-3-alkoxypropionamides
EP2444390B1 (en) 2010-10-19 2017-02-01 Euticals GmbH Process for producing Lacosamide
EP2468261A1 (en) 2010-12-02 2012-06-27 UCB Pharma GmbH Formulation of lacosamide
US20130251813A1 (en) 2010-12-02 2013-09-26 Ucb Pharma Gmbh Formulation of lacosamide
CN104771356A (zh) * 2014-01-09 2015-07-15 山东方明药业集团股份有限公司 一种拉科酰胺注射液及其制备方法
US11278634B1 (en) 2021-02-12 2022-03-22 Extrovis Ag Stable parenteral composition of lacosamide

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5378729A (en) * 1985-02-15 1995-01-03 Research Corporation Technologies, Inc. Amino acid derivative anticonvulsant
ATE62222T1 (de) * 1985-02-15 1991-04-15 Res Corp Technologies Inc Aminosaeure-derivate und ihre anwendung zur herstellung eines antikrampfmittels.

Also Published As

Publication number Publication date
EP1038522B1 (en) 2004-06-02
DE122009000010I2 (de) 2010-10-21
EP1038522A3 (en) 2003-01-15
AU718577B2 (en) 2000-04-13
DE69729392D1 (de) 2004-07-08
DK1038522T3 (da) 2004-10-11
EP1038522A2 (en) 2000-09-27
PT888289E (pt) 2001-09-28
EP0888289A1 (en) 1999-01-07
ATE268169T1 (de) 2004-06-15
DE69705210T2 (de) 2001-09-20
DK0888289T3 (da) 2001-09-03
CA2248317A1 (en) 1997-09-18
AU2539497A (en) 1997-10-01
DE69705210D1 (de) 2001-07-19
FR09C0006I1 (es) 2009-04-17
PT1038522E (pt) 2004-10-29
EP0888289B1 (en) 2001-06-13
JP2000505476A (ja) 2000-05-09
FR09C0006I2 (fr) 2009-12-18
JP3145414B2 (ja) 2001-03-12
NL300376I1 (nl) 2009-05-06
ATE202079T1 (de) 2001-06-15
DE122009000010I1 (de) 2009-05-20
CA2248317C (en) 2003-12-02
WO1997033861A1 (en) 1997-09-18
ES2218024T3 (es) 2004-11-16
DE69729392T2 (de) 2005-06-02

Similar Documents

Publication Publication Date Title
NL300376I1 (nl) Enantiomere anticonvulsieaminozuurderivaten
BR9810841A (pt) Inibidores de metaloprotease alicìclicos
ATE168007T1 (de) Zur behandlung von erkrankungen des zentralnervensystems verwendbare benzimidazole
BR9808281A (pt) Compostos, composições farmacêuticas, processo para tratar doenças proliferativas e/ou distúrbios do sistema imune e para preparar um composto, e, uso de um composto
BR9804352A (pt) Composição e processo para controlar o crescimento microbiológico.
EA199900620A1 (ru) Фталазиноны
DK0699439T3 (da) Behandling af sygdomme forårsaget af talgkirtellidelser med acyl-CoA-cholesterolacyltransferaseinhibitorer
DE69229442T2 (de) Substituierte dibenzooxazepin-verbindungen, pharmazeutische zusammensetzungen und verfahren zur verwendung
ES2180564T3 (es) 2-fenil-3-azoilbenzotiofenos para aumentar la expresion de trombomodulina.
ES552348A0 (es) Procedimiento de preparar agentes anticonvulsivos derivados de aminoacidos
ATE156359T1 (de) Phosphatdiester zur behandlung von proliferativen erkrankungen der epidermis
ATE194912T1 (de) Mittel zur vorsorge und heilung von typ i allergischen krankheiten
ATE264104T1 (de) Immunmodulierende arzneimittelzusammenstellung
ES2058085T3 (es) Composicion anticonvulsivante que contiene un derivado de aminoacido, y utilizacion de dicho derivado de aminoacido.
ES2191763T3 (es) Inhibidor del desarrollo de dependencia/tolerancia a un agente analgesico narcotico.
EA199900888A1 (ru) Противоревматические средства
BR9813775A (pt) Uso de um composto, processo para o tratamento de uma condição de cefaléia vascular, e, composição farmacêutica adequada para uso no tratamento de uma condição de cefaléia vascular.
ATE283269T1 (de) 5-(heteroaryl)alkyl)-3-oxo-pyrido(1,2- a)benzimidazol-4-carboxamid (pbi) derivate zur behandlung von störungen des zentralen nervensystems
BR9900024A (pt) Biciclo[3.1.0]hexanos e compostos relacionados.
DK0810223T3 (da) Adamantylsubstituerede oxindoler som farmaceutiske midler
EA200101043A1 (ru) Способ лечения неврологических или нейропсихиатрических расстройств
TH20641A (th) 6-[ไทรแอโซลิล[3-(ไทรฟลูออโรเมธิล)เฟนิล]เมธิล]-2-ควิโนลิโนนและ-ควิโนลีนไธโอน
HUP9902191A2 (hu) Az érképződést gátló anyag

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 888289

Country of ref document: ES