AU718577B2 - Anticonvulsant enantiomeric amino acid derivatives - Google Patents

Anticonvulsant enantiomeric amino acid derivatives Download PDF

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Publication number
AU718577B2
AU718577B2 AU25394/97A AU2539497A AU718577B2 AU 718577 B2 AU718577 B2 AU 718577B2 AU 25394/97 A AU25394/97 A AU 25394/97A AU 2539497 A AU2539497 A AU 2539497A AU 718577 B2 AU718577 B2 AU 718577B2
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AU
Australia
Prior art keywords
compound
compound according
mmol
animal
pct
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired, expires
Application number
AU25394/97A
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English (en)
Other versions
AU2539497A (en
Inventor
Harold Kohn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Corp Technologies Inc
Original Assignee
Research Corp Technologies Inc
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Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21760388&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU718577(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Research Corp Technologies Inc filed Critical Research Corp Technologies Inc
Publication of AU2539497A publication Critical patent/AU2539497A/en
Application granted granted Critical
Publication of AU718577B2 publication Critical patent/AU718577B2/en
Adjusted expiration legal-status Critical
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU25394/97A 1996-03-15 1997-03-17 Anticonvulsant enantiomeric amino acid derivatives Expired AU718577B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1352296P 1996-03-15 1996-03-15
US60/013522 1996-03-15
PCT/US1997/004579 WO1997033861A1 (en) 1996-03-15 1997-03-17 Anticonvulsant enantiomeric amino acid derivatives

Publications (2)

Publication Number Publication Date
AU2539497A AU2539497A (en) 1997-10-01
AU718577B2 true AU718577B2 (en) 2000-04-13

Family

ID=21760388

Family Applications (1)

Application Number Title Priority Date Filing Date
AU25394/97A Expired AU718577B2 (en) 1996-03-15 1997-03-17 Anticonvulsant enantiomeric amino acid derivatives

Country Status (12)

Country Link
EP (2) EP1038522B1 (enExample)
JP (1) JP3145414B2 (enExample)
AT (2) ATE202079T1 (enExample)
AU (1) AU718577B2 (enExample)
CA (1) CA2248317C (enExample)
DE (3) DE69705210T2 (enExample)
DK (2) DK1038522T3 (enExample)
ES (2) ES2218024T3 (enExample)
FR (1) FR09C0006I2 (enExample)
NL (1) NL300376I1 (enExample)
PT (2) PT888289E (enExample)
WO (1) WO1997033861A1 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6048899A (en) * 1997-03-17 2000-04-11 Research Corporation Tech., Inc. Anticonvulsant enantiomeric amino acid derivatives
EP1642889A1 (en) * 2004-10-02 2006-04-05 Schwarz Pharma Ag Improved synthesis scheme for lacosamide
EP1873527A1 (en) 2006-06-30 2008-01-02 Schwarz Pharma Ag Method for identifying CRMP modulators
US8093426B2 (en) * 2007-12-04 2012-01-10 Ranbaxy Laboratories Limited Intermediate compounds and their use in preparation of lacosamide
DE102008059155A1 (de) 2008-11-27 2010-06-02 Ratiopharm Gmbh Trockenverarbeitung und neue Formen von Lacosamid
CN102596897A (zh) 2009-08-06 2012-07-18 麦迪凯姆股份公司 一种n-(苯基甲基)丙酰胺衍生物的多种固体形态及制备方法
JP5564570B2 (ja) * 2009-09-25 2014-07-30 カディラ・ヘルスケア・リミテッド ラコサミドおよびその中間体の調製方法
IT1398044B1 (it) * 2010-01-29 2013-02-07 Archimica Srl Processo per la preparazione della lacosamide
US8759582B2 (en) 2010-02-08 2014-06-24 Natco Pharma Limited Process for the preparation of lacosamide
US8907132B2 (en) * 2010-02-09 2014-12-09 Msn Laboratories Private Limited Process for preparing (R)-2-acetamido-N-benzyl-3-methoxy-propionamide
EP2399901A1 (en) 2010-06-23 2011-12-28 Archimica GmbH Intermediate for producing lacosamide and a process for its preparation and conversion to lacosamide
WO2012041986A1 (en) 2010-10-01 2012-04-05 Ucb Pharma Gmbh Process for the preparation of amino acid derivatives
WO2012051551A1 (en) * 2010-10-15 2012-04-19 Nektar Therapeutics N-optionally substituted aryl-2-oligomer-3-alkoxypropionamides
PL2444390T3 (pl) 2010-10-19 2017-06-30 Euticals Gmbh Sposób wytwarzania Lakozamidu
EP2645997B1 (en) 2010-12-02 2022-08-10 UCB Pharma GmbH Once daily formulation of lacosamide
EP2468261A1 (en) 2010-12-02 2012-06-27 UCB Pharma GmbH Formulation of lacosamide
CN104771356A (zh) * 2014-01-09 2015-07-15 山东方明药业集团股份有限公司 一种拉科酰胺注射液及其制备方法
US11278634B1 (en) 2021-02-12 2022-03-22 Extrovis Ag Stable parenteral composition of lacosamide

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5378729A (en) * 1985-02-15 1995-01-03 Research Corporation Technologies, Inc. Amino acid derivative anticonvulsant

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3678469D1 (de) * 1985-02-15 1991-05-08 Res Corp Technologies Inc Aminosaeure-derivate und ihre anwendung zur herstellung eines antikrampfmittels.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5378729A (en) * 1985-02-15 1995-01-03 Research Corporation Technologies, Inc. Amino acid derivative anticonvulsant

Also Published As

Publication number Publication date
PT888289E (pt) 2001-09-28
JP2000505476A (ja) 2000-05-09
DE69729392T2 (de) 2005-06-02
EP1038522A3 (en) 2003-01-15
EP0888289A1 (en) 1999-01-07
EP0888289B1 (en) 2001-06-13
ATE268169T1 (de) 2004-06-15
FR09C0006I2 (fr) 2009-12-18
DK0888289T3 (da) 2001-09-03
DE69705210D1 (de) 2001-07-19
ES2157567T3 (es) 2001-08-16
JP3145414B2 (ja) 2001-03-12
AU2539497A (en) 1997-10-01
CA2248317C (en) 2003-12-02
PT1038522E (pt) 2004-10-29
ATE202079T1 (de) 2001-06-15
CA2248317A1 (en) 1997-09-18
DE122009000010I2 (de) 2010-10-21
EP1038522A2 (en) 2000-09-27
DE69705210T2 (de) 2001-09-20
EP1038522B1 (en) 2004-06-02
WO1997033861A1 (en) 1997-09-18
ES2218024T3 (es) 2004-11-16
NL300376I1 (nl) 2009-05-06
DK1038522T3 (da) 2004-10-11
DE122009000010I1 (de) 2009-05-20
FR09C0006I1 (enExample) 2009-04-17
DE69729392D1 (de) 2004-07-08

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