ES2207108T3 - Derivados de acido aril carboxilico y tetrazol con un grupo de carbamoiloxi. - Google Patents

Derivados de acido aril carboxilico y tetrazol con un grupo de carbamoiloxi.

Info

Publication number
ES2207108T3
ES2207108T3 ES99125027T ES99125027T ES2207108T3 ES 2207108 T3 ES2207108 T3 ES 2207108T3 ES 99125027 T ES99125027 T ES 99125027T ES 99125027 T ES99125027 T ES 99125027T ES 2207108 T3 ES2207108 T3 ES 2207108T3
Authority
ES
Spain
Prior art keywords
acid
compound according
acetic acid
compound
mmol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99125027T
Other languages
English (en)
Spanish (es)
Inventor
Francisco Javier Lopez-Tapia
Alexander Victor Muehldorf
Counde O'yang
Daniel Lee Severance
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2207108T3 publication Critical patent/ES2207108T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
ES99125027T 1998-12-23 1999-12-15 Derivados de acido aril carboxilico y tetrazol con un grupo de carbamoiloxi. Expired - Lifetime ES2207108T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11344698P 1998-12-23 1998-12-23
US113446P 1998-12-23
US15181499P 1999-08-30 1999-08-30
US151814P 1999-08-30

Publications (1)

Publication Number Publication Date
ES2207108T3 true ES2207108T3 (es) 2004-05-16

Family

ID=26811078

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99125027T Expired - Lifetime ES2207108T3 (es) 1998-12-23 1999-12-15 Derivados de acido aril carboxilico y tetrazol con un grupo de carbamoiloxi.

Country Status (29)

Country Link
US (1) US6335459B1 (fr)
EP (1) EP1013639B1 (fr)
JP (1) JP3415085B2 (fr)
KR (1) KR100378335B1 (fr)
CN (1) CN1167670C (fr)
AR (1) AR029320A1 (fr)
AT (1) ATE251125T1 (fr)
AU (1) AU735640B2 (fr)
BR (1) BR9905974A (fr)
CA (1) CA2292921C (fr)
DE (1) DE69911726T2 (fr)
DK (1) DK1013639T3 (fr)
ES (1) ES2207108T3 (fr)
HR (1) HRP990394A2 (fr)
HU (1) HUP9904659A3 (fr)
ID (1) ID25983A (fr)
IL (1) IL133578A (fr)
MA (1) MA26713A1 (fr)
NO (1) NO316171B1 (fr)
NZ (1) NZ501891A (fr)
PE (1) PE20001368A1 (fr)
PL (1) PL337419A1 (fr)
PT (1) PT1013639E (fr)
RU (1) RU2179969C2 (fr)
SG (1) SG90086A1 (fr)
TR (1) TR199903310A3 (fr)
TW (1) TWI221834B (fr)
UY (1) UY25876A1 (fr)
YU (1) YU69699A (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9828442D0 (en) 1998-12-24 1999-02-17 Karobio Ab Novel thyroid receptor ligands and method II
SE0100158D0 (sv) * 2001-01-19 2001-01-19 Synphora Ab Novel method and composition for local treatment of Meniere´s disease and tinnitus
DE60210058T2 (de) * 2001-03-02 2006-11-09 F. Hoffmann-La Roche Ag Alkoxycarbonylamino-heteroaryl-carbonsäurederivate als ip-antagonisten
US20060217421A1 (en) 2003-05-09 2006-09-28 Hajimu Kurumatani Fortifier
UA93548C2 (uk) 2006-05-05 2011-02-25 Айерем Елелсі Сполуки та композиції як модулятори хеджхогівського сигнального шляху
US9669381B2 (en) 2007-06-27 2017-06-06 Hrd Corporation System and process for hydrocracking
AU2009226151B2 (en) 2008-03-18 2013-10-31 Arena Pharmaceuticals, Inc. Modulators of the prostacyclin (PGI2) receptor useful for the treatment of disorders related thereto
MY163762A (en) 2008-07-23 2017-10-31 Toray Industries Therapeutic agent for chronic renal failure
ES2645725T3 (es) 2010-06-11 2017-12-07 Rhodes Technologies Procesos catalizados por metales de transición para la preparación de compuestos de N-alilo y uso de los mismos
EP2580218B1 (fr) 2010-06-11 2015-02-25 Rhodes Technologies Traitement de n-désalkylation d'amines tertiaires
IL268997B2 (en) 2017-03-01 2023-09-01 Arena Pharm Inc Preparations containing pgi2 receptor agonists and processes for their preparation
WO2023158634A1 (fr) 2022-02-15 2023-08-24 United Therapeutics Corporation Agoniste du récepteur de prostacycline (ip) cristalline et ses utilisations

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1079414A (en) 1965-06-30 1967-08-16 Smith & Nephew Derivatives of acetic acid and a process for their preparation
GB1185539A (en) 1967-11-03 1970-03-25 Smith & Nephew Substituted Tetrazoles
DE2432560A1 (de) 1974-07-06 1976-01-22 Boehringer Mannheim Gmbh Neue phenoxyalkylcarbonsaeurederivate und verfahren zur herstellung derselben
JPS5832859A (ja) 1981-08-20 1983-02-25 Dainippon Pharmaceut Co Ltd Ｎ，ｎ−ジメチルカルバミン酸ベンジルエステル誘導体
JPH0725725B2 (ja) 1987-07-23 1995-03-22 保土谷化学工業株式会社 ベンズアミド誘導体
US5084466A (en) 1989-01-31 1992-01-28 Hoffmann-La Roche Inc. Novel carboxamide pyridine compounds which have useful pharmaceutical utility
CA2090283A1 (fr) 1992-02-28 1993-08-29 Nobuyuki Hamanaka Derives de l'acide phenoxyacetique
CA2183063A1 (fr) 1994-02-10 1995-08-17 Atsushi Ichikawa Recepteur de la prostaglandine i2
CA2185104A1 (fr) 1994-03-10 1995-09-14 Kiyoshi Taniguchi Derives du naphtalene, agonistes de la prostaglandine 12
US5753700A (en) 1994-12-28 1998-05-19 Ono Pharmaceutical Co., Ltd. Naphthyloxyacetic acid derivatives
TW401408B (en) 1995-07-21 2000-08-11 Fujisawa Pharmaceutical Co Heterocyclic compounds having prostaglandin I2 agonism
EP0845451A4 (fr) 1995-07-26 1999-10-13 Ono Pharmaceutical Co Derives d'acide naphtyloxyacetique et medicaments integrant ces derives comme principes actifs
AUPP029197A0 (en) 1997-11-10 1997-12-04 Fujisawa Pharmaceutical Co., Ltd. Benzocycloheptene derivatives
AUPP109097A0 (en) 1997-12-22 1998-01-22 Fujisawa Pharmaceutical Co., Ltd. Napthalene derivatives

Also Published As

Publication number Publication date
IL133578A (en) 2004-07-25
NO996366D0 (no) 1999-12-21
EP1013639A1 (fr) 2000-06-28
DE69911726T2 (de) 2004-07-29
AU735640B2 (en) 2001-07-12
HUP9904659A2 (hu) 2000-11-28
UY25876A1 (es) 2001-07-31
JP2000191523A (ja) 2000-07-11
ATE251125T1 (de) 2003-10-15
AU6534099A (en) 2000-07-06
SG90086A1 (en) 2002-07-23
CA2292921C (fr) 2004-08-17
EP1013639B1 (fr) 2003-10-01
DK1013639T3 (da) 2004-02-09
YU69699A (sh) 2001-12-26
BR9905974A (pt) 2000-09-12
HU9904659D0 (en) 2000-02-28
NZ501891A (en) 2001-10-26
CN1167670C (zh) 2004-09-22
TR199903310A2 (xx) 2000-10-23
MA26713A1 (fr) 2004-12-20
HRP990394A2 (en) 2000-08-31
DE69911726D1 (de) 2003-11-06
KR20000048322A (ko) 2000-07-25
CN1266054A (zh) 2000-09-13
IL133578A0 (en) 2001-04-30
ID25983A (id) 2000-11-16
JP3415085B2 (ja) 2003-06-09
TR199903310A3 (tr) 2000-10-23
US6335459B1 (en) 2002-01-01
AR029320A1 (es) 2003-06-25
RU2179969C2 (ru) 2002-02-27
PT1013639E (pt) 2004-02-27
KR100378335B1 (ko) 2003-03-29
PE20001368A1 (es) 2000-12-14
CA2292921A1 (fr) 2000-06-23
TWI221834B (en) 2004-10-11
NO316171B1 (no) 2003-12-22
PL337419A1 (en) 2000-07-03
NO996366L (no) 2000-06-26
HUP9904659A3 (en) 2000-12-28

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