ES2180580T3 - Compuestos de oxazolilo sustituidos para el tratamiento de la inflamacion. - Google Patents

Compuestos de oxazolilo sustituidos para el tratamiento de la inflamacion.

Info

Publication number
ES2180580T3
ES2180580T3 ES94917983T ES94917983T ES2180580T3 ES 2180580 T3 ES2180580 T3 ES 2180580T3 ES 94917983 T ES94917983 T ES 94917983T ES 94917983 T ES94917983 T ES 94917983T ES 2180580 T3 ES2180580 T3 ES 2180580T3
Authority
ES
Spain
Prior art keywords
treatment
oxazolil
inflammation
compounds substituted
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94917983T
Other languages
English (en)
Inventor
Bryan H Norman
Len F Lee
Jaime L Masferrer
John J Talley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22064709&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2180580(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by GD Searle LLC filed Critical GD Searle LLC
Application granted granted Critical
Publication of ES2180580T3 publication Critical patent/ES2180580T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE PRESENTA UNA CLASE DE COMPUESTOS DE OXAZOLILO SUSTITUIDO PARA SU USO EN EL TRATAMIENTO DE ENFERMEDADES INFLAMATORIAS Y RELACIONADAS CON LA INFLAMACION. COMPUESTOS DE INTERES PARTICULAR SON LOS DEFINIDOS POR LA FORMULA (I) EN LA QUE R SE SELECCIONA ENTRE ALQUILO, HIDROXIALQUILO, HALOALQUILO, CICLOALQUILO, CICLOALQUILALQUILO, ARILO OPCIONALMENTE SUSTITUIDO EN UNA PARTE SUSTITUIBLE POR CARBOXIDO, ALQUILO, ALCOXIDO Y HALO, ARALQUILO OPCIONALMENTE SUSTITUIDO EN UNA POSICION SUSTITUIBLE SOBRE EL RADICAL DE ARILO POR CARBOXIDO, ALQUILO, ALCOXIDO Y HALO, ARILOXIALQUILO OPCIONALMENTE SUSTITUIDO EN UNA POSICION SUSTITUIBLE SOBRE EL RADICAL DE ARILO CON HALO, CARBOXIDO, ALQUILO Y ALCOXIDO, ARALCOXIALQUILO OPCIONALMENTE SUSTITUIDO POR UNA POSICION SUSTITUIBLE POR ALQUILO, CARBOXIDO, ALCOXIDO Y HALO, HETEROARILOXIDOALQUILO OPCIONALMENTE SUSTITUIDO EN UNA POSICION SUSTITUIBLE CON HALO, CARBOXIDO, ALQUILO Y ALCOXIDO, ALCOXICARBONILALQUILO, CARBOXIALQUILO Y AMINOCARBONILALQUILO; EN DONDE R{SUB, 1} SE SELECCIONA ENTRE CICLOALQUILO, CICLOALQUENILO, HETEROARILO Y ARILO U OPCIONALMENTE SUSTITUIDO EN UNA POSICION SUSTITUIBLE POR ALQUILO, ALCOXIDO Y HALO, Y EN DONDE R{SUB, 2} ES ALQUILO; TAMBIEN SE PRESENTAN LAS SALES FARMACOLOGICAMENTE ACEPTABLES DE LOS COMPUESTOS; TENIENDO EN CUENTA QUE R{SUB, 1} NO SERA FENILO CUANDO R{SUB, 2} SEA METILO Y R{SUB, 3} SE ISOPROPILO O TER-BUTILO.
ES94917983T 1993-05-21 1994-05-19 Compuestos de oxazolilo sustituidos para el tratamiento de la inflamacion. Expired - Lifetime ES2180580T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/065,730 US5380738A (en) 1993-05-21 1993-05-21 2-substituted oxazoles further substituted by 4-fluorophenyl and 4-methylsulfonylphenyl as antiinflammatory agents

Publications (1)

Publication Number Publication Date
ES2180580T3 true ES2180580T3 (es) 2003-02-16

Family

ID=22064709

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94917983T Expired - Lifetime ES2180580T3 (es) 1993-05-21 1994-05-19 Compuestos de oxazolilo sustituidos para el tratamiento de la inflamacion.

Country Status (11)

Country Link
US (2) US5380738A (es)
EP (1) EP0699192B1 (es)
JP (1) JPH08510736A (es)
AT (1) ATE221054T1 (es)
AU (1) AU6949594A (es)
CA (1) CA2161769A1 (es)
DE (1) DE69431056T2 (es)
DK (1) DK0699192T3 (es)
ES (1) ES2180580T3 (es)
PT (1) PT699192E (es)
WO (1) WO1994027980A1 (es)

Families Citing this family (178)

* Cited by examiner, † Cited by third party
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US5719163A (en) 1998-02-17
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US5380738A (en) 1995-01-10
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