ES2179666T3 - Transferencia de materiales al interior de celulas empleando silicio poroso o policristalino. - Google Patents

Transferencia de materiales al interior de celulas empleando silicio poroso o policristalino.

Info

Publication number
ES2179666T3
ES2179666T3 ES99934933T ES99934933T ES2179666T3 ES 2179666 T3 ES2179666 T3 ES 2179666T3 ES 99934933 T ES99934933 T ES 99934933T ES 99934933 T ES99934933 T ES 99934933T ES 2179666 T3 ES2179666 T3 ES 2179666T3
Authority
ES
Spain
Prior art keywords
porous
polycrystalline silicon
transfer
materials inside
inside cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99934933T
Other languages
English (en)
Inventor
Leigh Trevor Canham
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Psimedica Ltd
Original Assignee
Psimedica Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Psimedica Ltd filed Critical Psimedica Ltd
Application granted granted Critical
Publication of ES2179666T3 publication Critical patent/ES2179666T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/89—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microinjection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/89—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microinjection
    • C12N15/895—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microinjection using biolistic methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Dermatology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Sustainable Development (AREA)
  • Medicinal Chemistry (AREA)
  • Medical Informatics (AREA)
  • Epidemiology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Silicon Compounds (AREA)
  • Electrotherapy Devices (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Battery Electrode And Active Subsutance (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Un procedimiento para transferir una sustancia al interior de una célula que comprende usar silicio poroso o policristalino para transportar la sustancia al interior de la célula.
ES99934933T 1998-07-22 1999-07-22 Transferencia de materiales al interior de celulas empleando silicio poroso o policristalino. Expired - Lifetime ES2179666T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9815819.9A GB9815819D0 (en) 1998-07-22 1998-07-22 Transferring materials into cells and a microneedle array

Publications (1)

Publication Number Publication Date
ES2179666T3 true ES2179666T3 (es) 2003-01-16

Family

ID=10835869

Family Applications (2)

Application Number Title Priority Date Filing Date
ES99934933T Expired - Lifetime ES2179666T3 (es) 1998-07-22 1999-07-22 Transferencia de materiales al interior de celulas empleando silicio poroso o policristalino.
ES04030257T Expired - Lifetime ES2400472T3 (es) 1998-07-22 1999-07-22 Transferencia de materiales en células utilizando silicio poroso

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES04030257T Expired - Lifetime ES2400472T3 (es) 1998-07-22 1999-07-22 Transferencia de materiales en células utilizando silicio poroso

Country Status (15)

Country Link
US (2) US6770480B1 (es)
EP (3) EP1522578B1 (es)
JP (1) JP4585119B2 (es)
KR (1) KR100633273B1 (es)
CN (1) CN1252275C (es)
AT (1) ATE223479T1 (es)
AU (1) AU753542B2 (es)
CA (1) CA2337331C (es)
DE (1) DE69902794T2 (es)
DK (1) DK1098957T3 (es)
ES (2) ES2179666T3 (es)
GB (1) GB9815819D0 (es)
HK (1) HK1039146B (es)
NZ (1) NZ509142A (es)
WO (1) WO2000005339A1 (es)

Families Citing this family (121)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9808052D0 (en) 1998-04-17 1998-06-17 Secr Defence Implants for administering substances and methods of producing implants
GB9815819D0 (en) * 1998-07-22 1998-09-16 Secr Defence Transferring materials into cells and a microneedle array
GB0008494D0 (en) 2000-04-07 2000-05-24 Secr Defence Microprojectile delivery system
GB2363115A (en) * 2000-06-10 2001-12-12 Secr Defence Porous or polycrystalline silicon orthopaedic implants
US6533949B1 (en) * 2000-08-28 2003-03-18 Nanopass Ltd. Microneedle structure and production method therefor
US6821281B2 (en) 2000-10-16 2004-11-23 The Procter & Gamble Company Microstructures for treating and conditioning skin
US7828827B2 (en) 2002-05-24 2010-11-09 Corium International, Inc. Method of exfoliation of skin using closely-packed microstructures
US6902933B2 (en) 2000-11-03 2005-06-07 Regents Of The University Of Michigan Surface transfection and expression procedure
US6897067B2 (en) 2000-11-03 2005-05-24 Regents Of The University Of Michigan Surface transfection and expression procedure
CA2427916C (en) * 2000-11-03 2012-01-17 The Regents Of The University Of Michigan Surface transfection and expression procedure
DE60216735D1 (de) * 2001-02-21 2007-01-25 Univ Rochester Mikrokavitätsbiosensor, herstellungsverfahren und verwendungen davon
GB0104383D0 (en) 2001-02-22 2001-04-11 Psimedica Ltd Cancer Treatment
US6663820B2 (en) * 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
WO2002088165A1 (en) * 2001-04-30 2002-11-07 Doranz Benjamin J Elucidation of gene function
US20040087992A1 (en) * 2002-08-09 2004-05-06 Vladimir Gartstein Microstructures for delivering a composition cutaneously to skin using rotatable structures
US7429258B2 (en) 2001-10-26 2008-09-30 Massachusetts Institute Of Technology Microneedle transport device
US6908453B2 (en) * 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
JP2004121064A (ja) * 2002-10-01 2004-04-22 Jfe Steel Kk 遺伝子制御用のセラミック被覆針
AU2003222691A1 (en) * 2002-04-30 2003-11-17 Morteza Shirkhanzadeh Arrays of microneedles comprising porous calcium phosphate coating and bioactive agents
US6864692B1 (en) * 2002-06-20 2005-03-08 Xsilogy, Inc. Sensor having improved selectivity
CA2492867C (en) 2002-07-19 2011-07-05 3M Innovative Properties Company Microneedle devices and microneedle delivery apparatus
US7244513B2 (en) * 2003-02-21 2007-07-17 Nano-Proprietary, Inc. Stain-etched silicon powder
US7578954B2 (en) * 2003-02-24 2009-08-25 Corium International, Inc. Method for manufacturing microstructures having multiple microelements with through-holes
US20070087436A1 (en) * 2003-04-11 2007-04-19 Atsushi Miyawaki Microinjection method and device
CA2536249A1 (en) 2003-08-25 2005-03-10 3M Innovative Properties Company Delivery of immune response modifier compounds
GB0402131D0 (en) * 2004-01-30 2004-03-03 Isis Innovation Delivery method
EP1718452A1 (en) * 2004-02-23 2006-11-08 3M Innovative Properties Company Method of molding for microneedle arrays
CA2560840C (en) 2004-03-24 2014-05-06 Corium International, Inc. Transdermal delivery device
US7591806B2 (en) * 2004-05-18 2009-09-22 Bai Xu High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances
US20090208556A1 (en) * 2004-10-29 2009-08-20 Regents Of The University Of California, The Porous photonic crystals for drug delivery to the eye
DE602005021541D1 (de) 2004-12-07 2010-07-08 3M Innovative Properties Co Verfahren zum formen einer mikronadel
US20060276047A1 (en) * 2005-03-14 2006-12-07 University Of Rochester Macroporous silicon microcavity with tunable pore size
EP1888459A4 (en) * 2005-05-09 2010-12-29 Vesta Res Ltd SILICON NANOEPONGES PARTICLES
US8048017B2 (en) * 2005-05-18 2011-11-01 Bai Xu High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances
US8043250B2 (en) * 2005-05-18 2011-10-25 Nanomed Devices, Inc. High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances
CA2612005C (en) 2005-06-17 2013-10-29 Georgia Tech Research Corporation Coated microstructures and method of manufacture thereof
EP1896115B2 (en) 2005-06-27 2020-01-22 3M Innovative Properties Company Microneedle cartridge assembly
CN101227940A (zh) * 2005-07-25 2008-07-23 纳米技术维多利亚有限公司 微阵列装置
US20070066934A1 (en) * 2005-09-19 2007-03-22 Transport Pharmaceuticals, Inc. Electrokinetic delivery system and methods therefor
US20070185432A1 (en) * 2005-09-19 2007-08-09 Transport Pharmaceuticals, Inc. Electrokinetic system and method for delivering methotrexate
US20080262416A1 (en) * 2005-11-18 2008-10-23 Duan Daniel C Microneedle Arrays and Methods of Preparing Same
CA2629193C (en) * 2005-11-18 2016-03-29 3M Innovative Properties Company Coatable compositions, coatings derived therefrom and microarrays having such coatings
EP1962942A1 (en) * 2005-12-21 2008-09-03 3M Innovative Properties Company Microneedle devices
WO2007076458A1 (en) * 2005-12-21 2007-07-05 Primegen Biotech Llc Microinjector chip
US9339641B2 (en) 2006-01-17 2016-05-17 Emkinetics, Inc. Method and apparatus for transdermal stimulation over the palmar and plantar surfaces
US9610459B2 (en) 2009-07-24 2017-04-04 Emkinetics, Inc. Cooling systems and methods for conductive coils
US20100168501A1 (en) * 2006-10-02 2010-07-01 Daniel Rogers Burnett Method and apparatus for magnetic induction therapy
DE102006028781A1 (de) * 2006-06-23 2007-12-27 Robert Bosch Gmbh Verfahren zur Herstellung von porösen Mikronadeln und ihre Verwendung
WO2008042902A2 (en) 2006-10-02 2008-04-10 Emkinetics, Inc. Method and apparatus for magnetic induction therapy
US9005102B2 (en) 2006-10-02 2015-04-14 Emkinetics, Inc. Method and apparatus for electrical stimulation therapy
US11224742B2 (en) 2006-10-02 2022-01-18 Emkinetics, Inc. Methods and devices for performing electrical stimulation to treat various conditions
US10786669B2 (en) 2006-10-02 2020-09-29 Emkinetics, Inc. Method and apparatus for transdermal stimulation over the palmar and plantar surfaces
WO2008076465A1 (en) * 2006-12-21 2008-06-26 Primegen Biotech, Llc Microinjector chip
US10525246B2 (en) 2006-12-22 2020-01-07 Nanomed Skincare, Inc. Microdevice and method for transdermal delivery and sampling of active substances
US20080214987A1 (en) * 2006-12-22 2008-09-04 Nanomed Devices, Inc. Microdevice And Method For Transdermal Delivery And Sampling Of Active Substances
CN100998901B (zh) * 2007-01-12 2012-10-10 中国科学院上海微系统与信息技术研究所 多孔硅无痛注射微针阵列及其制备方法
DE102007002832A1 (de) * 2007-01-19 2008-07-24 Robert Bosch Gmbh Verfahren zur Herstellung einer Vorrichtung umfassend eine Anordnung von Mikronadeln auf einem Träger und nach diesem Verfahren herstellbare Vorrichtung
WO2008091602A2 (en) 2007-01-22 2008-07-31 Corium International, Inc. Applicators for microneedle arrays
CN101678166B (zh) * 2007-03-02 2012-08-22 特克法马许可公司 模块化的给药系统
US20090017562A1 (en) * 2007-03-13 2009-01-15 Iowa State University Research Foundation, Inc. Raman-active reagents
CA2686093C (en) * 2007-04-16 2018-05-08 Corium International, Inc. Solvent-cast microneedle arrays containing active
AU2014200648B2 (en) * 2007-04-16 2015-09-24 Corium Pharma Solutions, Inc. Solvent-cast microneedle arrays containing active
CA2685544C (en) * 2007-04-27 2016-08-09 Board Of Regents Of The University Of Texas System Porous particles and methods of making thereof
AU2008275181B2 (en) * 2007-07-10 2014-06-26 The Regents Of The University Of California Materials and methods for delivering compositions to selected tissues
CN103083794B (zh) 2007-08-14 2016-03-02 弗雷德哈钦森癌症研究中心 用于递送治疗药物的针阵列组件和方法
WO2009048607A1 (en) 2007-10-10 2009-04-16 Corium International, Inc. Vaccine delivery via microneedle arrays
JP5178132B2 (ja) * 2007-10-11 2013-04-10 キヤノン株式会社 画像処理システム並びに画像処理方法
US9220678B2 (en) 2007-12-24 2015-12-29 The University Of Queensland Coating method
EP2247527A4 (en) 2008-02-07 2014-10-29 Univ Queensland PATCH PRODUCTION
EP2100850A1 (en) * 2008-03-11 2009-09-16 Stichting Voor De Technische Wetenschappen Microneedle array and a method for manufacturing microneedles
US9387000B2 (en) 2008-05-23 2016-07-12 The University Of Queensland Analyte detection using a needle projection patch
EP2429627B1 (en) * 2009-04-24 2017-06-14 Corium International, Inc. Methods for manufacturing microprojection arrays
CN105476951A (zh) 2009-05-04 2016-04-13 普西维达公司 多孔硅药物洗脱颗粒
AU2010313487A1 (en) 2009-10-26 2012-05-24 Emkinetics, Inc. Method and apparatus for electromagnetic stimulation of nerve, muscle, and body tissues
MX2012012567A (es) 2010-04-28 2012-11-21 Kimberly Clark Co Metodo para aumentar la permeabilidad de una barrera epitelial.
CA2797205C (en) 2010-04-28 2019-04-16 Kimberly-Clark Worldwide, Inc. Medical devices for delivery of sirna
JP5868953B2 (ja) 2010-04-28 2016-02-24 キンバリー クラーク ワールドワイド インコーポレイテッド 射出成形型マイクロニードルアレイ及びその製造方法
JP5860032B2 (ja) 2010-04-28 2016-02-16 キンバリー クラーク ワールドワイド インコーポレイテッド 関節リウマチ薬の送達のためのデバイス
JP6327852B2 (ja) 2010-05-04 2018-05-23 コリウム インターナショナル， インコーポレイテッド 微小突起アレイを使用した副甲状腺ホルモンの経皮送達のための方法及びデバイス
US8588884B2 (en) 2010-05-28 2013-11-19 Emkinetics, Inc. Microneedle electrode
WO2012006677A1 (en) 2010-07-14 2012-01-19 The University Of Queensland Patch applying apparatus
WO2012061377A1 (en) * 2010-11-01 2012-05-10 Psivida Us, Inc. Bioerodible silicon-based devices for delivery of therapeutic agents
US9394369B2 (en) 2011-01-03 2016-07-19 The Regents Of The University Of California Luminescent porous silicon nanoparticles for targeted delivery and immunization
WO2012159058A2 (en) * 2011-05-18 2012-11-22 Brigham Young University Apparatuses and related methods for delivering biological material into a cell
GB2492167C (en) 2011-06-24 2018-12-05 Nexeon Ltd Structured particles
AU2012323782B2 (en) 2011-10-12 2017-04-06 Vaxxas Pty Limited Delivery device
EP3542851B1 (en) 2011-10-27 2021-12-15 Sorrento Therapeutics, Inc. Implantable devices for delivery of bioactive agents
US20170246439A9 (en) 2011-10-27 2017-08-31 Kimberly-Clark Worldwide, Inc. Increased Bioavailability of Transdermally Delivered Agents
KR102145638B1 (ko) 2011-10-27 2020-08-18 소렌토 쎄라퓨틱스, 인코포레이티드 고점도 생체활성 제제의 경피 전달 방법
CA2851828A1 (en) 2011-10-28 2013-05-02 Presage Biosciences, Inc. Methods for drug delivery
CN102553066B (zh) * 2011-12-28 2013-07-17 上海交通大学 基于多孔微针结构的经皮给药系统
KR20140128379A (ko) 2012-01-30 2014-11-05 넥세온 엘티디 에스아이／씨 전기활성 물질의 조성물
GB2499984B (en) 2012-02-28 2014-08-06 Nexeon Ltd Composite particles comprising a removable filler
GB2502625B (en) 2012-06-06 2015-07-29 Nexeon Ltd Method of forming silicon
WO2014053081A1 (en) 2012-10-01 2014-04-10 The Hong Kong University Of Science And Technology Design and manufacture of nonelectronic, active-infusion patch and device for transdermal delivery across skin
GB2507535B (en) 2012-11-02 2015-07-15 Nexeon Ltd Multilayer electrode
AU2013364053B2 (en) 2012-12-21 2018-08-30 Corium Pharma Solutions, Inc. Microarray for delivery of therapeutic agent and methods of use
CN105025974A (zh) * 2013-03-12 2015-11-04 普西维达公司 包含硅基载体粒子的药物递送装置
RU2674083C2 (ru) 2013-03-12 2018-12-04 Кориум Интернэшнл, Инк. Аппликаторы с микровыступами
US10384046B2 (en) 2013-03-15 2019-08-20 Corium, Inc. Microarray for delivery of therapeutic agent and methods of use
CA2903459C (en) 2013-03-15 2024-02-20 Corium International, Inc. Multiple impact microprojection applicators and methods of use
WO2014150293A1 (en) 2013-03-15 2014-09-25 Corium International, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
WO2014151381A1 (en) 2013-03-15 2014-09-25 Psivida Us, Inc. Bioerodible silicon-based compositions for delivery of therapeutic agents
ES2761580T3 (es) 2013-03-15 2020-05-20 Corium Inc Micromatrices para suministro de agente terapéutico, métodos de uso y métodos de fabricación
KR101567203B1 (ko) 2014-04-09 2015-11-09 (주)오렌지파워 이차 전지용 음극 활물질 및 이의 방법
KR101604352B1 (ko) 2014-04-22 2016-03-18 (주)오렌지파워 음극 활물질 및 이를 포함하는 리튬 이차 전지
EP3188714A1 (en) 2014-09-04 2017-07-12 Corium International, Inc. Microstructure array, methods of making, and methods of use
KR101549086B1 (ko) * 2014-11-10 2015-09-02 주식회사 스몰랩 마이크로 니들 및 마이크로 니들 패치
GB2533161C (en) 2014-12-12 2019-07-24 Nexeon Ltd Electrodes for metal-ion batteries
US11147954B2 (en) 2015-02-02 2021-10-19 Vaxxas Pty Limited Microprojection array applicator and method
US10857093B2 (en) 2015-06-29 2020-12-08 Corium, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
JP6894423B2 (ja) 2015-07-09 2021-06-30 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアＴｈｅ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃａｌｉｆｏｒｎｉａ 融合性リポソーム被覆多孔質ケイ素ナノ粒子
WO2017045031A1 (en) 2015-09-18 2017-03-23 Vaxxas Pty Limited Microprojection arrays with microprojections having large surface area profiles
JP2017176652A (ja) * 2016-03-31 2017-10-05 花王株式会社 微細中空突起具
KR102413416B1 (ko) 2016-06-14 2022-06-27 넥세온 엘티디 금속-이온 전지들용 전극들
KR101746024B1 (ko) * 2016-07-14 2017-06-12 경북대학교 산학협력단 다공성 코팅층이 코팅된 마이크로니들과 이것의 제조 방법 그리고 마이크로니들이 구비된 마이크로니들패치
WO2018176102A1 (en) 2017-03-31 2018-10-04 Vaxxas Pty Limited Device and method for coating surfaces
AU2018285954A1 (en) 2017-06-13 2019-12-19 Vaxxas Pty Limited Quality control of substrate coatings
AU2018309562A1 (en) 2017-08-04 2020-02-20 Vaxxas Pty Limited Compact high mechanical energy storage and low trigger force actuator for the delivery of microprojection array patches (MAP)
CN109529186B (zh) * 2018-12-17 2021-05-11 广东工业大学 一种药物涂层非晶合金微针及其制作方法
CN110251824B (zh) * 2019-04-30 2021-03-16 山东大学 一种用于透皮给药的柔性微针贴片及其制作方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4784737A (en) * 1986-04-18 1988-11-15 The United States Department Of Energy Electromicroinjection of particles into living cells
US5262128A (en) * 1989-10-23 1993-11-16 The United States Of America As Represented By The Department Of Health And Human Services Array-type multiple cell injector
GB8927709D0 (en) * 1989-12-07 1990-02-07 Secretary Of The State For Def Silicon quantum wires
WO1992001802A1 (en) * 1990-07-19 1992-02-06 Chris Brinegar Methods and apparatus for ice-medicated introduction of substances into biological material in a non-lethal manner
JPH0634361A (ja) * 1992-07-15 1994-02-08 Canon Inc マイクロティップ及びこれを用いた原子間力顕微鏡装置
US5635216A (en) * 1993-12-16 1997-06-03 Eli Lilly And Company Microparticle compositions containing peptides, and methods for the preparation thereof
EP0887867B1 (en) * 1993-11-02 2004-04-21 Matsushita Electric Industrial Co., Ltd Semiconductor device comprising an aggregate of semiconductor micro-needles
US5457041A (en) * 1994-03-25 1995-10-10 Science Applications International Corporation Needle array and method of introducing biological substances into living cells using the needle array
US5591139A (en) * 1994-06-06 1997-01-07 The Regents Of The University Of California IC-processed microneedles
US5484720A (en) * 1994-09-08 1996-01-16 Genentech, Inc. Methods for calcium phosphate transfection
CA2201315A1 (en) 1994-09-30 1996-04-11 Peter Ping Ling Direct introduction of foreign materials into cells
JP2697645B2 (ja) * 1994-10-31 1998-01-14 日本電気株式会社 半導体装置の製造方法
DE19525607A1 (de) * 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneales Arzneimittelfreigabesystem
GB9611437D0 (en) * 1995-08-03 1996-08-07 Secr Defence Biomaterial
US6284345B1 (en) * 1997-12-08 2001-09-04 Washington University Designer particles of micron and submicron dimension
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
GB9815819D0 (en) * 1998-07-22 1998-09-16 Secr Defence Transferring materials into cells and a microneedle array
GB0008494D0 (en) * 2000-04-07 2000-05-24 Secr Defence Microprojectile delivery system

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ATE223479T1 (de) 2002-09-15
JP2002521024A (ja) 2002-07-16
US6770480B1 (en) 2004-08-03
ES2400472T3 (es) 2013-04-10
EP1231259A3 (en) 2003-11-19
NZ509142A (en) 2004-01-30
WO2000005339A1 (en) 2000-02-03
AU5055499A (en) 2000-02-14
EP1522578B1 (en) 2013-01-09
EP1522578A1 (en) 2005-04-13
HK1039146A1 (en) 2002-04-12
KR100633273B1 (ko) 2006-10-16
KR20010072050A (ko) 2001-07-31
DE69902794T2 (de) 2003-08-07
CN1252275C (zh) 2006-04-19
EP1231259A2 (en) 2002-08-14
JP4585119B2 (ja) 2010-11-24
HK1039146B (zh) 2006-10-27
US7332339B2 (en) 2008-02-19
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AU753542B2 (en) 2002-10-24
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