ATE223479T1 - Einbringen von materialien in zellen mittels porösem oder polykrystallinem silizium - Google Patents

Einbringen von materialien in zellen mittels porösem oder polykrystallinem silizium

Info

Publication number
ATE223479T1
ATE223479T1 AT99934933T AT99934933T ATE223479T1 AT E223479 T1 ATE223479 T1 AT E223479T1 AT 99934933 T AT99934933 T AT 99934933T AT 99934933 T AT99934933 T AT 99934933T AT E223479 T1 ATE223479 T1 AT E223479T1
Authority
AT
Austria
Prior art keywords
polycrystalline silicon
porous
introduction
cells
materials
Prior art date
Application number
AT99934933T
Other languages
English (en)
Inventor
Leigh Trevor Canham
Original Assignee
Psimedica Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Psimedica Ltd filed Critical Psimedica Ltd
Application granted granted Critical
Publication of ATE223479T1 publication Critical patent/ATE223479T1/de

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/89Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microinjection
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/89Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microinjection
    • C12N15/895Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microinjection using biolistic methods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046Solid microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053Methods for producing microneedles
AT99934933T 1998-07-22 1999-07-22 Einbringen von materialien in zellen mittels porösem oder polykrystallinem silizium ATE223479T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9815819.9A GB9815819D0 (en) 1998-07-22 1998-07-22 Transferring materials into cells and a microneedle array
PCT/GB1999/002383 WO2000005339A1 (en) 1998-07-22 1999-07-22 Transferring materials into cells using porous silicon

Publications (1)

Publication Number Publication Date
ATE223479T1 true ATE223479T1 (de) 2002-09-15

Family

ID=10835869

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99934933T ATE223479T1 (de) 1998-07-22 1999-07-22 Einbringen von materialien in zellen mittels porösem oder polykrystallinem silizium

Country Status (15)

Country Link
US (2) US6770480B1 (de)
EP (3) EP1098957B1 (de)
JP (1) JP4585119B2 (de)
KR (1) KR100633273B1 (de)
CN (1) CN1252275C (de)
AT (1) ATE223479T1 (de)
AU (1) AU753542B2 (de)
CA (1) CA2337331C (de)
DE (1) DE69902794T2 (de)
DK (1) DK1098957T3 (de)
ES (2) ES2400472T3 (de)
GB (1) GB9815819D0 (de)
HK (1) HK1039146B (de)
NZ (1) NZ509142A (de)
WO (1) WO2000005339A1 (de)

Families Citing this family (121)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9808052D0 (en) 1998-04-17 1998-06-17 Secr Defence Implants for administering substances and methods of producing implants
GB9815819D0 (en) * 1998-07-22 1998-09-16 Secr Defence Transferring materials into cells and a microneedle array
GB0008494D0 (en) * 2000-04-07 2000-05-24 Secr Defence Microprojectile delivery system
GB2363115A (en) * 2000-06-10 2001-12-12 Secr Defence Porous or polycrystalline silicon orthopaedic implants
US6533949B1 (en) * 2000-08-28 2003-03-18 Nanopass Ltd. Microneedle structure and production method therefor
US7828827B2 (en) 2002-05-24 2010-11-09 Corium International, Inc. Method of exfoliation of skin using closely-packed microstructures
US6821281B2 (en) 2000-10-16 2004-11-23 The Procter & Gamble Company Microstructures for treating and conditioning skin
JP2005505231A (ja) 2000-11-03 2005-02-24 リージェンツ オブ ザ ユニバーシティ オブ ミシガン 表面トランスフェクションおよび発現法
US6897067B2 (en) 2000-11-03 2005-05-24 Regents Of The University Of Michigan Surface transfection and expression procedure
US6902933B2 (en) 2000-11-03 2005-06-07 Regents Of The University Of Michigan Surface transfection and expression procedure
US7226733B2 (en) * 2001-02-21 2007-06-05 University Of Rochester Microcavity biosensor and uses thereof
GB0104383D0 (en) 2001-02-22 2001-04-11 Psimedica Ltd Cancer Treatment
US6663820B2 (en) * 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
EP1390382A4 (de) * 2001-04-30 2007-10-31 Benjamin J Doranz Aufklärung von genfunktion
US20040087992A1 (en) * 2002-08-09 2004-05-06 Vladimir Gartstein Microstructures for delivering a composition cutaneously to skin using rotatable structures
US7429258B2 (en) 2001-10-26 2008-09-30 Massachusetts Institute Of Technology Microneedle transport device
US6908453B2 (en) * 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
JP2004121064A (ja) * 2002-10-01 2004-04-22 Jfe Steel Kk 遺伝子制御用のセラミック被覆針
AU2003222691A1 (en) * 2002-04-30 2003-11-17 Morteza Shirkhanzadeh Arrays of microneedles comprising porous calcium phosphate coating and bioactive agents
US6864692B1 (en) * 2002-06-20 2005-03-08 Xsilogy, Inc. Sensor having improved selectivity
AU2003251831B2 (en) 2002-07-19 2009-06-11 3M Innovative Properties Company Microneedle devices and microneedle delivery apparatus
US7244513B2 (en) * 2003-02-21 2007-07-17 Nano-Proprietary, Inc. Stain-etched silicon powder
US7578954B2 (en) * 2003-02-24 2009-08-25 Corium International, Inc. Method for manufacturing microstructures having multiple microelements with through-holes
WO2004092369A1 (ja) * 2003-04-11 2004-10-28 Riken マイクロインジェクション方法および装置
US8961477B2 (en) 2003-08-25 2015-02-24 3M Innovative Properties Company Delivery of immune response modifier compounds
GB0402131D0 (en) * 2004-01-30 2004-03-03 Isis Innovation Delivery method
WO2005082596A1 (en) * 2004-02-23 2005-09-09 3M Innovative Properties Company Method of molding for microneedle arrays
CA2560840C (en) 2004-03-24 2014-05-06 Corium International, Inc. Transdermal delivery device
US7591806B2 (en) * 2004-05-18 2009-09-22 Bai Xu High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances
US20090208556A1 (en) * 2004-10-29 2009-08-20 Regents Of The University Of California, The Porous photonic crystals for drug delivery to the eye
WO2006062974A2 (en) 2004-12-07 2006-06-15 3M Innovative Properties Company Method of molding a microneedle
US20060276047A1 (en) * 2005-03-14 2006-12-07 University Of Rochester Macroporous silicon microcavity with tunable pore size
WO2006121870A2 (en) * 2005-05-09 2006-11-16 Vesta Research, Ltd. Silicon nanosponge particles
US8043250B2 (en) * 2005-05-18 2011-10-25 Nanomed Devices, Inc. High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances
US8048017B2 (en) * 2005-05-18 2011-11-01 Bai Xu High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances
CA2612005C (en) 2005-06-17 2013-10-29 Georgia Tech Research Corporation Coated microstructures and method of manufacture thereof
EP1896115B2 (de) * 2005-06-27 2020-01-22 3M Innovative Properties Company Mikronadelkartuschenanordnung
JP2009502261A (ja) * 2005-07-25 2009-01-29 ナノテクノロジー ビクトリア ピーティーワイ リミテッド マイクロアレイデバイス
US20070066934A1 (en) * 2005-09-19 2007-03-22 Transport Pharmaceuticals, Inc. Electrokinetic delivery system and methods therefor
US20070185432A1 (en) * 2005-09-19 2007-08-09 Transport Pharmaceuticals, Inc. Electrokinetic system and method for delivering methotrexate
WO2007061781A1 (en) * 2005-11-18 2007-05-31 3M Innovative Properties Company Coatable compositions, coatings derived therefrom and microarrays having such coatings
US20080262416A1 (en) * 2005-11-18 2008-10-23 Duan Daniel C Microneedle Arrays and Methods of Preparing Same
WO2007076458A1 (en) * 2005-12-21 2007-07-05 Primegen Biotech Llc Microinjector chip
EP1962942A1 (de) * 2005-12-21 2008-09-03 3M Innovative Properties Company Mikronadelvorrichtungen
US9610459B2 (en) 2009-07-24 2017-04-04 Emkinetics, Inc. Cooling systems and methods for conductive coils
US9339641B2 (en) 2006-01-17 2016-05-17 Emkinetics, Inc. Method and apparatus for transdermal stimulation over the palmar and plantar surfaces
US20100168501A1 (en) * 2006-10-02 2010-07-01 Daniel Rogers Burnett Method and apparatus for magnetic induction therapy
DE102006028781A1 (de) * 2006-06-23 2007-12-27 Robert Bosch Gmbh Verfahren zur Herstellung von porösen Mikronadeln und ihre Verwendung
WO2008042902A2 (en) * 2006-10-02 2008-04-10 Emkinetics, Inc. Method and apparatus for magnetic induction therapy
US11224742B2 (en) 2006-10-02 2022-01-18 Emkinetics, Inc. Methods and devices for performing electrical stimulation to treat various conditions
US10786669B2 (en) 2006-10-02 2020-09-29 Emkinetics, Inc. Method and apparatus for transdermal stimulation over the palmar and plantar surfaces
US9005102B2 (en) 2006-10-02 2015-04-14 Emkinetics, Inc. Method and apparatus for electrical stimulation therapy
WO2008076465A1 (en) * 2006-12-21 2008-06-26 Primegen Biotech, Llc Microinjector chip
US20080214987A1 (en) * 2006-12-22 2008-09-04 Nanomed Devices, Inc. Microdevice And Method For Transdermal Delivery And Sampling Of Active Substances
US10525246B2 (en) 2006-12-22 2020-01-07 Nanomed Skincare, Inc. Microdevice and method for transdermal delivery and sampling of active substances
CN100998901B (zh) * 2007-01-12 2012-10-10 中国科学院上海微系统与信息技术研究所 多孔硅无痛注射微针阵列及其制备方法
DE102007002832A1 (de) * 2007-01-19 2008-07-24 Robert Bosch Gmbh Verfahren zur Herstellung einer Vorrichtung umfassend eine Anordnung von Mikronadeln auf einem Träger und nach diesem Verfahren herstellbare Vorrichtung
CA2676221C (en) 2007-01-22 2016-12-20 Corium International, Inc. Applicators for microneedles
EP2125073A1 (de) * 2007-03-02 2009-12-02 TecPharma Licensing AG Modulares verabreichungssystem
US20090017562A1 (en) * 2007-03-13 2009-01-15 Iowa State University Research Foundation, Inc. Raman-active reagents
EP2146689B1 (de) 2007-04-16 2020-08-12 Corium, Inc. Einen wirkstoff enthaltende lösungsmittel-gegossene mikronadelanordnungen
AU2014200648B2 (en) * 2007-04-16 2015-09-24 Corium Pharma Solutions, Inc. Solvent-cast microneedle arrays containing active
US8911749B2 (en) 2007-04-16 2014-12-16 Corium International, Inc. Vaccine delivery via microneedle arrays
EP2150493A1 (de) * 2007-04-27 2010-02-10 Board Of Regents Of The University Of Texas Poröse partikel und herstellungsverfahren dafür
KR20170084358A (ko) * 2007-07-10 2017-07-19 더 리전트 오브 더 유니버시티 오브 캘리포니아 선택된 조직에 조성물을 전달하는 물질 및 방법
US8349554B2 (en) 2007-08-14 2013-01-08 Fred Hutchinson Cancer Research Center Needle array assembly and method for delivering therapeutic agents
JP5178132B2 (ja) * 2007-10-11 2013-04-10 キヤノン株式会社 画像処理システム並びに画像処理方法
US9220678B2 (en) 2007-12-24 2015-12-29 The University Of Queensland Coating method
AU2009212106B9 (en) 2008-02-07 2014-05-22 Vaxxas Pty Limited Patch production
EP2100850A1 (de) * 2008-03-11 2009-09-16 Stichting Voor De Technische Wetenschappen Mikronadelarray und Verfahren zur Mikronadelherstellung
AU2009250341A1 (en) 2008-05-23 2009-11-26 The University Of Queensland Analyte detection using a needle projection patch
CA2759850C (en) * 2009-04-24 2019-10-22 Corium International, Inc. Methods for manufacturing microprojection arrays
WO2010129545A2 (en) 2009-05-04 2010-11-11 Psivida Us, Inc. Porous silicon drug-eluting particles
AU2010313487A1 (en) 2009-10-26 2012-05-24 Emkinetics, Inc. Method and apparatus for electromagnetic stimulation of nerve, muscle, and body tissues
RU2585159C2 (ru) 2010-04-28 2016-05-27 Кимберли-Кларк Ворлдвайд, Инк. Устройство доставки лекарственного средства, применяемого при ревматоидном артрите
CA2796965C (en) 2010-04-28 2019-04-16 Kimberly-Clark Worldwide, Inc. Method for increasing permeability of an epithelial barrier
EP2563453B1 (de) 2010-04-28 2017-02-08 Kimberly-Clark Worldwide, Inc. Nanostrukturierte medizinische vorrichtung mit verstärkter zelleninteraktion und verfahren deren herstellung
MX336139B (es) 2010-04-28 2016-01-08 Kimberly Clark Co Dispositivos medicos para la entrega de arn de interferencia corta.
JP6327852B2 (ja) 2010-05-04 2018-05-23 コリウム インターナショナル, インコーポレイテッド 微小突起アレイを使用した副甲状腺ホルモンの経皮送達のための方法及びデバイス
US8588884B2 (en) 2010-05-28 2013-11-19 Emkinetics, Inc. Microneedle electrode
US9943673B2 (en) 2010-07-14 2018-04-17 Vaxxas Pty Limited Patch applying apparatus
CN104622790A (zh) * 2010-11-01 2015-05-20 普西维达公司 用于递送治疗剂的可生物侵蚀的硅基装置
US9394369B2 (en) 2011-01-03 2016-07-19 The Regents Of The University Of California Luminescent porous silicon nanoparticles for targeted delivery and immunization
US20120295345A1 (en) * 2011-05-18 2012-11-22 Aten Quentin T Apparatuses and related methods for delivering biological material into a cell
GB2492167C (en) 2011-06-24 2018-12-05 Nexeon Ltd Structured particles
US11179553B2 (en) 2011-10-12 2021-11-23 Vaxxas Pty Limited Delivery device
CN104039382B (zh) 2011-10-27 2018-01-12 金伯利-克拉克环球有限公司 高粘度生物活性剂的经皮递送
KR20140079429A (ko) * 2011-10-27 2014-06-26 킴벌리-클라크 월드와이드, 인크. 생체활성 제제를 전달하기 위한 이식형 기구
US20170246439A9 (en) 2011-10-27 2017-08-31 Kimberly-Clark Worldwide, Inc. Increased Bioavailability of Transdermally Delivered Agents
WO2013063530A2 (en) 2011-10-28 2013-05-02 Presage Biosciences, Inc. Methods for drug delivery
CN102553066B (zh) * 2011-12-28 2013-07-17 上海交通大学 基于多孔微针结构的经皮给药系统
WO2013114094A1 (en) 2012-01-30 2013-08-08 Nexeon Limited Composition of si/c electro active material
GB2499984B (en) 2012-02-28 2014-08-06 Nexeon Ltd Composite particles comprising a removable filler
GB2502625B (en) 2012-06-06 2015-07-29 Nexeon Ltd Method of forming silicon
US10548854B2 (en) 2012-10-01 2020-02-04 The Hong Kong University Of Science And Technology Manufacture of nonelectronic, active-infusion patch and device for transdermal delivery across skin
GB2507535B (en) 2012-11-02 2015-07-15 Nexeon Ltd Multilayer electrode
CA2896188C (en) 2012-12-21 2021-02-23 Corium International, Inc. Microarray for delivery of therapeutic agent and methods of use
US10245422B2 (en) 2013-03-12 2019-04-02 Corium International, Inc. Microprojection applicators and methods of use
CA2904204A1 (en) * 2013-03-12 2014-10-09 Psivida Us, Inc. Drug delivery device comprising silicon-based carrier particles
EP2968751B1 (de) 2013-03-15 2022-11-30 Corium, Inc. Mehrfachberührungs-mikroprojektionsapplikatoren
WO2014151381A1 (en) 2013-03-15 2014-09-25 Psivida Us, Inc. Bioerodible silicon-based compositions for delivery of therapeutic agents
CA2906541C (en) 2013-03-15 2022-06-21 Corium International, Inc. Microarray for delivery of therapeutic agent and methods of use
AU2014233541B2 (en) 2013-03-15 2018-11-22 Corium Pharma Solutions, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
US10384045B2 (en) 2013-03-15 2019-08-20 Corium, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
KR101567203B1 (ko) 2014-04-09 2015-11-09 (주)오렌지파워 이차 전지용 음극 활물질 및 이의 방법
KR101604352B1 (ko) 2014-04-22 2016-03-18 (주)오렌지파워 음극 활물질 및 이를 포함하는 리튬 이차 전지
US10624843B2 (en) 2014-09-04 2020-04-21 Corium, Inc. Microstructure array, methods of making, and methods of use
KR101549086B1 (ko) * 2014-11-10 2015-09-02 주식회사 스몰랩 마이크로 니들 및 마이크로 니들 패치
GB2533161C (en) 2014-12-12 2019-07-24 Nexeon Ltd Electrodes for metal-ion batteries
EP4218892A1 (de) 2015-02-02 2023-08-02 Vaxxas Pty Limited Mikroprojektionsarrayapplikator
WO2017004067A1 (en) 2015-06-29 2017-01-05 Corium International, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
AU2016291224B2 (en) 2015-07-09 2021-12-23 The Regents Of The University Of California Fusogenic liposome-coated porous silicon nanoparticles
US11103259B2 (en) 2015-09-18 2021-08-31 Vaxxas Pty Limited Microprojection arrays with microprojections having large surface area profiles
JP2017176652A (ja) 2016-03-31 2017-10-05 花王株式会社 微細中空突起具
EP4167312A3 (de) 2016-06-14 2023-05-03 Nexeon Limited Elektroden für metall-ionen-batterien
KR101746024B1 (ko) * 2016-07-14 2017-06-12 경북대학교 산학협력단 다공성 코팅층이 코팅된 마이크로니들과 이것의 제조 방법 그리고 마이크로니들이 구비된 마이크로니들패치
JP7152787B2 (ja) 2017-03-31 2022-10-13 ヴァクザス ピーティーワイ リミテッド 表面をコーティングするための装置および方法
US11175128B2 (en) 2017-06-13 2021-11-16 Vaxxas Pty Limited Quality control of substrate coatings
EP3661587A4 (de) 2017-08-04 2021-06-09 Vaxxas Pty Limited Kompakter hoher mechanischer energiespeicher und aktuator mit geringer auslösekraft für die abgabe von mikroprojektions-array-patches (map)
CN109529186B (zh) * 2018-12-17 2021-05-11 广东工业大学 一种药物涂层非晶合金微针及其制作方法
CN110251824B (zh) * 2019-04-30 2021-03-16 山东大学 一种用于透皮给药的柔性微针贴片及其制作方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4784737A (en) * 1986-04-18 1988-11-15 The United States Department Of Energy Electromicroinjection of particles into living cells
US5262128A (en) * 1989-10-23 1993-11-16 The United States Of America As Represented By The Department Of Health And Human Services Array-type multiple cell injector
GB8927709D0 (en) * 1989-12-07 1990-02-07 Secretary Of The State For Def Silicon quantum wires
AU8418091A (en) * 1990-07-19 1992-02-18 Chris Brinegar Methods and apparatus for ice-medicated introduction of substances into biological material in a non-lethal manner
JPH0634361A (ja) 1992-07-15 1994-02-08 Canon Inc マイクロティップ及びこれを用いた原子間力顕微鏡装置
US5635216A (en) * 1993-12-16 1997-06-03 Eli Lilly And Company Microparticle compositions containing peptides, and methods for the preparation thereof
EP0892445B1 (de) * 1993-11-02 2004-04-07 Matsushita Electric Industrial Co., Ltd. Halbleiterbauelement mit Aggregat von Mikro-Nadeln aus Halbleitermaterial
US5457041A (en) * 1994-03-25 1995-10-10 Science Applications International Corporation Needle array and method of introducing biological substances into living cells using the needle array
US5591139A (en) * 1994-06-06 1997-01-07 The Regents Of The University Of California IC-processed microneedles
US5484720A (en) * 1994-09-08 1996-01-16 Genentech, Inc. Methods for calcium phosphate transfection
WO1996010630A1 (en) * 1994-09-30 1996-04-11 Rutgers, The State University Direct introduction of foreign materials into cells
JP2697645B2 (ja) * 1994-10-31 1998-01-14 日本電気株式会社 半導体装置の製造方法
DE19525607A1 (de) * 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneales Arzneimittelfreigabesystem
GB9611437D0 (en) * 1995-08-03 1996-08-07 Secr Defence Biomaterial
US6284345B1 (en) * 1997-12-08 2001-09-04 Washington University Designer particles of micron and submicron dimension
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
GB9815819D0 (en) * 1998-07-22 1998-09-16 Secr Defence Transferring materials into cells and a microneedle array
GB0008494D0 (en) * 2000-04-07 2000-05-24 Secr Defence Microprojectile delivery system

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AU753542B2 (en) 2002-10-24
CA2337331A1 (en) 2000-02-03
KR100633273B1 (ko) 2006-10-16
CN1252275C (zh) 2006-04-19
HK1039146B (zh) 2006-10-27
CN1310755A (zh) 2001-08-29
EP1231259A3 (de) 2003-11-19
AU5055499A (en) 2000-02-14
ES2400472T3 (es) 2013-04-10
DE69902794D1 (de) 2002-10-10
HK1039146A1 (en) 2002-04-12
DE69902794T2 (de) 2003-08-07
EP1522578B1 (de) 2013-01-09
US6770480B1 (en) 2004-08-03
US7332339B2 (en) 2008-02-19
WO2000005339A1 (en) 2000-02-03
JP4585119B2 (ja) 2010-11-24
JP2002521024A (ja) 2002-07-16
US20040220535A1 (en) 2004-11-04
DK1098957T3 (da) 2003-01-06
NZ509142A (en) 2004-01-30
KR20010072050A (ko) 2001-07-31
CA2337331C (en) 2012-08-28
EP1522578A1 (de) 2005-04-13
ES2179666T3 (es) 2003-01-16
GB9815819D0 (en) 1998-09-16
EP1098957A1 (de) 2001-05-16
EP1098957B1 (de) 2002-09-04
EP1231259A2 (de) 2002-08-14

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