ATE223479T1 - Einbringen von materialien in zellen mittels porösem oder polykrystallinem silizium - Google Patents

Einbringen von materialien in zellen mittels porösem oder polykrystallinem silizium

Info

Publication number
ATE223479T1
ATE223479T1 AT99934933T AT99934933T ATE223479T1 AT E223479 T1 ATE223479 T1 AT E223479T1 AT 99934933 T AT99934933 T AT 99934933T AT 99934933 T AT99934933 T AT 99934933T AT E223479 T1 ATE223479 T1 AT E223479T1
Authority
AT
Austria
Prior art keywords
polycrystalline silicon
porous
introduction
cells
materials
Prior art date
Application number
AT99934933T
Other languages
English (en)
Inventor
Leigh Trevor Canham
Original Assignee
Psimedica Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Psimedica Ltd filed Critical Psimedica Ltd
Application granted granted Critical
Publication of ATE223479T1 publication Critical patent/ATE223479T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/89Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microinjection
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/89Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microinjection
    • C12N15/895Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microinjection using biolistic methods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046Solid microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053Methods for producing microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Dermatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Sustainable Development (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Silicon Compounds (AREA)
  • Electrotherapy Devices (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Battery Electrode And Active Subsutance (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT99934933T 1998-07-22 1999-07-22 Einbringen von materialien in zellen mittels porösem oder polykrystallinem silizium ATE223479T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9815819.9A GB9815819D0 (en) 1998-07-22 1998-07-22 Transferring materials into cells and a microneedle array
PCT/GB1999/002383 WO2000005339A1 (en) 1998-07-22 1999-07-22 Transferring materials into cells using porous silicon

Publications (1)

Publication Number Publication Date
ATE223479T1 true ATE223479T1 (de) 2002-09-15

Family

ID=10835869

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99934933T ATE223479T1 (de) 1998-07-22 1999-07-22 Einbringen von materialien in zellen mittels porösem oder polykrystallinem silizium

Country Status (15)

Country Link
US (2) US6770480B1 (de)
EP (3) EP1098957B1 (de)
JP (1) JP4585119B2 (de)
KR (1) KR100633273B1 (de)
CN (1) CN1252275C (de)
AT (1) ATE223479T1 (de)
AU (1) AU753542B2 (de)
CA (1) CA2337331C (de)
DE (1) DE69902794T2 (de)
DK (1) DK1098957T3 (de)
ES (2) ES2400472T3 (de)
GB (1) GB9815819D0 (de)
HK (1) HK1039146B (de)
NZ (1) NZ509142A (de)
WO (1) WO2000005339A1 (de)

Families Citing this family (123)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9808052D0 (en) 1998-04-17 1998-06-17 Secr Defence Implants for administering substances and methods of producing implants
GB9815819D0 (en) * 1998-07-22 1998-09-16 Secr Defence Transferring materials into cells and a microneedle array
GB0008494D0 (en) * 2000-04-07 2000-05-24 Secr Defence Microprojectile delivery system
GB2363115A (en) * 2000-06-10 2001-12-12 Secr Defence Porous or polycrystalline silicon orthopaedic implants
US6533949B1 (en) * 2000-08-28 2003-03-18 Nanopass Ltd. Microneedle structure and production method therefor
US7108681B2 (en) 2000-10-16 2006-09-19 Corium International, Inc. Microstructures for delivering a composition cutaneously to skin
US7828827B2 (en) 2002-05-24 2010-11-09 Corium International, Inc. Method of exfoliation of skin using closely-packed microstructures
US7056741B2 (en) 2000-11-03 2006-06-06 Regents Of The University Of Michigan Surface transfection and expression procedure
US6902933B2 (en) 2000-11-03 2005-06-07 Regents Of The University Of Michigan Surface transfection and expression procedure
US6897067B2 (en) 2000-11-03 2005-05-24 Regents Of The University Of Michigan Surface transfection and expression procedure
DE60216735D1 (de) * 2001-02-21 2007-01-25 Univ Rochester Mikrokavitätsbiosensor, herstellungsverfahren und verwendungen davon
GB0104383D0 (en) 2001-02-22 2001-04-11 Psimedica Ltd Cancer Treatment
US6663820B2 (en) * 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
CA2445884A1 (en) * 2001-04-30 2002-11-07 Benjamin J. Doranz Elucidation of gene function
US20040087992A1 (en) * 2002-08-09 2004-05-06 Vladimir Gartstein Microstructures for delivering a composition cutaneously to skin using rotatable structures
US7429258B2 (en) 2001-10-26 2008-09-30 Massachusetts Institute Of Technology Microneedle transport device
US6908453B2 (en) * 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
JP2004121064A (ja) * 2002-10-01 2004-04-22 Jfe Steel Kk 遺伝子制御用のセラミック被覆針
AU2003222691A1 (en) * 2002-04-30 2003-11-17 Morteza Shirkhanzadeh Arrays of microneedles comprising porous calcium phosphate coating and bioactive agents
US6864692B1 (en) * 2002-06-20 2005-03-08 Xsilogy, Inc. Sensor having improved selectivity
EP1523367A1 (de) 2002-07-19 2005-04-20 3M Innovative Properties Company Mikronadel anordnung und mikronadel verabreichungsgerät
US7244513B2 (en) * 2003-02-21 2007-07-17 Nano-Proprietary, Inc. Stain-etched silicon powder
US7578954B2 (en) * 2003-02-24 2009-08-25 Corium International, Inc. Method for manufacturing microstructures having multiple microelements with through-holes
US20070087436A1 (en) * 2003-04-11 2007-04-19 Atsushi Miyawaki Microinjection method and device
AU2004268616B2 (en) 2003-08-25 2010-10-07 3M Innovative Properties Company Delivery of immune response modifier compounds
GB0402131D0 (en) * 2004-01-30 2004-03-03 Isis Innovation Delivery method
EP1718452A1 (de) * 2004-02-23 2006-11-08 3M Innovative Properties Company Verfahren zum formen von mikronadelanordnungen
EP1737357B1 (de) 2004-03-24 2019-12-11 Corium, Inc. Vorrichtung zur transdermalen abgabe
US7591806B2 (en) * 2004-05-18 2009-09-22 Bai Xu High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances
EP3381446A1 (de) 2004-10-29 2018-10-03 The Regents of The University of California Poröse photonische kristalle zur verabreichung von wirkstoffen ins auge
EP2067599B1 (de) 2004-12-07 2016-10-26 3M Innovative Properties Company Verfahren zum Formen einer Mikronadel
US20060276047A1 (en) * 2005-03-14 2006-12-07 University Of Rochester Macroporous silicon microcavity with tunable pore size
AU2006295332A1 (en) 2005-05-09 2007-04-05 Vesta Research, Ltd. Porous silicon particles
US8048017B2 (en) * 2005-05-18 2011-11-01 Bai Xu High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances
US8043250B2 (en) * 2005-05-18 2011-10-25 Nanomed Devices, Inc. High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances
US20080213461A1 (en) * 2005-06-17 2008-09-04 Georgia Tech Research Corporation Coated Microstructures and Methods of Manufacture Thereof
JP2008543528A (ja) * 2005-06-27 2008-12-04 スリーエム イノベイティブ プロパティズ カンパニー マイクロニードルカートリッジアセンブリ及び適用方法
WO2007012114A1 (en) * 2005-07-25 2007-02-01 Nanotechnology Victoria Pty Ltd Microarray device
US20070066934A1 (en) * 2005-09-19 2007-03-22 Transport Pharmaceuticals, Inc. Electrokinetic delivery system and methods therefor
US20070185432A1 (en) * 2005-09-19 2007-08-09 Transport Pharmaceuticals, Inc. Electrokinetic system and method for delivering methotrexate
CA2629193C (en) * 2005-11-18 2016-03-29 3M Innovative Properties Company Coatable compositions, coatings derived therefrom and microarrays having such coatings
US20080262416A1 (en) * 2005-11-18 2008-10-23 Duan Daniel C Microneedle Arrays and Methods of Preparing Same
WO2007075614A1 (en) * 2005-12-21 2007-07-05 3M Innovative Properties Company Microneedle devices
US20070142781A1 (en) * 2005-12-21 2007-06-21 Sayre Chauncey B Microinjector chip
US9339641B2 (en) 2006-01-17 2016-05-17 Emkinetics, Inc. Method and apparatus for transdermal stimulation over the palmar and plantar surfaces
US9610459B2 (en) 2009-07-24 2017-04-04 Emkinetics, Inc. Cooling systems and methods for conductive coils
US20100168501A1 (en) * 2006-10-02 2010-07-01 Daniel Rogers Burnett Method and apparatus for magnetic induction therapy
DE102006028781A1 (de) * 2006-06-23 2007-12-27 Robert Bosch Gmbh Verfahren zur Herstellung von porösen Mikronadeln und ihre Verwendung
US11224742B2 (en) 2006-10-02 2022-01-18 Emkinetics, Inc. Methods and devices for performing electrical stimulation to treat various conditions
US10786669B2 (en) 2006-10-02 2020-09-29 Emkinetics, Inc. Method and apparatus for transdermal stimulation over the palmar and plantar surfaces
US9005102B2 (en) 2006-10-02 2015-04-14 Emkinetics, Inc. Method and apparatus for electrical stimulation therapy
CA2665134A1 (en) * 2006-10-02 2008-04-10 Emkinetics, Inc. Method and apparatus for magnetic induction therapy
WO2008076465A1 (en) * 2006-12-21 2008-06-26 Primegen Biotech, Llc Microinjector chip
US10525246B2 (en) 2006-12-22 2020-01-07 Nanomed Skincare, Inc. Microdevice and method for transdermal delivery and sampling of active substances
US20080214987A1 (en) * 2006-12-22 2008-09-04 Nanomed Devices, Inc. Microdevice And Method For Transdermal Delivery And Sampling Of Active Substances
CN100998901B (zh) * 2007-01-12 2012-10-10 中国科学院上海微系统与信息技术研究所 多孔硅无痛注射微针阵列及其制备方法
DE102007002832A1 (de) * 2007-01-19 2008-07-24 Robert Bosch Gmbh Verfahren zur Herstellung einer Vorrichtung umfassend eine Anordnung von Mikronadeln auf einem Träger und nach diesem Verfahren herstellbare Vorrichtung
WO2008091602A2 (en) 2007-01-22 2008-07-31 Corium International, Inc. Applicators for microneedle arrays
CN101678166B (zh) * 2007-03-02 2012-08-22 特克法马许可公司 模块化的给药系统
US20090017562A1 (en) * 2007-03-13 2009-01-15 Iowa State University Research Foundation, Inc. Raman-active reagents
AU2014200648B2 (en) * 2007-04-16 2015-09-24 Corium Pharma Solutions, Inc. Solvent-cast microneedle arrays containing active
AU2008241470B2 (en) 2007-04-16 2013-11-07 Corium Pharma Solutions, Inc. Solvent-cast microneedle arrays containing active
CN101778796B (zh) * 2007-04-27 2012-11-14 得克萨斯大学体系董事会 多孔颗粒及其制备方法
CN101815504B (zh) 2007-07-10 2013-11-20 加利福尼亚大学董事会 用于向所选择组织递送组合物的材料和方法
SG183726A1 (en) 2007-08-14 2012-09-27 Hutchinson Fred Cancer Res Needle array assembly and method for delivering therapeutic agents
WO2009048607A1 (en) 2007-10-10 2009-04-16 Corium International, Inc. Vaccine delivery via microneedle arrays
JP5178132B2 (ja) * 2007-10-11 2013-04-10 キヤノン株式会社 画像処理システム並びに画像処理方法
EP2231257A4 (de) 2007-12-24 2013-11-06 Univ Queensland Beschichtungsverfahren
WO2009097660A1 (en) 2008-02-07 2009-08-13 The University Of Queensland Patch production
EP2100850A1 (de) * 2008-03-11 2009-09-16 Stichting Voor De Technische Wetenschappen Mikronadelarray und Verfahren zur Mikronadelherstellung
AU2009250341A1 (en) 2008-05-23 2009-11-26 The University Of Queensland Analyte detection using a needle projection patch
JP5820805B2 (ja) * 2009-04-24 2015-11-24 コリウム インターナショナル, インコーポレイテッド マイクロプロジェクションのアレイの製造のためのプロセス
CA2758607C (en) 2009-05-04 2018-05-15 Psivida Us, Inc. Porous silicon drug-eluting particles
JP2013508119A (ja) 2009-10-26 2013-03-07 エムキネティクス, インコーポレイテッド 神経、筋肉および身体組織の電磁刺激のための方法および装置
US9586044B2 (en) 2010-04-28 2017-03-07 Kimberly-Clark Worldwide, Inc. Method for increasing the permeability of an epithelial barrier
PT2563450T (pt) 2010-04-28 2017-08-28 Kimberly Clark Co Dispositivo para entrega de medicação para a artrite reumatóide
JP5860453B2 (ja) 2010-04-28 2016-02-16 キンバリー クラーク ワールドワイド インコーポレイテッド 表面にナノ構造体を含む複合マイクロニードルアレイ
CN102985131B (zh) 2010-04-28 2016-06-29 金伯利-克拉克环球有限公司 用于递送siRNA的医疗装置
AU2011248108B2 (en) 2010-05-04 2016-05-26 Corium Pharma Solutions, Inc. Method and device for transdermal delivery of parathyroid hormone using a microprojection array
US8588884B2 (en) 2010-05-28 2013-11-19 Emkinetics, Inc. Microneedle electrode
US9943673B2 (en) 2010-07-14 2018-04-17 Vaxxas Pty Limited Patch applying apparatus
US9333173B2 (en) 2010-11-01 2016-05-10 Psivida Us, Inc. Bioerodible silicon-based devices for delivery of therapeutic agents
US9394369B2 (en) 2011-01-03 2016-07-19 The Regents Of The University Of California Luminescent porous silicon nanoparticles for targeted delivery and immunization
US20120295345A1 (en) * 2011-05-18 2012-11-22 Aten Quentin T Apparatuses and related methods for delivering biological material into a cell
GB2492167C (en) 2011-06-24 2018-12-05 Nexeon Ltd Structured particles
EP3881781B1 (de) 2011-10-12 2023-03-29 Vaxxas Pty Limited Abgabegerät
US20170246439A9 (en) 2011-10-27 2017-08-31 Kimberly-Clark Worldwide, Inc. Increased Bioavailability of Transdermally Delivered Agents
EP3574950B1 (de) 2011-10-27 2021-02-17 Sorrento Therapeutics, Inc. Transdermale freisetzung von hochviskosen bioaktiven wirkstoffen
PL3542851T3 (pl) * 2011-10-27 2022-04-25 Sorrento Therapeutics, Inc. Wszczepialne urządzenia do dostarczania środków biologicznie czynnych
CN104023760A (zh) 2011-10-28 2014-09-03 普莱萨格生命科学公司 药物递送方法
CN102553066B (zh) * 2011-12-28 2013-07-17 上海交通大学 基于多孔微针结构的经皮给药系统
WO2013114095A1 (en) 2012-01-30 2013-08-08 Nexeon Limited Composition of si/c electro active material
GB2499984B (en) 2012-02-28 2014-08-06 Nexeon Ltd Composite particles comprising a removable filler
GB2502625B (en) 2012-06-06 2015-07-29 Nexeon Ltd Method of forming silicon
CN105073102B (zh) 2012-10-01 2018-06-19 香港科技大学 透皮贴装置
GB2507535B (en) 2012-11-02 2015-07-15 Nexeon Ltd Multilayer electrode
KR102265808B1 (ko) 2012-12-21 2021-06-16 코리움, 인크. 치료제의 전달을 위한 마이크로어레이 및 그것의 사용방법
CN105025974A (zh) * 2013-03-12 2015-11-04 普西维达公司 包含硅基载体粒子的药物递送装置
JP6487899B2 (ja) 2013-03-12 2019-03-20 コリウム インターナショナル, インコーポレイテッド 微小突起アプリケータ
MX2015012933A (es) 2013-03-15 2016-09-19 Corium Int Inc Micrordenamiento para suministro de agente terapeutico y metodos de uso.
JP2016514133A (ja) 2013-03-15 2016-05-19 コリウム インターナショナル, インコーポレイテッド ポリマーを含まない微細構造物を含むマイクロアレイ、製造方法および使用方法
EP4194028A1 (de) 2013-03-15 2023-06-14 Corium Pharma Solutions, Inc. Mehrfachaufprall-mikroprojektionsapplikatoren
CA2904077A1 (en) 2013-03-15 2014-09-25 Psivida Us, Inc. Bioerodible silicon-based compositions for delivery of therapeutic agents
AU2014233541B2 (en) 2013-03-15 2018-11-22 Corium Pharma Solutions, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
KR101567203B1 (ko) 2014-04-09 2015-11-09 (주)오렌지파워 이차 전지용 음극 활물질 및 이의 방법
KR101604352B1 (ko) 2014-04-22 2016-03-18 (주)오렌지파워 음극 활물질 및 이를 포함하는 리튬 이차 전지
EP3188714A1 (de) 2014-09-04 2017-07-12 Corium International, Inc. Mikrostrukturanordnung, verfahren zur herstellung und verfahren zur verwendung
KR101549086B1 (ko) * 2014-11-10 2015-09-02 주식회사 스몰랩 마이크로 니들 및 마이크로 니들 패치
GB2533161C (en) 2014-12-12 2019-07-24 Nexeon Ltd Electrodes for metal-ion batteries
EP3253440B1 (de) 2015-02-02 2022-12-21 Vaxxas Pty Limited Mikroprojektionsarrayapplikator
US10857093B2 (en) 2015-06-29 2020-12-08 Corium, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
CA2990247C (en) 2015-07-09 2023-10-03 The Regents Of The University Of California Fusogenic liposome-coated porous silicon nanoparticles
WO2017045031A1 (en) 2015-09-18 2017-03-23 Vaxxas Pty Limited Microprojection arrays with microprojections having large surface area profiles
US20180264244A1 (en) 2015-09-28 2018-09-20 Vaxxas Pty Limited Microprojection arrays with enhanced skin penetrating properties and methods thereof
JP2017176652A (ja) 2016-03-31 2017-10-05 花王株式会社 微細中空突起具
EP3469644B1 (de) 2016-06-14 2022-11-09 Nexeon Limited Elektroden für metall-ionen-batterien
KR101746024B1 (ko) * 2016-07-14 2017-06-12 경북대학교 산학협력단 다공성 코팅층이 코팅된 마이크로니들과 이것의 제조 방법 그리고 마이크로니들이 구비된 마이크로니들패치
CN115923337A (zh) 2017-03-31 2023-04-07 瓦克萨斯私人有限公司 用于涂覆表面的设备和方法
CA3065371A1 (en) 2017-06-13 2018-12-20 Vaxxas Pty Limited Quality control of substrate coatings
EP3661587A4 (de) 2017-08-04 2021-06-09 Vaxxas Pty Limited Kompakter hoher mechanischer energiespeicher und aktuator mit geringer auslösekraft für die abgabe von mikroprojektions-array-patches (map)
CN109529186B (zh) * 2018-12-17 2021-05-11 广东工业大学 一种药物涂层非晶合金微针及其制作方法
CN110251824B (zh) * 2019-04-30 2021-03-16 山东大学 一种用于透皮给药的柔性微针贴片及其制作方法
JP7466181B2 (ja) * 2020-03-24 2024-04-12 国立研究開発法人産業技術総合研究所 マイクロニードルアレイ及びそれを用いた植物細胞への物質導入方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4784737A (en) * 1986-04-18 1988-11-15 The United States Department Of Energy Electromicroinjection of particles into living cells
US5262128A (en) 1989-10-23 1993-11-16 The United States Of America As Represented By The Department Of Health And Human Services Array-type multiple cell injector
GB8927709D0 (en) * 1989-12-07 1990-02-07 Secretary Of The State For Def Silicon quantum wires
AU8418091A (en) * 1990-07-19 1992-02-18 Chris Brinegar Methods and apparatus for ice-medicated introduction of substances into biological material in a non-lethal manner
JPH0634361A (ja) * 1992-07-15 1994-02-08 Canon Inc マイクロティップ及びこれを用いた原子間力顕微鏡装置
US5635216A (en) * 1993-12-16 1997-06-03 Eli Lilly And Company Microparticle compositions containing peptides, and methods for the preparation thereof
EP0892444B1 (de) * 1993-11-02 2004-04-21 Matsushita Electric Industrial Co., Ltd Halbleiterbauelement mit einem Aggregat von Mikro-Nadeln aus Halbleitermaterial
US5457041A (en) 1994-03-25 1995-10-10 Science Applications International Corporation Needle array and method of introducing biological substances into living cells using the needle array
US5591139A (en) * 1994-06-06 1997-01-07 The Regents Of The University Of California IC-processed microneedles
US5484720A (en) * 1994-09-08 1996-01-16 Genentech, Inc. Methods for calcium phosphate transfection
WO1996010630A1 (en) 1994-09-30 1996-04-11 Rutgers, The State University Direct introduction of foreign materials into cells
JP2697645B2 (ja) * 1994-10-31 1998-01-14 日本電気株式会社 半導体装置の製造方法
DE19525607A1 (de) * 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneales Arzneimittelfreigabesystem
GB9611437D0 (en) * 1995-08-03 1996-08-07 Secr Defence Biomaterial
US6284345B1 (en) * 1997-12-08 2001-09-04 Washington University Designer particles of micron and submicron dimension
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
GB9815819D0 (en) * 1998-07-22 1998-09-16 Secr Defence Transferring materials into cells and a microneedle array
GB0008494D0 (en) * 2000-04-07 2000-05-24 Secr Defence Microprojectile delivery system

Also Published As

Publication number Publication date
CA2337331C (en) 2012-08-28
NZ509142A (en) 2004-01-30
KR100633273B1 (ko) 2006-10-16
AU753542B2 (en) 2002-10-24
CA2337331A1 (en) 2000-02-03
ES2400472T3 (es) 2013-04-10
DK1098957T3 (da) 2003-01-06
US6770480B1 (en) 2004-08-03
US20040220535A1 (en) 2004-11-04
JP4585119B2 (ja) 2010-11-24
WO2000005339A1 (en) 2000-02-03
CN1310755A (zh) 2001-08-29
DE69902794T2 (de) 2003-08-07
EP1231259A2 (de) 2002-08-14
EP1098957A1 (de) 2001-05-16
AU5055499A (en) 2000-02-14
KR20010072050A (ko) 2001-07-31
CN1252275C (zh) 2006-04-19
ES2179666T3 (es) 2003-01-16
GB9815819D0 (en) 1998-09-16
JP2002521024A (ja) 2002-07-16
HK1039146B (zh) 2006-10-27
HK1039146A1 (en) 2002-04-12
DE69902794D1 (de) 2002-10-10
EP1231259A3 (de) 2003-11-19
EP1522578B1 (de) 2013-01-09
EP1522578A1 (de) 2005-04-13
US7332339B2 (en) 2008-02-19
EP1098957B1 (de) 2002-09-04

Similar Documents

Publication Publication Date Title
ATE223479T1 (de) Einbringen von materialien in zellen mittels porösem oder polykrystallinem silizium
DE69718327D1 (de) Graphitteilchen und lithiumsekundärzelle in denen dieselben als kathodematerial verwendet werden
AU3240602A (en) Dry powder cells and cell culture reagents and methods of production thereof
DE60142072D1 (de) Positivelektrodenmaterial und dieses enthaltende zelle
AU1592501A (en) Cell analysis and sorting apparatus for manipulation of cells
EP1302534A4 (de) Zellfraktion mit zellen welche in der lage sind sich in nervenzellen zu differenzieren
DE60000488D1 (de) Glaskeramik enthaltender Verbundelektrolyt und Lithium-Sekundärbatterie
NO983842D0 (no) Rimelig, stabilt luftelektrodemateriale for elektrokjemiske celler med elektrolytt av fast oksid
DE69926045D1 (de) Kohlenstoffhaltiges Material für Elektrode und nicht-wässerige Sekundärbatterie unter Verwendung dieses Materials
DE69819395D1 (de) Positivelektrodematerial für Verwendung in Nichtwässriger Elektrolyt enthaltende Batterie und Verfahren zur seiner Herstellung und Nichtwässriger Elektrolyt enthaltende Batterie
IL141308A0 (en) Methods, instruments and materials for chondrocyte cell transplantation
DE69838244D1 (de) Sekundärzelle mit nichtwässrigem elektrolyten und verfahren zur herstellung positiver aktiver materialien dafür
EP0485085A3 (en) Oxide modified air electrode surface for high temperature electrochemical cells
AU2142400A (en) Novel ion-conducting materials suitable for use in electrochemical applications and methods related thereto
DE69816266D1 (de) Prismatische aufladbare oder primäre Zelle mit steifem und zusammendrückendem Halter
DE69609766D1 (de) Material zur Verwendung in positiven Elektroden von Lithiumbatterien; dessen Herstellung und dieses Material enthaltende Lithiumbatterien
HUP0001937A2 (hu) Új vegyületek, eljárás előállításukra és alkalmazásuk nukleinsavak sejtekbe való bevitelére
ATE237186T1 (de) Verfahren zur durchführung elektrochemischer reaktionen mit einem elektrokatalysator
GB2306761B (en) Electrode materials suitable for electrochemical cells
IL139435A0 (en) Antibodies to dendritic cells and human dendritic cell populations and uses thereof
DE69837190D1 (de) Elektroden-Materialien zur Verwendung in Batterien,und Elektroden und Batterien, in denen diese verwendet werden
AU1215901A (en) Method of treating separator for use in electrochemical cell devices
ES2144626T3 (es) Uso de peptidos de adhesion celular para la modificacion del poder de adhesion de celulas eucarioticas entre si.
DE60022697D1 (de) Chinoxalinharz zur Verwendung als aktives Material in Batterie und Kapazitor
AU2275697A (en) Use of cell membrane permeants in the treatment of cellular proliferative disea ses

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1098957

Country of ref document: EP