ES2174968T3 - Preparacion de microcapsulas huecas. - Google Patents
Preparacion de microcapsulas huecas.Info
- Publication number
- ES2174968T3 ES2174968T3 ES95936688T ES95936688T ES2174968T3 ES 2174968 T3 ES2174968 T3 ES 2174968T3 ES 95936688 T ES95936688 T ES 95936688T ES 95936688 T ES95936688 T ES 95936688T ES 2174968 T3 ES2174968 T3 ES 2174968T3
- Authority
- ES
- Spain
- Prior art keywords
- solvent
- solution
- water
- microcapsules
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003094 microcapsule Substances 0.000 title abstract 3
- 239000002904 solvent Substances 0.000 abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 239000007788 liquid Substances 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 102000009027 Albumins Human genes 0.000 abstract 1
- 108010088751 Albumins Proteins 0.000 abstract 1
- 239000002872 contrast media Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000002604 ultrasonography Methods 0.000 abstract 1
- 230000008016 vaporization Effects 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
- B01J13/043—Drying and spraying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Acoustics & Sound (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Abstract
UN PROCESO DE ELABORACION DE MICROCAPSULAS QUE CONSISTE DE (I) APORTAR UNA SOLUCION DE UNA PROTEINA EN UN DISOLVENTE ACUOSO Y (II) VAPORIZAR DICHA SOLUCION PARA CONVERTIRLA EN UN GAS DE MODO QUE SE EVAPORE EL DISOLVENTE ACUOSO, FORMANDO ASI MICROCAPSULAS HUECAS, CARACTERIZADAS POR CONTENER LA SOLUCION ACUOSA UN LIQUIDO MAS VOLATIL QUE EL AGUA. LA PROTEINA ES PREFERIBLEMENTE ALBUMINA Y EL LIQUIDO VOLATIL ES PREFERIBLEMENTE ETANOL. LAS MICROCAPSULAS PUEDEN USARSE COMO AGENTES DE CONTRASTE ECOGENICOS DE ULTRASONIDO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9423419A GB9423419D0 (en) | 1994-11-19 | 1994-11-19 | Preparation of hollow microcapsules |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2174968T3 true ES2174968T3 (es) | 2002-11-16 |
Family
ID=10764705
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95936688T Expired - Lifetime ES2174968T3 (es) | 1994-11-19 | 1995-11-15 | Preparacion de microcapsulas huecas. |
Country Status (19)
Country | Link |
---|---|
US (2) | US5741478A (es) |
EP (1) | EP0743860B2 (es) |
JP (1) | JP4592831B2 (es) |
KR (1) | KR100188356B1 (es) |
CN (1) | CN1072966C (es) |
AT (1) | ATE216595T1 (es) |
AU (1) | AU681815B2 (es) |
CA (1) | CA2177492C (es) |
DE (1) | DE69526491T3 (es) |
DK (1) | DK0743860T3 (es) |
ES (1) | ES2174968T3 (es) |
GB (2) | GB9423419D0 (es) |
HK (1) | HK1013405A1 (es) |
NO (1) | NO313491B1 (es) |
PT (1) | PT743860E (es) |
RU (1) | RU2193397C2 (es) |
SG (1) | SG81230A1 (es) |
WO (1) | WO1996015814A1 (es) |
ZA (1) | ZA959801B (es) |
Families Citing this family (68)
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US5976501A (en) * | 1996-06-07 | 1999-11-02 | Molecular Biosystems, Inc. | Use of pressure resistant protein microspheres encapsulating gases as ultrasonic imaging agents for vascular perfusion |
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US5977313A (en) * | 1996-10-10 | 1999-11-02 | Quadrant Healthcare Limited | Platelet substitutes and conjugation methods suitable for their preparation |
EP0949932A1 (en) * | 1996-10-19 | 1999-10-20 | Quadrant Healthcare (UK) Limited | Use of hollow microcapsules in diagnosis and therapy |
PL332820A1 (en) * | 1996-10-21 | 1999-10-11 | Nycomed Imaging As | Improved contrast media |
US6068600A (en) * | 1996-12-06 | 2000-05-30 | Quadrant Healthcare (Uk) Limited | Use of hollow microcapsules |
US20030203036A1 (en) * | 2000-03-17 | 2003-10-30 | Gordon Marc S. | Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients |
GB9701274D0 (en) | 1997-01-22 | 1997-03-12 | Andaris Ltd | Ultrasound contrast imaging |
JP2002503254A (ja) | 1997-06-05 | 2002-01-29 | ヘモスフィア,インコーポレイテッド | フィブリノゲンをコーティングしたミクロスフィア |
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US20020017295A1 (en) * | 2000-07-07 | 2002-02-14 | Weers Jeffry G. | Phospholipid-based powders for inhalation |
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US8404217B2 (en) | 2000-05-10 | 2013-03-26 | Novartis Ag | Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use |
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US6797257B2 (en) * | 2001-06-26 | 2004-09-28 | The Board Of Trustees Of The University Of Illinois | Paramagnetic polymerized protein microspheres and methods of preparation thereof |
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SI1458360T1 (sl) | 2001-12-19 | 2011-08-31 | Novartis Ag | Pulmonalno dajanje aminoglikozidov |
GB0216562D0 (en) * | 2002-04-25 | 2002-08-28 | Bradford Particle Design Ltd | Particulate materials |
US9339459B2 (en) | 2003-04-24 | 2016-05-17 | Nektar Therapeutics | Particulate materials |
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US7985058B2 (en) * | 2007-01-12 | 2011-07-26 | Mark Gray | Method and apparatus for making uniformly sized particles |
WO2008136699A1 (fr) * | 2007-05-04 | 2008-11-13 | Igor Alexandrovich Bazikov | Patch transdermique à microcapsules et procédé de fabrication correspondant |
US9827205B2 (en) * | 2008-12-12 | 2017-11-28 | Mallinckrodt Pharma Ip Trading D.A.C. | Dry powder fibrin sealant |
CN102448443A (zh) | 2009-05-28 | 2012-05-09 | 普罗菲布瑞克斯公司 | 干粉纤维蛋白密封剂 |
GB0918450D0 (en) | 2009-10-21 | 2009-12-09 | Innovata Ltd | Composition |
JP6246712B2 (ja) | 2012-07-12 | 2017-12-13 | 武田薬品工業株式会社 | マイクロカプセル粉末の製造方法 |
CN104288793B (zh) * | 2014-10-31 | 2017-08-01 | 苏州大学 | 纳米超声/荧光双模态造影剂、其制备方法与应用 |
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CN111389315A (zh) * | 2020-03-27 | 2020-07-10 | 南京芬之怡生物科技有限公司 | 一种绿色除异净化剂及其制备方法 |
CN114265256B (zh) * | 2021-12-30 | 2023-04-28 | 广东志慧芯屏科技有限公司 | 一种电子纸显示设备的制造方法 |
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IL104084A (en) * | 1992-01-24 | 1996-09-12 | Bracco Int Bv | Sustainable aqueous suspensions of pressure-resistant and gas-filled blisters, their preparation, and contrast agents containing them |
US5674468A (en) | 1992-03-06 | 1997-10-07 | Nycomed Imaging As | Contrast agents comprising gas-containing or gas-generating polymer microparticles or microballoons |
ATE204750T1 (de) * | 1992-06-12 | 2001-09-15 | Teijin Ltd | Pharmazeutische zubereitung zur anwendung in den atemwegen |
ES2177544T3 (es) * | 1992-06-12 | 2002-12-16 | Teijin Ltd | Polvo ultrafinno para inhalar y metodo para su preparacion. |
GB9221329D0 (en) * | 1992-10-10 | 1992-11-25 | Delta Biotechnology Ltd | Preparation of further diagnostic agents |
DE59309257D1 (de) * | 1992-10-26 | 1999-02-11 | Sanol Arznei Schwarz Gmbh | Verfahren zur herstellung von mikrokapseln |
DK0693924T4 (da) * | 1993-02-22 | 2008-08-04 | Abraxis Bioscience Inc | Fremgangsmåde til (in vivo) levering af biologiske materialer og sammensætninger, der er egnede dertil |
ES2231775T5 (es) * | 1993-07-30 | 2011-02-02 | Imcor Pharmaceutical Co. | Composición de microburbujas estabilizadas para ecografía. |
GB9423419D0 (en) * | 1994-11-19 | 1995-01-11 | Andaris Ltd | Preparation of hollow microcapsules |
EP0796090B1 (en) * | 1994-12-16 | 2003-03-12 | Elan Drug Delivery Limited | Cross-linked microparticles and their use as therapeutic vehicles |
-
1994
- 1994-11-19 GB GB9423419A patent/GB9423419D0/en active Pending
-
1995
- 1995-11-15 CA CA002177492A patent/CA2177492C/en not_active Expired - Fee Related
- 1995-11-15 ES ES95936688T patent/ES2174968T3/es not_active Expired - Lifetime
- 1995-11-15 GB GB9610968A patent/GB2298628B/en not_active Expired - Fee Related
- 1995-11-15 WO PCT/GB1995/002673 patent/WO1996015814A1/en active IP Right Grant
- 1995-11-15 DK DK95936688T patent/DK0743860T3/da active
- 1995-11-15 JP JP51665396A patent/JP4592831B2/ja not_active Expired - Fee Related
- 1995-11-15 PT PT95936688T patent/PT743860E/pt unknown
- 1995-11-15 AT AT95936688T patent/ATE216595T1/de not_active IP Right Cessation
- 1995-11-15 SG SG9800856A patent/SG81230A1/en unknown
- 1995-11-15 KR KR1019960703464A patent/KR100188356B1/ko not_active IP Right Cessation
- 1995-11-15 RU RU96116133/14A patent/RU2193397C2/ru not_active IP Right Cessation
- 1995-11-15 EP EP95936688A patent/EP0743860B2/en not_active Expired - Lifetime
- 1995-11-15 DE DE69526491T patent/DE69526491T3/de not_active Expired - Lifetime
- 1995-11-15 AU AU38533/95A patent/AU681815B2/en not_active Ceased
- 1995-11-15 US US08/676,344 patent/US5741478A/en not_active Expired - Lifetime
- 1995-11-15 CN CN95191282A patent/CN1072966C/zh not_active Expired - Fee Related
- 1995-11-17 ZA ZA959801A patent/ZA959801B/xx unknown
-
1996
- 1996-07-18 NO NO19962994A patent/NO313491B1/no not_active IP Right Cessation
-
1998
- 1998-02-13 US US09/023,696 patent/US6623722B1/en not_active Expired - Fee Related
- 1998-12-22 HK HK98114794A patent/HK1013405A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
NO962994L (no) | 1996-07-18 |
DE69526491D1 (de) | 2002-05-29 |
PT743860E (pt) | 2002-10-31 |
DK0743860T3 (da) | 2002-08-12 |
DE69526491T2 (de) | 2002-10-31 |
GB2298628A (en) | 1996-09-11 |
US6623722B1 (en) | 2003-09-23 |
CA2177492C (en) | 2003-03-25 |
GB2298628B (en) | 1998-08-05 |
SG81230A1 (en) | 2001-06-19 |
NO962994D0 (no) | 1996-07-18 |
GB9610968D0 (en) | 1996-07-31 |
NO313491B1 (no) | 2002-10-14 |
AU681815B2 (en) | 1997-09-04 |
KR100188356B1 (ko) | 1999-06-01 |
GB9423419D0 (en) | 1995-01-11 |
HK1013405A1 (en) | 1999-08-27 |
WO1996015814A1 (en) | 1996-05-30 |
DE69526491T3 (de) | 2009-07-30 |
EP0743860A1 (en) | 1996-11-27 |
MX9602851A (es) | 1997-12-31 |
ATE216595T1 (de) | 2002-05-15 |
JPH09508067A (ja) | 1997-08-19 |
EP0743860B2 (en) | 2008-12-31 |
AU3853395A (en) | 1996-06-17 |
CN1138828A (zh) | 1996-12-25 |
JP4592831B2 (ja) | 2010-12-08 |
EP0743860B1 (en) | 2002-04-24 |
ZA959801B (en) | 1996-08-28 |
CA2177492A1 (en) | 1996-05-30 |
CN1072966C (zh) | 2001-10-17 |
US5741478A (en) | 1998-04-21 |
RU2193397C2 (ru) | 2002-11-27 |
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