ES2174968T3 - Preparacion de microcapsulas huecas. - Google Patents
Preparacion de microcapsulas huecas.Info
- Publication number
- ES2174968T3 ES2174968T3 ES95936688T ES95936688T ES2174968T3 ES 2174968 T3 ES2174968 T3 ES 2174968T3 ES 95936688 T ES95936688 T ES 95936688T ES 95936688 T ES95936688 T ES 95936688T ES 2174968 T3 ES2174968 T3 ES 2174968T3
- Authority
- ES
- Spain
- Prior art keywords
- solvent
- solution
- water
- microcapsules
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003094 microcapsule Substances 0.000 title abstract 3
- 239000002904 solvent Substances 0.000 abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 239000007788 liquid Substances 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 102000009027 Albumins Human genes 0.000 abstract 1
- 108010088751 Albumins Proteins 0.000 abstract 1
- 239000002872 contrast media Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000002604 ultrasonography Methods 0.000 abstract 1
- 230000008016 vaporization Effects 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
- B01J13/043—Drying and spraying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Acoustics & Sound (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Abstract
UN PROCESO DE ELABORACION DE MICROCAPSULAS QUE CONSISTE DE (I) APORTAR UNA SOLUCION DE UNA PROTEINA EN UN DISOLVENTE ACUOSO Y (II) VAPORIZAR DICHA SOLUCION PARA CONVERTIRLA EN UN GAS DE MODO QUE SE EVAPORE EL DISOLVENTE ACUOSO, FORMANDO ASI MICROCAPSULAS HUECAS, CARACTERIZADAS POR CONTENER LA SOLUCION ACUOSA UN LIQUIDO MAS VOLATIL QUE EL AGUA. LA PROTEINA ES PREFERIBLEMENTE ALBUMINA Y EL LIQUIDO VOLATIL ES PREFERIBLEMENTE ETANOL. LAS MICROCAPSULAS PUEDEN USARSE COMO AGENTES DE CONTRASTE ECOGENICOS DE ULTRASONIDO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9423419A GB9423419D0 (en) | 1994-11-19 | 1994-11-19 | Preparation of hollow microcapsules |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2174968T3 true ES2174968T3 (es) | 2002-11-16 |
Family
ID=10764705
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95936688T Expired - Lifetime ES2174968T3 (es) | 1994-11-19 | 1995-11-15 | Preparacion de microcapsulas huecas. |
Country Status (19)
Country | Link |
---|---|
US (2) | US5741478A (es) |
EP (1) | EP0743860B2 (es) |
JP (1) | JP4592831B2 (es) |
KR (1) | KR100188356B1 (es) |
CN (1) | CN1072966C (es) |
AT (1) | ATE216595T1 (es) |
AU (1) | AU681815B2 (es) |
CA (1) | CA2177492C (es) |
DE (1) | DE69526491T3 (es) |
DK (1) | DK0743860T3 (es) |
ES (1) | ES2174968T3 (es) |
GB (2) | GB9423419D0 (es) |
HK (1) | HK1013405A1 (es) |
NO (1) | NO313491B1 (es) |
PT (1) | PT743860E (es) |
RU (1) | RU2193397C2 (es) |
SG (1) | SG81230A1 (es) |
WO (1) | WO1996015814A1 (es) |
ZA (1) | ZA959801B (es) |
Families Citing this family (68)
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US6391343B1 (en) | 1991-01-15 | 2002-05-21 | Hemosphere, Inc. | Fibrinogen-coated particles for therapeutic use |
GB9107628D0 (en) | 1991-04-10 | 1991-05-29 | Moonbrook Limited | Preparation of diagnostic agents |
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US7425543B2 (en) * | 1992-11-16 | 2008-09-16 | The Corporation Of Mercer University | Microencapsulated materials and method of making same |
US6051256A (en) * | 1994-03-07 | 2000-04-18 | Inhale Therapeutic Systems | Dispersible macromolecule compositions and methods for their preparation and use |
GB9423419D0 (en) | 1994-11-19 | 1995-01-11 | Andaris Ltd | Preparation of hollow microcapsules |
GB9610830D0 (en) * | 1996-05-23 | 1996-07-31 | Andaris Ltd | Use of hollow microcapsules |
US5874064A (en) * | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
US5985309A (en) * | 1996-05-24 | 1999-11-16 | Massachusetts Institute Of Technology | Preparation of particles for inhalation |
US5976501A (en) * | 1996-06-07 | 1999-11-02 | Molecular Biosystems, Inc. | Use of pressure resistant protein microspheres encapsulating gases as ultrasonic imaging agents for vascular perfusion |
US6017310A (en) * | 1996-09-07 | 2000-01-25 | Andaris Limited | Use of hollow microcapsules |
US5977313A (en) * | 1996-10-10 | 1999-11-02 | Quadrant Healthcare Limited | Platelet substitutes and conjugation methods suitable for their preparation |
JP2002515887A (ja) * | 1996-10-19 | 2002-05-28 | クウォドラント、ヘルスケアー、(ユーケー)、リミテッド | 診断および治療における中空マイクロカプセルの使用 |
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US6068600A (en) * | 1996-12-06 | 2000-05-30 | Quadrant Healthcare (Uk) Limited | Use of hollow microcapsules |
US20030203036A1 (en) * | 2000-03-17 | 2003-10-30 | Gordon Marc S. | Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients |
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US20060165606A1 (en) | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
ATE239447T1 (de) * | 1997-09-29 | 2003-05-15 | Inhale Therapeutic Syst | In verneblern verwendbare, stabilisierte zubereitungen |
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US6309623B1 (en) | 1997-09-29 | 2001-10-30 | Inhale Therapeutic Systems, Inc. | Stabilized preparations for use in metered dose inhalers |
US6946117B1 (en) | 1997-09-29 | 2005-09-20 | Nektar Therapeutics | Stabilized preparations for use in nebulizers |
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US8404217B2 (en) | 2000-05-10 | 2013-03-26 | Novartis Ag | Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use |
EP1280520B2 (en) | 2000-05-10 | 2018-03-21 | Novartis AG | Phospholipid-based powders for drug delivery |
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DE10115740A1 (de) * | 2001-03-26 | 2002-10-02 | Ulrich Speck | Zubereitung für die Restenoseprophylaxe |
US6797257B2 (en) * | 2001-06-26 | 2004-09-28 | The Board Of Trustees Of The University Of Illinois | Paramagnetic polymerized protein microspheres and methods of preparation thereof |
GB0120123D0 (en) * | 2001-08-17 | 2001-10-10 | Upperton Ltd | Preparation of microparticles |
US8524279B2 (en) | 2001-11-01 | 2013-09-03 | Novartis Ag | Spray drying methods and related compositions |
US6753017B2 (en) * | 2001-11-07 | 2004-06-22 | Jrs Pharma Lp | Process for preparing dry extracts |
TWI324518B (en) | 2001-12-19 | 2010-05-11 | Nektar Therapeutics | Pulmonary delivery of aminoglycosides |
GB0216562D0 (en) * | 2002-04-25 | 2002-08-28 | Bradford Particle Design Ltd | Particulate materials |
US9339459B2 (en) | 2003-04-24 | 2016-05-17 | Nektar Therapeutics | Particulate materials |
DE10234165B4 (de) * | 2002-07-26 | 2008-01-03 | Advanced Micro Devices, Inc., Sunnyvale | Verfahren zum Füllen eines Grabens, der in einem Substrat gebildet ist, mit einem isolierenden Material |
US20040105821A1 (en) * | 2002-09-30 | 2004-06-03 | Howard Bernstein | Sustained release pharmaceutical formulation for inhalation |
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US7985058B2 (en) * | 2007-01-12 | 2011-07-26 | Mark Gray | Method and apparatus for making uniformly sized particles |
WO2008136699A1 (fr) * | 2007-05-04 | 2008-11-13 | Igor Alexandrovich Bazikov | Patch transdermique à microcapsules et procédé de fabrication correspondant |
US9827205B2 (en) * | 2008-12-12 | 2017-11-28 | Mallinckrodt Pharma Ip Trading D.A.C. | Dry powder fibrin sealant |
ES2593584T3 (es) | 2009-05-28 | 2016-12-09 | Profibrix Bv | Sellante de fibrina en polvo seco |
GB0918450D0 (en) | 2009-10-21 | 2009-12-09 | Innovata Ltd | Composition |
WO2014010614A1 (ja) | 2012-07-12 | 2014-01-16 | 武田薬品工業株式会社 | マイクロカプセル粉末の製造方法 |
CN104288793B (zh) * | 2014-10-31 | 2017-08-01 | 苏州大学 | 纳米超声/荧光双模态造影剂、其制备方法与应用 |
US10384185B2 (en) * | 2015-05-29 | 2019-08-20 | Givaudan S.A. | Spray drying |
CN111389315A (zh) * | 2020-03-27 | 2020-07-10 | 南京芬之怡生物科技有限公司 | 一种绿色除异净化剂及其制备方法 |
CN114265256B (zh) * | 2021-12-30 | 2023-04-28 | 广东志慧芯屏科技有限公司 | 一种电子纸显示设备的制造方法 |
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US5674468A (en) | 1992-03-06 | 1997-10-07 | Nycomed Imaging As | Contrast agents comprising gas-containing or gas-generating polymer microparticles or microballoons |
ES2177544T3 (es) * | 1992-06-12 | 2002-12-16 | Teijin Ltd | Polvo ultrafinno para inhalar y metodo para su preparacion. |
AU660824B2 (en) * | 1992-06-12 | 1995-07-06 | Teijin Limited | Pharmaceutical preparation for intra-airway administration |
GB9221329D0 (en) * | 1992-10-10 | 1992-11-25 | Delta Biotechnology Ltd | Preparation of further diagnostic agents |
ATE175132T1 (de) * | 1992-10-26 | 1999-01-15 | Sanol Arznei Schwarz Gmbh | Verfahren zur herstellung von mikrokapseln |
DK0693924T4 (da) * | 1993-02-22 | 2008-08-04 | Abraxis Bioscience Inc | Fremgangsmåde til (in vivo) levering af biologiske materialer og sammensætninger, der er egnede dertil |
PT711179E (pt) * | 1993-07-30 | 2005-03-31 | Imcor Pharmaceutical Company | Composicoes de microbolhas estabilizadas para ultra-som |
GB9423419D0 (en) * | 1994-11-19 | 1995-01-11 | Andaris Ltd | Preparation of hollow microcapsules |
EP0796090B1 (en) * | 1994-12-16 | 2003-03-12 | Elan Drug Delivery Limited | Cross-linked microparticles and their use as therapeutic vehicles |
-
1994
- 1994-11-19 GB GB9423419A patent/GB9423419D0/en active Pending
-
1995
- 1995-11-15 RU RU96116133/14A patent/RU2193397C2/ru not_active IP Right Cessation
- 1995-11-15 CA CA002177492A patent/CA2177492C/en not_active Expired - Fee Related
- 1995-11-15 US US08/676,344 patent/US5741478A/en not_active Expired - Lifetime
- 1995-11-15 GB GB9610968A patent/GB2298628B/en not_active Expired - Fee Related
- 1995-11-15 EP EP95936688A patent/EP0743860B2/en not_active Expired - Lifetime
- 1995-11-15 AU AU38533/95A patent/AU681815B2/en not_active Ceased
- 1995-11-15 JP JP51665396A patent/JP4592831B2/ja not_active Expired - Fee Related
- 1995-11-15 CN CN95191282A patent/CN1072966C/zh not_active Expired - Fee Related
- 1995-11-15 KR KR1019960703464A patent/KR100188356B1/ko not_active IP Right Cessation
- 1995-11-15 WO PCT/GB1995/002673 patent/WO1996015814A1/en active IP Right Grant
- 1995-11-15 ES ES95936688T patent/ES2174968T3/es not_active Expired - Lifetime
- 1995-11-15 SG SG9800856A patent/SG81230A1/en unknown
- 1995-11-15 DK DK95936688T patent/DK0743860T3/da active
- 1995-11-15 PT PT95936688T patent/PT743860E/pt unknown
- 1995-11-15 AT AT95936688T patent/ATE216595T1/de not_active IP Right Cessation
- 1995-11-15 DE DE69526491T patent/DE69526491T3/de not_active Expired - Lifetime
- 1995-11-17 ZA ZA959801A patent/ZA959801B/xx unknown
-
1996
- 1996-07-18 NO NO19962994A patent/NO313491B1/no not_active IP Right Cessation
-
1998
- 1998-02-13 US US09/023,696 patent/US6623722B1/en not_active Expired - Fee Related
- 1998-12-22 HK HK98114794A patent/HK1013405A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
GB9423419D0 (en) | 1995-01-11 |
HK1013405A1 (en) | 1999-08-27 |
SG81230A1 (en) | 2001-06-19 |
DE69526491D1 (de) | 2002-05-29 |
US6623722B1 (en) | 2003-09-23 |
RU2193397C2 (ru) | 2002-11-27 |
NO962994L (no) | 1996-07-18 |
ZA959801B (en) | 1996-08-28 |
EP0743860B1 (en) | 2002-04-24 |
NO313491B1 (no) | 2002-10-14 |
JPH09508067A (ja) | 1997-08-19 |
WO1996015814A1 (en) | 1996-05-30 |
CA2177492C (en) | 2003-03-25 |
ATE216595T1 (de) | 2002-05-15 |
AU681815B2 (en) | 1997-09-04 |
DE69526491T3 (de) | 2009-07-30 |
EP0743860A1 (en) | 1996-11-27 |
NO962994D0 (no) | 1996-07-18 |
CN1138828A (zh) | 1996-12-25 |
US5741478A (en) | 1998-04-21 |
CA2177492A1 (en) | 1996-05-30 |
KR100188356B1 (ko) | 1999-06-01 |
PT743860E (pt) | 2002-10-31 |
AU3853395A (en) | 1996-06-17 |
MX9602851A (es) | 1997-12-31 |
GB9610968D0 (en) | 1996-07-31 |
DE69526491T2 (de) | 2002-10-31 |
EP0743860B2 (en) | 2008-12-31 |
JP4592831B2 (ja) | 2010-12-08 |
GB2298628A (en) | 1996-09-11 |
DK0743860T3 (da) | 2002-08-12 |
CN1072966C (zh) | 2001-10-17 |
GB2298628B (en) | 1998-08-05 |
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