ES2162857T3 - Derivados fenilicos trisustituidos utilizados como inhibidores de fosfodiesterasa. - Google Patents

Derivados fenilicos trisustituidos utilizados como inhibidores de fosfodiesterasa.

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Publication number
ES2162857T3
ES2162857T3 ES94902931T ES94902931T ES2162857T3 ES 2162857 T3 ES2162857 T3 ES 2162857T3 ES 94902931 T ES94902931 T ES 94902931T ES 94902931 T ES94902931 T ES 94902931T ES 2162857 T3 ES2162857 T3 ES 2162857T3
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Spain
Prior art keywords
group
rent
hydrogen atom
optionally replaced
inhibitors
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Expired - Lifetime
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ES94902931T
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English (en)
Spanish (es)
Inventor
Graham John Warrellow
Ewan Campbell Boyd
Rikki Peter Alexander
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Celltech R&D Ltd
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Celltech R&D Ltd
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Priority claimed from GB929226831A external-priority patent/GB9226831D0/en
Priority claimed from GB939315966A external-priority patent/GB9315966D0/en
Application filed by Celltech R&D Ltd filed Critical Celltech R&D Ltd
Application granted granted Critical
Publication of ES2162857T3 publication Critical patent/ES2162857T3/es
Anticipated expiration legal-status Critical
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    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
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    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
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    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
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ES94902931T 1992-12-23 1993-12-22 Derivados fenilicos trisustituidos utilizados como inhibidores de fosfodiesterasa. Expired - Lifetime ES2162857T3 (es)

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PT626939E (pt) 2002-04-29
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DE69331095T2 (de) 2002-07-04
AU5709294A (en) 1994-07-19
JP3581713B2 (ja) 2004-10-27
HUT70559A (en) 1995-10-30
RU94044677A (ru) 1996-08-20
FI108031B (fi) 2001-11-15
PL304892A1 (en) 1995-01-09
DK0626939T3 (da) 2001-12-31
CZ291040B6 (cs) 2002-12-11
FI943856A0 (fi) 1994-08-22
NO943091D0 (no) 1994-08-22
TW263495B (en:Method) 1995-11-21
ATE208362T1 (de) 2001-11-15
IS1816B (is) 2002-07-08
CA2129039C (en) 2005-02-22
AU680224B2 (en) 1997-07-24
EP0626939B1 (en) 2001-11-07
HU211857A9 (en) 1995-12-28
CN1054603C (zh) 2000-07-19
NO304783B1 (no) 1999-02-15
PL178481B1 (pl) 2000-05-31
CZ203494A3 (en) 1994-12-15
GB2279075B (en) 1997-03-05
NZ258982A (en) 1997-02-24
FI943856A7 (fi) 1994-08-22
JPH07504442A (ja) 1995-05-18
MX9400175A (es) 1994-07-29
HU9402408D0 (en) 1994-10-28
GB2279075A (en) 1994-12-21
GB9416346D0 (en) 1994-10-05
CA2129039A1 (en) 1994-07-07
IL108132A0 (en) 1994-04-12
SA94140678B1 (ar) 2005-07-02
HU221451B (en) 2002-10-28
CN1092064A (zh) 1994-09-14
RU2188188C2 (ru) 2002-08-27
EP0626939A1 (en) 1994-12-07
IL108132A (en) 1999-06-20
DE69331095D1 (de) 2001-12-13
WO1994014742A1 (en) 1994-07-07

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