MX9207595A - Compuestos de tiazolidina, su preparacion y sus usos terapeuticos. - Google Patents

Compuestos de tiazolidina, su preparacion y sus usos terapeuticos.

Info

Publication number
MX9207595A
MX9207595A MX9207595A MX9207595A MX9207595A MX 9207595 A MX9207595 A MX 9207595A MX 9207595 A MX9207595 A MX 9207595A MX 9207595 A MX9207595 A MX 9207595A MX 9207595 A MX9207595 A MX 9207595A
Authority
MX
Mexico
Prior art keywords
alkyl
hydrogen
preparation
therapeutic uses
optionally substituted
Prior art date
Application number
MX9207595A
Other languages
English (en)
Inventor
Yuichi Aizawa
Kunio Wada
Takashi Fujita
Hiroyoshi Horikishi
Takao Yoshioka
Takahide Nishi
Tsumotu Kanai
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of MX9207595A publication Critical patent/MX9207595A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Los compuestos de la fórmula (I) en donde R1 es alquilo; R2 y R3 son cada uno alquilo o alcoxi, o R2 y R3 forman en conjunto un anillo de benceno opcionalmente substituido y, cuando R2 y R3 forman en conjunto dicho anillo de benceno, r1 es hidrógeno, halógeno o alquilo; R4 y R5 son hidrógeno, o R4 y R5 representan en conjunto una sola ligadura de carbono a carbono; Y1 y Y2 son cada uno hidrógeno, alquilo, acilo, o benzoilo opcionalmente substituido, o un grupo benzoilo, naftoilo, piridincarbonilo o quinolincarbonilo opcionalmente substituido; W es una sola ligadura o alquileno; y Z es hidrógeno o un catión tienen actividades terapéuticas y profilácticas valiosas, incluyendo actividades antidiabéticas.
MX9207595A 1991-12-26 1992-12-28 Compuestos de tiazolidina, su preparacion y sus usos terapeuticos. MX9207595A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP34457191 1991-12-26

Publications (1)

Publication Number Publication Date
MX9207595A true MX9207595A (es) 1994-06-30

Family

ID=18370304

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9207595A MX9207595A (es) 1991-12-26 1992-12-28 Compuestos de tiazolidina, su preparacion y sus usos terapeuticos.

Country Status (21)

Country Link
EP (1) EP0549365B1 (es)
JP (1) JP2833949B2 (es)
CN (1) CN1032751C (es)
AT (1) ATE126221T1 (es)
AU (1) AU654223B2 (es)
CA (1) CA2086277A1 (es)
CZ (1) CZ389792A3 (es)
DE (1) DE69204041T2 (es)
DK (1) DK0549365T3 (es)
ES (1) ES2078671T3 (es)
FI (1) FI925849A (es)
GR (1) GR3017632T3 (es)
HK (1) HK196095A (es)
HU (1) HU215450B (es)
IL (1) IL104238A (es)
MX (1) MX9207595A (es)
NO (1) NO302471B1 (es)
NZ (1) NZ245612A (es)
RU (1) RU2095354C1 (es)
TW (1) TW211007B (es)
ZA (1) ZA9210021B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO302519B1 (no) * 1991-12-26 1998-03-16 Sankyo Co Tiazolidinforbindelser som inneholder en kinongruppe, og farmasöytisk preparat
EP0783888A1 (en) * 1995-12-26 1997-07-16 Sankyo Company Limited Use of troglitazone and related thiazolidinediones in the manufacture of a medicament for the treatment and prophylaxis of osteoporosis
US6331633B1 (en) * 1998-05-08 2001-12-18 Calyx Therapeutics Inc. Heterocyclic analogs of diphenylethylene compounds
US6620830B2 (en) 2000-04-21 2003-09-16 Pfizer, Inc. Thyroid receptor ligands
EP1148054B1 (en) * 2000-04-21 2005-11-23 Pfizer Products Inc. Thyroid receptor ligands
WO2001081328A2 (en) * 2000-04-24 2001-11-01 Aryx Therapeutics Thiazolidinedione analogues and their use for the treatment of diabetes
US6768008B2 (en) 2000-04-24 2004-07-27 Aryx Therapeutics Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis
US6680387B2 (en) 2000-04-24 2004-01-20 Aryx Therapeutics Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis
JP2003040877A (ja) * 2001-07-24 2003-02-13 Sumika Fine Chemicals Co Ltd ５−［６−（２−フルオロベンジルオキシ）−２−ナフチル］メチル−２，４−チアゾリジンジオンの製造方法及びその精製方法
CN101454006B (zh) 2006-03-16 2012-12-26 新陈代谢解决方案开发公司 用于治疗高血压以及用于降低血脂的噻唑烷二酮类似物
CA2646207C (en) 2006-03-16 2016-01-19 Metabolic Solutions Development Company Thiazolidinedione analogues for the treatment of metabolic inflammation mediated disease
US8304441B2 (en) 2007-09-14 2012-11-06 Metabolic Solutions Development Company, Llc Thiazolidinedione analogues for the treatment of metabolic diseases
CA2699289C (en) * 2007-09-14 2016-01-19 Metabolic Solutions Development Company Thiazolidinedione analogues for the treatment of hypertension
US8912335B2 (en) 2009-12-15 2014-12-16 Metabolic Solutions Development Company, Llc PPAR-sparing thiazolidinedione salts for the treatment of metabolic diseases
WO2011133442A1 (en) * 2010-04-19 2011-10-27 Metabolic Solutions Development Company Novel synthesis for thiazolidinedione compounds
US20130281414A1 (en) * 2010-04-21 2013-10-24 Metabolic Solutions Development Company, Llc Thiazolidinedione analogues
EP2603498B1 (en) 2010-08-10 2016-11-09 Octeta Therapeutics, LLC Novel synthesis for thiazolidinedione compounds
CN115433144B (zh) * 2022-10-09 2023-09-19 燃点(南京)生物医药科技有限公司 一种脂肪酸酯类化合物及其制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5522636A (en) * 1978-08-04 1980-02-18 Takeda Chem Ind Ltd Thiazoliding derivative
JPS6051189A (ja) * 1983-08-30 1985-03-22 Sankyo Co Ltd チアゾリジン誘導体およびその製造法
JPH06779B2 (ja) * 1985-06-10 1994-01-05 武田薬品工業株式会社 チアゾリジオン誘導体およびそれを含んでなる医薬組成物
US5143930A (en) * 1990-02-07 1992-09-01 Sankyo Company, Limited Thiazolidine derivatives with anti-diabetic activity, their preparation and their use
NO302519B1 (no) * 1991-12-26 1998-03-16 Sankyo Co Tiazolidinforbindelser som inneholder en kinongruppe, og farmasöytisk preparat

Also Published As

Publication number Publication date
DK0549365T3 (da) 1995-12-18
DE69204041T2 (de) 1996-03-28
NZ245612A (en) 1994-06-27
AU3043192A (en) 1993-07-01
IL104238A (en) 1996-10-31
EP0549365B1 (en) 1995-08-09
EP0549365A1 (en) 1993-06-30
HU9204130D0 (en) 1993-04-28
NO924964D0 (no) 1992-12-22
RU2095354C1 (ru) 1997-11-10
ATE126221T1 (de) 1995-08-15
JPH05239041A (ja) 1993-09-17
AU654223B2 (en) 1994-10-27
ES2078671T3 (es) 1995-12-16
HU215450B (hu) 1999-04-28
FI925849A (fi) 1993-06-27
DE69204041D1 (de) 1995-09-14
FI925849A0 (fi) 1992-12-23
CZ389792A3 (en) 1994-01-19
JP2833949B2 (ja) 1998-12-09
NO924964L (no) 1993-06-28
TW211007B (es) 1993-08-11
NO302471B1 (no) 1998-03-09
HUT67788A (en) 1995-04-28
HK196095A (en) 1996-01-05
CN1032751C (zh) 1996-09-11
ZA9210021B (en) 1993-07-02
GR3017632T3 (en) 1996-01-31
CA2086277A1 (en) 1993-06-27
CN1074680A (zh) 1993-07-28

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Legal Events

Date Code Title Description
FG Grant or registration
MM Annulment or lapse due to non-payment of fees