ES2162188T3 - Procedimiento para la preparacion de derivados de imidazol, triazol y tetrazol y su uso como agonistas selectivos de receptores 5-ht-1. - Google Patents

Procedimiento para la preparacion de derivados de imidazol, triazol y tetrazol y su uso como agonistas selectivos de receptores 5-ht-1.

Info

Publication number
ES2162188T3
ES2162188T3 ES97200467T ES97200467T ES2162188T3 ES 2162188 T3 ES2162188 T3 ES 2162188T3 ES 97200467 T ES97200467 T ES 97200467T ES 97200467 T ES97200467 T ES 97200467T ES 2162188 T3 ES2162188 T3 ES 2162188T3
Authority
ES
Spain
Prior art keywords
sup
carbon
nitrogen
represent
sub
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97200467T
Other languages
English (en)
Inventor
Raymond Baker
Victor Matassa
Leslie J Street
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon Pharma UK Ltd
Original Assignee
Merck Sharp and Dohme Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27450619&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2162188(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB919102222A external-priority patent/GB9102222D0/en
Priority claimed from GB919106917A external-priority patent/GB9106917D0/en
Priority claimed from GB919113415A external-priority patent/GB9113415D0/en
Priority claimed from GB919122451A external-priority patent/GB9122451D0/en
Application filed by Merck Sharp and Dohme Ltd filed Critical Merck Sharp and Dohme Ltd
Application granted granted Critical
Publication of ES2162188T3 publication Critical patent/ES2162188T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epoxy Resins (AREA)
  • Paints Or Removers (AREA)
  • Lubricants (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Dental Preparations (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

UNA CLASE DE DERIVADOS DE IMIDAZOL, TRIAZOL Y TETRAZOL SUSTITUIDOS SON AGONISTAS SELECTIVOS DE RECEPTORES TIPO 5HT{SUB,1} Y POR TANTO SON UTILES EN EL TRATAMIENTO DE CONDICIONES CLINICAS, EN PARTICULAR MIGRAÑA Y TRASTORNOS ASOCIADOS, PARA LOS QUE SE INDICA UN AGONISTA SELECTIVO DE ESTOS RECEPTORES. EN DONDE EN CIRCULO DISCONTINUO REPRESENTA DOS ENLACES DOBLES NO ADYACENTES EN CUALQUIER POSICION EN EL ANILLO DE CINCO MIEMBROS; DOS, TRES O CUATRO DE V, W, X, Y Y Z REPRESENTAN NITROGENO Y EL RESTO REPRESENTA CARBONO CON TAL DE QUE, CUANDO DOS DE V, W, X, Y Y Z REPRESENTEN NITROGENO Y EL RESTO REPRESENTE CARBONO, ENTONCES LOS MENCIONADOS ATOMOS DE NITROGENO ESTEN EN POSICIONES NO ADYACENTES EN EL ANILLO DE CINCO MIEMBROS; A{SUP,1} REPRESENTA HIDROGENO, METILO, ETILO, BENCILO O AMINO; A{SUP,2} REPRESENTA UN PAR DE ELECTRON NO ENLAZADO CUANDO CUATRO DE V, W, X, Y Y Z REPRESENTAN NITROGENO Y EL OTRO REPRESENTA CARBONO; O, CUANDO DOS O TRES DE V, W, X, Y Y Z REPRESENTAN NITROGENO Y EL RESTO REPRESENTA CARBONO, A{SUP,2} REPRESENTA HIDROGENO, METILO, ETILO, BENCILO O AMINO; E REPRESENTA UN ENLACE O UNA CADENA DE ALQUILENO RECTA O RAMIFICADA QUE CONTIENE DE 1 A 4 ATOMOS DE CARBONO; F REPRESENTA UN GRUPO DE FORMULA U REPRESENTA NITROGENO O C-R{SUP,2}; B REPRESENTA OXIGENO, AZUFRE O N-R{SUP,3}; R{SUP,1} REPRESENTA -CH{SUB,2}.CHR{SUP,4}.NR{SUP,6}R{SUP,7} O UN GRUPO DE FORMULA EN LA QUE LA LINEA DISCONTINUA REPRESENTA UN ENLACE QUIMICO OPCIONAL; Y R{SUP,2}, R{SUP,3}, R{SUP,4}, R{SUP,5}, R{SUP,6} Y R{SUP,7} REPRESENTAN INDEPENDIENTEMENTE HIDROGENO O ALQUILO C{SUB,1-6}.
ES97200467T 1991-02-01 1992-01-24 Procedimiento para la preparacion de derivados de imidazol, triazol y tetrazol y su uso como agonistas selectivos de receptores 5-ht-1. Expired - Lifetime ES2162188T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB919102222A GB9102222D0 (en) 1991-02-01 1991-02-01 Therapeutic agents
GB919106917A GB9106917D0 (en) 1991-04-03 1991-04-03 Therapeutic agents
GB919113415A GB9113415D0 (en) 1991-06-21 1991-06-21 Therapeutic agents
GB919122451A GB9122451D0 (en) 1991-10-23 1991-10-23 Therapeutic agents

Publications (1)

Publication Number Publication Date
ES2162188T3 true ES2162188T3 (es) 2001-12-16

Family

ID=27450619

Family Applications (2)

Application Number Title Priority Date Filing Date
ES92300617T Expired - Lifetime ES2106822T3 (es) 1991-02-01 1992-01-24 Derivados de imidazol, triazol y tetrazol.
ES97200467T Expired - Lifetime ES2162188T3 (es) 1991-02-01 1992-01-24 Procedimiento para la preparacion de derivados de imidazol, triazol y tetrazol y su uso como agonistas selectivos de receptores 5-ht-1.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES92300617T Expired - Lifetime ES2106822T3 (es) 1991-02-01 1992-01-24 Derivados de imidazol, triazol y tetrazol.

Country Status (30)

Country Link
US (4) US5298520A (es)
EP (2) EP0778275B1 (es)
JP (1) JP2500280B2 (es)
KR (1) KR100212111B1 (es)
CN (4) CN1038681C (es)
AT (1) ATE158582T1 (es)
BG (1) BG62024B2 (es)
CA (2) CA2238140C (es)
CY (1) CY2095B1 (es)
CZ (1) CZ283018B6 (es)
DE (2) DE19975007I2 (es)
DK (1) DK0497512T3 (es)
ES (2) ES2106822T3 (es)
FI (1) FI107154B (es)
GR (2) GR3025026T3 (es)
HR (1) HRP930777B1 (es)
HU (2) HU222350B1 (es)
IE (1) IE920342A1 (es)
IL (1) IL100756A (es)
LU (1) LU90338I2 (es)
LV (1) LV12090B (es)
MX (1) MX9200405A (es)
NL (1) NL980019I1 (es)
NO (2) NO180447C (es)
NZ (1) NZ241394A (es)
SA (1) SA94140534B1 (es)
SG (1) SG50409A1 (es)
SI (1) SI9210101B (es)
SK (1) SK278998B6 (es)
YU (1) YU48236B (es)

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