ES2013664A6 - Un procedimiento para preparar derivados de nucleosidos de aciclopiramidina sustituidos en la posicion 6. - Google Patents

Un procedimiento para preparar derivados de nucleosidos de aciclopiramidina sustituidos en la posicion 6.

Info

Publication number
ES2013664A6
ES2013664A6 ES8901127A ES8901127A ES2013664A6 ES 2013664 A6 ES2013664 A6 ES 2013664A6 ES 8901127 A ES8901127 A ES 8901127A ES 8901127 A ES8901127 A ES 8901127A ES 2013664 A6 ES2013664 A6 ES 2013664A6
Authority
ES
Spain
Prior art keywords
group
acyclicpyrimidine
active ingredients
atom
antiviral agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES8901127A
Other languages
English (en)
Inventor
Tadashi Miyasaka
Hiromichi Tanaka
Clercq Eirk Desire A De
Masanori Baba
Richard Thomas Walker
Masaru Ubasawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Chemical Corp
Original Assignee
Mitsubishi Kasei Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Kasei Corp filed Critical Mitsubishi Kasei Corp
Publication of ES2013664A6 publication Critical patent/ES2013664A6/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE NUCLEOSIDOS DE ACICLOPIRIMIDINA SUSTITUIDOS EN LA POSICION 6 DE FORMULA GENERAL I: DONDE RBS1 REPRESENTA HIDROGENO, HALOGENO O UN GRUPO ORGANICO; RBS2 REPRESENTA UN GRUPO ORGANICO; RBS3 REPRESENTA UN GRUPO HIDROXIALQUILO EN EL QUE LA PORCION ALQUILO PUEDE CONTENER UN ATOMO DE OXIGENO; X REPRESENTA OXIGENO O AZUFRE O UN GRUPO AMINO; Y REPRESENTA OXIGENO O AZUFRE; Y A REPRESENTA =N- O -NH-. CONSISTE EN HACER REACCIONAR UN DERIVADO DE NUCLEOSIDO DE ACICLOPIRIMIDINA ADECUADO CON UN REACTIVO NUCLEOFILO, Y A CONTINUACION ELIMINAR LOS GRUPOS PROTECTORES. LOS COMPUESTOS DEL INVENTO SON UTILES COMO INGREDIENTES ACTIVOS DE MEDICAMENTOS ANTIVIRALES, PARTICULARMENTE ANTI-RETROVIRALES.
ES8901127A 1988-03-31 1989-03-31 Un procedimiento para preparar derivados de nucleosidos de aciclopiramidina sustituidos en la posicion 6. Expired - Lifetime ES2013664A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP7667788 1988-03-31

Publications (1)

Publication Number Publication Date
ES2013664A6 true ES2013664A6 (es) 1990-05-16

Family

ID=13612062

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8901127A Expired - Lifetime ES2013664A6 (es) 1988-03-31 1989-03-31 Un procedimiento para preparar derivados de nucleosidos de aciclopiramidina sustituidos en la posicion 6.

Country Status (12)

Country Link
US (1) US5112835A (es)
EP (1) EP0371139B1 (es)
KR (1) KR950006713B1 (es)
AT (1) ATE112767T1 (es)
CA (1) CA1334535C (es)
CH (1) CH676712A5 (es)
DD (1) DD283613A5 (es)
DE (1) DE68918804T2 (es)
ES (1) ES2013664A6 (es)
HU (1) HU206328B (es)
WO (1) WO1989009213A1 (es)
ZA (1) ZA892407B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU205917B (en) * 1989-09-29 1992-07-28 Mitsubishi Chem Ind Process for producing 6-substituted pyrimidine derivatives and antiviral pharmaceutical compositions containing them as active components
KR0155168B1 (ko) * 1989-09-29 1998-11-16 미우라 아끼라 6-치환된 아시클로피리미딘 뉴클레오시드 유도체 및 이를 활성성분으로 함유하는 항비루스제
USRE37979E1 (en) * 1989-09-29 2003-02-04 Mitsubishi Chemical Corporation Pyrimidine derivatives and anti-viral agent containing the same as active ingredient thereof
EP0449726B1 (en) * 1990-03-29 1997-06-11 Mitsubishi Chemical Corporation Pyrimidine nucleoside derivative and antiviral agent containing the derivative as active ingredient
JP3094036B2 (ja) * 1990-07-19 2000-10-03 ザ ウエルカム ファウンデーション リミテッド 酵素不活性化剤
GB9020930D0 (en) 1990-09-26 1990-11-07 Wellcome Found Pharmaceutical combinations
AU1994492A (en) * 1991-07-22 1993-02-23 Baker Cummins Pharmaceuticals, Inc. Acyclic 6-phenylselenenyl pyrimidine nucleosides
US5792868A (en) * 1991-09-18 1998-08-11 Ajinomoto Co., Inc. Process for producing acyclic nucleosides and process for separating purine nucleosides
US5476855A (en) * 1993-11-02 1995-12-19 Mahmoud H. el Kouni Enzyme inhibitors, their synthesis and methods for use
US6051576A (en) * 1994-01-28 2000-04-18 University Of Kentucky Research Foundation Means to achieve sustained release of synergistic drugs by conjugation
BR9408370A (pt) * 1994-02-28 1997-08-26 Sunkyong Ind Ltd Derivados aciclonucleosídeo de pirimidina
KR100219922B1 (ko) * 1996-05-16 1999-09-01 이서봉 신규한 항바이러스성 6-아릴옥시 및 6-아릴카르보닐 2,4-피리미딘디온 유도체 및 그의 제조 방법
US5998411A (en) * 1998-03-17 1999-12-07 Hughes Institute Heterocyclic nonnucleoside inhibitors of reverse transcriptase
UA70966C2 (uk) 1998-11-10 2004-11-15 Янссен Фармацевтика Н.В. Піримідини, що інгібують реплікацію віл
US6136335A (en) 1998-12-31 2000-10-24 Hughes Institute Phenethyl-5-bromopyridylthiourea (PBT) and dihydroalkoxybenzyloxopyrimidine (DABO) derivatives exhibiting spermicidal activity
OA12029A (en) * 1999-09-24 2006-04-28 Janssen Pharmaceutica Nv Antiviral compositions.
GB0400290D0 (en) * 2004-01-08 2004-02-11 Medivir Ab dUTPase inhibitors
EP2167476B1 (en) * 2007-06-29 2015-02-25 Korea Research Institute Of Chemical Technology Novel hiv reverse transcriptase inhibitors
KR20100041798A (ko) * 2007-06-29 2010-04-22 한국화학연구원 신규 ｈｉｖ 역전사효소 억제제
KR20100092960A (ko) * 2007-12-21 2010-08-23 한국화학연구원 Ｈｉｖ 역전사 효소 억제제의 제조 방법
HRPK20090508B3 (hr) 2009-09-25 2012-12-31 Sveučilište u Zagrebu Novi 6-supstituirani derivati pirimidina

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5434751B2 (es) * 1972-08-11 1979-10-29
US3947444A (en) * 1973-06-21 1976-03-30 Solomon Aronovich Giller Process for producing N1 -(Dihydroxyalkyl)-5-substituted uracils
JPS5032186A (es) * 1973-07-17 1975-03-28
JPS5188974A (es) * 1975-02-03 1976-08-04
JPS5738774A (en) * 1980-08-19 1982-03-03 Chugai Pharmaceut Co Ltd Uracil derivative and its preparation
US4347360A (en) * 1980-09-16 1982-08-31 Ens Bio Logicals Inc. Ring open nucleoside analogues
JP3245191B2 (ja) * 1991-07-30 2002-01-07 ヤマハ発動機株式会社 自動二輪車のメインスタンドロック装置
JPH05188974A (ja) * 1992-01-08 1993-07-30 Pioneer Electron Corp 多入力音量調整装置
JPH06156171A (ja) * 1992-11-18 1994-06-03 Mitsubishi Electric Corp 車載用レーダ装置

Also Published As

Publication number Publication date
AU3357589A (en) 1989-10-16
US5112835A (en) 1992-05-12
EP0371139A1 (en) 1990-06-06
KR900700463A (ko) 1990-08-13
EP0371139B1 (en) 1994-10-12
KR950006713B1 (ko) 1995-06-21
DD283613A5 (de) 1990-10-17
DE68918804D1 (de) 1994-11-17
ATE112767T1 (de) 1994-10-15
CA1334535C (en) 1995-02-21
CH676712A5 (es) 1991-02-28
ZA892407B (en) 1989-11-29
WO1989009213A1 (en) 1989-10-05
AU611284B2 (en) 1991-06-06
HU206328B (en) 1992-10-28
EP0371139A4 (en) 1991-08-28
DE68918804T2 (de) 1995-02-23

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Owner name: MITSUBISHI CHEMICAL CORPORATION