HRPK20090508B3 - Novi 6-supstituirani derivati pirimidina - Google Patents

Novi 6-supstituirani derivati pirimidina

Info

Publication number
HRPK20090508B3
HRPK20090508B3 HRP20090508AA HRP20090508A HRPK20090508B3 HR PK20090508 B3 HRPK20090508 B3 HR PK20090508B3 HR P20090508A A HRP20090508A A HR P20090508AA HR P20090508 A HRP20090508 A HR P20090508A HR PK20090508 B3 HRPK20090508 B3 HR PK20090508B3
Authority
HR
Croatia
Prior art keywords
chochph
come
general formula
pyrimidine derivatives
substituted pyrimidine
Prior art date
Application number
HRP20090508AA
Other languages
English (en)
Inventor
Silvana RAIĆ-MALIĆ
Tatjana Gazivoda
Svjetlana KRIŠTAFOR
Simon Mensah Ametamey
Original Assignee
Sveučilište u Zagrebu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sveučilište u Zagrebu filed Critical Sveučilište u Zagrebu
Priority to HRP20090508AA priority Critical patent/HRPK20090508B3/hr
Priority to PCT/HR2010/000033 priority patent/WO2011036505A1/en
Publication of HRP20090508A2 publication Critical patent/HRP20090508A2/hr
Publication of HRPK20090508B3 publication Critical patent/HRPK20090508B3/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Izum se odnosi na nove 6-supstituirane derivate pirimidina opće formule I:Ri Rnezavisno jedan od drugog mogu biti H, CHZ, CHOH, CHOCHPh, CHOCPhPhOCH; Z=Br, F, Cl;pri čemu kad je R= i kad je jedan od Ri RCHZ (Z = Br, F, Cl), tada RiRtvore sa CHA, A = Cl, Br, F supstituirani nezasićeni peteročlani prsten i uz uvjet da kad je Rili R= H, tada drugi od njih ne može biti H; iR= CHOCHPh; R= CHOCHPh; ipri čemu F, ma na kojem se mjestu u molekuli pojavio, može doći u obliku radio izotopaF; jedan od ugljika na bilo kojem mjestu u spoju opće formule I može doći u obliku radioizotopaC, kao što ijedan od kisika na bilo kojem mjestu u spoju opće formule I može doći u obliku radioizotopaO, kao i na njihovu upotrebu kao supstrata u pozitron-emisijskoj tomografiji kao i njihovu upotrebu u terapiji tumora.
HRP20090508AA 2009-09-25 2009-09-25 Novi 6-supstituirani derivati pirimidina HRPK20090508B3 (hr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
HRP20090508AA HRPK20090508B3 (hr) 2009-09-25 2009-09-25 Novi 6-supstituirani derivati pirimidina
PCT/HR2010/000033 WO2011036505A1 (en) 2009-09-25 2010-09-24 New 6-substituted pyrimidine derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HRP20090508AA HRPK20090508B3 (hr) 2009-09-25 2009-09-25 Novi 6-supstituirani derivati pirimidina

Publications (2)

Publication Number Publication Date
HRP20090508A2 HRP20090508A2 (hr) 2011-07-31
HRPK20090508B3 true HRPK20090508B3 (hr) 2012-12-31

Family

ID=43385684

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20090508AA HRPK20090508B3 (hr) 2009-09-25 2009-09-25 Novi 6-supstituirani derivati pirimidina

Country Status (2)

Country Link
HR (1) HRPK20090508B3 (hr)
WO (1) WO2011036505A1 (hr)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE68918804T2 (de) 1988-03-31 1995-02-23 Mitsubishi Chem Ind Acyclische 6-substituierte pyrimidin nukleosid-abkömmlinge und antivirale mittel, die dieselben als aktive mittel enthalten.
HU205917B (en) 1989-09-29 1992-07-28 Mitsubishi Chem Ind Process for producing 6-substituted pyrimidine derivatives and antiviral pharmaceutical compositions containing them as active components
JPH07507813A (ja) 1993-03-22 1995-08-31 ゼネラル・エレクトリック・カンパニイ ２−フルオロ−２−デオキシグルコースの製造方法

Also Published As

Publication number Publication date
WO2011036505A1 (en) 2011-03-31
HRP20090508A2 (hr) 2011-07-31

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Legal Events

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A1OB Publication of a patent application
AKOB Publication of a request for the grant of a patent not including a substantive examination of a patent application (a consensual patent)
PKB1 Consensual patent granted
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Payment date: 20180912

Year of fee payment: 10

PK10 Patent expired after termination of 10 years for consensual patent

Effective date: 20190925