YU48236B - Postupak za dobijanje derivata imidazola, triazola i tetrazola - Google Patents

Postupak za dobijanje derivata imidazola, triazola i tetrazola

Info

Publication number
YU48236B
YU48236B YU10192A YU10192A YU48236B YU 48236 B YU48236 B YU 48236B YU 10192 A YU10192 A YU 10192A YU 10192 A YU10192 A YU 10192A YU 48236 B YU48236 B YU 48236B
Authority
YU
Yugoslavia
Prior art keywords
represent
nitrogen
carbon
chem
hydrogen
Prior art date
Application number
YU10192A
Other languages
English (en)
Other versions
YU10192A (sh
Inventor
R. Baker
V. Matassa
L. Street
Original Assignee
Merck Sharp & Dohme Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27450619&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=YU48236(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB919102222A external-priority patent/GB9102222D0/en
Priority claimed from GB919106917A external-priority patent/GB9106917D0/en
Priority claimed from GB919113415A external-priority patent/GB9113415D0/en
Priority claimed from GB919122451A external-priority patent/GB9122451D0/en
Application filed by Merck Sharp & Dohme Limited filed Critical Merck Sharp & Dohme Limited
Priority to SI9210101A priority Critical patent/SI9210101B/sl
Priority to HR930777A priority patent/HRP930777B1/xx
Publication of YU10192A publication Critical patent/YU10192A/sh
Publication of YU48236B publication Critical patent/YU48236B/sh

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epoxy Resins (AREA)
  • Paints Or Removers (AREA)
  • Lubricants (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Dental Preparations (AREA)
  • Steroid Compounds (AREA)

Abstract

POSTUPAK ZA DOBIJANJE DERIVATA IMIDAZOLA, TRIAZOLA I TETRAZOLA formule i njihovih pogodnih soli: u kojoj isprekidani krug pretstavlja dve nesusedne dvogube veze u svakom polozaju peto-clanom prstenu; dva, tri ili cetiri od V, W,X,Y i Z pretstavljaju azot a ostali pretstavljaju ugljenik, pod uslovom da, kada dva od V,W, X, Y i Z pretstavljaju azot ostali pretstavljaju ugljenik, tada su atomi azota u nesusednim polozajima unutar peto-clanog prstena; A1 pretstavlja vodonik, ugljovodonik, heterociklicnu grupu, halogen, cijano, trifluormetil, -ORx, -SRx, -NRxRy, -NRxCORy, -NRxCO2Ry, -NRxSO2Ry, ili -NRzCTNRxRy; A2 pretstavlja nevezani elektronski par kada cetiri od V, W, X, Y i Z pretstavljaju azot a drugi pretstavlja ugljenik; ili, kada dva ili tri od V, W,X, Y i Z pretstavljaju azot i ostali pretstavljaju ugljenik, A2 pretstavlja vodonik, ugljovodonik, heterociklicnu grupu, halogen, cijano, trifluormetil, -ORx, -SRx, -NRxRy, -NRxCORy, -NRxCO2Ry, -NRxSO2Ry, ili -NRz- CTNRxRy; E pretstavlja vezu ili ravan ili racvast alkilenski lanac koji sadrzi do 1 do 4 ugljenikovih atoma; F pretstavlja grupu formule U pretstavlja azot ili C-R2; B pretstavlja kiseonik, sumpor ili N-R3; R1 pretstavlja -CH2CHR4.NR6R7 ili grupu formule u kojoj isprekidana linija pretstavlja po izboru hemijsku vezu; R2, R3, R4, R5, R6 i R7 nezavisno pretstavljaju vodonik ili C1-6 alkil; Rx i Ry nezavisno pretstavljaju vodonik, ugljovodonik ili heterociklicnu grupu, ili Rx i Ry zajedno pretstavljaju C2-6 alkilen grupu; Rz pretstavlja vodonik, ugljovodonik ili heterociklicnu grupu; T pretstavlja kiseonik, sumpor ili grupu formule =N.G; i G pretstavlja ugljovodonik, heterociklicnu grupu ili grupu koja odvlaci elektron, naznacen time, sto (A) reaktivni derivat karboksilne kiseline formule Ra-CO2H reaguje sa jedinjenjem ili formule III ili formule IV, ili sa solju istoga: gde je jedan od Ra, Rb i Rc grupe formule A1, drugi je grupa formule A2, i treci je grupa formule -E-F, kako je definisano gore; ili (B) reaguje jedinjenje formule XIV u kojoj su A1, E i F kako su definisani gore, Hal pretstavlja halogen, i dva od Va, Wa, Xa, Ya i Za, za koji je grupa Hal zakacena pretstavljaju ugljenik a ostali pretstavljaju azot; sa reagensom koji daje anjon A2, gde je A2 kako je definisano gore; ili (C) se vrsi ciklododavanje alkilene formule Ra-C C-Rb sa azidom formule Rc-N3, gde su Ra, Rb i Rc kako su definisani gore; ili (D) se vrsi ciklododavanje nitrila formule N C-Rd sa azidom formule Rc-N3, gde jedan od Rd i Re pretstavlja grupu formule A1 a drugi je grupa formule -E-F, kako je definisano gore; ili (E) jedinjenje formule Re-L reaguje sa derivatom tetrazola formule XV: u kojoj jedan od Rd i Re pretstavlja grupu formule A1 a drugi je grupa formule -E-F, kako je definisano gore, i L pretstavlja podesnu grupu koja se odvaja; u prisustvu baze; ili (F) vrsi ciklododavanje nitrila formule N C-E-F, u kojoj su E i F kako su definisani gore, sa natrijum azidom, zatim se vrsi zakiseljavanje sa mineralnom kise
YU10192A 1991-02-01 1992-01-30 Postupak za dobijanje derivata imidazola, triazola i tetrazola YU48236B (sh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
SI9210101A SI9210101B (en) 1991-02-01 1992-01-30 Imidazole,triazole and tetrazole derivates.
HR930777A HRP930777B1 (en) 1991-02-01 1993-04-02 Imidazole, triazole and tetrazole derivatives

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB919102222A GB9102222D0 (en) 1991-02-01 1991-02-01 Therapeutic agents
GB919106917A GB9106917D0 (en) 1991-04-03 1991-04-03 Therapeutic agents
GB919113415A GB9113415D0 (en) 1991-06-21 1991-06-21 Therapeutic agents
GB919122451A GB9122451D0 (en) 1991-10-23 1991-10-23 Therapeutic agents

Publications (2)

Publication Number Publication Date
YU10192A YU10192A (sh) 1995-03-27
YU48236B true YU48236B (sh) 1997-08-22

Family

ID=27450619

Family Applications (1)

Application Number Title Priority Date Filing Date
YU10192A YU48236B (sh) 1991-02-01 1992-01-30 Postupak za dobijanje derivata imidazola, triazola i tetrazola

Country Status (30)

Country Link
US (4) US5298520A (sh)
EP (2) EP0778275B1 (sh)
JP (1) JP2500280B2 (sh)
KR (1) KR100212111B1 (sh)
CN (4) CN1038681C (sh)
AT (1) ATE158582T1 (sh)
BG (1) BG62024B2 (sh)
CA (2) CA2238140C (sh)
CY (1) CY2095B1 (sh)
CZ (1) CZ283018B6 (sh)
DE (2) DE69222329T2 (sh)
DK (1) DK0497512T3 (sh)
ES (2) ES2106822T3 (sh)
FI (1) FI107154B (sh)
GR (2) GR3025026T3 (sh)
HR (1) HRP930777B1 (sh)
HU (2) HU222350B1 (sh)
IE (1) IE920342A1 (sh)
IL (1) IL100756A (sh)
LU (1) LU90338I2 (sh)
LV (1) LV12090B (sh)
MX (1) MX9200405A (sh)
NL (1) NL980019I1 (sh)
NO (2) NO180447C (sh)
NZ (1) NZ241394A (sh)
SA (1) SA94140534B1 (sh)
SG (1) SG50409A1 (sh)
SI (1) SI9210101B (sh)
SK (1) SK278998B6 (sh)
YU (1) YU48236B (sh)

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