ES2129847T3 - Complejos cationicos trinucleares de platino que tienen actividad antitumoral y composiciones farmaceuticas que los contienen. - Google Patents

Complejos cationicos trinucleares de platino que tienen actividad antitumoral y composiciones farmaceuticas que los contienen.

Info

Publication number
ES2129847T3
ES2129847T3 ES95930319T ES95930319T ES2129847T3 ES 2129847 T3 ES2129847 T3 ES 2129847T3 ES 95930319 T ES95930319 T ES 95930319T ES 95930319 T ES95930319 T ES 95930319T ES 2129847 T3 ES2129847 T3 ES 2129847T3
Authority
ES
Spain
Prior art keywords
contain
pharmaceutical compositions
platinum complexes
antitumoral activity
cationic platinum
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95930319T
Other languages
English (en)
Inventor
Mariella Valsecchi
Marco Conti
Greco Luisa Del
Carlo Bugatti
Ernesto Menta
Ferdinando C Giuliani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2129847T3 publication Critical patent/ES2129847T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

COMPUESTOS DE FORMULA GENERAL(I) EN DONDE: N ES UN ENTERO DESDE 2 HASTA 7 INCLUIDO; Z{SUP,-M} ES UN ANION SELECCIONADO A PARTIR DE CLORURO, BROMURO, YODURO, NITRATO, SULFATO; M ES UN ENTERO 1 O 2.DICHOS COMPUESTOS TIENEN ACTIVIDAD ANTITUMORAL.
ES95930319T 1994-03-31 1995-03-22 Complejos cationicos trinucleares de platino que tienen actividad antitumoral y composiciones farmaceuticas que los contienen. Expired - Lifetime ES2129847T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI940610A IT1273391B (it) 1994-03-31 1994-03-31 Platino complessi cationici trinucleari ad attivita' antitumorale e composizioni farmaceutiche che li contengono

Publications (1)

Publication Number Publication Date
ES2129847T3 true ES2129847T3 (es) 1999-06-16

Family

ID=11368427

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95930319T Expired - Lifetime ES2129847T3 (es) 1994-03-31 1995-03-22 Complejos cationicos trinucleares de platino que tienen actividad antitumoral y composiciones farmaceuticas que los contienen.

Country Status (21)

Country Link
US (1) US5744497A (es)
EP (1) EP0753000B1 (es)
JP (1) JP2761297B2 (es)
KR (1) KR100239787B1 (es)
CN (1) CN1065537C (es)
AT (1) ATE176478T1 (es)
AU (1) AU682105B2 (es)
CA (1) CA2186731C (es)
CZ (1) CZ286404B6 (es)
DE (1) DE69507694T2 (es)
DK (1) DK0753000T3 (es)
ES (1) ES2129847T3 (es)
FI (1) FI116058B (es)
GR (1) GR3030048T3 (es)
HU (1) HU215129B (es)
IT (1) IT1273391B (es)
NO (1) NO308078B1 (es)
NZ (1) NZ283143A (es)
RU (1) RU2130941C1 (es)
WO (1) WO1995026968A1 (es)
ZA (1) ZA952636B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5380897A (en) * 1993-05-25 1995-01-10 Hoeschele; James D. Tri(platinum) complexes
IT1271089B (it) * 1994-11-24 1997-05-26 Boehringer Mannheim Italia Platino complessi cationici trinucleari ad attivita' antitumorale
ZA976422B (en) * 1996-07-22 1998-01-22 Boehringer Mannheim Italia New bis-platinum complexes with polymethylene derivatives as ligands having antitumor activity.
ZA976421B (en) * 1996-07-22 1998-01-22 Boehringer Mannheim Italia New bis-platinum complexes with polyamine ligands as antitumor agents.
IT1292481B1 (it) 1997-07-04 1999-02-08 Boehringer Mannheim Italia Platino complessi cationici tetra- e penta-nucleari ad attivita' antitumorale
KR100314720B1 (ko) * 1999-03-26 2001-11-26 박호군 포스파젠 삼합체에 도입된 백금 착물, 그의 제조방법 및 그를 유효성분으로 하는 항암제
EP1215199A1 (en) * 2000-12-08 2002-06-19 Sony International (Europe) GmbH Linker molecules for selective metallisation of nucleic acids and their uses
JP4007000B2 (ja) * 2001-12-25 2007-11-14 富士ゼロックス株式会社 導電性有機高分子
US7138520B2 (en) * 2003-01-13 2006-11-21 Massachusetts Institute Of Technology Coordination complexes having tethered therapeutic agents and/or targeting moieties, and methods of making and using the same
WO2006090931A1 (ja) * 2005-02-28 2006-08-31 Eisai R & D Management Co., Ltd. スルホンアミド化合物の抗癌剤との新規併用
CN102516315B (zh) * 2011-12-12 2014-12-10 中山大学 一种具有y型结构的三核铂配合物及其对人胃腺癌细胞的靶向性
RU2613513C2 (ru) * 2015-07-17 2017-03-16 Федеральное государственное бюджетное учреждение науки Институт проблем химической физики Российской академии наук (ИПХФ РАН) Способ получения комплексов платины (IV) с аминонитроксильными радикалами
RU2726826C2 (ru) * 2016-12-27 2020-07-15 Общество с ограниченной ответственностью "Плат-АН" (ООО "Плат-АН") Композиция на основе аминонитроксильного комплекса платины и доксорубицина и способ лечения опухолей
CN109988185B (zh) * 2019-05-09 2021-03-19 邵阳学院 具有抗肿瘤选择性的铂镝杂金属化合物及其制备方法
CN112745426B (zh) * 2019-10-31 2022-03-01 中国石油化工股份有限公司 用于制备烯烃-烯烃醇共聚物的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5107007A (en) * 1989-09-01 1992-04-21 The University Of Vermont And State Agricultural College Bis-platinum complexes as chemotherapeutic agents
US5049686A (en) * 1989-09-13 1991-09-17 Warner-Lambert Company Novel large-ring diamine platinum(II) and platinum(IV) chelates
GB9105037D0 (en) * 1991-03-09 1991-04-24 Johnson Matthey Plc Improvements in chemical compounds
US5380897A (en) * 1993-05-25 1995-01-10 Hoeschele; James D. Tri(platinum) complexes

Also Published As

Publication number Publication date
JP2761297B2 (ja) 1998-06-04
CN1065537C (zh) 2001-05-09
ATE176478T1 (de) 1999-02-15
AU2110995A (en) 1995-10-23
ITMI940610A1 (it) 1995-10-01
AU682105B2 (en) 1997-09-18
ZA952636B (en) 1996-01-02
CN1145624A (zh) 1997-03-19
FI963859A (fi) 1996-09-27
FI116058B (fi) 2005-09-15
HU215129B (hu) 1998-09-28
DK0753000T3 (da) 1999-09-20
DE69507694T2 (de) 1999-07-22
NO963926D0 (no) 1996-09-19
NO308078B1 (no) 2000-07-17
DE69507694D1 (de) 1999-03-18
NZ283143A (en) 1997-09-22
EP0753000A1 (en) 1997-01-15
CA2186731A1 (en) 1995-10-12
CZ284996A3 (en) 1997-04-16
HUT76293A (en) 1997-07-28
KR100239787B1 (ko) 2000-02-01
CA2186731C (en) 2005-06-07
CZ286404B6 (en) 2000-04-12
IT1273391B (it) 1997-07-08
JPH09506633A (ja) 1997-06-30
NO963926L (no) 1996-09-19
US5744497A (en) 1998-04-28
FI963859A0 (fi) 1996-09-27
KR970702287A (ko) 1997-05-13
RU2130941C1 (ru) 1999-05-27
GR3030048T3 (en) 1999-07-30
HU9602663D0 (en) 1996-11-28
ITMI940610A0 (it) 1994-03-31
EP0753000B1 (en) 1999-02-03
WO1995026968A1 (en) 1995-10-12

Similar Documents

Publication Publication Date Title
ES2129847T3 (es) Complejos cationicos trinucleares de platino que tienen actividad antitumoral y composiciones farmaceuticas que los contienen.
IL127352A (en) Pyridyl alkene- and pyridyl alkine-acid amides and pharmaceutical compositions containing them
TR200001973T2 (tr) 11 ß-halojen-7alfa-ile ikame edilmiş-estratrienler, bu 11ß-halojen-7alfa-ile ikame edilmiş-estratrienleri içeren farmasötik terkiplerin üretimi için yöntem ve ilaç üretiminde kullanımları.
GEP20002188B (en) (54) Taxoids, Preparation Thereof and Pharmaceutical Compositions Containing Same
ES2104090T3 (es) Nuevas 3',5'-di-t-butil-4'-hidroxi-flavonas, su procedimiento de preparacion y composiciones farmaceuticas que las contienen.
ES2039220T3 (es) Procedimiento para preparar complejos de cis-platino.
CA2323150A1 (en) New porphyrins and their use
ES476626A2 (es) Procedimiento para la preparacion de compuestos imidazoliniocuaternarios
IL114833A (en) Anthracyclinone derivatives for use as medicaments or for the manufacture of a medicament and pharmaceutical compositions comprising said derivatives for the treatment of amyloidosis, some such derivatives and processes for their preparation
MX9601635A (es) Derivados de antraciclina.
IL89501A0 (en) Platinum derivatives,pharmaceutical compositions containing the same and a process for the preparation thereof
IT1271089B (it) Platino complessi cationici trinucleari ad attivita' antitumorale
MY105589A (en) Sulfonyl derivatives of thieno-triazolo- diazepines, a preparation process of the same and therapeutic compositions containing them.
MX9604390A (es) Complejos de platino cationico trinucleares con actividad antitumoral y composiciones farmaceuticas que los contienen.
TW377355B (en) Trinuclear cationic platinum complexes having antitumor activity and pharmaceutical compositions containing them
WO1987007609A1 (en) 1,1,2-triaryl-1-butene derivatives
CA2200598A1 (en) Novel Anti-Oxidative, Tricyclic, Condensed Heterocyclic Compound
HUT41022A (en) Process for preparing 2-halogen-6-methyl-ergol-9-ene derivatives and acid additional salts thereof
DE69324476D1 (de) Neue Morphinzusammensetzungen für iontophoretische Verabreichung
KR960022546A (ko) 신규 백금 착화합물 및 이를 함유하는 악성 종양치료제
KR850007379A (ko) 뇌 조영(照影) 방사성 약제
GB2006213A (en) Platinum-amine complexes
ES8304106A1 (es) Un procedimiento para la preparacion de anilidas substitui- das
JPS5673004A (en) Fungicide for agriculture and horticulture containing ene-yne compound as effective component

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 753000

Country of ref document: ES