IT1271089B - Platino complessi cationici trinucleari ad attivita' antitumorale - Google Patents

Platino complessi cationici trinucleari ad attivita' antitumorale

Info

Publication number
IT1271089B
IT1271089B ITMI942383A ITMI942383A IT1271089B IT 1271089 B IT1271089 B IT 1271089B IT MI942383 A ITMI942383 A IT MI942383A IT MI942383 A ITMI942383 A IT MI942383A IT 1271089 B IT1271089 B IT 1271089B
Authority
IT
Italy
Prior art keywords
platinum
tumor activity
cationic complexes
trinuclear
trinuclear cationic
Prior art date
Application number
ITMI942383A
Other languages
English (en)
Inventor
Paolo Pavesi
Ernesto Menta
Carla Manzotti
Silvano Spinelli
Original Assignee
Boehringer Mannheim Italia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Italia filed Critical Boehringer Mannheim Italia
Publication of ITMI942383A0 publication Critical patent/ITMI942383A0/it
Priority to ITMI942383A priority Critical patent/IT1271089B/it
Priority to US08/836,667 priority patent/US6011166A/en
Priority to EP95937069A priority patent/EP0793667B1/en
Priority to DE69521810T priority patent/DE69521810T2/de
Priority to PT95937069T priority patent/PT793667E/pt
Priority to JP8516524A priority patent/JPH10509159A/ja
Priority to PCT/EP1995/004455 priority patent/WO1996016068A1/en
Priority to DK95937069T priority patent/DK0793667T3/da
Priority to ES95937069T priority patent/ES2161913T3/es
Priority to CA002205868A priority patent/CA2205868C/en
Priority to AU39286/95A priority patent/AU3928695A/en
Priority to AT95937069T priority patent/ATE203244T1/de
Priority to ZA959986A priority patent/ZA959986B/xx
Publication of ITMI942383A1 publication Critical patent/ITMI942383A1/it
Application granted granted Critical
Publication of IT1271089B publication Critical patent/IT1271089B/it
Priority to GR20010401793T priority patent/GR3036926T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

Si descrivono tri-platino complessi di formula (1): (FORMULA I) dove n è un intero da 2 a 7;z-m è un alogenuro (cloruro, bromuro, ioduro; m = 1), un anione nitrato (m = 1) o un anione solfato (m = 2).
ITMI942383A 1994-11-24 1994-11-24 Platino complessi cationici trinucleari ad attivita' antitumorale IT1271089B (it)

Priority Applications (14)

Application Number Priority Date Filing Date Title
ITMI942383A IT1271089B (it) 1994-11-24 1994-11-24 Platino complessi cationici trinucleari ad attivita' antitumorale
PCT/EP1995/004455 WO1996016068A1 (en) 1994-11-24 1995-11-13 Trinuclear cationic platinum complexes having antitumour activity and pharmaceutical compositions containing them
ES95937069T ES2161913T3 (es) 1994-11-24 1995-11-13 Complejos cationicos trinucleares de platino que tienen una actividad antitumoral y composiciones farmaceuticas que los contienen.
DE69521810T DE69521810T2 (de) 1994-11-24 1995-11-13 Dreikernige kationische platinkomplexe mit antitumor wirkung, und diese enthaltende arzneizusammensetzungen
PT95937069T PT793667E (pt) 1994-11-24 1995-11-13 Complexos trinucleares platina cationica com actividade antitumor e composicoes farmaceuticas que os contem
JP8516524A JPH10509159A (ja) 1994-11-24 1995-11-13 抗腫瘍活性を有する三核性カチオン性プラチナ錯体、及びそれらを含有する医薬組成物
US08/836,667 US6011166A (en) 1994-11-24 1995-11-13 Trinuclear cationic platinum complexes having antitumor activity and pharmaceutial compositions containing them
DK95937069T DK0793667T3 (da) 1994-11-24 1995-11-13 Trinukleare kationiske platinkomplekser med antitumoraktivitet og farmaceutiske præparater indeholdende disse
EP95937069A EP0793667B1 (en) 1994-11-24 1995-11-13 Trinuclear cationic platinum complexes having antitumour activity and pharmaceutical compositions containing them
CA002205868A CA2205868C (en) 1994-11-24 1995-11-13 Trinuclear cationic platinum complexes having antitumour activity and pharmaceutical compositions containing them
AU39286/95A AU3928695A (en) 1994-11-24 1995-11-13 Trinuclear cationic platinum complexes having antitumour activity and pharmaceutical compositions containing them
AT95937069T ATE203244T1 (de) 1994-11-24 1995-11-13 Dreikernige kationische platinkomplexe mit antitumor wirkung, und diese enthaltende arzneizusammensetzungen
ZA959986A ZA959986B (en) 1994-11-24 1995-11-23 Trinuclear cationic platinum complexes having antitumour activity and pharmaceutical compositions containing them
GR20010401793T GR3036926T3 (en) 1994-11-24 2001-10-18 Trinuclear cationic platinum complexes having antitumour activity and pharmaceutical compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI942383A IT1271089B (it) 1994-11-24 1994-11-24 Platino complessi cationici trinucleari ad attivita' antitumorale

Publications (3)

Publication Number Publication Date
ITMI942383A0 ITMI942383A0 (it) 1994-11-24
ITMI942383A1 ITMI942383A1 (it) 1996-05-24
IT1271089B true IT1271089B (it) 1997-05-26

Family

ID=11369905

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI942383A IT1271089B (it) 1994-11-24 1994-11-24 Platino complessi cationici trinucleari ad attivita' antitumorale

Country Status (14)

Country Link
US (1) US6011166A (it)
EP (1) EP0793667B1 (it)
JP (1) JPH10509159A (it)
AT (1) ATE203244T1 (it)
AU (1) AU3928695A (it)
CA (1) CA2205868C (it)
DE (1) DE69521810T2 (it)
DK (1) DK0793667T3 (it)
ES (1) ES2161913T3 (it)
GR (1) GR3036926T3 (it)
IT (1) IT1271089B (it)
PT (1) PT793667E (it)
WO (1) WO1996016068A1 (it)
ZA (1) ZA959986B (it)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1292481B1 (it) 1997-07-04 1999-02-08 Boehringer Mannheim Italia Platino complessi cationici tetra- e penta-nucleari ad attivita' antitumorale
AU2003251955A1 (en) * 2002-07-16 2004-02-02 Sonus Pharmaceuticals, Inc. Platinum compound
US7138520B2 (en) * 2003-01-13 2006-11-21 Massachusetts Institute Of Technology Coordination complexes having tethered therapeutic agents and/or targeting moieties, and methods of making and using the same
US6963002B2 (en) 2003-07-04 2005-11-08 Glenmark Pharmaceuticals Limited Process for the preparation of 4,4-dimethyl-6-ethynylthiochroman
CA2560059A1 (en) 2004-03-15 2005-09-29 Sonus Pharmaceuticals, Inc. Platinum carboxylate anticancer compounds
US7611733B2 (en) * 2004-03-26 2009-11-03 Cell Therapeutics Europe S.R.L. Nanoparticle formulations of platinum compounds
JP5327751B2 (ja) 2008-01-16 2013-10-30 天真堂製薬株式会社 白金錯体化合物およびその利用
CN102516315B (zh) * 2011-12-12 2014-12-10 中山大学 一种具有y型结构的三核铂配合物及其对人胃腺癌细胞的靶向性

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5380897A (en) * 1993-05-25 1995-01-10 Hoeschele; James D. Tri(platinum) complexes
IT1273391B (it) * 1994-03-31 1997-07-08 Boehringer Mannheim Italia Platino complessi cationici trinucleari ad attivita' antitumorale e composizioni farmaceutiche che li contengono

Also Published As

Publication number Publication date
EP0793667B1 (en) 2001-07-18
DE69521810T2 (de) 2002-04-04
DE69521810D1 (de) 2001-08-23
CA2205868A1 (en) 1996-05-30
JPH10509159A (ja) 1998-09-08
ITMI942383A0 (it) 1994-11-24
US6011166A (en) 2000-01-04
AU3928695A (en) 1996-06-17
ES2161913T3 (es) 2001-12-16
PT793667E (pt) 2001-12-28
WO1996016068A1 (en) 1996-05-30
ZA959986B (en) 1996-06-10
ATE203244T1 (de) 2001-08-15
CA2205868C (en) 2007-03-20
DK0793667T3 (da) 2001-10-22
ITMI942383A1 (it) 1996-05-24
GR3036926T3 (en) 2002-01-31
EP0793667A1 (en) 1997-09-10

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19971129