ES2107546T3 - Procedimiento para la preparacion de desmetilepipodofilotoxina. - Google Patents

Procedimiento para la preparacion de desmetilepipodofilotoxina.

Info

Publication number
ES2107546T3
ES2107546T3 ES92915482T ES92915482T ES2107546T3 ES 2107546 T3 ES2107546 T3 ES 2107546T3 ES 92915482 T ES92915482 T ES 92915482T ES 92915482 T ES92915482 T ES 92915482T ES 2107546 T3 ES2107546 T3 ES 2107546T3
Authority
ES
Spain
Prior art keywords
group
formula
haloacetil
alcanoyl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92915482T
Other languages
English (en)
Inventor
Pietro Allevi
Mario Anastasia
Ettore Bigatti
Peter Macdonald
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SICOR Societa Italiana Corticosteroidi SRL
Original Assignee
SICOR Societa Italiana Corticosteroidi SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11360401&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2107546(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by SICOR Societa Italiana Corticosteroidi SRL filed Critical SICOR Societa Italiana Corticosteroidi SRL
Application granted granted Critical
Publication of ES2107546T3 publication Critical patent/ES2107546T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

SE PRESENTA UN PROCESO PARA PRODUCIR NUEVOS DMEP-(BETA)-D-GLUCOSIDOS DE LA FORMULA (I), EN LA QUE R1 ES UN GRUPO DE ALCANOIL, UN GRUPO DE HALOACETIL, O AMBAS R1, TOMADAS JUNTAS, FORMAN UN GRUPO DE HETEROARILALQUILIDENO, ALQUILIDENO, O ARILALQUILIDENO; R2 ES UN GRUPO DE HALOACETIL O ALCANOIL INFERIOR; R4 ES HIDROGENO, QUE SE CARACTERIZA EN QUE UN COMPUESTO DE LA FORMULA (III) EN EL QUE R4 ES HIDROGENO, SE HACE REACCIONAR CON UN COMPUESTO DE LA FORMULA (II) EN DONDE R1 ES UN GRUPO DE ALCANOIL INFERIOR, UN GRUPO DE HALOACETIL, O AMBAS R1, TOMADAS JUNTAS, FORMAN UN GRUPO DE HETEROARILALQUILIDENO, ARILALQUILIDENO O ALQUILIDENO; R2 ES UN GRUPO DE HALOACETIL O ALCANOIL INFERIOR; R3 ES HIDROGENO O UN GRUPO DE TRIALQUILSILIL, EN LA PRESENCIA DE UN ACIDO LEWIS TAL COMO TRIFLUORURO DE BORO. LOS COMPUESTOS DE LA FORMULA (I) ASI PREPARADOS SON PRODUCTOS INTERMEDIOS VALIOSOS PARA LA PRODUCCION DE DMEP-(BETA)-D-GLUCOSIDOS INCLUYENDO ETOPOSIDO (I, AMBAS R1 = ETILIDENO, R2 = H, R4 = H) Y TENIPOSIDO (I, R1 =TENILIDENO, R2 = H, R4 = H).
ES92915482T 1991-07-23 1992-07-15 Procedimiento para la preparacion de desmetilepipodofilotoxina. Expired - Lifetime ES2107546T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI912025A IT1250692B (it) 1991-07-23 1991-07-23 Procedimento per la preparazione di demetilepipodofillotossina- beta-d-glucosidi.

Publications (1)

Publication Number Publication Date
ES2107546T3 true ES2107546T3 (es) 1997-12-01

Family

ID=11360401

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92915482T Expired - Lifetime ES2107546T3 (es) 1991-07-23 1992-07-15 Procedimiento para la preparacion de desmetilepipodofilotoxina.

Country Status (16)

Country Link
US (1) US5688925A (es)
EP (1) EP0595888B1 (es)
JP (1) JP3231765B2 (es)
AT (1) ATE159026T1 (es)
AU (1) AU666322B2 (es)
CA (1) CA2113894C (es)
DE (1) DE69222643T2 (es)
DK (1) DK0595888T3 (es)
ES (1) ES2107546T3 (es)
FI (1) FI110782B (es)
GR (1) GR3025729T3 (es)
IL (1) IL102610A (es)
IT (1) IT1250692B (es)
MX (1) MX9204334A (es)
WO (1) WO1993002094A1 (es)
ZA (1) ZA925515B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2191733T3 (es) * 1995-12-04 2003-09-16 Nippon Kayaku Kk Procedimiento para producir etoposido.
ES2206917T3 (es) * 1997-06-02 2004-05-16 Bristol-Myers Squibb Company Procedimiento de preparacion de etoposido.
CA2343803A1 (en) 1998-09-10 2000-03-23 Ragina Naidu Synthetic method for the preparation of the antineoplastic agent etoposide
FR2791681B1 (fr) * 1999-03-29 2001-06-22 Pf Medicament Nouveau procede de preparation de l'etoposide
GB0019124D0 (en) * 2000-08-03 2000-09-27 Pfizer Novel process
AU2006207321B2 (en) 2005-01-21 2012-09-06 Astex Therapeutics Limited Pharmaceutical compounds
JP5528807B2 (ja) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド 複合薬剤
JP5528806B2 (ja) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド 複合薬剤
TR201808733T4 (tr) 2011-10-03 2018-07-23 Mx Adjuvac Ab Kanser tedavisini ve gıda ile ilgili bileşikleri içeren tıp alanlarında amfipatik veya hidrofobik moleküller için taşıyıcı olarak nano-parçacıklar, preparasyon için proses ve bunların kullanımı.
WO2014163558A1 (en) 2013-04-01 2014-10-09 Moreinx Ab Nanoparticles, composed of sterol and saponin from quillaja saponaria molina process for preparation and use thereof as carrier for amphipatic of hydrphobic molecules in fields of medicine including cancer treatment and food related compounds
EP3616688A1 (en) 2018-08-27 2020-03-04 Centre National de la Recherche Scientifique - CNRS Preparation of nanosuspension comprising nanocrystals of active pharmaceutical ingredients with little or no stabilizing agents
EP3669890A1 (en) 2018-12-18 2020-06-24 Croda International PLC Filamentous nanoparticles having vaccine adjuvant effect
CN113121618A (zh) * 2021-04-07 2021-07-16 梯尔希（南京）药物研发有限公司 两种依托泊苷杂质的制备方法
CN115197281B (zh) * 2021-04-09 2024-06-14 四川汇宇制药股份有限公司 依托泊苷中间体的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3374317D1 (en) * 1982-11-26 1987-12-10 Nippon Kayaku Kk Process for producing 4'-demethyl-epipodophyllotoxin-beta-d-ethylidene-glucoside and acyl-derivative thereof
JPS60246393A (ja) * 1984-05-22 1985-12-06 Nippon Kayaku Co Ltd エトポシドの新規製造法
IL77334A (en) * 1985-12-16 1991-04-15 Univ Bar Ilan Synthesis of 9-epipodophyllotoxin glucoside derivatives and some novel intermediates therefor
DK39886D0 (da) * 1986-01-27 1986-01-27 Hans Goeran Magnusson Hydroxybeskyttelsesgrupper
US4904768A (en) * 1987-08-04 1990-02-27 Bristol-Myers Company Epipodophyllotoxin glucoside 4'-phosphate derivatives
US4965348A (en) * 1989-05-19 1990-10-23 Bristol-Myers Company Dimeric epipodophyllotoxin glucoside derivatives
US5036055A (en) * 1989-06-07 1991-07-30 Bristol-Myers Company Acylated derivatives of etoposide
DE3935016A1 (de) * 1989-10-20 1991-04-25 Behringwerke Ag Glycosyl-etoposid-prodrugs, verfahren zu ihrer herstellung und ihre anwendung in kombination mit funktionalisiertem tumorspezifischen enzym-konjugaten
FR2658824B1 (fr) * 1990-02-27 1992-07-03 Pf Medicament Tris acetyl-2",3",4' ethylidene-4",6" beta-d-glucopyranosides, leur preparation et leur utilisation pour la preparation d'ethylidene beta-d-glucopyranoside de demethyl-4' epipodophyllotoxine.
US5081234A (en) * 1990-04-30 1992-01-14 Bristol-Myers Squibb Co. 4'-demethylepipodophyllotoxin glycosides
CN1025918C (zh) * 1990-06-07 1994-09-14 国家医药管理局上海医药工业研究院 抗肿瘤药表鬼臼毒吡喃糖甙的合成新工艺

Also Published As

Publication number Publication date
ZA925515B (en) 1993-04-28
US5688925A (en) 1997-11-18
MX9204334A (es) 1993-02-01
EP0595888B1 (en) 1997-10-08
FI940280A0 (fi) 1994-01-20
CA2113894C (en) 2003-12-16
JPH06509334A (ja) 1994-10-20
ATE159026T1 (de) 1997-10-15
IL102610A (en) 1997-03-18
ITMI912025A0 (it) 1991-07-23
AU666322B2 (en) 1996-02-08
AU2326592A (en) 1993-02-23
EP0595888A1 (en) 1994-05-11
DE69222643D1 (de) 1997-11-13
IT1250692B (it) 1995-04-21
DK0595888T3 (da) 1998-05-18
FI110782B (fi) 2003-03-31
DE69222643T2 (de) 1998-02-05
FI940280L (fi) 1994-01-20
GR3025729T3 (en) 1998-03-31
JP3231765B2 (ja) 2001-11-26
ITMI912025A1 (it) 1993-01-23
CA2113894A1 (en) 1993-02-04
WO1993002094A1 (en) 1993-02-04

Similar Documents

Publication Publication Date Title
ES2107546T3 (es) Procedimiento para la preparacion de desmetilepipodofilotoxina.
ES2086505T3 (es) Procedimiento de preparacion de un derivado n-fenilacetico de tetrahidrotieno(3,2-c)piridina y su producto intermedio de sintesis.
ES391497A1 (es) Procedimiento para la preparacion de nuevos derivados de ciclohepteno.
ES2007543A6 (es) Procedimiento de preparacion de 1,4-dihidropiridinas.
AR241593A1 (es) Procedimiento para preparar derivados de acido quinolin-3-carboxilico.
ES2071016T3 (es) Derivados de piridazinona.
ES2043785T3 (es) Procedimiento para la preparacion de 9(11)-deshidro-esteroides.
PE26691A1 (es) Procedimiento de preparacion de azabencimidazoles, utiles en el tratamiento de asma, artritis y enfermedades relacionadas
AR245935A1 (es) Procedimiento para la preparacion de alquil-1 nitro-5 imidazoles.
ES8300332A1 (es) Un procedimiento para la preparacion de nuevos derivados de imidazoquinazolinas
ES8706602A1 (es) Un procedimiento para preparar eteres alcoximetilicos y esteres alcoximetilicos de gliceroles
HUT40793A (en) Process for preparing hexene-carboxylic acid derivatives
IT1228972B (it) Procedimento per la preparazione di acido 3 alfa 7 beta diidrossicolanico di elevata purezza.
ES2055429T3 (es) Proceso para preparar derivados del acido 9-alfa-hidroxi-3-oxo-4,24(25)-estigmastadieno-26-oico, asi como composiciones farmaceuticas que contienen estos compuestos.
HUT48262A (en) Onestage process for producing mixed substituted 1,2-diacyl-sn-glycero-3-phosphokolines
UA6027A1 (uk) Спосіб одержання похідних ерголіна або його солей
ES2104897T3 (es) Preparacion de compuestos de fosforo sustituidos con 2-(piridil)etilo.
ES8106489A1 (es) Un procedimiento para la preparacion de un derivado de 15 sulfonamidoprostaglandina.
JPS53108933A (en) Production of amidinoformic acid derivative
JPS5728095A (en) Production of ethynylmagnesium chloride
JPS6446A (en) Production of 4-hydroxy-2-cyclopentenone derivative
ES8301872A1 (es) Un procedimiento para la preparacion de nuevos derivados de 4-2-hidroxi-4(sustituido) fenil-naftalen-2-1h-onas y 2-oles.
JPS5430144A (en) Preparation of isocamphane
ES459401A1 (es) Un procedimiento para la produccion de nuevos compuestos 6, 11-dihidrodibenzo b.e.tiepin- -11-ona
JPS5663953A (en) Novel preparation of n- 1-ethyl-2-pyrrolidinylmethyl -2- methoxy-5-sulfamoylbenzamide

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 595888

Country of ref document: ES