DE69222643D1 - Verfahren zur herstellung von demethylepypodophyllotoxin - Google Patents

Verfahren zur herstellung von demethylepypodophyllotoxin

Info

Publication number
DE69222643D1
DE69222643D1 DE69222643T DE69222643T DE69222643D1 DE 69222643 D1 DE69222643 D1 DE 69222643D1 DE 69222643 T DE69222643 T DE 69222643T DE 69222643 T DE69222643 T DE 69222643T DE 69222643 D1 DE69222643 D1 DE 69222643D1
Authority
DE
Germany
Prior art keywords
demethylepipodophyllotoxin
beta
alkylidene
react
ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69222643T
Other languages
English (en)
Other versions
DE69222643T2 (de
Inventor
Pietro Allevi
Mario Anastasia
Ettore Bigatti
Peter Macdonald
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SICOR Societa Italiana Corticosteroidi SRL
Original Assignee
SICOR Societa Italiana Corticosteroidi SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11360401&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69222643(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by SICOR Societa Italiana Corticosteroidi SRL filed Critical SICOR Societa Italiana Corticosteroidi SRL
Publication of DE69222643D1 publication Critical patent/DE69222643D1/de
Application granted granted Critical
Publication of DE69222643T2 publication Critical patent/DE69222643T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69222643T 1991-07-23 1992-07-15 Verfahren zur herstellung von demethylepypodophyllotoxin Expired - Fee Related DE69222643T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI912025A IT1250692B (it) 1991-07-23 1991-07-23 Procedimento per la preparazione di demetilepipodofillotossina- beta-d-glucosidi.
PCT/EP1992/001605 WO1993002094A1 (en) 1991-07-23 1992-07-15 A process for the preparation of demethylepypodophyllotoxin

Publications (2)

Publication Number Publication Date
DE69222643D1 true DE69222643D1 (de) 1997-11-13
DE69222643T2 DE69222643T2 (de) 1998-02-05

Family

ID=11360401

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69222643T Expired - Fee Related DE69222643T2 (de) 1991-07-23 1992-07-15 Verfahren zur herstellung von demethylepypodophyllotoxin

Country Status (16)

Country Link
US (1) US5688925A (de)
EP (1) EP0595888B1 (de)
JP (1) JP3231765B2 (de)
AT (1) ATE159026T1 (de)
AU (1) AU666322B2 (de)
CA (1) CA2113894C (de)
DE (1) DE69222643T2 (de)
DK (1) DK0595888T3 (de)
ES (1) ES2107546T3 (de)
FI (1) FI110782B (de)
GR (1) GR3025729T3 (de)
IL (1) IL102610A (de)
IT (1) IT1250692B (de)
MX (1) MX9204334A (de)
WO (1) WO1993002094A1 (de)
ZA (1) ZA925515B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69627277T2 (de) * 1995-12-04 2004-03-04 Nippon Kayaku K.K. Verfahren zur Herstellung von Etoposide
DE69818460T2 (de) * 1997-06-02 2004-07-01 Bristol-Myers Squibb Co., Wallingford Verfahren zur herstellung von etoposid
EP1117671A2 (de) * 1998-09-10 2001-07-25 Phytogen Life Sciences Inc. Verfahren zur herstellung von dem antineoplastischen wirkstoff etoposid
FR2791681B1 (fr) * 1999-03-29 2001-06-22 Pf Medicament Nouveau procede de preparation de l'etoposide
GB0019124D0 (en) * 2000-08-03 2000-09-27 Pfizer Novel process
CN101146532B (zh) 2005-01-21 2012-05-09 阿斯泰克斯治疗有限公司 药物化合物
WO2008044045A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
JP5528806B2 (ja) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド 複合薬剤
IN2014DN03485A (de) 2011-10-03 2015-06-05 Moreinx Ab
WO2014163558A1 (en) 2013-04-01 2014-10-09 Moreinx Ab Nanoparticles, composed of sterol and saponin from quillaja saponaria molina process for preparation and use thereof as carrier for amphipatic of hydrphobic molecules in fields of medicine including cancer treatment and food related compounds
EP3616688A1 (de) 2018-08-27 2020-03-04 Centre National de la Recherche Scientifique - CNRS Herstellung von nanosuspensionshaltigen nanokristallen von pharmazeutischen wirkstoffen mit geringen oder keinen stabilisatoren
EP3669890A1 (de) 2018-12-18 2020-06-24 Croda International PLC Filamentöse nanopartikel mit impfstoffadjuvanswirkung
CN113121618A (zh) * 2021-04-07 2021-07-16 梯尔希（南京）药物研发有限公司 两种依托泊苷杂质的制备方法
CN115197281A (zh) * 2021-04-09 2022-10-18 四川汇宇制药股份有限公司 依托泊苷中间体的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0111058B1 (de) * 1982-11-26 1987-11-04 Nippon Kayaku Kabushiki Kaisha Verfahren zur Herstellung von 4'-Demethyl-epipodophylotoxin-beta-D-ethyliden-glucosid und Acylderivate davon
JPS60246393A (ja) * 1984-05-22 1985-12-06 Nippon Kayaku Co Ltd エトポシドの新規製造法
IL77334A (en) * 1985-12-16 1991-04-15 Univ Bar Ilan Synthesis of 9-epipodophyllotoxin glucoside derivatives and some novel intermediates therefor
DK39886D0 (da) * 1986-01-27 1986-01-27 Hans Goeran Magnusson Hydroxybeskyttelsesgrupper
US4904768A (en) * 1987-08-04 1990-02-27 Bristol-Myers Company Epipodophyllotoxin glucoside 4'-phosphate derivatives
US4965348A (en) * 1989-05-19 1990-10-23 Bristol-Myers Company Dimeric epipodophyllotoxin glucoside derivatives
US5036055A (en) * 1989-06-07 1991-07-30 Bristol-Myers Company Acylated derivatives of etoposide
DE3935016A1 (de) * 1989-10-20 1991-04-25 Behringwerke Ag Glycosyl-etoposid-prodrugs, verfahren zu ihrer herstellung und ihre anwendung in kombination mit funktionalisiertem tumorspezifischen enzym-konjugaten
FR2658824B1 (fr) * 1990-02-27 1992-07-03 Pf Medicament Tris acetyl-2",3",4' ethylidene-4",6" beta-d-glucopyranosides, leur preparation et leur utilisation pour la preparation d'ethylidene beta-d-glucopyranoside de demethyl-4' epipodophyllotoxine.
US5081234A (en) * 1990-04-30 1992-01-14 Bristol-Myers Squibb Co. 4'-demethylepipodophyllotoxin glycosides
CN1025918C (zh) * 1990-06-07 1994-09-14 国家医药管理局上海医药工业研究院 抗肿瘤药表鬼臼毒吡喃糖甙的合成新工艺

Also Published As

Publication number Publication date
CA2113894A1 (en) 1993-02-04
AU2326592A (en) 1993-02-23
US5688925A (en) 1997-11-18
ZA925515B (en) 1993-04-28
FI110782B (fi) 2003-03-31
FI940280A0 (fi) 1994-01-20
CA2113894C (en) 2003-12-16
JP3231765B2 (ja) 2001-11-26
EP0595888B1 (de) 1997-10-08
AU666322B2 (en) 1996-02-08
JPH06509334A (ja) 1994-10-20
IT1250692B (it) 1995-04-21
GR3025729T3 (en) 1998-03-31
ES2107546T3 (es) 1997-12-01
IL102610A (en) 1997-03-18
FI940280A (fi) 1994-01-20
ATE159026T1 (de) 1997-10-15
MX9204334A (es) 1993-02-01
WO1993002094A1 (en) 1993-02-04
ITMI912025A1 (it) 1993-01-24
EP0595888A1 (de) 1994-05-11
DE69222643T2 (de) 1998-02-05
ITMI912025A0 (it) 1991-07-23
DK0595888T3 (da) 1998-05-18

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Legal Events

Date Code Title Description
8363 Opposition against the patent
8339 Ceased/non-payment of the annual fee