ES2191733T3 - Procedimiento para producir etoposido. - Google Patents
Procedimiento para producir etoposido.Info
- Publication number
- ES2191733T3 ES2191733T3 ES96119336T ES96119336T ES2191733T3 ES 2191733 T3 ES2191733 T3 ES 2191733T3 ES 96119336 T ES96119336 T ES 96119336T ES 96119336 T ES96119336 T ES 96119336T ES 2191733 T3 ES2191733 T3 ES 2191733T3
- Authority
- ES
- Spain
- Prior art keywords
- protected
- halogen
- type
- epipodofilotoxina
- demetil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
UNA 4''-DEMETIL-4-EPIPODOFILOTOXINA PROTEGIDA SE HACE REACCIONAR CON UN DERIVADO DE GLUCOSA PROTEGIDO EN UN SOLVENTE ORGANICO DE TIPO NO HALOGENO EN UNA PARTE DE 0,1 A 7 PARTES POR VOLUMEN BASADO EN 1 PARTE POR PESO DE LA 4''-DEMETIL-4-EPIPODOFILOTOXINA PROTEGIDA PARA PROPORCIONAR UN DERIVADO DE ETOPOSIDO DE FORMULA (3) QUE ESTE PROTEGIDO EN SUS GRUPOS FUNCIONALES: EN DONDE CADA R{SUB,1} Y R{SUB,2} ES CADA UNO UN GRUPO PROTECTOR, SEGUIDO DE LA RETIRADA DE ESTOS GRUPOS PROTECTORES. MEDIANTE EL USO DEL SOLVENTE ORGANICO DE TIPO NO HALOGENO EN LUGAR DE CUALQUIER SOLVENTE DE TIPO HALOGENO PELIGROSO, LA FORMACION DE SUBPRODUCTOS NO DESEABLES PUEDE SER MINIMIZADA DE FORMA QUE LOS ETOPOSIDOS PUEDAN OBTENERSE EN UN ALTO RENDIMIENTO Y ELEVADA PUREZA.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP33772095 | 1995-12-04 | ||
JP34511495 | 1995-12-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2191733T3 true ES2191733T3 (es) | 2003-09-16 |
Family
ID=26575893
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES96119336T Expired - Lifetime ES2191733T3 (es) | 1995-12-04 | 1996-12-03 | Procedimiento para producir etoposido. |
Country Status (9)
Country | Link |
---|---|
US (1) | US5821348A (es) |
EP (1) | EP0778282B1 (es) |
KR (1) | KR100414706B1 (es) |
CN (1) | CN1067402C (es) |
AU (1) | AU712060B2 (es) |
DE (1) | DE69627277T2 (es) |
ES (1) | ES2191733T3 (es) |
IL (1) | IL119749A (es) |
TW (1) | TW416959B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2343803A1 (en) | 1998-09-10 | 2000-03-23 | Ragina Naidu | Synthetic method for the preparation of the antineoplastic agent etoposide |
AU775373B2 (en) | 1999-10-01 | 2004-07-29 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
CN1101819C (zh) * | 1999-10-21 | 2003-02-19 | 国家医药管理局上海医药工业研究院 | 具有抗肿瘤活性的4-β-碳取代-4-脱氧-4'-去甲表鬼臼毒素衍生物及合成方法和中间体 |
US6894075B2 (en) | 2000-11-20 | 2005-05-17 | Song-Bae Kim | 4′-demethyl-4′-O-substituted-1-deoxypodophyllotoxin derivative and geometric isomer thereof, process for the preparation thereof and anti-cancer composition comprising the same |
CN105566412A (zh) * | 2016-01-18 | 2016-05-11 | 江西师范大学 | 一种依托泊苷和替尼泊苷及其类似物的制备方法 |
CN112079879B (zh) * | 2020-08-21 | 2022-01-14 | 华润双鹤药业股份有限公司沧州分公司 | 一种替尼泊苷中间体的合成新方法及替尼泊苷的合成方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60246393A (ja) * | 1984-05-22 | 1985-12-06 | Nippon Kayaku Co Ltd | エトポシドの新規製造法 |
DE3913326A1 (de) | 1989-04-22 | 1990-11-08 | Behringwerke Ag | Verfahren zur herstellung von etoposiden |
DE3913327A1 (de) * | 1989-04-22 | 1990-10-25 | Behringwerke Ag | Verfahren zur herstellung von glucosaminyl-epi-podo-phyllotoxin-derivaten |
CA2017916C (en) * | 1989-06-07 | 1999-02-02 | Minoru Aoki | Etoposide preparations |
US5036055A (en) * | 1989-06-07 | 1991-07-30 | Bristol-Myers Company | Acylated derivatives of etoposide |
IT1250692B (it) * | 1991-07-23 | 1995-04-21 | Procedimento per la preparazione di demetilepipodofillotossina- beta-d-glucosidi. | |
US5459248A (en) * | 1993-11-04 | 1995-10-17 | Bristol-Myers Squibb Company | Process of preparing etoposide phosphate and etoposide |
-
1996
- 1996-12-03 EP EP96119336A patent/EP0778282B1/en not_active Expired - Lifetime
- 1996-12-03 ES ES96119336T patent/ES2191733T3/es not_active Expired - Lifetime
- 1996-12-03 DE DE69627277T patent/DE69627277T2/de not_active Expired - Lifetime
- 1996-12-03 IL IL11974996A patent/IL119749A/xx not_active IP Right Cessation
- 1996-12-04 TW TW085114942A patent/TW416959B/zh not_active IP Right Cessation
- 1996-12-04 AU AU74141/96A patent/AU712060B2/en not_active Ceased
- 1996-12-04 CN CN96121862A patent/CN1067402C/zh not_active Expired - Lifetime
- 1996-12-04 US US08/760,647 patent/US5821348A/en not_active Expired - Lifetime
- 1996-12-04 KR KR1019960061554A patent/KR100414706B1/ko not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
US5821348A (en) | 1998-10-13 |
IL119749A (en) | 2001-03-19 |
TW416959B (en) | 2001-01-01 |
KR100414706B1 (ko) | 2004-07-27 |
DE69627277D1 (de) | 2003-05-15 |
AU712060B2 (en) | 1999-10-28 |
AU7414196A (en) | 1997-06-12 |
CN1067402C (zh) | 2001-06-20 |
IL119749A0 (en) | 1997-03-18 |
DE69627277T2 (de) | 2004-03-04 |
EP0778282B1 (en) | 2003-04-09 |
CN1154968A (zh) | 1997-07-23 |
EP0778282A1 (en) | 1997-06-11 |
KR970042580A (ko) | 1997-07-24 |
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