ES2089844T3 - Sistema de administracion de medicamentos a base de dicetopiperazina. - Google Patents

Sistema de administracion de medicamentos a base de dicetopiperazina.

Info

Publication number
ES2089844T3
ES2089844T3 ES93920574T ES93920574T ES2089844T3 ES 2089844 T3 ES2089844 T3 ES 2089844T3 ES 93920574 T ES93920574 T ES 93920574T ES 93920574 T ES93920574 T ES 93920574T ES 2089844 T3 ES2089844 T3 ES 2089844T3
Authority
ES
Spain
Prior art keywords
microparticles
stable
diketopiperazine
drug
dicetopiperazine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93920574T
Other languages
English (en)
Inventor
Robert Feldstein
John Glass
Solomon S Steiner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mannkind Corp
Original Assignee
Pharmaceutical Discovery Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmaceutical Discovery Corp filed Critical Pharmaceutical Discovery Corp
Application granted granted Critical
Publication of ES2089844T3 publication Critical patent/ES2089844T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Saccharide Compounds (AREA)

Abstract

SE HAN DESARROLLADO SISTEMAS DE DISTRIBUCION DEL MEDICAMENTO BASANDOSE EN LA FORMACION DE MICROPARTICULAS DE DICETOPIPERAZINA (O ANALOGOS). EN LA PUESTA EN PRACTICA PREFERENTE LA MICROPARTICULA ES ESTABLE A PH BAJO Y SE DESINTEGRA A PH FISIOLOGICO, Y ES PARTICULARMENTE UTIL PARA LA DISTRIBUCION ORAL DE MEDICAMENTOS. EN LA PUESTA EN PRACTICA MAS PREFERENTE LAS MICROPARTICULAS SE FORMAN EN PRESENCIA DEL MEDICAMENTO QUE VA A SER DISTRIBUIDO, POR EJEMPLO INSULINA O HEPARINA. LOS INTERMEDIOS SINTETICOS DE LA DICETOPIPERAZINA SE FORMAN PREFERIBLEMENTE MEDIANTE CICLODIMERIZACION PARA FORMAR DERIVADOS DE LA DICETOPIPERAZINA EN CONDICIONES ELEVADAS BAJO CONDICIONES DE DESHIDRATACION, LUEGO SE PRECIPITAN CON EL MEDICAMENTO PARA INCORPORARSE EN MICROPARTICULAS.
ES93920574T 1992-03-11 1993-03-11 Sistema de administracion de medicamentos a base de dicetopiperazina. Expired - Lifetime ES2089844T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/849,186 US5352461A (en) 1992-03-11 1992-03-11 Self assembling diketopiperazine drug delivery system

Publications (1)

Publication Number Publication Date
ES2089844T3 true ES2089844T3 (es) 1996-10-01

Family

ID=25305266

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93920574T Expired - Lifetime ES2089844T3 (es) 1992-03-11 1993-03-11 Sistema de administracion de medicamentos a base de dicetopiperazina.

Country Status (11)

Country Link
US (2) US5352461A (es)
EP (1) EP0630236B1 (es)
JP (1) JP2617273B2 (es)
AT (1) ATE132744T1 (es)
AU (1) AU680408B2 (es)
CA (1) CA2131366C (es)
DE (1) DE69301311T2 (es)
DK (1) DK0630236T3 (es)
ES (1) ES2089844T3 (es)
GR (1) GR3019622T3 (es)
WO (1) WO1993018754A1 (es)

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US5352461A (en) 1994-10-04
AU680408B2 (en) 1997-07-31
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EP0630236A1 (en) 1994-12-28
JP2617273B2 (ja) 1997-06-04
DE69301311D1 (de) 1996-02-22
US5503852A (en) 1996-04-02
WO1993018754A1 (en) 1993-09-30
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GR3019622T3 (en) 1996-07-31
DK0630236T3 (da) 1996-06-03

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