BR0313613A - Variantes do principal alérgeno phl p 1 de capim-timóteo - Google Patents

Variantes do principal alérgeno phl p 1 de capim-timóteo

Info

Publication number
BR0313613A
BR0313613A BR0313613-2A BR0313613A BR0313613A BR 0313613 A BR0313613 A BR 0313613A BR 0313613 A BR0313613 A BR 0313613A BR 0313613 A BR0313613 A BR 0313613A
Authority
BR
Brazil
Prior art keywords
phl
timothy grass
variants
main
main allergen
Prior art date
Application number
BR0313613-2A
Other languages
English (en)
Other versions
BRPI0313613B1 (pt
Inventor
Roland Suck
Helmut Fiebig
Oliver Cromwell
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of BR0313613A publication Critical patent/BR0313613A/pt
Publication of BRPI0313613B1 publication Critical patent/BRPI0313613B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Botany (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Otolaryngology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

"VARIANTES DO PRINCIPAL ALéRGENO PHL P1 DE CAPIM-TIMóTEO". A presente invenção refere-se a variantes do principal alérgeno Phl p 1 de capim-timóteo, caracterizadas pelo fato de que uma preparação, até então não possível, de moléculas monoméricas que são solúveis e estáveis no meio fisiológico, pode ser realizada com a ajuda de sistemas de expressão procariótica e subseq³ente purificação das mesmas.
BRPI0313613A 2002-08-19 2003-07-31 variantes do principal alérgeno phl p 1 de capim-timóteo, suas formas de enovelamento lm e hm, seus usos e seus processos de preparação e de purificação, molécula de dna, vetor de expressão de dna recombinante e seu uso, e composições farmacêuticas BRPI0313613B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02018157 2002-08-19
PCT/EP2003/008471 WO2004022588A1 (de) 2002-08-19 2003-07-31 Varianten des majorallergens phl p 1 aus lieschgras

Publications (2)

Publication Number Publication Date
BR0313613A true BR0313613A (pt) 2005-06-21
BRPI0313613B1 BRPI0313613B1 (pt) 2016-06-07

Family

ID=31970262

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0313613A BRPI0313613B1 (pt) 2002-08-19 2003-07-31 variantes do principal alérgeno phl p 1 de capim-timóteo, suas formas de enovelamento lm e hm, seus usos e seus processos de preparação e de purificação, molécula de dna, vetor de expressão de dna recombinante e seu uso, e composições farmacêuticas

Country Status (12)

Country Link
US (2) US7731970B2 (pt)
EP (1) EP1532169B1 (pt)
JP (2) JP4668616B2 (pt)
CN (1) CN100509844C (pt)
AU (1) AU2003251674B2 (pt)
BR (1) BRPI0313613B1 (pt)
CA (1) CA2495825C (pt)
ES (1) ES2400181T3 (pt)
PL (1) PL212891B1 (pt)
PT (1) PT1532169E (pt)
RU (1) RU2323942C2 (pt)
WO (1) WO2004022588A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100509844C (zh) * 2002-08-19 2009-07-08 默克专利股份公司 来自梯牧草的主要过敏原Phl p1的变异体
DE102004035337A1 (de) * 2004-07-21 2006-03-16 Merck Patent Gmbh Varianten der Gruppe 1-Allergene aus Poaceae mit reduzierter Allergenität und erhaltener T-Zellreaktivität
KR20140129124A (ko) 2012-02-07 2014-11-06 라 졸라 인스티튜트 포 앨러지 앤드 이뮤놀로지 티모시 그라스 알레르겐들 및 면역반응 조절을 위한 방법들 및 용도들
JP6102442B2 (ja) * 2013-04-04 2017-03-29 日産自動車株式会社 リチウムイオン二次電池
JOP20210197A1 (ar) * 2019-01-17 2023-01-30 Leti Pharma S L طريقة تنقية مستخلص مسبب للحساسية

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992003550A1 (en) * 1990-08-17 1992-03-05 The University Of Melbourne Ryegrass pollen allergen
IL115177A0 (en) * 1994-09-16 1995-12-31 Immunomedics Inc Phosphorus-32 labeling of antibodies for cancer therapy
US6281332B1 (en) * 1994-12-02 2001-08-28 The Johns Hopkins University School Of Medicine Hedgehog-derived polypeptides
WO1998030576A1 (en) * 1996-10-07 1998-07-16 The Johns Hopkins University School Of Medicine Novel hedgehog-derived polypeptides
JP2002500198A (ja) * 1998-01-09 2002-01-08 サーカシア リミテッド 脱感作のための方法及び組成物
US20070011783A1 (en) * 1999-05-06 2007-01-11 Jingdong Liu Nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement
US20100293669A2 (en) * 1999-05-06 2010-11-18 Jingdong Liu Nucleic Acid Molecules and Other Molecules Associated with Plants and Uses Thereof for Plant Improvement
IT1318692B1 (it) 2000-09-12 2003-08-27 Consiglio Nazionale Ricerche Varianti di proteine allergeniche di phleum pratense.
US7001743B2 (en) * 2001-04-19 2006-02-21 The Penn State Research Foundation Expansin polynucleotides, related polypeptides and methods of use
CN100509844C (zh) * 2002-08-19 2009-07-08 默克专利股份公司 来自梯牧草的主要过敏原Phl p1的变异体

Also Published As

Publication number Publication date
BRPI0313613B1 (pt) 2016-06-07
JP2006516382A (ja) 2006-07-06
CA2495825A1 (en) 2004-03-18
RU2005107782A (ru) 2005-11-20
PL373069A1 (en) 2005-08-08
US7731970B2 (en) 2010-06-08
PL212891B1 (pl) 2012-12-31
JP5868587B2 (ja) 2016-02-24
WO2004022588A1 (de) 2004-03-18
AU2003251674A1 (en) 2004-03-29
CA2495825C (en) 2015-03-17
ES2400181T3 (es) 2013-04-08
JP2011097940A (ja) 2011-05-19
PT1532169E (pt) 2013-03-18
US9453058B2 (en) 2016-09-27
EP1532169A1 (de) 2005-05-25
RU2323942C2 (ru) 2008-05-10
CN100509844C (zh) 2009-07-08
JP4668616B2 (ja) 2011-04-13
AU2003251674B2 (en) 2009-09-03
CN1675240A (zh) 2005-09-28
US20120263741A1 (en) 2012-10-18
US20060251682A1 (en) 2006-11-09
EP1532169B1 (de) 2012-12-19

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according art. 34 industrial property law
B07D Technical examination (opinion) related to article 229 of industrial property law
B07E Notice of approval relating to section 229 industrial property law

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06A Notification to applicant to reply to the report for non-patentability or inadequacy of the application according art. 36 industrial patent law
B06A Notification to applicant to reply to the report for non-patentability or inadequacy of the application according art. 36 industrial patent law
B09A Decision: intention to grant
B16A Patent or certificate of addition of invention granted

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 07/06/2016, OBSERVADAS AS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 15A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2473 DE 29-05-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.